| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnieszka Szyposzynska, Aleksandra Bielawska-Pohl, Marek Murawski, Rafal Sozanski, Grzegorz Chodaczek, Aleksandra Klimcza. Mesenchymal Stem Cell Microvesicles from Adipose Tissue: Unraveling Their Impact on Primary Ovarian Cancer Cells and Their Therapeutic Opportunities. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958844. |
the results suggests that the anti-cancer effect of hatmsc2-mvs, with high probability, is contributed by the delivery of molecules that induce cell cycle arrest and apoptosis (p21, tumor suppressor p53, executor caspase 3) and proapoptotic regulators (bad, bim, fas, fasl, p27, trail-r1, trail-r2), and their presence has been confirmed by apoptotic protein antibody array. |
2023-11-14 |
2023-11-20 |
human |
| Xiaopeng Meng, Yiran Yang, Jing Zhang, Jianting Su, Gang Li, Shuxia Li. Synergistic toxicity of some food additives used in non-alcoholic beverages on renal tubular epithelial cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953561. |
the current study implied the synergistic cytotoxic effect caused by multiple fas at no toxic dosages via activated cellular transduction pathways regulating cell survival and apoptosis function, which warning of the synergistic toxic effects of different types of fas. |
2023-11-13 |
2023-11-20 |
human |
| Taku Fujimura, Koji Yoshino, Motoki Nakamura, Hiroshi Kato, Takamichi Ito, Takeo Maekawa, Yasuhiro Fujisawa, Shigeto Matsushita, Ryo Amagai, Emi Yamazaki, Manami Takahashi, Erika Tamabuchi, Akira Hashimoto, Yumi Kambayashi, Naoya Yamazaki, Toshio Miyata, Yoshihide Asan. Efficacy and safety of TM5614 in combination with paclitaxel in the treatment of paclitaxel-resistant cutaneous angiosarcoma: Phase II study protocol. Experimental dermatology. 2023-11-10. PMID:37946551. |
since pai-1 protects endothelial cells from fas ligand-mediated apoptosis, pai-1 inhibition might induce apoptosis of endothelial cell-derived tumours such as cas. |
2023-11-10 |
2023-11-20 |
Not clear |
| Dacheng Zhao, Jinwen He, Xiaobing Zhao, Xiaoyun Sheng, Zhiwei Feng, Xingwen Wang, Chengjun Zhang, Shenghong Wang, Bin Geng, Yayi Xi. A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis. International journal of biological macromolecules. 2023-11-04. PMID:37924900. |
the results showed that overexpression of c-fos leads to an increase in downstream fas protein, which subsequently leads to osteoblast apoptosis and hinders osteogenesis. |
2023-11-04 |
2023-11-08 |
Not clear |
| Teng Ge, Bo Ning, Yongqing Wu, Xiaolin Chen, Hongfei Qi, Haifang Wang, Mingjun Zha. MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia-reperfusion injury. Molecular and cellular biochemistry. 2023-10-25. PMID:37878166. |
microrna-139 modulates the extrinsic death signal of fas, while microrna-145 regulates endoplasmic reticulum calcium overload, both of which exert regulatory effects on cardiomyocyte apoptosis. |
2023-10-25 |
2023-11-08 |
Not clear |
| Yanping Qin, Weitao Wan, Jiangwei Li, Zhongyu Wang, Yue Yang, Jun Li, Haitao Ma, Ziniu Yu, Zhiming Xiang, Yuehuan Zhan. A novel Fas ligand plays an important role in cell apoptosis of Frontiers in immunology. vol 14. 2023-10-24. PMID:37868973. |
a novel fas ligand plays an important role in cell apoptosis of apoptosis regulates normal development, homeostasis, immune tolerance and response to environmental stress by eliminating unwanted or diseased cells, and plays a key role in non-specific immunity of invertebrates. |
2023-10-24 |
2023-11-08 |
Not clear |
| Ying Cai, Binyu Zhu, Xiaoting Shan, Lingli Zhou, Xujie Sun, Anqi Xia, Binhao Wu, Yang Yu, Helen He Zhu, Pengcheng Zhang, Yaping L. Inhibiting Endothelial Cell-Mediated T Lymphocyte Apoptosis with Integrin-Targeting Peptide-Drug Conjugate Filaments for Chemoimmunotherapy of Triple-Negative Breast Cancer. Advanced materials (Deerfield Beach, Fla.). 2023-10-17. PMID:37847869. |
tumor-associated endothelial cells (tecs) limit anti-tumor immunity via inducing apoptosis of infiltrating t lymphocytes through a fas ligand (fasl)-mediated mechanism. |
2023-10-17 |
2023-11-08 |
Not clear |
| Christopher Failing, Jennifer R Blase, Kelly Walkovic. Understanding the Spectrum of Immune Dysregulation Manifestations in Autoimmune Lymphoproliferative Syndrome and Autoimmune Lymphoproliferative Syndrome-like Disorders. Rheumatic diseases clinics of North America. vol 49. issue 4. 2023-10-11. PMID:37821199. |
as a disorder of immune dysregulation, autoimmune lymphoproliferative syndrome (alps) stems from pathogenic variants in the first apoptosis signal-mediated apoptosis (fas) and fas-ligand pathway that result in elevations of cd3+ tcr\xce\xb1\xce\xb2+ cd4- cd8- t\xc2\xa0cells along with chronic lymphoproliferation, a heightened risk for malignancy, and importantly for the rheumatologist, increased risk of autoimmunity. |
2023-10-11 |
2023-10-15 |
Not clear |
| Tik Shing Cheung, Chiara Giacomini, Matteo Cereda, Alvaro Avivar-Valderas, Daria Capece, Giuliana Minani Bertolino, Olga delaRosa, Ryan Hicks, Rachele Ciccocioppo, Guido Franzoso, Antonio Galleu, Francesca D Ciccarelli, Francesco Dazz. Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome that correlates with clinical responses in Crohn's disease patients. Molecular therapy : the journal of the American Society of Gene Therapy. 2023-10-08. PMID:37805713. |
we analyzed the transcriptomes of mscs undergoing apoptosis and identified several immunomodulatory factors and chemokines dependent on caspase activation following fas stimulation. |
2023-10-08 |
2023-10-15 |
human |
| Haiyi Chen, Yue Guo, Shengqing Ye, Jintu Zhang, Haotian Zhang, Na Liu, Rui Zhou, Tingjun Hou, Hongguang Xia, Yu Kang, Mojie Dua. On the Dynamic Mechanism of Long-Flexible Fatty Acid Binding to Fatty Acid Binding Protein: Resolving the Long-Standing Debate. Journal of chemical information and modeling. 2023-08-14. PMID:37574904. |
fatty acids (fas) are one of the essential energy sources for physiological processes, and they play a vital role in regulating immune and inflammatory responses, promoting cell differentiation and apoptosis, and inhibiting tumor growth. |
2023-08-14 |
2023-08-16 |
Not clear |
| Jalal Naghinezhad, Anita Alenabi, Hossein Ayatollahi, Maryam Sheikhi, Mohammad Hadi Sadeghian, Zahra Khoshnegah, Samaneh Boroumand-Noughab. Expression of DR4, DR5, FAS, Caspase-8 and, DDIAS Genes in AML Patients. Medical journal of the Islamic Republic of Iran. vol 37. 2023-08-14. PMID:37575689. |
in this study, gene expression levels of 5 key players of apoptosis, including dr4, dr5, fas, caspase 8, and dna damage-induced apoptosis suppressor (ddias), have been evaluated in aml patients compared with controls, aiming to evaluate their possible role and prognostic impact. |
2023-08-14 |
2023-08-16 |
Not clear |
| Jiayi M Sun, Wing-Yuk Chow, Gufeng Xu, M John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing Ng, Aaron M Taylor, Alexander Yu, Jason E Farrar, Donald A Barkauskas, Richard Gorlick, Jaime M Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong Man, Ching C Lau, On Behalf Of The Target Osteosarcoma Consortiu. The Role of FAS Receptor Methylation in Osteosarcoma Metastasis. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569529. |
the interaction of fasl and its cell surface receptor, fas, triggers apoptosis in normal cells; however, this function is altered in cancer cells. |
2023-08-12 |
2023-08-16 |
mouse |
| Fangfang Ge, Yulu Wang, Amit Sharma, Yu Yang, Hongde Liu, Markus Essler, Ulrich Jaehde, Ingo G H Schmidt-Wol. Cytokine-Induced Killer Cells in Combination with Heat Shock Protein 90 Inhibitors Functioning via the Fas/FasL Axis Provides Rationale for a Potential Clinical Benefit in Burkitt's lymphoma. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569852. |
subsequent analyses revealed that the increased expression of fas on the surface of bl cells, which induces caspase 3/7-dependent apoptosis, may account for this effect. |
2023-08-12 |
2023-08-16 |
Not clear |
| Sujan Kumar Mondal, Derick Haas, Jie Han, Theresa L Whitesid. Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells. Communications biology. vol 6. issue 1. 2023-08-04. PMID:37542121. |
here we show that tumor cell-derived exosomes (tex) carrying surface pdl-1, pd-1, fas, fasl, trail, ctla-4 and tgf-\xce\xb21 induce apoptosis of cd8 |
2023-08-04 |
2023-08-14 |
Not clear |
| Robert Sulak, Xiaonan Liu, Adrian Smedowsk. The concept of gene therapy for glaucoma: the dream that has not come true yet. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488850. |
reported gene therapy-based neuroprotection of retinal ganglion cells is targeting specific genes translating to growth factors (i.e., brain derived neurotrophic factor, and its receptor trkb), regulation of apoptosis and neurodegeneration (i.e., bcl-xl, xiap, fas system, nicotinamide mononucleotide adenylyl transferase 2, digit3 and sarm1), immunomodulation (i.e., crry, c3 complement), modulation of neuroinflammation (i.e., erythropoietin), reduction of excitotoxicity (i.e., camkii\xce\xb1) and transcription regulation (i.e., max, nrf2). |
2023-07-25 |
2023-08-14 |
mouse |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| Hanbo Liu, Miaojuan Chen, Fen Ning, Yixin Ye, Qinsheng Lu, Shenjiao Lu, Yaoyun Duan, Xiaowen Gan, Mingguang Zhao, Kaimin Guo, Gendie E Las. Extravillous trophoblast cell derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p. Molecular human reproduction. 2023-06-27. PMID:37369038. |
furthermore, fas ligand was also expressed on the evt-exosomes and may play a coordinated role in apoptosis induction. |
2023-06-27 |
2023-08-14 |
Not clear |
| Guojun Yao, Ling Deng, Xinquan Long, Yufan Zhou, Xiang Zho. An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis. Aging. vol 15. 2023-06-24. PMID:37354488. |
focal adhesions (fas) allow cells to contact the extracellular matrix, helping to maintain tension and enabling signal transmission in cell migration, differentiation, and apoptosis. |
2023-06-24 |
2023-08-14 |
Not clear |
| Seham Abou Shousha, Suzan Baheeg, Hossam Ghoneim, Malak Zoheir, Mahmoud Hemida, Yasmine Shahin. The effect of Fas/FasL pathway blocking on apoptosis and stemness within breast cancer tumor microenvironment (preclinical study). Breast disease. vol 42. issue 1. 2023-06-19. PMID:37334575. |
fas/fasl expression is linked to the maintenance of cancer stem cells (cscs) within the tme, contributing to tumor aggressiveness, metastasis, recurrence, and chemoresistance.this study is considered the first study designed to block the overexpressed fasl on the tumor cells within tme mimicking tissue culture system using rfas molecules and supplementing the fas enriched tissue culture system with blocked fas - peripheral blood mononuclear cells pbmcs (using anti-fas mab) to protect them from tumor counterattack and augment their ability to induce tumor cell apoptosis and stemness inhibition.a significantly increased level of apoptosis and decreased expression of cd 44 (cscs marker) was observed within the east tumor tissue culture system enriched with fas molecules and anti-fas treated pbmcs and the one enriched with fas molecules only compared to the breast tumor tissues cultured alone (p <\xc2\xa00.001). |
2023-06-19 |
2023-08-14 |
Not clear |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
we stimulated tm4 cells, a mouse sertoli cell line, with lps (200 or 1000\xc2\xa0ng/ml) or ril-18 (0.1-100\xc2\xa0ng/ml) at levels that induced leydig cell apoptosis in our previous study and assessed caspase 3 cleavage and the mrna expression of inflammatory cytokines and markers of apoptotic pathways (tnfr1, fasl, fas, fadd) after stimulation. |
2023-06-01 |
2023-08-14 |
mouse |