| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeny N Imyanitov, Tomasz Byrsk. Systemic treatment for hereditary cancers: a 2012 update. Hereditary cancer in clinical practice. vol 11. issue 1. 2013-04-12. PMID:23548133. |
down-regulation of mtor kinase by everolimus has been successfully used for the therapy of subependymal giant-cell astrocytomas in patients with tuberous sclerosis. |
2013-04-12 |
2023-08-12 |
Not clear |
| Tanjala T Gipson, Michael V Johnsto. Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders. Neural plasticity. vol 2012. 2013-04-03. PMID:22619737. |
to review the recent literature on the clinical features, genetic mutations, neurobiology associated with dysregulation of mtor (mammalian target of rapamycin), and clinical trials for tuberous sclerosis complex (tsc), neurofibromatosis-1 (nf1) and fragile x syndrome (fxs), and phosphatase and tensin homolog hamartoma syndromes (pths), which are neurogenetic disorders associated with abnormalities in synaptic plasticity and mtor signaling. |
2013-04-03 |
2023-08-12 |
Not clear |
| Yuning Zhou, Qingding Wang, Zheng Guo, Heidi L Weiss, B Mark Ever. Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells. Molecular biology of the cell. vol 23. issue 15. 2013-04-03. PMID:22696685. |
we identified redd1, a negative regulator of mammalian target of rapamycin (mtor) through the tuberous sclerosis complex (tsc1/2 complex), as a new molecular target of nfatc3. |
2013-04-03 |
2023-08-12 |
human |
| Carlos A Lafourcade, Tiffany V Lin, David M Feliciano, Longbo Zhang, Lawrence S Hsieh, Angélique Borde. Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 6. 2013-04-01. PMID:23392671. |
mammalian target of rapamycin (mtor) hyperactivity in perinatal neural progenitor cells (npcs) of tuberous sclerosis complex 1 (tsc1) heterozygote mice leads to heterotopia and abnormal neuronal morphogenesis as seen in patients with tuberous sclerosis. |
2013-04-01 |
2023-08-12 |
mouse |
| Karl Katholnig, Christopher C Kaltenecker, Hiroko Hayakawa, Margit Rosner, Caroline Lassnig, Gerhard J Zlabinger, Matthias Gaestel, Mathias Müller, Markus Hengstschläger, Walter H Hörl, Jin Mo Park, Marcus D Säemann, Thomas Weichhar. p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 4. 2013-03-28. PMID:23315073. |
cellular stress induced p38α-mediated mtor activation that was independent of pi3k but dependent on the mapk-activated protein kinase 2 and on the inhibition of tuberous sclerosis 1 and 2, a negative regulatory complex of mtor signaling. |
2013-03-28 |
2023-08-12 |
Not clear |
| Wenjuan Ru, Yanxi Peng, Ling Zhong, Shao-Jun Tan. A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2). Journal of molecular neuroscience : MN. vol 47. issue 2. 2013-03-26. PMID:22492229. |
a role of the mammalian target of rapamycin (mtor) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (tsc2). |
2013-03-26 |
2023-08-12 |
Not clear |
| Wenjuan Ru, Yanxi Peng, Ling Zhong, Shao-Jun Tan. A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2). Journal of molecular neuroscience : MN. vol 47. issue 2. 2013-03-26. PMID:22492229. |
it is well established that the gtpase-activating protein tuberous sclerosis complex proteins (2tsc2) is an upstream inhibitor of mtor. |
2013-03-26 |
2023-08-12 |
Not clear |
| Adam L Hartman, Polan Santos, Alison Dolce, J Marie Hardwic. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. PloS one. vol 7. issue 9. 2013-03-05. PMID:22984623. |
compounds that inhibit mtor kinase activity such as rapamycin and everolimus can suppress seizures in some chronic animal models and in patients with tuberous sclerosis. |
2013-03-05 |
2023-08-12 |
mouse |
| David Neal Franz, Elena Belousova, Steven Sparagana, E Martina Bebin, Michael Frost, Rachel Kuperman, Olaf Witt, Michael H Kohrman, J Robert Flamini, Joyce Y Wu, Paolo Curatolo, Petrus J de Vries, Vicky H Whittemore, Elizabeth A Thiele, James P Ford, Gaurav Shah, Helene Cauwel, David Lebwohl, Tarek Sahmoud, Sergiusz Jozwia. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet (London, England). vol 381. issue 9861. 2013-02-01. PMID:23158522. |
tuberous sclerosis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin (mtor) and growth of benign tumours in several organs. |
2013-02-01 |
2023-08-12 |
Not clear |
| M Luz Ruiz-Falcó Roja. [Therapeutic update in tuberous sclerosis complex: the role of mTOR pathway inhibitors]. Revista de neurologia. vol 54 Suppl 3. 2013-01-29. PMID:22605628. |
[therapeutic update in tuberous sclerosis complex: the role of mtor pathway inhibitors]. |
2013-01-29 |
2023-08-12 |
Not clear |
| M Luz Ruiz-Falcó Roja. [Therapeutic update in tuberous sclerosis complex: the role of mTOR pathway inhibitors]. Revista de neurologia. vol 54 Suppl 3. 2013-01-29. PMID:22605628. |
it has been shown that in tuberous sclerosis complex the genes tsc1 and tsc2 alter the mtor enzyme cascade, which sets off inhibition of this pathway. |
2013-01-29 |
2023-08-12 |
Not clear |
| John McMahon, Xiaoxing Huang, Jun Yang, Masaaki Komatsu, Zhenyu Yue, Jiang Qian, Xinjun Zhu, Yunfei Huan. Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 45. 2013-01-23. PMID:23136410. |
certain mutations within the mammalian target of rapamycin (mtor) pathway, most notably those affecting the tuberous sclerosis complex (tsc), lead to aberrant activation of mtor and result in a high incidence of epilepsy in humans and animal models. |
2013-01-23 |
2023-08-12 |
mouse |
| Elizabeth P Henske, Francis X McCormac. Lymphangioleiomyomatosis - a wolf in sheep's clothing. The Journal of clinical investigation. vol 122. issue 11. 2013-01-15. PMID:23114603. |
lam is caused by mutations in the tuberous sclerosis genes, resulting in activation of the mtor complex 1 signaling network. |
2013-01-15 |
2023-08-12 |
human |
| Chia-Jui Yen, Yih-Jyh Lin, Chia-Sheng Yen, Hung-Wen Tsai, Ting-Fen Tsai, Kwang-Yu Chang, Wei-Chien Huang, Pin-Wen Lin, Chi-Wu Chiang, Ting-Tsung Chan. Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma. PloS one. vol 7. issue 7. 2013-01-10. PMID:22848663. |
we investigated novel signaling pathways underlying hbx-induced liver tumorigenesis and found that the signaling pathway involving iκb kinase β (ikkβ), tuberous sclerosis complex 1 (tsc1), and mammalian target of rapamycin (mtor) downstream effector s6 kinase (s6k1), was upregulated when hbx was overexpressed in hepatoma cells. |
2013-01-10 |
2023-08-12 |
mouse |
| Sangyeul Han, Sun Kim, Samira Bahl, Lin Li, Clara F Burande, Nicole Smith, Marianne James, Roberta L Beauchamp, Pradeep Bhide, Aaron DiAntonio, Vijaya Rames. The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. The Journal of biological chemistry. vol 287. issue 36. 2012-11-19. PMID:22798074. |
our earlier studies identified pam to be associated with tuberous sclerosis complex (tsc) proteins, ubiquitinating tsc2 and regulating mammalian/mechanistic target of rapamycin (mtor) signaling. |
2012-11-19 |
2023-08-12 |
mouse |
| Robin C C Ryther, Michael Won. Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22544534. |
mtor inhibitors have antiepileptogenic and antiseizure effects in animal models of the genetic disease, tuberous sclerosis complex. |
2012-11-08 |
2023-08-12 |
human |
| Robin C C Ryther, Michael Won. Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22544534. |
clinical studies of rapamycin in human epilepsy are limited, but suggest that mtor inhibitors at least have antiseizure effects in tuberous sclerosis patients. |
2012-11-08 |
2023-08-12 |
human |
| Yoh Dobashi, Yasutaka Watanabe, Chihiro Miwa, Sakae Suzuki, Shinichiro Koyam. Mammalian target of rapamycin: a central node of complex signaling cascades. International journal of clinical and experimental pathology. vol 4. issue 5. 2012-10-31. PMID:21738819. |
mtor signaling occurs in concert with upstream akt and tuberous sclerosis complex (tsc) and several downstream effectors. |
2012-10-31 |
2023-08-12 |
human |
| Gopa Iyer, Aphrothiti J Hanrahan, Matthew I Milowsky, Hikmat Al-Ahmadie, Sasinya N Scott, Manickam Janakiraman, Mono Pirun, Chris Sander, Nicholas D Socci, Irina Ostrovnaya, Agnes Viale, Adriana Heguy, Luke Peng, Timothy A Chan, Bernard Bochner, Dean F Bajorin, Michael F Berger, Barry S Taylor, David B Soli. Genome sequencing identifies a basis for everolimus sensitivity. Science (New York, N.Y.). vol 338. issue 6104. 2012-10-19. PMID:22923433. |
among the somatic mutations was a loss-of-function mutation in tsc1 (tuberous sclerosis complex 1), a regulator of mtor pathway activation. |
2012-10-19 |
2023-08-12 |
Not clear |
| Avinash L Mohan, Marissa D Friedman, D Ryan Ormond, Michael Tobias, Raj Murali, Meena Jhanwar-Uniya. PI3K/mTOR signaling pathways in medulloblastoma. Anticancer research. vol 32. issue 8. 2012-10-15. PMID:22843885. |
recent studies have implicated sonic hedgehog (shh) and insulin growth factor (igf) as important mediators in deregulated pathways, which directly inactivate tuberous sclerosis complex, leading to activation of the serine/threonine kinase, mammalian target of rapamycin (mtor). |
2012-10-15 |
2023-08-12 |
Not clear |