| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B D Manning, L C Cantle. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773158. |
a recent escalation of research in this area has come from the discovery of the tuberous sclerosis complex gene products, tuberin and hamartin, as central regulators of mtor activation. |
2004-03-23 |
2023-08-12 |
human |
| David J Kwiatkowsk. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer biology & therapy. vol 2. issue 5. 2004-03-08. PMID:14614311. |
rhebbing up mtor: new insights on tsc1 and tsc2, and the pathogenesis of tuberous sclerosis. |
2004-03-08 |
2023-08-12 |
human |
| Thurl E Harris, John C Lawrenc. TOR signaling. Science's STKE : signal transduction knowledge environment. vol 2003. issue 212. 2004-02-23. PMID:14668532. |
the signaling pathway downstream of akt leading to mtor involves the protein products of the genes mutated in tuberous sclerosis, tsc1 and tsc2, and the small guanosine triphosphatase, rheb. |
2004-02-23 |
2023-08-12 |
Not clear |
| Andrew R Tee, Brendan D Manning, Philippe P Roux, Lewis C Cantley, John Bleni. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current biology : CB. vol 13. issue 15. 2004-01-23. PMID:12906785. |
tuberous sclerosis complex gene products, tuberin and hamartin, control mtor signaling by acting as a gtpase-activating protein complex toward rheb. |
2004-01-23 |
2023-08-12 |
Not clear |
| Nisreen El-Hashemite, Victoria Walker, Hongbing Zhang, David J Kwiatkowsk. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer research. vol 63. issue 17. 2003-11-06. PMID:14500340. |
tuberous sclerosis complex (tsc) gene products negatively regulate mammalian target of rapamycin (mtor) activity. |
2003-11-06 |
2023-08-12 |
mouse |
| Ariel F Castro, John F Rebhun, Geoffrey J Clark, Lawrence A Quillia. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12842888. |
recently the tuberous sclerosis complex 2 (tsc2) tumor suppressor gene product has been identified as a negative regulator of protein synthesis upstream of the mtor and ribosomal s6 kinases. |
2003-10-02 |
2023-08-12 |
Not clear |
| D J Kwiatkowsk. Tuberous sclerosis: from tubers to mTOR. Annals of human genetics. vol 67. issue Pt 1. 2003-08-01. PMID:12556239. |
tuberous sclerosis: from tubers to mtor. |
2003-08-01 |
2023-08-12 |
drosophila_melanogaster |
| Andrew R Tee, Diane C Fingar, Brendan D Manning, David J Kwiatkowski, Lewis C Cantley, John Bleni. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 21. 2002-12-04. PMID:12271141. |
tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mtor)-mediated downstream signaling. |
2002-12-04 |
2023-08-12 |
Not clear |
| Heidi L Kenerson, Lauri D Aicher, Lawrence D True, Raymond S Yeun. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer research. vol 62. issue 20. 2002-11-29. PMID:12384518. |
here we demonstrate that primary tumors from tuberous sclerosis complex (tsc) patients and the eker rat model of tsc expressed elevated levels of phosphorylated mammalian target of rapamycin (mtor) and its effectors: p70s6k, s6 ribosomal protein, 4e-bp1, and eif4g. |
2002-11-29 |
2023-08-12 |
rat |
| Anja Jaeschke, Joerg Hartkamp, Masao Saitoh, Wendy Roworth, Takahiro Nobukuni, Angela Hodges, Julian Sampson, George Thomas, Richard Lam. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. The Journal of cell biology. vol 159. issue 2. 2002-11-22. PMID:12403809. |
tuberous sclerosis complex tumor suppressor-mediated s6 kinase inhibition by phosphatidylinositide-3-oh kinase is mtor independent. |
2002-11-22 |
2023-08-12 |
drosophila_melanogaster |