| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henrique Fernando Lopes-Araujo, Maria Carolina Santos Guedes, Luiz Cláudio Arraes De Alencar, Wlisses Henrique Veloso Carvalho-Silva, Lílian Maria Lapa Montenegro, Rafael Lima Guimarãe. The influence of extrinsic apoptosis gene expression on immunological reconstitution of male ART-treated PLHIV. BMC infectious diseases. vol 25. issue 1. 2025-03-19. PMID:40102787. |
thus, this study aimed to evaluate the expression profile of extrinsic apoptosis pathway genes (casp3, fas, faslg) in adult male hiv patients on art. |
2025-03-19 |
2025-03-21 |
Not clear |
| Kang Li, Yating Zhu, Zhichao Fang, Ming Geng, Jiansong Zhang, Yuying Zheng, Yi Cao, Xiumei Wei, Jialong Yan. Fish requires FasL to facilitate CD8+ T-cell function and antimicrobial immunity. Journal of immunology (Baltimore, Md. : 1950). 2025-03-12. PMID:40073091. |
mechanistically, tilapia t cells utilize mtorc1/c-myc axis to regulate pathogen-induced fasl expression, which binds to fas and activates caspase-8/caspase-3 pathway, mediating apoptosis in target cells and t cells themselves. |
2025-03-12 |
2025-03-15 |
Not clear |
| Abraham L Bayer, Zoie Magri, Hayley Muendlein, Alexander Poltorak, Pilar Alcaid. MyD88 determines T cell fate through BCAP-PI3K signaling. Journal of immunology (Baltimore, Md. : 1950). 2025-03-12. PMID:40073160. |
here, we report a central regulatory role for myd88 in t cell apoptosis after tcr activation and fas ligation through an association with the b cell adaptor for phosphoinositide 3-kinase (b cell activating protein [bcap]). |
2025-03-12 |
2025-03-15 |
Not clear |
| Shuhan Wang, Yaqi Yang, Jiahong Lin, Weishan Zhang, Cuizhu Yang, Runheng Zhang, Chang Zhou, Li Zhang, Xin Wang, Jing Liu, Xiaobao Jin, Yuxin M. Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway. Free radical biology & medicine. 2025-03-03. PMID:40032030. |
interestingly, consistent with the action of pathway fas inhibitor kr-33493, ast could activate autophagy of aβ1-42 injured c8d1a cells while inhibit their apoptosis. |
2025-03-03 |
2025-03-06 |
mouse |
| Junyi Lai, Chen Tan, Yunsheng Qiao, Xinghuai Sun, Junyi Che. MicroRNA-106a regulates the apoptosis and oxidative stress of porcine trabecular meshwork cells by targeting FAS. Experimental eye research. 2025-03-03. PMID:40032150. |
microrna-106a regulates the apoptosis and oxidative stress of porcine trabecular meshwork cells by targeting fas. |
2025-03-03 |
2025-03-06 |
Not clear |
| Jianrong Yin, Qiqiang Zhu, Chunqiang Yu, Lianhuan Wang, Rongling Ge, Lei Wang, Jin Wan. Identification of key autophagy-related genes in arrhythmogenic right ventricular cardiomyopathy through gene expression profiling. Medicine. vol 104. issue 7. 2025-02-17. PMID:39960965. |
at the same time, combined with previous research reports in cardiomyopathy, we can speculate that fas may affect the occurrence and development of arvc through tumor necrosis factor signaling pathway mediating apoptosis. |
2025-02-17 |
2025-02-23 |
Not clear |
| Vera Rotondi Aufiero, Giuseppe Iacomino, Giovanni De Chiara, Errico Picariello, Gaetano Iaquinto, Riccardo Troncone, Giuseppe Mazzarell. Neutralizing IL-15 Inhibits Tissue-Damaging Immune Response in Ex Vivo Cultured Untreated Celiac Intestinal Mucosa. Cells. vol 14. issue 3. 2025-02-12. PMID:39937025. |
our findings suggest that neutralizing the effects of il-15 in ex vivo cultured untreated ced intestinal mucosa could block apoptosis by downregulating fas and hla-e expression and the release of cytotoxic proteins, such as perforin. |
2025-02-12 |
2025-02-14 |
Not clear |
| Essaikiammal Sodalai Muthu Konar, Sebastian Brachs, Knut Mai, Swapnil Gorakh Waghmare, Tomas Policar, Azadeh Mohagheghi Samarin, Azin Mohagheghi Samari. Aging Oocytes: Exploring Apoptosis and Its Impact on Embryonic Development in Common Carp (Cyprinus carpio). Journal of animal science. 2025-01-25. PMID:39761344. |
this process included an increase in proapoptotic transcripts (fas, bax, cathepsin d, caspase 8, caspase 9, and caspase 3a) (p < 0.05), elevated levels of caspase 3 protein (p < 0.05), and activation of caspase 3 enzyme (p < 0.001), a key player in apoptosis, in aging oocytes. |
2025-01-25 |
2025-01-27 |
Not clear |
| Martina Antoniolli, Maria Solovey, Johannes Adrian Hildebrand, Tabea Freyholdt, Carolin Dorothea Strobl, Deepak Bararia, William David Keay, Louisa Adolph, Michael Heide, Verena Passerini, Lis Winter, Lucas Wange, Wolfgang Enard, Susanne Thieme, Helmut Blum, Martina Rudelius, Julia Mergner, Christina Ludwig, Sebastian Bultmann, Marc Schmidt-Supprian, Heinrich Leonhardt, Marion Subklewe, Michael von Bergwelt-Baildon, Maria Colomé-Tatché, Oliver Weiger. ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression. Cell death and differentiation. 2025-01-22. PMID:39843653. |
the reduced fas levels induced by arid1a loss rendered lymphoma cells resistant to both soluble and t cell membrane-anchored faslg-induced apoptosis, and significantly diminished car t cell killing in functional experiments. |
2025-01-22 |
2025-01-25 |
Not clear |
| Zejun Fang, Chaoju Gong, Yanyan Hu, Tingting Cui, Min Lin, Sha Lin, Ming Y. Acetylation of E2F1 at K125 facilitates cell apoptosis under serum stress. Translational oncology. vol 52. 2024-12-28. PMID:39731810. |
the upregulation of fas and bax activated the cleavage of caspase-3 and facilitated the apoptosis of hcc cells experiencing serum stress. |
2024-12-28 |
2024-12-31 |
Not clear |
| Safura Pournajaf, Nastaran Afsordeh, Hadi Bayat, Mohammad Hossein Pourgholam. Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo. Clinical and experimental pharmacology & physiology. vol 52. issue 1. 2024-12-03. PMID:39623929. |
cell shrinkage coupled with ao/eb and pi staining of the fingolimod-treated cells indicated apoptosis, subsequently confirmed by measuring the expression levels of the candidate genes involved in apoptosis and cell cycle, such as bax/bcl2, p53, cytochrome c and caspases 9/3, fas, fadd, tnfrsf1a, cdkn1a, and ccnd1, at rna and protein levels, indicating both extrinsic and mitochondrial apoptosis and cell cycle arrest at sub-g1 phase in fingolimod-treated cells. |
2024-12-03 |
2024-12-06 |
rat |
| Pouya Goleij, Mohammad Amin Khazeei Tabari, Mohanna Khandan, Mohadeseh Poudineh, Aryan Rezaee, Sarvin Sadreddini, Pantea Majma Sanaye, Haroon Khan, Danaé S Larsen, Maria Dagli. Genistein in focus: pharmacological effects and immune pathway modulation in cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2024-11-27. PMID:39601821. |
genistein also affects t-cell execution markers, including granzyme b, tnf-α, and fas ligand in cancer by influencing key proteins involved in immune response and apoptosis. |
2024-11-27 |
2024-11-29 |
Not clear |
| Huaping Zhong, Minyu Wu, Heping Xie, Xu Chen, Jiayi Li, Zhisheng Duan, Hong Chen, Ziyou Liu, Wei Liao, Yijian Che. Fas Apoptosis Inhibitory Molecule 2 Inhibits Pathological Cardiac Hypertrophy by Regulating the MAPK Signaling Pathway. Journal of the American Heart Association. 2024-11-15. PMID:39547961. |
fas apoptosis inhibitory molecule 2 inhibits pathological cardiac hypertrophy by regulating the mapk signaling pathway. |
2024-11-15 |
2024-11-18 |
Not clear |
| Cheng Zhong, Shijun Wang, Lei Xia, Xiaoman Yang, Liguang Fang, Xianyi Zhang, Mengyue Wang, Haijun Zhao, Guanghui Wang, Jinglong Wu, Ruijian Guo, Ming Zhong, Eiichi Gohd. The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway. Cancer biology & therapy. vol 25. issue 1. 2024-11-14. PMID:39540618. |
the tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of fas expression mediated by the nf-κb signaling pathway. |
2024-11-14 |
2024-11-17 |
Not clear |
| Mohit Sharma, Smitha Sammith Shetty, Sonal Soi, Raghu Radhakrishna. Myofibroblasts persist through immune privilege mechanisms to mediate oral submucous fibrosis: Uncovering the pathogenesis. Journal of oral biology and craniofacial research. vol 14. issue 6. 2024-11-06. PMID:39502133. |
however, increased matrix stiffness, in addition to activating tgf-β, reduces fas surface expression in myofibroblasts, increasing their resistance to apoptosis. |
2024-11-06 |
2024-11-08 |
Not clear |
| Zahra Mozooni, Rezvaneh Ghadyani, Shahrzad Soleimani, Ehsan Rouhollahpour Ahangar, Mojgan Sheikhpour, Mehrdad Haghighi, Marzieh Motallebi, Abolfazl Movafagh, Seyed Mohsen Aghaei-Zarc. TNF-α, and TNFRs in gastrointestinal cancers. Pathology, research and practice. vol 263. 2024-10-23. PMID:39442225. |
in contrast, binding of cytokines to certain family members, such as tnf ri and fas ligand (fas l), leads to the secretion and initiation of apoptosis. |
2024-10-23 |
2024-10-26 |
Not clear |
| Wioleta Justyna Omeljaniuk, Marzena Garley, Anna Pryczynicz, Joanna Motyka, Angelika Edyta Charkiewicz, Elżbieta Milewska, Piotr Laudański, Wojciech Milty. NLRP3 Inflammasome in the Pathogenesis of Miscarriages. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408839. |
in the placental tissue, the expression of nlrp3, il-1β, il-18, and caspase-1 as well as that of the classical apoptosis biomarkers fas, fasl, bcl-2, and ca was evaluated by means of immunohistochemistry techniques. |
2024-10-16 |
2024-10-18 |
Not clear |
| Yuan-Yuan Liu, Ning Li, Xing-Yuan Chen, Hui Wang, Shao-Wei Zhu, Lan Yang, Fang-Yi Quan, Jian-Chun Ma, Jian-Wei Dai, Ya-le Jiang, Zhou-Fu Xiang, Qi Cheng, Wei-Hao Zhang, Ke-Han Chen, Wei Hou, Hai-Rong Xion. MicroRNA let-7a regulation of Hantaan virus replication by Targeting FAS Signaling Pathways. Virology. vol 600. 2024-10-09. PMID:39383773. |
mirna let-7a mimics and inhibitors validated the predicted targets, including cell apoptosis genes (fas, caspase-8, and caspase-3) and inflammatory factors (il-6 and its related factors). |
2024-10-09 |
2024-10-12 |
human |
| Malgorzata Krzyzowska, Magdalena Patrycy, Marcin Chodkowski, Martyna Janicka, Andrzej Kowalczyk, Katarzyna Skulska, Karolina Thörn, Kristina Eriksso. Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery from HSV-2-Mediated Spinal Cord Infection. Viruses. vol 16. issue 9. 2024-09-28. PMID:39339840. |
in vitro, we confirmed that fas and fasl is required for the induction of leucocyte apoptosis, but also show that the fas/fasl pathway is required for adequate cytokine and chemokine production by glial cells. |
2024-09-28 |
2024-10-01 |
mouse |
| Zahra Tahmasebi Far. Evaluation of the Effect of Menopausal Status and BMI on Polymorphisms in Fas/Fas L and the Risk of Breast Cancer. Clinical breast cancer. 2024-08-30. PMID:39214844. |
fas and fas ligand play an essential role in cell apoptosis. |
2024-08-30 |
2024-09-04 |
Not clear |