| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Haidinger, Manfred Hecking, Thomas Weichhart, Marko Poglitsch, Wolfgang Enkner, Karin Vonbank, Daniela Prayer, Alexandra Geusau, Rainer Oberbauer, Gerhard J Zlabinger, Afschin Soleiman, Walter H Hörl, Marcus D Säeman. Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Transplant international : official journal of the European Society for Organ Transplantation. vol 23. issue 8. 2010-10-25. PMID:20070623. |
tuberous sclerosis complex (tsc) is caused by constitutively activated mammalian target of rapamycin (mtor) resulting in nonmalignant tumours of several organs and consequently renal failure. |
2010-10-25 |
2023-08-12 |
Not clear |
| Namiko Abe, Steven H Borson, Michael J Gambello, Fan Wang, Valeria Cavall. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20615870. |
furthermore, genetic up-regulation of mtor activity by deletion of tuberous sclerosis complex 2 (tsc2) in drgs is sufficient to enhance axonal growth capacity in vitro and in vivo. |
2010-10-05 |
2023-08-12 |
Not clear |
| Ruhee Dere, Patricia D Wilson, Richard N Sandford, Cheryl Lyn Walke. Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PloS one. vol 5. issue 2. 2010-09-30. PMID:20169078. |
here we demonstrate a mechanism by which the intracellular, carboxy-terminal tail of polycystin-1 (cp1) regulates mtor signaling by altering the subcellular localization of the tuberous sclerosis complex 2 (tsc2) tumor suppressor, a gatekeeper for mtor activity. |
2010-09-30 |
2023-08-12 |
human |
| Jennifer M Spangle, Karl Münge. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. Journal of virology. vol 84. issue 18. 2010-09-20. PMID:20631133. |
it was previously reported that the human papillomavirus type 16 (hpv16) e6 oncoprotein may activate the s6 protein kinase (s6k) through binding and e6ap-mediated degradation of the mtor inhibitor tuberous sclerosis complex 2 (tsc2) (z. lu, x. hu, y. li, l. zheng, y. zhou, h. jiang, t. ning, z. basang, c. zhang, and y. ke, j. biol. |
2010-09-20 |
2023-08-12 |
human |
| Debbie Clements, Lee J Markwick, Nidhi Puri, Simon R Johnso. Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 3. 2010-09-08. PMID:20585037. |
lam cells have biallelic loss of either tuberous sclerosis complex gene (but predominantly tsc-2) and resultant dysregulation of the mammalian target of rapamycin (mtor) pathway. |
2010-09-08 |
2023-08-12 |
Not clear |
| L Krischock, R Beach, J Taylo. Sirolimus and tuberous sclerosis-associated renal angiomyolipomas. Archives of disease in childhood. vol 95. issue 5. 2010-07-07. PMID:20457704. |
tuberous sclerosis, caused by germline mutations in the tsc1 or tsc2 genes, is associated with aberrant upregulation of the mammalian target of rapamycin (mtor) signalling pathway, resulting in growth of tumours, including renal angiomyolipomas (amls). |
2010-07-07 |
2023-08-12 |
Not clear |
| Alberto Bartolomé, Carlos Guillén, Manuel Benit. Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20427478. |
tuberous sclerosis complex proteins 1-2 (tsc1-tsc2) complex integrates both nutrient and hormonal signaling and is a critical negative regulator of mammalian target of rapamycin (mtor) complex 1. |
2010-07-05 |
2023-08-12 |
Not clear |
| John D Short, Ruhee Dere, Kevin D Houston, Sheng-Li Cai, Jinhee Kim, Judith M Bergeron, Jianjun Shen, Jiyong Liang, Mark T Bedford, Gordon B Mills, Cheryl Lyn Walke. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Molecular carcinogenesis. vol 49. issue 5. 2010-06-04. PMID:20146253. |
the tuberous sclerosis complex 2 (tsc2) gene product, tuberin, acts as a negative regulator of mtor signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart, and lungs. |
2010-06-04 |
2023-08-12 |
Not clear |
| Elizabeth M Matthew, Lori S Hart, Aristotelis Astrinidis, Arunasalam Navaraj, Nathan G Dolloff, David T Dicker, Elizabeth P Henske, Wafik S El-Deir. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell cycle (Georgetown, Tex.). vol 8. issue 24. 2010-05-13. PMID:20054236. |
tuberous sclerosis complex 1 (tsc1) inhibits mammalian target of rapamycin (mtor), a central promotor of cell growth and proliferation. |
2010-05-13 |
2023-08-12 |
mouse |
| M Rosner, H Dolznig, C Fuchs, N Siegel, A Valli, M Hengstschläge. CDKs as therapeutic targets for the human genetic disease tuberous sclerosis? European journal of clinical investigation. vol 39. issue 12. 2010-05-12. PMID:19744185. |
the tuberous sclerosis gene 2 product tuberin is an important regulator of the mammalian target of rapamycin (mtor). |
2010-05-12 |
2023-08-12 |
human |
| Mitsunori Miyazaki, John J McCarthy, Karyn A Esse. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes. The FEBS journal. vol 277. issue 9. 2010-05-05. PMID:20412061. |
the present study aimed to test the hypothesis that igf-1 activation of mtor in c2c12 myotubes requires a phosphorylation-dependent, altered distribution of the tuberous sclerosis complex (tsc)1/tsc2 complex from the membrane to the cytosol. |
2010-05-05 |
2023-08-12 |
human |
| Bobby Bhatia, Zaher Nahlé, Anna Marie Kenne. Double trouble: when sonic hedgehog signaling meets TSC inactivation. Cell cycle (Georgetown, Tex.). vol 9. issue 3. 2010-05-04. PMID:20081363. |
igf activates the mammalian target of rapamycin (mtor), a growth-promoting kinase normally kept in check by the tumor suppressive tuberous sclerosis complex (tsc), comprised of tsc1 and tsc2. |
2010-05-04 |
2023-08-12 |
mouse |
| Hsu-Ping Kuo, Dung-Fang Lee, Chun-Te Chen, Mo Liu, Chao-Kai Chou, Hong-Jen Lee, Yi Du, Xiaoming Xie, Yongkun Wei, Weiya Xia, Zhang Weihua, Jer-Yen Yang, Chia-Jui Yen, Tzu-Hsuan Huang, Minjia Tan, Gang Xing, Yingming Zhao, Chien-Hsing Lin, Shih-Feng Tsai, Isaiah J Fidler, Mien-Chie Hun. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science signaling. vol 3. issue 108. 2010-04-27. PMID:20145209. |
mammalian target of rapamycin (mtor) regulates various cellular functions, including tumorigenesis, and is inhibited by the tuberous sclerosis 1 (tsc1)-tsc2 complex. |
2010-04-27 |
2023-08-12 |
Not clear |
| Michael Won. Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia. vol 51. issue 1. 2010-04-09. PMID:19817806. |
mammalian target of rapamycin (mtor) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies. |
2010-04-09 |
2023-08-12 |
mouse |
| Michael Won. Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia. vol 51. issue 1. 2010-04-09. PMID:19817806. |
the importance of the mtor pathway in epileptogenesis is best illustrated by tuberous sclerosis complex (tsc), one of the most common genetic causes of epilepsy. |
2010-04-09 |
2023-08-12 |
mouse |
| Duyu Nie, Alessia Di Nardo, Juliette M Han, Hasani Baharanyi, Ioannis Kramvis, Thanhthao Huynh, Sandra Dabora, Simone Codeluppi, Pier Paolo Pandolfi, Elena B Pasquale, Mustafa Sahi. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nature neuroscience. vol 13. issue 2. 2010-02-18. PMID:20062052. |
tuberous sclerosis complex is a disease caused by mutations in the tsc1 or tsc2 genes, which encode a protein complex that inhibits mtor kinase signaling by inactivating the rheb gtpase. |
2010-02-18 |
2023-08-12 |
mouse |
| Milena Morel, Julien Couturier, Claire Lafay-Chebassier, Marc Paccalin, Guylène Pag. PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease. Journal of cellular and molecular medicine. vol 13. issue 8A. 2010-02-05. PMID:19602051. |
recently, we showed that p53, regulated protein in development and dna damage response 1 and tuberous sclerosis complex 2 could represent molecular links between pkr and mtor signalling pathways. |
2010-02-05 |
2023-08-12 |
Not clear |
| D Ehninger, P J de Vries, A J Silv. From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. Journal of intellectual disability research : JIDR. vol 53. issue 10. 2010-01-04. PMID:19694899. |
from mtor to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. |
2010-01-04 |
2023-08-12 |
Not clear |
| Milena Morel, Julien Couturier, Raymond Pontcharraud, Roger Gil, Bernard Fauconneau, Marc Paccalin, Guylène Pag. Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity: role of p53, Redd1 and TSC2. Neurobiology of disease. vol 36. issue 1. 2009-12-07. PMID:19631745. |
this study analysed the crosslink between the up regulation of double-stranded rna-dependent-protein kinase (pkr) and the down regulation of mammalian target of rapamycin (mtor) signalling pathways via p53, the protein regulated in the development and dna damage response 1 (redd1) and the tuberous sclerosis complex (tsc2) factors in two beta-amyloid peptide (abeta) neurotoxicity models. |
2009-12-07 |
2023-08-12 |
rat |
| Po-Cheng Chiang, Ssu-Chia Lin, Shiow-Lin Pan, Ching-Hua Kuo, I-Lin Tsai, Mao-Tien Kuo, Wu-Che Wen, Peini Chen, Jih-Hwa Gu. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochemical pharmacology. vol 79. issue 2. 2009-12-07. PMID:19723512. |
antroquinonol induced the assembly of tuberous sclerosis complex (tsc)-1/tsc2, leading to the blockade of cellular protein synthesis through inhibition of protein phosphorylation including mtor (ser(2448)), p70(s6k) (thr(421)/ser(424) and thr(389)) and 4e-bp1 (thr(37)/thr(46) and thr(70)). |
2009-12-07 |
2023-08-12 |
human |