| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Vincent, K Roessner, D Lynch, D Wilson, S M Cooper, J Tschopp, L H Sigal, R C Bud. Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976167. |
furthermore, synovial gamma delta t cell clones express elevated and sustained levels of the ligand for fas (apo-1, cd95) compared to alpha beta t cells, and induce apoptosis of fashigh cd4+ synovial lymphocytes. |
1997-01-30 |
2023-08-12 |
human |
| F Silvestris, S Nagata, P Cafforio, N Silvestris, F Dammacc. Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976184. |
cross-linking of fas by antibodies to a peculiar domain of gp120 v3 loop can enhance t cell apoptosis in hiv-1-infected patients. |
1997-01-30 |
2023-08-12 |
mouse |
| F Silvestris, S Nagata, P Cafforio, N Silvestris, F Dammacc. Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976184. |
since anti-fas were reactive to gp120, it is conceivable that antibodies binding that domain within the v3 region are effective cross-linkers of fas and increase apoptosis in peripheral t cells. |
1997-01-30 |
2023-08-12 |
mouse |
| S D D'Souza, B Bonetti, V Balasingam, N R Cashman, P A Barker, A B Troutt, C S Raine, J P Ante. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976190. |
in contrast to the activity of fas in other cellular systems, dying ols did not exhibit evidence of apoptosis, assessed morphologically and by terminal transferase-mediated d-uridine triphosphate-biotin nick-end-labeling staining for dna fragmentation. |
1997-01-30 |
2023-08-12 |
human |
| J E Castro, J A Listman, B A Jacobson, Y Wang, P A Lopez, S Ju, P W Finn, D L Perkin. Fas modulation of apoptosis during negative selection of thymocytes. Immunity. vol 5. issue 6. 1997-01-30. PMID:8986720. |
fas modulation of apoptosis during negative selection of thymocytes. |
1997-01-30 |
2023-08-12 |
mouse |
| J E Castro, J A Listman, B A Jacobson, Y Wang, P A Lopez, S Ju, P W Finn, D L Perkin. Fas modulation of apoptosis during negative selection of thymocytes. Immunity. vol 5. issue 6. 1997-01-30. PMID:8986720. |
fas, a member of the tnf receptor family, has been shown to induce apoptosis in mature peripheral t cells; however, the effects of fas on negative selection of thymocytes have not been previously detected. |
1997-01-30 |
2023-08-12 |
mouse |
| J E Castro, J A Listman, B A Jacobson, Y Wang, P A Lopez, S Ju, P W Finn, D L Perkin. Fas modulation of apoptosis during negative selection of thymocytes. Immunity. vol 5. issue 6. 1997-01-30. PMID:8986720. |
using a sensitive terminal deoxynucleotidyl transferase method to detect apoptotic cells, we found that mutant fas molecules in lpr mice decrease the sensitivity of thymocytes to t cell receptor-mediated apoptosis and that blockade of fas-fas ligand interactions in vivo can inhibit antigen-induced apoptosis of thymocytes in non-lpr mice. |
1997-01-30 |
2023-08-12 |
mouse |
| J E Castro, J A Listman, B A Jacobson, Y Wang, P A Lopez, S Ju, P W Finn, D L Perkin. Fas modulation of apoptosis during negative selection of thymocytes. Immunity. vol 5. issue 6. 1997-01-30. PMID:8986720. |
thus, we have shown that fas, in conjunction with antigen-specific signals, can modulate apoptosis during negative selection of thymocytes. |
1997-01-30 |
2023-08-12 |
mouse |
| P K Kim, A S Dutra, S C Chandrasekharappa, J M Puc. Genomic structure and mapping of human FADD, an intracellular mediator of lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 12. 1997-01-23. PMID:8955195. |
cross-linking of fas mediates apoptosis in a variety of cells, primarily peripheral t lymphocytes, for which this pathway plays a major role in mature lymphocyte homeostasis. |
1997-01-23 |
2023-08-12 |
human |
| M Boirivant, R Pica, R DeMaria, R Testi, F Pallone, W Strobe. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. The Journal of clinical investigation. vol 98. issue 11. 1997-01-23. PMID:8958226. |
finally, we showed that increased apoptosis of lp t cells induced by cd2-pathway stimulation is inhibited when fas antigen is blocked by a nonstimulatory anti-fas antibody. |
1997-01-23 |
2023-08-12 |
human |
| M Boirivant, R Pica, R DeMaria, R Testi, F Pallone, W Strobe. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. The Journal of clinical investigation. vol 98. issue 11. 1997-01-23. PMID:8958226. |
these studies suggest that lp t cells are characterized by increased susceptibility to fas-mediated apoptosis most due to a downstream change in the fas signaling pathway. |
1997-01-23 |
2023-08-12 |
human |
| S Sieg, Z Yildirim, D Smith, N Kayagaki, H Yagita, Y Huang, D Kapla. Herpes simplex virus type 2 inhibition of Fas ligand expression. Journal of virology. vol 70. issue 12. 1997-01-23. PMID:8971002. |
in this report we demonstrate the capacity of hsv-2, but not hsv-1, to inhibit the activity and cell surface expression of fas ligand, an important molecule involved in t-cell apoptosis and cell-mediated cytotoxicity. |
1997-01-23 |
2023-08-12 |
human |
| J Usami, K Hiromatsu, Y Aoki, N Kobayashi, M Makino, H Yagita, Y Matsumoto, K Maeda, Y Yoshika. Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. Journal of virology. vol 70. issue 12. 1997-01-23. PMID:8971021. |
apoptosis by cd95 (fas)-dependent and -independent mechanisms in peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. |
1997-01-23 |
2023-08-12 |
mouse |
| J Usami, K Hiromatsu, Y Aoki, N Kobayashi, M Makino, H Yagita, Y Matsumoto, K Maeda, Y Yoshika. Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. Journal of virology. vol 70. issue 12. 1997-01-23. PMID:8971021. |
cd95 (fas)/cd95 ligand (cd95 l)-mediated apoptosis is thought to be involved in the delayed progression of murine aids (maids) induced by lp-bm5 murine leukemia virus (mulv). |
1997-01-23 |
2023-08-12 |
mouse |
| P Juo, C J Kuo, S E Reynolds, R F Konz, J Raingeaud, R J Davis, H P Biemann, J Bleni. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972182. |
the fas receptor mediates a signalling cascade resulting in programmed cell death (apoptosis) within hours of receptor cross-linking. |
1997-01-22 |
2023-08-12 |
Not clear |
| P Juo, C J Kuo, S E Reynolds, R F Konz, J Raingeaud, R J Davis, H P Biemann, J Bleni. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972182. |
fas activation of p38 correlated temporally with the onset of apoptosis, and transfection of constitutively active mkk3 (glu), an upstream regulator of p38, potentiated fas-induced cell death, suggesting a potential involvement of the mkk3/p38 activation pathway in fas-mediated apoptosis. |
1997-01-22 |
2023-08-12 |
Not clear |
| P Juo, C J Kuo, S E Reynolds, R F Konz, J Raingeaud, R J Davis, H P Biemann, J Bleni. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972182. |
fas has been shown to require ice (interleukin-1 beta-converting enzyme) family proteases to induce apoptosis from studies utilizing the cowpox ice inhibitor protein crma, the synthetic tetrapeptide ice inhibitor yvad-cmk, and the tripeptide pan-ice inhibitor z-vad-fmk. |
1997-01-22 |
2023-08-12 |
Not clear |
| J M Lenczowski, L Dominguez, A M Eder, L B King, C M Zacharchuk, J D Ashwel. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972197. |
cross-linking of fas (cd95) induces apoptosis, a response that has been reported to depend upon the ras activation pathway. |
1997-01-22 |
2023-08-12 |
Not clear |
| J M Lenczowski, L Dominguez, A M Eder, L B King, C M Zacharchuk, J D Ashwel. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972197. |
furthermore, maximally effective concentrations of anti-fas did not cause jnk activation if apoptosis was blocked by a cysteine protease inhibitor, suggesting that under these conditions, activation of jnk may be secondary to the stress of apoptosis rather than a direct result of fas engagement. |
1997-01-22 |
2023-08-12 |
Not clear |
| J M Lenczowski, L Dominguez, A M Eder, L B King, C M Zacharchuk, J D Ashwel. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972197. |
thus, induction of jnk activity in jurkat cells by ligation of fas at levels sufficient to cause cell death is likely a result, rather than a cause, of the apoptotic response, and ap-1 function is not required for fas-induced apoptosis. |
1997-01-22 |
2023-08-12 |
Not clear |