| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeyu Yang, Hongdan Chen, Supeng Yin, Hongbiao Mo, Fan Chai, Peng Luo, Yao Li, Le Ma, Ziying Yi, Yizeng Sun, Yan Chen, Jie Wu, Weihua Wang, Tingjie Yin, Junping Zhu, Chunmeng Shi, Fan Zhan. PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells. Cancer letters. 2024-03-31. PMID:38556106. |
furthermore, disruption of pgr-kitlg signaling by knocking down pgr or using the specific kitlg-ckit inhibitor isck03 potently enhanced the sensitivity of hr(+) bc cells to mc-induced apoptosis and exerted anti-tumor activity. |
2024-03-31 |
2024-04-03 |
Not clear |
| Martin Köhne, Emilia Diel, Eva-Maria Packeiser, Denny Böttcher, Anna Tönissen, Christin Unruh, Sandra Goericke-Pesch, Reiner Ulrich, Harald Siem. Analysis of gene and protein expression in the endometrium for validation of an ex vivo model of the equine uterus using PCR, digital and visual histopathology. Theriogenology. vol 221. 2024-03-27. PMID:38537320. |
mrna expression levels of progesterone (pgr), estrogen (esr1) and oxytocin (oxtr) receptor as well as of mki67 (marker of cell growth) and casp3 (marker of apoptosis) were analyzed by rt-qpcr, and correlation to protein abundance was validated by immunohistochemical staining. |
2024-03-27 |
2024-03-30 |
Not clear |
| Hongwei Duan, Shuai Yang, Jianlin Zeng, Jianshu Lv, Lihong Zhang, Xianghong Du, Junjie Hu, Yong Zhang, Xingxu Zha. The effect of melatonin on sheep endometrial epithelial cell apoptosis through the receptor and non-receptor pathways. General and comparative endocrinology. 2022-12-01. PMID:36455642. |
the results showed that melatonin inhibits the apoptosis of seecs to varying degrees to regulate the expression of estrogen receptors (ers) and progesterone receptors (pgr) via its interaction with mt1 and mt2. |
2022-12-01 |
2023-08-14 |
Not clear |
| Hongwei Duan, Shuai Yang, Jianlin Zeng, Jianshu Lv, Lihong Zhang, Xianghong Du, Junjie Hu, Yong Zhang, Xingxu Zha. The effect of melatonin on sheep endometrial epithelial cell apoptosis through the receptor and non-receptor pathways. General and comparative endocrinology. 2022-12-01. PMID:36455642. |
in addition, the er antagonist partially relieved the inhibitory effect of melatonin on the apoptosis of seecs, while the pgr antagonist did not. |
2022-12-01 |
2023-08-14 |
Not clear |
| Michał M Hryciuk, Katarina Jewgenow, Beate C Brau. Cloprostenol, a synthetic analog of prostaglandin F2α induces functional regression in cultured luteal cells of felids†. Biology of reproduction. vol 105. issue 1. 2021-11-17. PMID:33864060. |
gene-expression analysis by real-time pcr revealed that treatment with cloprostenol did not have an influence on expression of selected genes coding for enzymes of steroidogenesis (star, hsd3b, cyp11a1) or prostaglandin synthesis (ptgs2, pges), nor did it effect hormone receptors (ar, esr1, pgr, ptger2), an anti-oxidative enzyme (sod1) or factors of cell apoptosis (fas, casp3, tnfrsf1b, bcl2) over the studied period. |
2021-11-17 |
2023-08-13 |
cat |
| Ming Qi, Bie Tan, Jing Wang, Simeng Liao, Jianjun Li, Zhijuan Cui, Yirui Shao, Peng Ji, Yulong Yi. Postnatal growth retardation is associated with deteriorated intestinal mucosal barrier function using a porcine model. Journal of cellular physiology. vol 236. issue 4. 2021-09-20. PMID:32853405. |
our data demonstrated that pgr piglets exhibited impaired jejunal and ileal epithelial villous morphology and permeability, accompanied by decreased cell proliferation ability and increased apoptosis rate. |
2021-09-20 |
2023-08-13 |
Not clear |
| John Mark P Pabona, Alexander F Burnett, Dustin M Brown, Charles M Quick, Frank A Simmen, Maria Theresa E Montales, Shi J Liu, Tyler Rose, Iad Alhallak, Eric R Siegel, Rosalia Cm Simme. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 1. 2020-12-07. PMID:32046384. |
endometrial tumors obtained at surgery (met, n = 4; con, n = 4) were analyzed for proliferation (ki67), apoptosis (tunel), and nuclear expression of erα, pgr, pten, and klf9 proteins in tumor glandular epithelial (ge) and stromal (st) cells. |
2020-12-07 |
2023-08-13 |
human |
| Yasmin M Vasquez, Xiaoqiu Wang, Margeaux Wetendorf, Heather L Franco, Qianxing Mo, Tianyuan Wang, Rainer B Lanz, Steven L Young, Bruce A Lessey, Thomas E Spencer, John P Lydon, Francesco J DeMay. FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS genetics. vol 14. issue 11. 2019-02-26. PMID:30452456. |
analysis of the uterine transcriptome after foxo1 ablation identified alterations in gene expression for transcripts involved in the activation of cell invasion, molecular transport, apoptosis, β-catenin (ctnnb1) signaling pathway, and an increase in pgr signaling. |
2019-02-26 |
2023-08-13 |
mouse |
| Mahmoud Moussa, Meng-Qi Li, Hai-Ying Zheng, Chun-Yan Yang, Sheng-Fei Yan, Nong-Qi Yu, Jia-Xiang Huang, Jiang-Hua Shan. Buffalo oocyte-secreted factors promote cumulus cells apoptosis and the rate of cGMP production but not steroidogenesis. Reproduction in domestic animals = Zuchthygiene. vol 53. issue 6. 2019-01-23. PMID:30058188. |
after 24 hr of ivm, ccs were harvested for evaluation of the relative mrna abundance of the genes encoding gap junction (gja1), glycolysis (pfkp and ldha), apoptosis (caspase-3 and bcl-2) and steroidogenesis (er-β and pgr) by qrt-pcr, and caspase-3 proteins, using western blot. |
2019-01-23 |
2023-08-13 |
Not clear |
| M P Kirillina, K S Loskutova, E L Lushnikova, L M Nepomnyaschi. IMMUNOHISTOCHEMICAL ANALYSIS OF MAMMARY EPITHELIAL CELLS AT TUMORAL GROWTH IN REPUBLIC OF SAKHA (YAKUTIA). Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 68. issue 4. 2016-03-16. PMID:26887131. |
the analysis of results histological examination of surgical material of breast cancer from 294 women with subsequent immunohistochemical determination of estrogen (er)--and progesterone (pgr)--receptors, proliferative activity (ki-67), expression of the mutant suppressor gene (p53) and gene-inhibitor apoptosis (bcl-2) was carried out. |
2016-03-16 |
2023-08-13 |
Not clear |
| Hatice S Kaya, Alison M Hantak, Lisa J Stubbs, Robert N Taylor, Indrani C Bagchi, Milan K Bagch. Roles of progesterone receptor A and B isoforms during human endometrial decidualization. Molecular endocrinology (Baltimore, Md.). vol 29. issue 6. 2016-02-22. PMID:25875046. |
this study revealed the gene networks that operate downstream of each pgr isoform to mediate critical functions, such as regulation of the cell cycle, angiogenesis, lysosomal activation, insulin receptor signaling, and apoptosis, during decidualization in the human. |
2016-02-22 |
2023-08-13 |
human |
| Hitomi Kurose, Masa-Aki Shibata, Munekazu Iinuma, Yoshinori Otsuk. Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp. Journal of biomedicine & biotechnology. vol 2012. 2012-10-02. PMID:22577295. |
in this study, we investigated the influence of α-mangostin on apoptosis and cell cycle in the human breast cancer cell line mda-mb231 (carrying a p53 mutation, and her2, er, and pgr negative) in order to elucidate its anticancer mechanisms. |
2012-10-02 |
2023-08-12 |
mouse |
| Lesley-Ann Martin, Giles L S Davies, Marion T Weigel, Nadine Betambeau, Margaret J Hills, Janine Salter, Geraldine Walsh, Roger A'Hern, Mitch Dowset. Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. Breast cancer research and treatment. vol 123. issue 3. 2011-01-14. PMID:20697803. |
celecoxib did not significantly affect apoptosis, cox-2, er or pgr expression. |
2011-01-14 |
2023-08-12 |
Not clear |
| Lesley-Ann Martin, Giles L S Davies, Marion T Weigel, Nadine Betambeau, Margaret J Hills, Janine Salter, Geraldine Walsh, Roger A'Hern, Mitch Dowset. Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. Breast cancer research and treatment. vol 123. issue 3. 2011-01-14. PMID:20697803. |
paired baseline and endpoint biopsies were analysed for ki67, apoptosis, cox-2, cd31, estrogen receptor (er) and progesterone receptor (pgr). |
2011-01-14 |
2023-08-12 |
Not clear |
| Chen-Yu Liu, Michael C Wu, Feng Chen, Monica Ter-Minassian, Kofi Asomaning, Rihong Zhai, Zhaoxi Wang, Li Su, Rebecca S Heist, Matthew H Kulke, Xihong Lin, Geoffrey Liu, David C Christian. A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. vol 31. issue 7. 2010-07-12. PMID:20453000. |
in conclusion, this study suggests that the genetic variants of casp7 and casp9 in the apoptosis pathway may be important predictive markers for ea susceptibility and that pgr in the sex hormone signaling pathway may be associated with the gender differences in ea risk. |
2010-07-12 |
2023-08-12 |
Not clear |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Molecular and cellular endocrinology. vol 315. issue 1-2. 2010-07-05. PMID:19818377. |
we have identified novel, early gene targets of pgr that may be involved in the control of apoptosis and other biologically significant functions in periovulatory granulosa cells. |
2010-07-05 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Molecular and cellular endocrinology. vol 315. issue 1-2. 2010-07-05. PMID:19818377. |
progesterone, acting via the nuclear progesterone receptor (pgr), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of lh. |
2010-07-05 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of reproduction. vol 80. issue 6. 2009-07-30. PMID:19208546. |
inhibition of p4 synthesis was more effective in inducing apoptosis than treatment with pgr antagonists. |
2009-07-30 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of reproduction. vol 80. issue 6. 2009-07-30. PMID:19208546. |
inhibition of p4 synthesis by cyanoketone similarly induced apoptosis but required greater inhibition of p4 synthesis than that seen after treatment with pgr antagonists. |
2009-07-30 |
2023-08-12 |
rat |
| P Anders Friberg, D G Joakim Larsson, Håkan Billi. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of reproduction. vol 80. issue 6. 2009-07-30. PMID:19208546. |
however, cotreatment with pgr antagonists protected cells from the additional effects of cyanoketone, indicating partial agonist effects of the antagonists and a dominating role for pgr in p4-mediated regulation of apoptosis. |
2009-07-30 |
2023-08-12 |
rat |