| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Xu, Wei Xiong, Ming Zhou, Heran Wang, Jing Yang, Xiayu Li, Pan Chen, Qianjin Liao, Hao Deng, Xiaoling Li, Guiyuan Li, Zhaoyang Zen. Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network. Molecular and cellular biochemistry. vol 411. issue 1-2. 2016-10-28. PMID:26407966. |
furthermore, we validated birc2, birc3, txn2, and notch1 genes as direct, functional brd7 targets, which were involved in the cell cycle and apoptosis pathways. |
2016-10-28 |
2023-08-13 |
human |
| Wenbao Lu, Huan Ning, Ling Gu, Hui Peng, Qinghong Wang, Rong Hou, Mingui Fu, Daniel F Hoft, Jianguo Li. MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression. Cancer research. vol 76. issue 6. 2016-07-25. PMID:26833120. |
in this study, we demonstrate that mcpip1 functions as a potent tumor suppressor that induces apoptosis of breast tumor cells by selectively enhancing mrna decay of antiapoptotic gene transcripts, including bcl2l1, bcl2a1, relb, birc3, and bcl3. |
2016-07-25 |
2023-08-13 |
Not clear |
| Azusa Yamato, Manabu Soda, Toshihide Ueno, Shinya Kojima, Kyuto Sonehara, Masahito Kawazu, Eirin Sai, Yoshihiro Yamashita, Takahide Nagase, Hiroyuki Man. Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential. Cancer science. vol 106. issue 9. 2015-12-15. PMID:26094954. |
birc2 and birc3 are closely related members of the inhibitor of apoptosis (iap) family of proteins and play pivotal roles in regulation of nuclear factor-κb (nf-κb) signaling and apoptosis. |
2015-12-15 |
2023-08-13 |
Not clear |
| Natasha R Catlin, Susan M Huse, Kim Boekelheid. The stage-specific testicular germ cell apoptotic response to low-dose radiation and 2,5-hexanedione combined exposure. II: qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicologic pathology. vol 42. issue 8. 2015-08-11. PMID:24670816. |
the apoptosis pcr arrays identified significant dose-dependent treatment effects on several genes, with downregulation of death receptor 5 (dr5), naip2, sphk2, casp7, aven, birc3, and upregulation of fas. |
2015-08-11 |
2023-08-12 |
rat |
| Leila Zarepoor, Jenifer T Lu, Claire Zhang, Wenqing Wu, Dion Lepp, Lindsay Robinson, Janitha Wanasundara, Steve Cui, Sébastien Villeneuve, Bourlaye Fofana, Rong Tsao, Geoffrey A Wood, Krista A Powe. Dietary flaxseed intake exacerbates acute colonic mucosal injury and inflammation induced by dextran sodium sulfate. American journal of physiology. Gastrointestinal and liver physiology. vol 306. issue 12. 2014-08-15. PMID:24763556. |
dietary fs exacerbated dss-induced acute colitis, as indicated by a heightened disease activity index and an increase in colonic injury and inflammatory biomarkers [histological damage, apoptosis, myeloperoxidase, inflammatory cytokines (il-6 and il-1β), and nf-κb signaling-related genes (nfkb1, ccl5, bcl2a1a, egfr, relb, birc3, and atf1)]. |
2014-08-15 |
2023-08-13 |
mouse |
| Agata A Fili. New boys in town: prognostic role of SF3B1, NOTCH1 and other cryptic alterations in chronic lymphocytic leukemia and how it works. Leukemia & lymphoma. vol 54. issue 9. 2014-03-06. PMID:23343182. |
recent studies have identified new recurrent mutations in cll cells, including mutation of the gene encoding one of the spliceosome subunits, sf3b1, mutation or rearrangement of notch1, a gene of well-known tumorigenesis association, and disruption of birc3, a member of the inhibitors of apoptosis (iap) family. |
2014-03-06 |
2023-08-12 |
Not clear |
| Bei Huang, Djeda Belharazem, Li Li, Susanne Kneitz, Philipp A Schnabel, Ralf J Rieker, Daniel Körner, Wilfred Nix, Berthold Schalke, Hans Konrad Müller-Hermelink, German Ott, Andreas Rosenwald, Philipp Ströbel, Alexander Mar. Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c. Frontiers in oncology. vol 3. 2014-01-15. PMID:24427739. |
in contrast to several other cancer cell lines, the birc3-positive tscc cell line, 1889c showed spontaneous apoptosis after birc3 knock-down. |
2014-01-15 |
2023-08-12 |
Not clear |
| Casandra M Cartagena, Kara E Schmid, Katie L Phillips, Frank C Tortella, Jitendra R Dav. Changes in apoptotic mechanisms following penetrating ballistic-like brain injury. Journal of molecular neuroscience : MN. vol 49. issue 2. 2013-06-27. PMID:22684621. |
for the mitochondria-mediated apoptosis pathway, rqs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. |
2013-06-27 |
2023-08-12 |
Not clear |
| Ying Hu, Hui-Xin Liu, Yuqi He, Yaping Fang, Jianwen Fang, Yu-Jui Yvonne Wa. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Biochemical pharmacology. vol 85. issue 7. 2013-05-07. PMID:23396089. |
however, fenretinide specifically induced fas/tnfα-mediated apoptosis by increasing the expression of pro-apoptotic genes i.e., dedd2, casp8, casp4, and hspa1a/b; whereas, atra induced the expression of birc3 and tnfaip3, which inhibit apoptosis by interacting with traf2. |
2013-05-07 |
2023-08-12 |
human |
| P Smolewski, T Roba. Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies. Current molecular medicine. vol 11. issue 8. 2012-09-21. PMID:21902653. |
the following iaps have been described so far: naip (neuronal apoptosis inhibitory protein; birc1), ciap1 and ciap2 (cellular inhibitor of apoptosis 1 and 2; birc2 and birc3, respectively), xiap (x-chromosome binding iap; birc4), survivin (birc5), bruce (apollon; birc6), livin (birc7) and ts-iap (testis-specific iap; birc8). |
2012-09-21 |
2023-08-12 |
human |
| Nikki L Neubauer, Erin C Ward, Parin Patel, Zhenxiao Lu, Irene Lee, Leen J Blok, Payman Hanifi-Moghaddam, Julian Schink, J Julie Ki. Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis. Hormones & cancer. vol 2. issue 3. 2011-11-29. PMID:21760855. |
progesterone receptor-b induction of birc3 protects endometrial cancer cells from ap1-59-mediated apoptosis. |
2011-11-29 |
2023-08-12 |
Not clear |
| Julia C Knight, Eugene L Scharf, Yang Mao-Draaye. Fas activation increases neural progenitor cell survival. Journal of neuroscience research. vol 88. issue 4. 2010-03-25. PMID:19830835. |
further investigation of this effect revealed that the antiapoptotic effects of fasl are mediated by the up-regulation of birc3, an inhibitor of apoptosis protein (iap). |
2010-03-25 |
2023-08-12 |
Not clear |
| Julia C Knight, Eugene L Scharf, Yang Mao-Draaye. Fas activation increases neural progenitor cell survival. Journal of neuroscience research. vol 88. issue 4. 2010-03-25. PMID:19830835. |
activation of fas increased cell survival by decreasing apoptosis through birc3 up-regulation. |
2010-03-25 |
2023-08-12 |
Not clear |
| Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Yang Dai, Lance D Miller, Chin-Yo Lin, Adina Stanculesc. Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer. Cancer research. vol 69. issue 23. 2009-12-21. PMID:19920189. |
consistent with their prosurvival roles, er and nf-kappab and their target gene, birc3, are involved in protecting breast cancer cells against apoptosis. |
2009-12-21 |
2023-08-12 |
Not clear |
| Nicola Conran, Camila B Almeida, Carolina Lanaro, Renata Proença Ferreira, Fabiola Traina, Sara T O Saad, Fernando F Cost. Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients. British journal of haematology. vol 139. issue 1. 2007-11-08. PMID:17711515. |
birc2 (encoding cellular inhibitor of apoptosis protein 1, ciap(1)), mcl1 and bax expression were unaltered in scd neutrophils; however, birc3 (encoding the caspase inhibitor, ciap(2)), was expressed at significantly higher levels. |
2007-11-08 |
2023-08-12 |
Not clear |
| P C Lucas, P Kuffa, S Gu, D Kohrt, D S L Kim, K Siu, X Jin, J Swenson, L M McAllister-Luca. A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment. Oncogene. vol 26. issue 38. 2007-09-28. PMID:17334391. |
this translocation generates a chimeric protein composed of n-terminal sequences of inhibitor of apoptosis 2 (api2, also known as birc3 and ciap2) fused to c-terminal sequences of malt1. |
2007-09-28 |
2023-08-12 |
Not clear |
| Héctor Hernández-Vargas, Socorro María Rodríguez-Pinilla, Mercedes Julián-Tendero, Pedro Sánchez-Rovira, Cristóbal Cuevas, Antonio Antón, Maria Jesus Ríos, José Palacios, Gema Moreno-Buen. Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast cancer research and treatment. vol 102. issue 2. 2007-07-31. PMID:17039268. |
activation of genes related with cell cycle, cell growth and apoptosis (bnip3l, ccng2, ddit4, tgfb2, tp53bp1, tp53inp1, and vegf) was the main finding in the p53-wild type cell line mcf7, while the p53-non-functional cell line mda-mb-231 was characterized by the regulation of nf-kappab target genes (birc3, cxcl1/gro1, irak2, tnf, tnfaip and traf1). |
2007-07-31 |
2023-08-12 |
Not clear |