| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esma Kirimlioglu, Asli Okan Oflamaz, Enis Hidisoglu, Sukru Ozen, Piraye Yargicoglu, Necdet Demi. Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis. Histochemistry and cell biology. 2024-07-12. PMID:38997526. |
ers markers grp78 and phosphorylated perk (p-perk) levels and ers-related apoptosis markers chop and caspase 12 were investigated by immunohistochemistry, immunoblotting, and quantitative real-time polymerase chain reaction (qpcr). |
2024-07-12 |
2024-07-15 |
rat |
| Vicky Yamamoto, Dat P Ha, Ze Liu, Miller Huang, Soma Samanta, Nouri Neamati, Amy S Le. GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors. Neoplasia (New York, N.Y.). vol 55. 2024-07-11. PMID:38991376. |
using multiple myc-dependent cancer models including head and neck squamous cell carcinoma and their cisplatin-resistant clones, breast and pancreatic adenocarcinoma, our studies revealed that grp78 knockdown by sirna or inhibition of its activity by small molecule inhibitors (yum70 or ha15) reduced c-myc expression, leading to onset of apoptosis and loss of cell viability. |
2024-07-11 |
2024-07-14 |
human |
| Jiahui Liu, Yu Fan, Jinyu Chen, Meili Zhao, Changchun Jian. FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription. Neurotoxicity research. vol 42. issue 4. 2024-06-27. PMID:38935306. |
through the evaluation of tyrosine hydroxylase, dopamine transporter, reactive oxygen species (ros), and c/ebp homologous protein (chop) levels and neuronal loss in mice, as well as the examination of chop, glucose-regulated protein 94 (grp94), grp78, caspase-12, sarco/endoplasmic reticulum calcium atpase 2, malondialdehyde, and superoxide dismutase levels in sh-sy5y cells, we observed that pon2 overexpression mitigated er stress, os, and neuronal apoptosis both in vivo and in vitro. |
2024-06-27 |
2024-06-29 |
mouse |
| Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi W. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI insight. vol 9. issue 12. 2024-06-24. PMID:38912589. |
stra8-cre/pdifl/fl spermatocytes had significantly upregulated er stress-related proteins (grp78 and xbp1) and apoptosis-related proteins (cleaved caspase-3 and bax), together with cell apoptosis. |
2024-06-24 |
2024-06-26 |
mouse |
| Huey-Liang Kuo, Haw-Ling Chuang, Chang-Mu Chen, Yu-Ya Chen, Yu-Syuan Chen, Ssu-Chia Lin, Pei-Yu Weng, Ting-Chun Liu, Pei-Yun Wang, Chun-Fa Huang, Siao-Syun Guan, Shing-Hwa Liu, Shun-Fa Yang, Cheng-Tien W. Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology. vol 977. 2024-06-08. PMID:38815787. |
furthermore, wogonin treatment mitigated endoplasmic reticulum (er) stress-associated molecular markers (grp78, grp94, atf4, chop, and the caspase cascade) and suppressed apoptosis. |
2024-06-08 |
2024-06-11 |
mouse |
| Xiaohan Jiang, Benzhi Zhu, Guoxun Li, Shuyu Cui, Jiaying Yang, Rui Jiang, Bing Wan. p20BAP31 promotes cell apoptosis via interaction with GRP78 and activating the PERK pathway in colorectal cancer. International journal of biological macromolecules. 2024-06-06. PMID:38844291. |
p20bap31 promotes cell apoptosis via interaction with grp78 and activating the perk pathway in colorectal cancer. |
2024-06-06 |
2024-06-10 |
Not clear |
| Sheng-Yan He, Wen Liu, Chu-Man Huang, Hui-Mei Huang, Qi-Long Cao, Yun-Xiao Li, Yong-Nan Xu, Nam-Hyung Kim, Ying-Hua L. Enhancing antioxidant levels and mitochondrial function in porcine oocyte maturation and embryonic development through notoginsenoside R1 supplementation. Reproduction in domestic animals = Zuchthygiene. vol 59. issue 6. 2024-06-03. PMID:38828566. |
furthermore, ngr1 supplementation resulted in decreased apoptosis, reduced caspase 3 (cas3) and bcl2-associated x (bax) mrna levels and decreased glucose-regulated protein 78 kd (grp78) immunofluorescence in porcine oocytes undergoing in vitro maturation. |
2024-06-03 |
2024-06-05 |
cat |
| Juanjuan Shen, Chunjie Hu, Yuan Li, Xiaoling Shang, Yue Deng, Jiajuan Guo, Lina Zhang, Jinfeng Wang, Wenfeng Zhan. The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829134. |
moreover, htjdtld significantly inhibited the gene and protein expression of grp78, jnk, traf2, and caspase 3, which are involved mainly in the endoplasmic reticulum (er) stress-induced apoptosis pathway. |
2024-06-03 |
2024-06-05 |
rat |
| Yu-Qing Li, Liang-Li Wei, Yu-Qi Yuan, Zi-Teng Yang, Ning Wang, Biao Cai, Guang-Yun Wan. [Ginsenoside Rg_1 ameliorates OGD/R-induced PC12 cell injury by inhibiting autography via IRE1-JNK-CHOP pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 10. 2024-05-30. PMID:38812175. |
compared with the ogd/r+grg_1(10 μmol·l~(-1)) group, ogd/r+grg_1+rapamycin and ogd/r+grg_1+tunicamycin groups showed increased apoptosis rate and mdc fluorescence intensity, up-regulated protein levels of beclin1, lc3-Ⅱ, p-ire1, p-jnk, grp78, and chop, decreased relative cell survival rate, and down-regulated protein level of p62. |
2024-05-30 |
2024-06-08 |
rat |
| Wen-Xuan Chen, Wen-Long Zhang, Huan-Huan Zhang, Yuan-Zhen Lai, Jun Huang, Yang Lei, Yan-Juan Liu, Xiao-Li Wang, Hua-Fei Den. UNVEILING THE PROTECTIVE MECHANISMS OF PUERARIN AGAINST ACUTE LUNG INJURY: A COMPREHENSIVE EXPLORATION OF THE ROLES AND MECHANISMS OF MST1/ERS SIGNALING. Shock (Augusta, Ga.). vol 61. issue 6. 2024-05-24. PMID:38598838. |
puerarin also attenuated lps-induced increase in apoptosis, tnf-α and il-1β, fd40 flux, and mst1, grp78, chop, and caspase12 expression in huvec cells. |
2024-05-24 |
2024-06-03 |
mouse |
| Xiaoran Chang, Yidi Guo, Qun Zhang, Xuebo Zheng, Xuyuan Cui, Junying Hu, Zhiyuan Zhang, Fan Zhang, Xinping Wan. GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB. Journal of virology. 2024-05-22. PMID:38775480. |
these findings demonstrate a new role of grp78 in regulating host innate immunity in response to viral infection and provide new insights into the mechanism underlying enterovirus replication and nf-κb activation.importancegrp78 is known as a molecular chaperone for protein folding and plays a critical role in maintaining protein folding and participating in cell proliferation, cell survival, apoptosis, and metabolism. |
2024-05-22 |
2024-05-27 |
human |
| Jiajie Gan, Haoming Ma, Yeyun Ma, Mengyuan Zhou, Ying Li, Weiping Yan, Zibo Don. Silybin prevented avermectin-induced cardiotoxicity in carp by modulating oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial apoptosis, and autophagy. Fish & shellfish immunology. 2024-05-13. PMID:38740228. |
silybin exerted anti-inflammatory effects through the nuclear factor kappa b (nf-κb) pathway, antioxidant effects through the nuclear factor erythroid 2-related factor 2 (nrf2) - kelch-like ech-associated protein 1 (keap1) pathway, alleviated cardiac er stress through the glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6)/c/ebp homologous protein (chop) axis, suppressed apoptosis through the mitochondrial pathway, and inhibited excessive autophagy initiation through the pten-induced putative kinase 1 (pink1)/ parkin rbr e3 ubiquitin protein ligase (parkin) signaling pathway. |
2024-05-13 |
2024-05-27 |
Not clear |
| Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. |
a study on expression of grp78 and chop in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. |
2024-05-10 |
2024-05-27 |
human |
| Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. |
the expressions of endoplasmic reticulum specific glucose regulatory protein 78 (grp78), c/ebp homologous protein (chop), apoptosis signal-regulating kinase 1 (ask1), bcl-2-like 11 (bim), death receptor 5 (dr5), c-jun n-terminal kinases (jnk) and p38 were detected by western blot and pcr. |
2024-05-10 |
2024-05-27 |
human |
| Jinchuan Zhao, Ping Yang, L I Lu, Tao Yi, Yunfeng Li, Wei Mao, Qin Zhou, K E Li. A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis. Journal of biosciences. vol 49. 2024-05-10. PMID:38726820. |
grp78 protein and chop protein may be involved in the pathological process of neutrophil apoptosis in sepsis. |
2024-05-10 |
2024-05-27 |
human |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Maria B Pazi, Daria V Belan, Elena Y Komarova, Irina V Ekimov. Intranasal Administration of GRP78 Protein (HSPA5) Confers Neuroprotection in a Lactacystin-Induced Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612761. |
grp78 overexpression can modulate the upr, block apoptosis, and promote the survival of nigral dopamine neurons in a rat model of α-synuclein pathology. |
2024-04-13 |
2024-04-15 |
rat |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |