| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaodan Xu, Yuanyuan He, Jungang Li. Berberine: A multifaceted agent for lung cancer treatment-from molecular insight to clinical applications. Gene. 2024-10-20. PMID:39427827. |
abbreviations: bbr, berberine; emt, epithelial-mesenchymal transition; nsclc, non-small cell lung cancer; ros, reactive oxygen species; ask1, apoptosis signal-regulating kinase 1; jnk, c-jun n-terminal kinase; bhc, berberine hydrochloride; dsb, double-strand breaks; csn, cop9 signalosome; nir, near-infrared; llc, lewis lung carcinoma; rtk, receptor tyrosine kinase; b-phyt-lcns, berberine-phytantriol liquid crystalline nanoparticles; er, endoplasmic reticulum; ber-lcns, berberine-loaded liquid crystalline nanoparticles; bns, berberine nanostructure; ber-cs-nps, berberine-loaded chitosan nanoparticles; b-phyt-lcns, berberine-phytantriol liquid crystalline nanoparticles; b-phyt-lcns, berberine-loaded liquid crystalline nanoparticles; ber-lcns, berberine-loaded liquid crystalline nanoparticles; b-zno nps, berberine-loaded zinc oxide nanoparticles; b-c60, berberine-c60 complex; ltp, low-temperature plasma. |
2024-10-20 |
2024-10-23 |
Not clear |
| Marwa H Hassan, Ibrahim A Emam, Haitham Farghali, Marwa A Ibrahim, Neven H Hassan, Khaled Y Farroh, Eman I Hassane. Toxicological screening of zinc oxide nanoparticles in mongrel dogs after seven days of repeated subcutaneous injections. BMC veterinary research. vol 20. issue 1. 2024-10-19. PMID:39425163. |
it was concluded that the daily sc injections of dogs with zno nps at concentrations of 50 and 100 ppm caused extensive oxidative stress damage in various organs which provoked serious pathological processes such as apoptosis and inflammation. |
2024-10-19 |
2024-10-21 |
Not clear |
| Xueyan Hou, Jingjing Xu, Yuxin Wang, Jingya Zhao, Yalin Guan, Xue Yang, Tenglong Xu, Kun Du, Sisi He, Yongli Sh. Triggering Pyroptosis by Doxorubicin-Loaded Multifunctional Nanoparticles in Combination with Decitabine for Breast Cancer Chemoimmunotherapy. ACS applied materials & interfaces. 2024-10-16. PMID:39413405. |
in vivo experiments further demonstrated the antitumor efficacy of dac + dox@fpsd nps, and the 4t1-bearing mice treated with dac + dox@fpsd nps exhibited reduced tumor volumes, minimized tumor weights, decreased ki67-positive cells, increased tunel apoptosis ratios, and pronounced lesions in h&e staining. |
2024-10-16 |
2024-10-19 |
mouse |
| Wenjun Hou, Yifan Zou, Jie Li, Hui Jiang, Jinyu Li, Jie Wu, Senlin Zhu, Yan Ding, Huae Xu, Feng Jia, Xiaolin L. Synergistic Therapy of Melanoma by Co-Delivery of Dacarbazine and Ferroptosis-Inducing Ursolic Acid Using Biomimetic Nanoparticles. ACS omega. vol 9. issue 40. 2024-10-14. PMID:39398166. |
mtt, apoptosis assay, wound healing assay, colony formation assay, and immunohistochemistry were used to assess the antitumor effect of nps and rnps. |
2024-10-14 |
2024-10-16 |
Not clear |
| Cai-Shi Lin, Meng-Qi He, Meng-Ying An, Qi-Hang Zhao, Zhou-Hang Zhang, Ke-Yu Deng, Yongjian Ai, Hong-Bo Xi. Ultra-Small Copper-Based Multienzyme-Like Nanoparticles Protect Against Hepatic Ischemia-Reperfusion Injury Through Scavenging Reactive Oxygen Species in Mice. Small (Weinheim an der Bergstrasse, Germany). 2024-10-08. PMID:39377344. |
finally, it is demonstrated that the protective effects of cmp nps on hepatic iri are related to suppressing inflammation and hepatocytic apoptosis and maintaining endothelial functions through scavenging ros in liver tissues. |
2024-10-08 |
2024-10-10 |
mouse |
| Jialong Fan, Yan Qin, Wensheng Qiu, Jiahao Liang, Chang Xiao, Qian Xie, Chunyi Tong, Liqin Yuan, Ying Long, Bin Li. Gamabufotalin loaded micro-nanocomposites for multimodal therapy of metastatic TNBC by efficiently inducing ICD. Biomaterials. vol 314. 2024-10-04. PMID:39366186. |
in vitro and in vivo results have confirmed that cs-6@cpb nps were efficiently delivered to neoplastic tissue by the tumor hypoxic chemotaxis property of s.lux, wherein the nanomedicine induced significant tumor cell necroptosis and apoptosis via photothermal therapy (ptt) of cpb nps and chemotherapy of cs-6, which elicited icd and inhibited pd-l1 expression, resulting in dendritic cells (dcs) maturation and effector t cells activation to comprehensively eliminate tumors. |
2024-10-04 |
2024-10-07 |
Not clear |
| Yiming Li, Yucong Ye, Xiaoyi Zhu, Siwen Li, Na Rihan, Zongli Yao, Zhen Sun, Pengcheng Gao, Yunlong Zhao, Qifang La. Polystyrene nanoplastics induce apoptosis, histopathological damage, and glutathione metabolism disorder in the intestine of juvenile East Asian river prawns (Macrobrachium nipponense). The Science of the total environment. 2024-10-04. PMID:39366565. |
therefore, we used nps concentrations of 0, 5, 10, 20, 40 mg/l for 28 days of stress, evaluated the effects of nps exposure on intestinal cell apoptosis, histopathological damage, and glutathione (gsh) metabolism of juvenile east asian river prawns (macrobrachium nipponense). |
2024-10-04 |
2024-10-07 |
Not clear |
| Yiming Li, Yucong Ye, Xiaoyi Zhu, Siwen Li, Na Rihan, Zongli Yao, Zhen Sun, Pengcheng Gao, Yunlong Zhao, Qifang La. Polystyrene nanoplastics induce apoptosis, histopathological damage, and glutathione metabolism disorder in the intestine of juvenile East Asian river prawns (Macrobrachium nipponense). The Science of the total environment. 2024-10-04. PMID:39366565. |
our results showed that exposure to nps may induce apoptosis of intestinal tissue cells, induce autophagy, and inhibit gsh metabolism, thereby reducing intestinal immune function of m. nipponense. |
2024-10-04 |
2024-10-07 |
Not clear |
| Congjian He, Jiahui Zhou, Xixi Wu, Yujin Zhou, Siya Wang, Bo Liu, Ting Luo, Ying Chen, Jia Yuan, Di Wang, Chen Zhang, Jinfeng Sh. Hyaluronic acid-zein shell-core biopolymer nanoparticles enhance hepatocellular carcinoma therapy of celastrol via CD44-mediated cellular uptake. International journal of biological macromolecules. 2024-10-01. PMID:39353524. |
further studies revealed that cel/zein@ha nps induced apoptosis in hepatocellular carcinoma cells by modulating bax and bcl-2 expression, while also inhibiting tumor angiogenesis by decreasing cd31 and vegf levels. |
2024-10-01 |
2024-10-05 |
mouse |
| Yijing Zhao, Cong Song, Haijun Wang, Chengcheng Gai, Tingting Li, Yahong Cheng, Junjie Liu, Yan Song, Qian Luo, Bing Gu, Weiyang Liu, Liwei Chai, Dexiang Liu, Zhen Wan. Polydopamine-Cloaked Nanoarchitectonics of Prussian Blue Nanoparticles Promote Functional Recovery in Neonatal and Adult Ischemic Stroke Models. Biomaterials research. vol 28. 2024-09-19. PMID:39296854. |
apart from attenuating oxidative stress, pb@pda nps also suppressed neuronal apoptosis and counteracted inflammation, which effectively promote a short- and long-term functional recovery in hi mice. |
2024-09-19 |
2024-09-21 |
mouse |
| Zihan Xing, Zimin Cai, Liuya Mi, Juan Zhang, Jiaying Wang, Lizhu Chen, Mingzhe Xu, Bangguo Ma, Ruijia Tao, Bowen Yang, Xinmeng Lv, Lei Wang, Yancui Zhao, Xiaoli Liu, Liping Yo. Toxic effects of ZnO NPs on immune response and tissue pathology in Mytilus galloprovincialis. Aquatic toxicology (Amsterdam, Netherlands). vol 276. 2024-09-17. PMID:39288657. |
there was a downward trend in lysosomal membrane stability of m. galloprovincialis after exposure to zno nps for 96 h and 30 days, while ros and apoptosis rates increased significantly. |
2024-09-17 |
2024-09-20 |
human |
| Rongkai Cao, Yuxin Guo, Jiayue Liu, Yaqiong Guo, Xiang Li, Fuwei Xie, Yaqing Wang, Jianhua Qi. Assessment of nanotoxicity in a human placenta-on-a-chip from trophoblast stem cells. Ecotoxicology and environmental safety. vol 285. 2024-09-17. PMID:39288735. |
subsequent analysis indicated that cuo nps disrupted the autophagic flux in trophoblasts and induced apoptosis. |
2024-09-17 |
2024-09-20 |
human |
| Hanan I Elhenawy, Noura A Toto, Abdelazeem S Eltaweil, Hussein K Hussein, Maria Augustyniak, Lamia M El-Sama. Assessing the toxicity of green Agaricus bisporus-based Cadmium Sulfide nanoparticles on Musca domestica as a biological model. Scientific reports. vol 14. issue 1. 2024-09-14. PMID:39277622. |
cds nps caused disruptions in heat shock protein 70, cell apoptosis, and various biochemical components. |
2024-09-14 |
2024-09-18 |
Not clear |
| Fatemeh Shiridokht, Hamed Dadashi, Somayeh Vandghanooni, Morteza Eskandani, Alireza Farajollah. Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy. Colloids and surfaces. B, Biointerfaces. vol 245. 2024-09-13. PMID:39270400. |
flow cytometry analysis demonstrated a 67.58 % apoptosis rate in cells pretreated with met nps, compared to 30.42 % in cells pretreated with plain metformin. |
2024-09-13 |
2024-09-16 |
Not clear |
| Shulin Liu, Muhammad Junaid, Chong Wang, Jun Wan. Eco-corona enhanced the interactive effects of nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonate in zebrafish embryos. The Science of the total environment. 2024-09-13. PMID:39270866. |
additionally, nfb (bsa-corona, 1 mg/l nps + 200 μg/l f-53b + 10 mg/l bsa), nfh (ha-corona, 1 mg/l nps + 200 μg/l f-53b + 10 mg/l ha) and nfhb (bsa-ha-corona, 1 mg/l nps + 200 μg/l f-53b + 10 mg/l bsa + 10 mg/l ha) showed elevated bioaccumulation of nps, ros generation and induction of apoptosis. |
2024-09-13 |
2024-09-16 |
cattle |
| Felicia Aswathy W, Jiya Jose, E I Anil. Assessing Anticancer Properties of PEGylated Platinum Nanoparticles on Human Breast Cancer Cell lines using in-vitro Assays. Biomedical physics & engineering express. 2024-09-11. PMID:39260382. |
in the dual staining apoptosis assay, it was observed that the mortality of cells cultured in conjunction with platinum nanoparticles intensified and the proliferative activity of mcf-7 cells gradually diminished over time in correlation with the increasing concentration of the pegylated pt nps sample. |
2024-09-11 |
2024-09-14 |
human |
| Le-Na Thi Nguyen, Xuan-Hai Do, Hanh B Pham, Dinh Duy-Thanh, Uyen Thi Trang Than, Thu-Huyen Nguyen, Van-Ba Nguyen, Duc-Son Le, Dinh-Thang Nguyen, Kien Trung Kieu, Phuc Trong Nguyen, Manh Duc Vu, Nghia Trung Tran, Thanh Lai Nguyen, Lien T H Nghiem, Toan D Nguyen, Nga Thi Hang Nguyen, Nhung-Thi My Hoan. Different Biocompatibility and Radioprotective Activity of Squid Melanin Nanoparticles on Human Stromal Cells. ACS omega. vol 9. issue 35. 2024-09-09. PMID:39246473. |
the expression levels of functional genes involved in angiogenesis, apoptosis, antioxidant activity, and radiation sensitivity were altered in nps subjected to huvecs but were not affected in hfbs and ucmscs. |
2024-09-09 |
2024-09-11 |
human |
| Zhen Liu, Junhong Ling, Nan Wang, Xiao-Kun Ouyan. Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy. Journal of colloid and interface science. vol 678. issue Pt A. 2024-09-05. PMID:39236435. |
in this paper, we developed novel copper-chelated polydopamine (pda) nanoparticles (nps) functionalized with hyaluronic acid (ha) (cu-pda-ha nps) to induce apoptosis and cuproptosis-induced cell death, synergistically combining ptt and cdt. |
2024-09-05 |
2024-09-08 |
Not clear |
| Anton L Popov, Danil D Kolmanovich, Nikita N Chukavin, Ivan V Zelepukin, Gleb V Tikhonowski, Andrei I Pastukhov, Anton A Popov, Alexander E Shemyakov, Sergey M Klimentov, Vladimir A Ryabov, Sergey M Deyev, Irina N Zavestovskaya, Andrei V Kabashi. Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization. Molecules (Basel, Switzerland). vol 29. issue 16. 2024-08-29. PMID:39203014. |
our experiments showed that the combined effect of b nps and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. |
2024-08-29 |
2024-09-04 |
Not clear |
| Tian Zhu, Chunxia Yao, Shuang Hong, Weiguo Song, Norlaila Mohd Zanuri, Weiwei Lv, Qichen Jian. Multi-omics reveal toxicity mechanisms underpinning nanoplastic in redclaw crayfish (Cherax quadricarinatus). The Science of the total environment. 2024-08-22. PMID:39173758. |
transcriptomic analyses revealed that nps influenced apoptosis, drug metabolism-cytochrome p450, and p53 signaling pathways. |
2024-08-22 |
2024-08-25 |
Not clear |