| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Xing, Yan-Xia Liu, Xin Liu, Shu-Lin Wang, Ping Li, Xiao-Hua Lin, Cong-Lu Sui, Cai Xu, Bing Qi, Qing Ton. Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome. Experimental and therapeutic medicine. vol 13. issue 6. 2020-09-29. PMID:28588681. |
expression levels of beclin-1, light chain (lc)3, mechanistic target of rapamycin (mtor), tumor suppressor p53 (p53), adenosine monophosphate-activated protein kinase (ampk), sestrin2 and tuberous sclerosis protein 1/2 were evaluated using quantitative polymerase chain reaction and western blotting. |
2020-09-29 |
2023-08-13 |
rat |
| Ming Hong Shen, Paulina Samsel, Louise L Shen, Kalin Narov, Jian Yang, Julian R Sampso. Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1 Translational oncology. vol 10. issue 5. 2020-09-29. PMID:28844017. |
tuberous sclerosis (tsc) is a tumor syndrome caused by tsc1 or tsc2 mutations that lead to aberrant activation of mtor and tumor formation in multiple organs. |
2020-09-29 |
2023-08-13 |
mouse |
| Chunjia Li, Hongyu Chen, Zhou Lan, Shaozong He, Rongrong Chen, Fang Wang, Zhibo Liu, Kai Li, Lili Cheng, Ye Liu, Kun Sun, Xiaofeng Wan, Xinxin Chen, Haiyong Peng, Li Li, Yanjun Zhang, Yanling Jing, Min Huang, Yanan Wang, Yan Wang, Jiandong Jiang, Xiaojun Zha, Ligong Chen, Hongbing Zhan. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell death and differentiation. vol 26. issue 10. 2020-09-28. PMID:30760873. |
loss of either tsc1 or tsc2 causes tuberous sclerosis complex (tsc) via activation of mtor signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yifeng Ding, Ji Wang, Shuizhen Zhou, Yuanfeng Zhou, Linmei Zhang, Lifei Yu, Yi Wan. Genotype and Phenotype Analysis of Chinese Children With Tuberous Sclerosis Complex: A Pediatric Cohort Study. Frontiers in genetics. vol 11. 2020-09-28. PMID:32211034. |
tuberous sclerosis complex (tsc) is a genetic condition characterized by the occurrence of hamartomatous wounds stemming from the dysfunction of the mammalian target of rapamycin (mtor) pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| A Mühlebner, A Bongaarts, H B Sarnat, T Scholl, E Aronic. New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives. Journal of anatomy. vol 235. issue 3. 2020-09-11. PMID:30901081. |
a broad spectrum of malformations of cortical development, such as focal cortical dysplasia (fcd) and tuberous sclerosis complex (tsc), have been linked to either germline or somatic mutations in mtor pathway-related genes, commonly summarised under the umbrella term 'mtoropathies'. |
2020-09-11 |
2023-08-13 |
Not clear |
| Martina Bonucci, Nicolas Kuperwasser, Serena Barbe, Vonda Koka, Delphine de Villeneuve, Chi Zhang, Nishit Srivastava, Xiaoying Jia, Matthew P Stokes, Frank Bienaimé, Virginie Verkarre, Jean Baptiste Lopez, Fanny Jaulin, Marco Pontoglio, Fabiola Terzi, Benedicte Delaval, Matthieu Piel, Mario Pend. mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Nature communications. vol 11. issue 1. 2020-08-26. PMID:32581239. |
mtor activation is essential and sufficient to cause polycystic kidneys in tuberous sclerosis complex (tsc) and other genetic disorders. |
2020-08-26 |
2023-08-13 |
mouse |
| Zhixiang Wu, Hongguang Wu, Shafiquzzaman Md, Guo Yu, Samy L Habib, Baojie Li, Jing L. Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse. Scientific reports. vol 9. issue 1. 2020-08-04. PMID:30696882. |
tuberous sclerosis complex (tsc) is caused by mutations in tsc1 or tsc2, which encode negative regulators of the mtor signaling pathway. |
2020-08-04 |
2023-08-13 |
mouse |
| Simone Bonazzi, Carleton P Goold, Audrey Gray, Noel M Thomsen, Jill Nunez, Rajeshri G Karki, Aakruti Gorde, Jonathan D Biag, Hasnain A Malik, Yingchuan Sun, Guiqing Liang, Danuta Lubicka, Sarah Salas, Nancy Labbe-Giguere, Erin P Keaney, Stephanie McTighe, Shanming Liu, Lin Deng, Grazia Piizzi, Franco Lombardo, Doug Burdette, Jean-Cosme Dodart, Christopher J Wilson, Stefan Peukert, Daniel Curtis, Lawrence G Hamann, Leon O Murph. Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders. Journal of medicinal chemistry. vol 63. issue 3. 2020-08-03. PMID:31955578. |
recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (tsc), a disease with overactivated mechanistic target of rapamycin (mtor) signaling, has demonstrated the therapeutic value of mtor inhibitors for central nervous system (cns) indications. |
2020-08-03 |
2023-08-13 |
Not clear |
| Qi Xu, Shimrit Uliel-Sibony, Christopher Dunham, Harvey Sarnat, Laura Flores-Sarnat, Ledia Brunga, Scott Davidson, Winnie Lo, Adam Shlien, Mary Connolly, Cyrus Boelman, Anita Datt. mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report. Journal of child neurology. vol 34. issue 3. 2020-06-16. PMID:30514132. |
dysregulation of the mtor pathway can result in malformations of cortical development, and mtor inhibitors can effectively reduce seizures in tuberous sclerosis complex. |
2020-06-16 |
2023-08-13 |
Not clear |
| Cristiana Pelorosso, Françoise Watrin, Valerio Conti, Emmanuelle Buhler, Antoinette Gelot, Xiaoxu Yang, Davide Mei, Jennifer McEvoy-Venneri, Jean-Bernard Manent, Valentina Cetica, Laurel L Ball, Anna Maria Buccoliero, Antonin Vinck, Carmen Barba, Joseph G Gleeson, Renzo Guerrini, Alfonso Repres. Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy. Human molecular genetics. vol 28. issue 22. 2020-06-15. PMID:31411685. |
single germline or somatic activating mutations of mammalian target of rapamycin (mtor) pathway genes are emerging as a major cause of type ii focal cortical dysplasia (fcd), hemimegalencephaly (hme) and tuberous sclerosis complex (tsc). |
2020-06-15 |
2023-08-13 |
Not clear |
| Chang-Ching Wei, Jeng-Daw Tsai, Ji-Nan Sheu, Sung-Lang Chen, Teng-Fu Tsao, Sheng-Hui Yang, Jeng-Dau Tsa. Continuous low-dose everolimus shrinkage tuberous sclerosis complex-associated renal angiomyolipoma: a 48-month follow-up study. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 67. issue 3. 2020-05-27. PMID:30455224. |
tuberous sclerosis complex (tsc) is a rare disease that causes multisystem benign neoplasm, induced by dysregulation of the mammalian target of the rapamycin pathway (mtor). |
2020-05-27 |
2023-08-13 |
Not clear |
| Charlotte Q Wu, David S Wolf, Edwin A Smit. Fate of Pediatric Renal Angiomyolipoma During mTOR Inhibitor Treatment in Tuberous Sclerosis Complex. Urology. vol 139. 2020-05-18. PMID:32081671. |
fate of pediatric renal angiomyolipoma during mtor inhibitor treatment in tuberous sclerosis complex. |
2020-05-18 |
2023-08-13 |
Not clear |
| Charlotte Q Wu, David S Wolf, Edwin A Smit. Fate of Pediatric Renal Angiomyolipoma During mTOR Inhibitor Treatment in Tuberous Sclerosis Complex. Urology. vol 139. 2020-05-18. PMID:32081671. |
to evaluate the clinical and radiographic follow-up of renal angiomyolipoma (aml) in pediatric patients with tuberous sclerosis complex (tsc) on mtor inhibitors. |
2020-05-18 |
2023-08-13 |
Not clear |
| Rong Wu, Fabin Dang, Peng Li, Pengfei Wang, Qian Xu, Zhengshuai Liu, Yu Li, Yuting Wu, Yaqiong Chen, Yi Li. The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex. Cell metabolism. vol 29. issue 3. 2020-05-11. PMID:30527742. |
here we show that period2 (per2), a core clock protein, functions as a scaffold protein to tether tuberous sclerosis complex 1 (tsc1), raptor, and mtor together to specifically suppress the activity of mtorc1 complex. |
2020-05-11 |
2023-08-13 |
mouse |
| Jerzy Lasota, Artur Kowalik, Anna Felisiak-Golabek, Sebastian Zięba, Zeng-Feng Wang, Markku Miettine. New Mechanisms of mTOR Pathway Activation in KIT-mutant Malignant GISTs. Applied immunohistochemistry & molecular morphology : AIMM. vol 27. issue 1. 2020-05-05. PMID:28777148. |
mutations were detected in 3 (21%) of 14 analyzed tumors: (1) c.3200a>t substitution in pik3cb encoding pi3k 110β subunit, (2) c.1040a>g substitution in tuberous sclerosis complex (tsc2) encoding tuberin, mtor down-regulator (3) c.6625c>g substitution in mtor. |
2020-05-05 |
2023-08-13 |
mouse |
| Charles M Lombar. Pulmonary lymphangioleiomyomatosis: A proposed state of neoplastic senescence. Medical hypotheses. vol 132. 2020-05-01. PMID:31494502. |
the hypothesis proposed here is that mutations in the tuberous sclerosis complex leading to mtor activation result in the specialized lam cells acquiring many of the cellular characteristics of the normal senescent cell, a state that i propose to characterize as a state of neoplastic senescence. |
2020-05-01 |
2023-08-13 |
Not clear |
| Ashley T Jones, Jian Yang, Kalin Narov, Elizabeth P Henske, Julian R Sampson, Ming Hong She. Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2 Neoplasia (New York, N.Y.). vol 21. issue 8. 2020-04-30. PMID:31207499. |
allosteric and atp-competitive inhibitors of mtor effectively suppress tumor progression-associated epithelial-mesenchymal transition in the kidneys of tsc2 in tuberous sclerosis (tsc)-associated tumors, mutations in the tsc genes lead to aberrant activation of the mechanistic target of rapamycin complex 1 (mtorc1) signaling pathway. |
2020-04-30 |
2023-08-13 |
Not clear |
| Yuan Li, Xiaojuan Chao, Shaogui Wang, Jessica A Williams, Hong-Min Ni, Wen-Xing Din. Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury. The American journal of pathology. vol 190. issue 1. 2020-04-21. PMID:31733185. |
to determine the role of adipose autophagy and mechanistic target of rapamycin (mtor) in alcohol-induced adipose and liver pathogenesis, we generated adipocyte-specific atg5 knockout (ko), adipocyte-specific mtor ko, adipocyte-specific raptor ko, and adipocyte-specific tuberous sclerosis complex 1 ko mice by crossing floxed mice with adipoq-cre. |
2020-04-21 |
2023-08-13 |
mouse |
| Yuan Li, Xiaojuan Chao, Shaogui Wang, Jessica A Williams, Hong-Min Ni, Wen-Xing Din. Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury. The American journal of pathology. vol 190. issue 1. 2020-04-21. PMID:31733185. |
adipocyte-specific raptor ko mice experienced exacerbated alcohol-induced steatosis, but neither adipocyte-specific mtor nor adipocyte-specific tuberous sclerosis complex 1 ko mice exhibited similar detrimental effects. |
2020-04-21 |
2023-08-13 |
mouse |
| Longbo Zhang, Tianxiang Huang, Shannon Teaw, Angélique Borde. Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity. Epilepsia. vol 60. issue 6. 2020-04-10. PMID:31125447. |
here, we further examined whether hypervascularization occurs in animal models of global and focal mcd with and without seizures, and whether it is sensitive to the mtor blocker, rapamycin, that is approved for epilepsy treatment in tuberous sclerosis complex. |
2020-04-10 |
2023-08-13 |
Not clear |