| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Fukuda, T Kobayashi, H Yasui, M Tsutsumi, Y Konishi, O Hin. Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry. Virchows Archiv : an international journal of pathology. vol 434. issue 4. 1999-06-03. PMID:10335945. |
alterations in the rat tuberous sclerosis gene (tsc2) are responsible for the hereditary renal carcinomas (rcs) of eker rat. |
1999-06-03 |
2023-08-12 |
rat |
| H Zhang, T Yamamoto, E Nanba, Y Kitamura, T Terada, S Akaboshi, I Yuasa, K Ohtani, S Nakamoto, K Takeshita, K Ohn. Novel TSC2 mutation in a patient with pulmonary tuberous sclerosis: lack of loss of heterozygosity in a lung cyst. American journal of medical genetics. vol 82. issue 5. 1999-05-17. PMID:10069705. |
novel tsc2 mutation in a patient with pulmonary tuberous sclerosis: lack of loss of heterozygosity in a lung cyst. |
1999-05-17 |
2023-08-12 |
Not clear |
| R Przkora, P Falkai, A von Deimling, O D Wiestler, M Albus, M Rietschel, W Maier, T A Baye. Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia. European archives of psychiatry and clinical neuroscience. vol 248. issue 6. 1999-04-20. PMID:9928911. |
analysis of a polymorphism in the tuberous sclerosis (tsc2) gene does not predispose to schizophrenia. |
1999-04-20 |
2023-08-12 |
Not clear |
| T Kobayashi, O Minowa, J Kuno, H Mitani, O Hino, T Nod. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer research. vol 59. issue 6. 1999-04-13. PMID:10096549. |
germ-line mutations of the human tsc2 tumor suppressor gene cause tuberous sclerosis (tsc), a disease characterized by the development of hamartomas in various organs. |
1999-04-13 |
2023-08-12 |
mouse |
| N Satake, T Kobayashi, E Kobayashi, K Izumi, O Hin. Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. Cancer research. vol 59. issue 4. 1999-03-04. PMID:10029074. |
in the eker rat, a germ-line mutation in the homologue of the human tuberous sclerosis gene (tsc2) causes renal cell carcinomas (rcs) with a complete penetrance in all heterozygotes. |
1999-03-04 |
2023-08-12 |
human |
| N Satake, T Kobayashi, E Kobayashi, K Izumi, O Hin. Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. Cancer research. vol 59. issue 4. 1999-03-04. PMID:10029074. |
because tuberous sclerosis patients with alteration of either of the two predisposing genes (tsc1 and tsc2) show identical symptoms, the products of these two genes are thought to be involved in a common biological pathway. |
1999-03-04 |
2023-08-12 |
human |
| G Rennebeck, E V Kleymenova, R Anderson, R S Yeung, K Artzt, C L Walke. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 26. 1999-01-28. PMID:9861021. |
germline defects in the tuberous sclerosis 2 (tsc2) tumor suppressor gene predispose humans and rats to benign and malignant lesions in a variety of tissues. |
1999-01-28 |
2023-08-12 |
mouse |
| T Soucek, R S Yeung, M Hengstschläge. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 26. 1999-01-28. PMID:9861025. |
the tuberous sclerosis complex gene-2 (tsc2) on chromosome 16 encodes the tumor suppressor protein tuberin. |
1999-01-28 |
2023-08-12 |
Not clear |
| K Imai, A H Sarker, K Akiyama, S Ikeda, M Yao, K Tsutsui, T Shohmori, S Sek. Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. Gene. vol 222. issue 2. 1999-01-21. PMID:9831664. |
the nthl1 gene lies immediately adjacent to the tuberous sclerosis 2 (tsc2) gene on chromosome 16p13.3 in a 5'-to-5' orientation. |
1999-01-21 |
2023-08-12 |
human |
| D C Wolf, T L Goldsworthy, E M Donner, R Harden, B Fitzpatrick, J I Everit. Estrogen treatment enhances hereditary renal tumor development in Eker rats. Carcinogenesis. vol 19. issue 11. 1998-12-23. PMID:9855022. |
we tested the hypothesis that estrogen treatment or ovariectomy of rats modulates renal tumor development using tuberous sclerosis 2 (tsc2) heterozygous mutant (eker) rats in which a germline mutation predisposes the animals to renal cell tumor development. |
1998-12-23 |
2023-08-12 |
rat |
| T Fukuda, H Mitani, M Tsutsumi, Y Konishi, O Hin. Specific induction of hepatocellular adenomas by transplacental administration of ENU in the tsc2 gene mutant (Eker) rat. International journal of oncology. vol 13. issue 5. 1998-12-09. PMID:9772285. |
eker rats develop dominantly inherited renal carcinomas (rcs), with hereditary mutation, and following somatic mutation (knudson's second hit) at tuberous sclerosis gene (tsc2). |
1998-12-09 |
2023-08-12 |
rat |
| T L Plank, R S Yeung, E P Hensk. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer research. vol 58. issue 21. 1998-11-18. PMID:9809973. |
tuberous sclerosis is an inherited syndrome associated with mutations in two tumor suppressor genes: tsc1 and tsc2. |
1998-11-18 |
2023-08-12 |
rat |
| T L Plank, R S Yeung, E P Hensk. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer research. vol 58. issue 21. 1998-11-18. PMID:9809973. |
if altered vesicular trafficking leads to tumorigenesis in tuberous sclerosis, tsc1 and tsc2 may have a novel mechanism of tumor suppression. |
1998-11-18 |
2023-08-12 |
rat |
| N Satake, S Urakami, Y Hirayama, K Izumi, O Hin. Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma. International journal of cancer. vol 77. issue 6. 1998-09-14. PMID:9714060. |
we have identified a germline mutation in the rat homologue of the human tuberous sclerosis (tsc2) predisposing gene in the eker rat model. |
1998-09-14 |
2023-08-12 |
human |
| R Sasi, L Puebla, S Khare, Y C Pate. Polymorphism in the 5' flanking region of the human somatostatin receptor subtype 5. Gene. vol 214. issue 1-2. 1998-08-31. PMID:9651476. |
this region is evolutionarily conserved in all vertebrate genomes from the puffer fish (fugu rubripes) to human, and also contains loci for genes associated with two common multisystemic disorders, adult polycystic kidney disease (pkd1) and tuberous sclerosis (tsc2). |
1998-08-31 |
2023-08-12 |
human |
| K Orimoto, H Tsuchiya, J Sakurai, M Nishizawa, O Hin. Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells. Biochemical and biophysical research communications. vol 247. issue 3. 1998-07-31. PMID:9647762. |
alteration of the rat homologue of the tuberous sclerosis 2 (tsc2) gene is associated with dominantly inherited cancer in the eker rat model, indicating a tumor suppressor nature. |
1998-07-31 |
2023-08-12 |
rat |
| M van Slegtenhorst, M Nellist, B Nagelkerken, J Cheadle, R Snell, A van den Ouweland, A Reuser, J Sampson, D Halley, P van der Sluij. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Human molecular genetics. vol 7. issue 6. 1998-06-19. PMID:9580671. |
tuberous sclerosis (tsc) is an autosomal dominant disorder caused by a mutation in either the tsc1 or tsc2 tumour suppressor gene. |
1998-06-19 |
2023-08-12 |
Not clear |
| T Soucek, G Hölzl, G Bernaschek, M Hengstschläge. A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene. vol 16. issue 17. 1998-06-16. PMID:9619828. |
such role is consistent with the phenotype of tuberous sclerosis patients, who inherit one defective tsc2 allele, and frequently lose the remaining normal allele in many of the tubers/hamartomas which develop in the central nervous system of these patients. |
1998-06-16 |
2023-08-12 |
Not clear |
| J R Yates, I van Bakel, T Sepp, S J Payne, D W Webb, N C Nevin, A J Gree. Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis. Human molecular genetics. vol 6. issue 13. 1998-03-18. PMID:9361032. |
the family were typed for polymorphic markers spanning the two genes known to cause tuberous sclerosis located at 9q34 (tsc1) and 16p13.3 (tsc2). |
1998-03-18 |
2023-08-12 |
human |
| M Mizuguchi, M Kato, H Yamanouchi, K Ikeda, S Takashim. Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis. Acta neuropathologica. vol 94. issue 6. 1998-02-20. PMID:9444353. |
we have studied immunohistochemically the expression of tuberin, the protein product of the tsc2 gene, in cerebral, renal and cardiac tissues obtained from patients with tuberous sclerosis and from control patients. |
1998-02-20 |
2023-08-12 |
Not clear |