| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of reproduction. vol 80. issue 6. 2009-07-30. PMID:19208546. |
therefore, the induction of apoptosis by pgr antagonists cannot be explained by decreased p4 synthesis alone. |
2009-07-30 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of reproduction. vol 80. issue 6. 2009-07-30. PMID:19208546. |
as little as 10 nm of two different pgr antagonists (org 31710 and ru 486) increased apoptosis measured as caspase 3/7 activity, which was reversed by cotreatment with the progestin r5020. |
2009-07-30 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Emilia Rung, Håkan Billi. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Molecular reproduction and development. vol 74. issue 10. 2007-11-09. PMID:17342739. |
in this study we hypothesized that the mechanism by which the nuclear pgr antagonist org 31,710 induces apoptosis in rat periovulatory granulosa cells, is by decreasing cholesterol synthesis and thereby general cell protein isoprenylation. |
2007-11-09 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Emilia Rung, Håkan Billi. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Molecular reproduction and development. vol 74. issue 10. 2007-11-09. PMID:17342739. |
the mechanisms involved are unclear but progesterone receptor (pgr) antagonists have been shown to inhibit cholesterol synthesis and induce apoptosis. |
2007-11-09 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Emilia Rung, Håkan Billi. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Molecular reproduction and development. vol 74. issue 10. 2007-11-09. PMID:17342739. |
in conclusion, we demonstrate that the pgr antagonist inhibits cholesterol synthesis in granulosa cells but reduced protein isoprenylation is not the mediating mechanism of increased apoptosis as previously hypothesized. |
2007-11-09 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Emilia Rung, Håkan Billi. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Molecular reproduction and development. vol 74. issue 10. 2007-11-09. PMID:17342739. |
it has been suggested that pgr antagonists in a similar manner induce apoptosis by decreasing cholesterol synthesis and thereby protein isoprenylation. |
2007-11-09 |
2023-08-12 |
rat |
| Jianmin Chen, Krista A Power, Jaskaren Mann, Astor Cheng, Lilian U Thompso. Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 8. 2007-10-19. PMID:17720953. |
tumor cell proliferation was significantly positively associated with expression of pgr and igf-1 and negatively associated with apoptosis and eralpha. |
2007-10-19 |
2023-08-12 |
mouse |
| Carmela Beger, Katrin Gerdes, Melchior Lauten, Wim J E Tissing, Ivonne Fernandez-Munoz, Martin Schrappe, Karl Welt. Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach. British journal of haematology. vol 122. issue 2. 2003-09-16. PMID:12846893. |
these data were correlated with cell survival, demonstrating a more pronounced induction of apoptosis in cells from patients with pgr as compared with ppr. |
2003-09-16 |
2023-08-12 |
human |
| W R Miller, J M Dixon, L Macfarlane, D Cameron, T J Anderso. Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen. European journal of cancer (Oxford, England : 1990). vol 39. issue 4. 2003-06-19. PMID:12751376. |
morphological characteristics, grading features, proliferation marker mib1, apoptosis (by tdt-mediated dutp-biotin nick-end labelling (tunel)), bcl-2 expression, oestrogen receptor (er) and progesterone receptor (pgr) status were compared in er-positive breast cancers before and after 3 months of neoadjuvant therapy with either letrozole or tamoxifen. |
2003-06-19 |
2023-08-12 |
Not clear |
| S Detre, J Salter, D M Barnes, S Riddler, M Hills, S R Johnston, C Gillett, R A'Hern, M Dowset. Time-related effects of estrogen withdrawal on proliferation- and cell death-related events in MCF-7 xenografts. International journal of cancer. vol 81. issue 2. 1999-04-13. PMID:10188736. |
changes in proliferation (ki-67), apoptosis, er, progesterone receptor (pgr), cyclin d1, p27kip1, bcl-2 and bax expression were assessed during the 2 weeks after estrogen deprivation. |
1999-04-13 |
2023-08-12 |
mouse |