All Relations between apoptosis and grp78

Publication Sentence Publish Date Extraction Date Species
Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi W. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI insight. vol 9. issue 12. 2024-06-24. PMID:38912589. stra8-cre/pdifl/fl spermatocytes had significantly upregulated er stress-related proteins (grp78 and xbp1) and apoptosis-related proteins (cleaved caspase-3 and bax), together with cell apoptosis. 2024-06-24 2024-06-26 mouse
Huey-Liang Kuo, Haw-Ling Chuang, Chang-Mu Chen, Yu-Ya Chen, Yu-Syuan Chen, Ssu-Chia Lin, Pei-Yu Weng, Ting-Chun Liu, Pei-Yun Wang, Chun-Fa Huang, Siao-Syun Guan, Shing-Hwa Liu, Shun-Fa Yang, Cheng-Tien W. Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology. vol 977. 2024-06-08. PMID:38815787. furthermore, wogonin treatment mitigated endoplasmic reticulum (er) stress-associated molecular markers (grp78, grp94, atf4, chop, and the caspase cascade) and suppressed apoptosis. 2024-06-08 2024-06-11 mouse
Xiaohan Jiang, Benzhi Zhu, Guoxun Li, Shuyu Cui, Jiaying Yang, Rui Jiang, Bing Wan. p20BAP31 promotes cell apoptosis via interaction with GRP78 and activating the PERK pathway in colorectal cancer. International journal of biological macromolecules. 2024-06-06. PMID:38844291. p20bap31 promotes cell apoptosis via interaction with grp78 and activating the perk pathway in colorectal cancer. 2024-06-06 2024-06-10 Not clear
Sheng-Yan He, Wen Liu, Chu-Man Huang, Hui-Mei Huang, Qi-Long Cao, Yun-Xiao Li, Yong-Nan Xu, Nam-Hyung Kim, Ying-Hua L. Enhancing antioxidant levels and mitochondrial function in porcine oocyte maturation and embryonic development through notoginsenoside R1 supplementation. Reproduction in domestic animals = Zuchthygiene. vol 59. issue 6. 2024-06-03. PMID:38828566. furthermore, ngr1 supplementation resulted in decreased apoptosis, reduced caspase 3 (cas3) and bcl2-associated x (bax) mrna levels and decreased glucose-regulated protein 78 kd (grp78) immunofluorescence in porcine oocytes undergoing in vitro maturation. 2024-06-03 2024-06-05 cat
Juanjuan Shen, Chunjie Hu, Yuan Li, Xiaoling Shang, Yue Deng, Jiajuan Guo, Lina Zhang, Jinfeng Wang, Wenfeng Zhan. The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829134. moreover, htjdtld significantly inhibited the gene and protein expression of grp78, jnk, traf2, and caspase 3, which are involved mainly in the endoplasmic reticulum (er) stress-induced apoptosis pathway. 2024-06-03 2024-06-05 rat
Yu-Qing Li, Liang-Li Wei, Yu-Qi Yuan, Zi-Teng Yang, Ning Wang, Biao Cai, Guang-Yun Wan. [Ginsenoside Rg_1 ameliorates OGD/R-induced PC12 cell injury by inhibiting autography via IRE1-JNK-CHOP pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812175. compared with the ogd/r+grg_1(10 μmol·l~(-1)) group, ogd/r+grg_1+rapamycin and ogd/r+grg_1+tunicamycin groups showed increased apoptosis rate and mdc fluorescence intensity, up-regulated protein levels of beclin1, lc3-Ⅱ, p-ire1, p-jnk, grp78, and chop, decreased relative cell survival rate, and down-regulated protein level of p62. 2024-05-30 2024-06-08 rat
Wen-Xuan Chen, Wen-Long Zhang, Huan-Huan Zhang, Yuan-Zhen Lai, Jun Huang, Yang Lei, Yan-Juan Liu, Xiao-Li Wang, Hua-Fei Den. UNVEILING THE PROTECTIVE MECHANISMS OF PUERARIN AGAINST ACUTE LUNG INJURY: A COMPREHENSIVE EXPLORATION OF THE ROLES AND MECHANISMS OF MST1/ERS SIGNALING. Shock (Augusta, Ga.). vol 61. issue 6. 2024-05-24. PMID:38598838. puerarin also attenuated lps-induced increase in apoptosis, tnf-α and il-1β, fd40 flux, and mst1, grp78, chop, and caspase12 expression in huvec cells. 2024-05-24 2024-06-03 mouse
Xiaoran Chang, Yidi Guo, Qun Zhang, Xuebo Zheng, Xuyuan Cui, Junying Hu, Zhiyuan Zhang, Fan Zhang, Xinping Wan. GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB. Journal of virology. 2024-05-22. PMID:38775480. these findings demonstrate a new role of grp78 in regulating host innate immunity in response to viral infection and provide new insights into the mechanism underlying enterovirus replication and nf-κb activation.importancegrp78 is known as a molecular chaperone for protein folding and plays a critical role in maintaining protein folding and participating in cell proliferation, cell survival, apoptosis, and metabolism. 2024-05-22 2024-05-27 human
Jiajie Gan, Haoming Ma, Yeyun Ma, Mengyuan Zhou, Ying Li, Weiping Yan, Zibo Don. Silybin prevented avermectin-induced cardiotoxicity in carp by modulating oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial apoptosis, and autophagy. Fish & shellfish immunology. 2024-05-13. PMID:38740228. silybin exerted anti-inflammatory effects through the nuclear factor kappa b (nf-κb) pathway, antioxidant effects through the nuclear factor erythroid 2-related factor 2 (nrf2) - kelch-like ech-associated protein 1 (keap1) pathway, alleviated cardiac er stress through the glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6)/c/ebp homologous protein (chop) axis, suppressed apoptosis through the mitochondrial pathway, and inhibited excessive autophagy initiation through the pten-induced putative kinase 1 (pink1)/ parkin rbr e3 ubiquitin protein ligase (parkin) signaling pathway. 2024-05-13 2024-05-27 Not clear
Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. a study on expression of grp78 and chop in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. 2024-05-10 2024-05-27 human
Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. the expressions of endoplasmic reticulum specific glucose regulatory protein 78 (grp78), c/ebp homologous protein (chop), apoptosis signal-regulating kinase 1 (ask1), bcl-2-like 11 (bim), death receptor 5 (dr5), c-jun n-terminal kinases (jnk) and p38 were detected by western blot and pcr. 2024-05-10 2024-05-27 human
Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. grp78 protein and chop protein may be involved in the pathological process of neutrophil apoptosis in sepsis. 2024-05-10 2024-05-27 human
Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. 2024-04-16 2024-04-18 rat
Maria B Pazi, Daria V Belan, Elena Y Komarova, Irina V Ekimov. Intranasal Administration of GRP78 Protein (HSPA5) Confers Neuroprotection in a Lactacystin-Induced Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612761. grp78 overexpression can modulate the upr, block apoptosis, and promote the survival of nigral dopamine neurons in a rat model of α-synuclein pathology. 2024-04-13 2024-04-15 rat
Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. 2024-03-26 2024-03-28 human
Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). 2024-03-16 2024-03-19 Not clear
Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. 2024-03-12 2024-03-14 chicken
Juan Feng, Yidong Liu, Xia Tian, Chen Shen, Zhiqiang Feng, Jingxu Zhang, Xiangli Yao, Meilin Pu, Xuguang Miao, Lan Ma, Shouxin Li. Discovery of novel peptide-dehydroepiandrosterone hybrids inducing endoplasmic reticulum stress with effective in vitro and in vivo anti-melanoma activities. European journal of medicinal chemistry. vol 269. 2024-03-11. PMID:38467086. further mechanism studies showed that compound iid would damage the endoplasmic reticulum and upregulate the ers markers c/ebp homologous protein (chop) and glucose-regulated protein 78 (grp78), which could further regulate caspase and bcl-2 family proteins and lead to cell apoptosis. 2024-03-11 2024-03-14 mouse
Libo Zhou, Fan Wu, Jing Wang, Yuqing Zhao, Gaoyi Wu, Yucheng S. Effects of endoplasmic reticulum stress on chondrocyte apoptosis via the PI3K/AKT signaling pathway. Tissue & cell. vol 87. 2024-03-06. PMID:38447334. protein expression of ers and apoptosis markers (grp78 and casp12) was analyzed by immunohistochemistry and western blotting. 2024-03-06 2024-03-09 rat
Xiaoli Li, Xin Yu, Fei Yu, Chunli Fu, Wenqian Zhao, Xiaosong Liu, Chaochao Dai, Haiqing Gao, Mei Cheng, Baoying L. D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway. Phytotherapy research : PTR. 2024-02-08. PMID:38311336. our results showed that dp reduced the blood glucose and ages, and increased the expression of heart optn in diabetic mice and h9c2 cells, thereby inhibiting the endoplasmic reticulum stress (grp78, chop) and glycophagy (stbd1, gabarapl1), and alleviating the myocardial apoptosis and fibrosis of dcm. 2024-02-08 2024-02-11 mouse