| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruirui Li, Cheng Zhang, Wenping Xu, Liming Tao, Jiagao Cheng, Zhong Li, Yang Zhan. Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2024-07-18. PMID:39025157. |
the results showed that nps induced cytotoxicity, caused oxidative dna damage and triggered mitochondria-mediated apoptosis. |
2024-07-18 |
2024-07-21 |
human |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
however, studies investigating mechanisms underlying oxidative stress (os), apoptosis, and inflammation induced by nps in fish remain limited. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
short-term exposure to nps also triggered apoptosis and inflammation in zebrafish larvae, evident from significant up-regulation in mrna expressions of proapoptotic factors and nf-κb proinflammatory signaling pathway, as well as increased transcription and protein levels of pro-inflammatory factors in larvae. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
inhibition of intracellular excessive ros effectively reduced the induction of apoptosis, nf-κb p65 nuclear migration levels, and cytokine secretion, underscoring os as a pivotal factor throughout the process of apoptosis and inflammatory responses induced by nps. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Yisheng Chen, Lei Huang, Zhiwen Luo, Dan Han, Wei Luo, Renwen Wan, Yan Li, Yunshen Ge, Wei-Wei Lin, Yuchun Xie, Mingming Sun, Qian Wang, Zhiwei Li, Shiyi Chen, Yi Yang, Bin Huang, Yuzhen X. Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy. Journal of controlled release : official journal of the Controlled Release Society. 2024-07-12. PMID:38996921. |
the pan@trf@liposome nps exhibit notable biocompatibility, showing no liver or kidney toxicity in vivo, while demonstrating stability and effectiveness in modulating crm1-mediated pkm2 nuclear translocation, thereby reducing neuroinflammation and neuronal apoptosis. |
2024-07-12 |
2024-07-15 |
Not clear |
| Ben Wang, Hui Zhou, Lu Chen, Yancheng Ding, Xinyue Zhang, Huiyu Chen, Hanyu Liu, Ping Li, Ying Chen, Chao Yin, Quli Fa. A Mitochondria-Targeted Photosensitizer for Combined Pyroptosis and Apoptosis with NIR-II Fluorescence/Photoacoustic Imaging-Guided Phototherapy. Angewandte Chemie (International ed. in English). 2024-07-07. PMID:38972844. |
through nano-precipitation method, z1 nanoparticles (nps) also demonstrated high ros generation (especially type-i ros) upon 808 nm laser irradiation, leading to efficient mitochondria dysfunction and combined pyroptosis and apoptosis. |
2024-07-07 |
2024-07-11 |
Not clear |
| Yiming Li, Yucong Ye, Xiaoyi Zhu, Xingguo Liu, Xinfeng Li, Yunlong Zhao, Xuan Ch. Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei. The Science of the total environment. 2024-07-03. PMID:38960190. |
high concentration (10 mg/l) of nps caused the destruction of hepatopancreas tissue structure, the shedding of microvilli, the increase number of hepatocyte apoptosis and autophagy structure. |
2024-07-03 |
2024-07-10 |
Not clear |
| Yiming Li, Yucong Ye, Xiaoyi Zhu, Xingguo Liu, Xinfeng Li, Yunlong Zhao, Xuan Ch. Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei. The Science of the total environment. 2024-07-03. PMID:38960190. |
transcriptional sequencing analysis showed that the pathway of differentially expressed genes in kegg enrichment mainly included lysosome (ko04142), apoptosis (ko04210) pathways, indicating that the nps mainly affected the immune regulatory mechanism. |
2024-07-03 |
2024-07-10 |
Not clear |
| Yiming Li, Yucong Ye, Xiaoyi Zhu, Xingguo Liu, Xinfeng Li, Yunlong Zhao, Xuan Ch. Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei. The Science of the total environment. 2024-07-03. PMID:38960190. |
our results indicated that nps exposure induced oxidative stress, apoptosis and autophagy in shrimps. |
2024-07-03 |
2024-07-10 |
Not clear |
| Ye Lin, Yuanyuan Tang, Ouyang Yi, Junping Zhu, Zhaoli Su, Gejing Li, Hua Zhou, Liang Liu, Bin Liu, Xiong Ca. Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage repolarization and arresting abnormal proliferation of fibroblast-like synoviocytes. Journal of nanobiotechnology. vol 22. issue 1. 2024-07-02. PMID:38951875. |
more notably, transcriptomic analyses revealed that ha@rfm@gp@sin nps suppressed the cell cycle pathway while inducing the cell apoptosis pathway. |
2024-07-02 |
2024-07-04 |
rat |
| Chongwen Ren, Qingqing Tu, Jinchao H. Fabrication of pH-responsive temozolomide (TMZ)-clacked tannic acid-altered zeolite imidazole nanoframeworks (ZIF-8) enhance anticancer activity and apoptosis induction in glioma cancer cells. Journal of biomaterials science. Polymer edition. 2024-07-02. PMID:38953298. |
the effectiveness of tmz@ta@zif-8 nps in inhibiting the migration and invasion of u251 glioma cancer cells, as well as promoting apoptosis, was confirmed through various tests, including mtt (3-(4,5)-dimethylthiahiazo(-z-y1)) assay, dapi/pi dual staining, and cell scratch assay. |
2024-07-02 |
2024-07-06 |
Not clear |
| Chongwen Ren, Qingqing Tu, Jinchao H. Fabrication of pH-responsive temozolomide (TMZ)-clacked tannic acid-altered zeolite imidazole nanoframeworks (ZIF-8) enhance anticancer activity and apoptosis induction in glioma cancer cells. Journal of biomaterials science. Polymer edition. 2024-07-02. PMID:38953298. |
the biochemical fluorescent staining assays showed that tmz@ta@zif-8 nps potentially improved ros, reduced mmp, and triggered apoptosis in u251 cells. |
2024-07-02 |
2024-07-06 |
Not clear |
| Hongjun Huang, Lerong Yang, Haoqiang He, Bo Zhou, Zainen Qin, Li Zheng, Chong She. Construction of mitochondrial-targeting nano-prodrug for enhanced Rhein delivery and treatment for osteoarthritis in vitro. International journal of pharmaceutics. 2024-06-30. PMID:38945463. |
moreover, rpt nps shows protection of mitochondrial membrane potential and inhibition of chondrocyte apoptosis. |
2024-06-30 |
2024-07-03 |
cat |
| Fahimeh Badparvar, Ahmad Poursattar Marjani, Roya Salehi, Fatemeh Ramezani, Hanieh Beyrampour Basmenj, Mehdi Taleb. Dual pH/redox-responsive size-switchable polymeric nano-carrier system for tumor microenvironment DTX release. Journal of biomaterials science. Polymer edition. 2024-06-30. PMID:38944817. |
the dtx-loaded nps showed more apoptosis (62.6 ± 3.7%) than the free dtx (51.8 ± 3.2%) in treated cells. |
2024-06-30 |
2024-07-02 |
Not clear |
| Huahui Zeng, Xiaohu Zeng, Can Wang, Guoqiang Wang, Qikang Tian, Junwei Zhao, Lingzhou Zhao, Ruiqin Li, Ying Luo, Haotian Peng, Zhenqiang Zhang, Xiaofang Li, Xiangxiang W. Combination therapy using Cel-CSO/Taxol NPs for reversing drug resistance in breast cancer through inhibiting PI3K/AKT/NF-κB/HIF-1α pathway. Drug delivery and translational research. 2024-06-26. PMID:38922561. |
nps effectively inhibited the overexpression of multidrug resistance-related protein p-gp, hypoxia inducible factor-1α (hif-1α), and triggered the mcf-7/taxol cell apoptosis through inhibiting the pi3k/akt/nf-κb/hif-1α pathway. |
2024-06-26 |
2024-06-29 |
mouse |
| Huahui Zeng, Xiaohu Zeng, Can Wang, Guoqiang Wang, Qikang Tian, Junwei Zhao, Lingzhou Zhao, Ruiqin Li, Ying Luo, Haotian Peng, Zhenqiang Zhang, Xiaofang Li, Xiangxiang W. Combination therapy using Cel-CSO/Taxol NPs for reversing drug resistance in breast cancer through inhibiting PI3K/AKT/NF-κB/HIF-1α pathway. Drug delivery and translational research. 2024-06-26. PMID:38922561. |
in tumor-bearing mice, nps exhibited significant curative effects in inducing apoptosis of mcf-7/taxol tumors which showed a low expression level of p-gp, microtubule-related proteins tubb3 and tau. |
2024-06-26 |
2024-06-29 |
mouse |
| Jinhong Guo, Wenjie Yan, Hao Duan, Diandian Wang, Yaxi Zhou, Duo Feng, Yue Zheng, Shiqi Zhou, Gaigai Liu, Xia Qi. Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms. Nutrients. vol 16. issue 11. 2024-06-19. PMID:38892575. |
finally, we analyze the potential mechanisms of nps in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. |
2024-06-19 |
2024-06-21 |
Not clear |
| Haiting Liu, Guangqing Cai, Shuai Yuan, Xionghui Zhou, Rong Gui, Rong Huan. Platelet Membrane-Camouflaged Silver Metal-Organic Framework Biomimetic Nanoparticles for the Treatment of Triple-Negative Breast Cancer. Molecular pharmaceutics. 2024-06-10. PMID:38857525. |
we further revealed that pm@mof-ag nps induced tumor cell death by overproducing reactive oxygen species and promoting cell apoptosis. |
2024-06-10 |
2024-06-14 |
Not clear |
| Haiting Liu, Guangqing Cai, Shuai Yuan, Xionghui Zhou, Rong Gui, Rong Huan. Platelet Membrane-Camouflaged Silver Metal-Organic Framework Biomimetic Nanoparticles for the Treatment of Triple-Negative Breast Cancer. Molecular pharmaceutics. 2024-06-10. PMID:38857525. |
moreover, pm@mof-ag nps enhanced apoptosis by upregulating the ratios of bax/bcl-2 and cleaved caspase3/pro-caspase3. |
2024-06-10 |
2024-06-14 |
Not clear |
| WeiLu Jia, Meng Yang, WenNing Zhang, WenJing Xu, YeWei Zhan. Carrier-Free Self-Assembled Nanomedicines for Promoting Apoptosis and Inhibiting Proliferation in Hepatocellular Carcinoma. ACS biomaterials science & engineering. 2024-06-06. PMID:38841860. |
bi nps possessed the synergistic effects of promoting apoptosis, inhibiting proliferation and metastasis of tumors, and phototherapeutic treatment. |
2024-06-06 |
2024-06-08 |
Not clear |