| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Oeckl, Fabian Metzger, Magdalena Nagl, Christine A F von Arnim, Steffen Halbgebauer, Petra Steinacker, Albert C Ludolph, Markus Ott. Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies. Molecular & cellular proteomics : MCP. vol 15. issue 10. 2017-06-14. PMID:27507836. |
βsyn shows a high correlation with csf tau concentrations (r = 0.86, p < 0.0001, n = 125).in conclusion, we could not confirm previous observations of reduced αsyn in pd and our results indicate that csf synuclein concentrations are rather general markers of synaptic degeneration than specific for synucleinopathies. |
2017-06-14 |
2023-08-13 |
Not clear |
| Michel Goedert, Masami Masuda-Suzukake, Benjamin Falco. Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration. Brain : a journal of neurology. vol 140. issue 2. 2017-05-12. PMID:27658420. |
in tauopathies and synucleinopathies, the normally soluble intracellular proteins tau and α-synuclein become insoluble and filamentous. |
2017-05-12 |
2023-08-13 |
human |
| Xuling Li, Simon James, Peng Le. Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders. Journal of molecular neuroscience : MN. vol 60. issue 3. 2017-03-23. PMID:27629562. |
the ability of tau and α-syn to affect each other directly or indirectly might contribute to the overlap in the clinical and pathological features of tauopathies and synucleinopathies. |
2017-03-23 |
2023-08-13 |
Not clear |
| Marion Delenclos, Simon Moussaud, Pamela J McLea. Untangling a role for tau in synucleinopathies. Biological psychiatry. vol 78. issue 10. 2016-07-27. PMID:26497280. |
untangling a role for tau in synucleinopathies. |
2016-07-27 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Marcos J Guerrero-Muñoz, Diana L Castillo-Carranza, Cristian A Lasagna-Reeves, Julia E Gerson, Adriana A Paulucci-Holthauzen, Shashirekha Krishnamurthy, Malika Farhed, George R Jackson, Rakez Kaye. Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies. Biological psychiatry. vol 78. issue 10. 2016-07-26. PMID:25676491. |
pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies. |
2016-07-26 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Marcos J Guerrero-Muñoz, Diana L Castillo-Carranza, Cristian A Lasagna-Reeves, Julia E Gerson, Adriana A Paulucci-Holthauzen, Shashirekha Krishnamurthy, Malika Farhed, George R Jackson, Rakez Kaye. Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies. Biological psychiatry. vol 78. issue 10. 2016-07-26. PMID:25676491. |
previous work from our laboratory and others has shown that oligomeric entities of α-synuclein and tau accumulate in their respective diseases, but their interrelationship at this higher order has yet to be shown in synucleinopathies. |
2016-07-26 |
2023-08-13 |
Not clear |
| A Li, R Paudel, R Johnson, R Courtney, A J Lees, J L Holton, J Hardy, T Revesz, H Houlde. Pantothenate kinase-associated neurodegeneration is not a synucleinopathy. Neuropathology and applied neurobiology. vol 39. issue 2. 2015-11-13. PMID:22416811. |
historically, nbia is considered a synucleinopathy with numerous reports of nbia cases with lewy bodies and lewy neurites and some cases reporting additional abnormal tau accumulation. |
2015-11-13 |
2023-08-12 |
Not clear |
| Bidisha Roy, George R Jackso. Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Human molecular genetics. vol 23. issue 11. 2015-01-12. PMID:24430504. |
misexpression of tau and α-syn enhanced a rough eye phenotype and loss of dopaminergic neurons in fly tauopathy and synucleinopathy models, respectively. |
2015-01-12 |
2023-08-12 |
drosophila_melanogaster |
| Steven E Arnold, Jon B Toledo, Dina H Appleby, Sharon X Xie, Li-San Wang, Young Baek, David A Wolk, Edward B Lee, Bruce L Miller, Virginia M-Y Lee, John Q Trojanowsk. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of comparative neurology. vol 521. issue 18. 2014-06-11. PMID:23881776. |
these include: 1) amyloid-β and tau lesions in alzheimer's disease; 2) tau lesions in three other tauopathies including pick's disease, progressive supranuclear palsy and corticobasal degeneration; 3) α-synuclein inclusion ratings in four synucleinopathies including parkinson's disease, parkinson's disease with dementia, dementia with lewy bodies, and multiple system atrophy; and 4) tdp-43 lesions in two tdp-43 proteinopathies, including frontotemporal lobar degeneration associated with tdp-43 and amyotrophic lateral sclerosis. |
2014-06-11 |
2023-08-12 |
Not clear |
| Valeriy Duka, Jae-Hoon Lee, Joel Credle, Jonathan Wills, Adam Oaks, Ciaran Smolinsky, Ketul Shah, Deborah C Mash, Eliezer Masliah, Anita Sidh. Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. PloS one. vol 8. issue 9. 2014-05-27. PMID:24073234. |
identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and alzheimer's diseases. |
2014-05-27 |
2023-08-12 |
Not clear |
| Gianmario Ciaccioli, Ana Martins, Cátia Rodrigues, Helena Vieira, Patrícia Calad. A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration. PloS one. vol 8. issue 2. 2013-08-26. PMID:23393603. |
several studies revealed consistent overlap between synucleinopathies and tauopathies, demonstrating that α-synuclein (asyn) and tau co-localize in neurofibrillary tangles and in lewy bodies from alzheimer's and parkinson's disease patients and corresponding animal models. |
2013-08-26 |
2023-08-12 |
human |
| b' Mart\\xc3\\xad Colom-Cadena, Ellen Gelpi, Mar\\xc3\\xada J Mart\\xc3\\xad, Sara Charif, Oriol Dols-Icardo, Rafael Blesa, Jordi Clarim\\xc3\\xb3n, Alberto Lle\\xc3\\xb. MAPT H1 haplotype is associated with enhanced \\xce\\xb1-synuclein deposition in dementia with Lewy bodies. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819391.' |
the microtubule-associated protein tau (mapt) h1 haplotype has been identified as a genetic risk factor for synucleinopathies. |
2013-05-24 |
2023-08-12 |
Not clear |
| Katsuhiko Yanagisaw. [Searching for biomarkers to diagnose dementia]. Nihon rinsho. Japanese journal of clinical medicine. vol 70. issue 5. 2012-08-02. PMID:22620001. |
in terms of biomarkers for other dementing neurodegenerative diseases, including synucleinopathies such as dementia with lewy bodies and multiple system atrophy, and tauopathies such as progressive supranuclear palsy, corticobasal degeneration, synuclein, tdp-43, progranulin and tau may be candidate proteins for possible biomarkers for these diseases. |
2012-08-02 |
2023-08-12 |
Not clear |
| G Natale, L Pasquali, A Paparelli, F Forna. Parallel manifestations of neuropathologies in the enteric and central nervous systems. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 12. 2012-04-16. PMID:21951862. |
these features are common for a-synuclein (in parkinson's disease and other synucleinopathies), β-amyloid and tau (in degenerative dementia), sod-1 and tdp43 (in amyotrophic lateral sclerosis), and prpsc (in prion diseases). |
2012-04-16 |
2023-08-12 |
Not clear |
| b' Nahuai Badiola, Rita Machado de Oliveira, Federico Herrera, Cristina Guardia-Laguarta, Susana A Gon\\xc3\\xa7alves, Marta Pera, Marc Su\\xc3\\xa1rez-Calvet, Jordi Clarimon, Tiago Fleming Outeiro, Alberto Lle\\xc3\\xb. Tau enhances \\xce\\xb1-synuclein aggregation and toxicity in cellular models of synucleinopathy. PloS one. vol 6. issue 10. 2012-02-28. PMID:22039514.' |
tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy. |
2012-02-28 |
2023-08-12 |
Not clear |
| Juan S Jiméne. Protein-DNA interaction at the origin of neurological diseases: a hypothesis. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847445. |
a number of neurodegenerative diseases, including alzheimer's disease, tauopathies, parkinson's disease, and synucleinopathies, polyglutamine diseases, including huntington's disease, amyotrophic lateral sclerosis, and transmissible spongiform encephalopathy, are characterized by the existence of a protein or peptide prone to aggregation specific to the disease: amyloid-β, tau protein, α-synuclein, atrophin 1, androgen receptor, prion protein, copper-zinc superoxide dismutase, α 1a subunit of cav2.1, tata-box binding protein, huntingtin, and ataxins 1, 2, 3, and 7. |
2011-03-09 |
2023-08-12 |
Not clear |
| B Mollenhauer, M Bibl, H Esselmann, P Steinacker, C Trenkwalder, J Wiltfang, M Ott. Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis? Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 7. 2009-11-23. PMID:17318305. |
the abeta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and alpha-synuclein on abeta-processing. |
2009-11-23 |
2023-08-12 |
Not clear |
| H C Fung, G Xiromerisiou, J R Gibbs, Y R Wu, J Eerola, V Gourbali, O Hellström, C M Chen, J Duckworth, A Papadimitriou, P J Tienari, G M Hadjigeorgiou, J Hardy, A B Singleto. Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts. Neuro-degenerative diseases. vol 3. issue 6. 2007-02-15. PMID:17192721. |
the overlap in the clinical and pathological features of tauopathies and synucleinopathies raises the possibility that the tau protein may be important in parkinson's disease (pd) pathogenesis. |
2007-02-15 |
2023-08-12 |
Not clear |
| Muhammad Abdul Alim, Qiu-Lan Ma, Kazuya Takeda, Takako Aizawa, Mamoru Matsubara, Minako Nakamura, Akiko Asada, Taro Saito, Hiroyuki Kaji, Mitsunobu Yoshii, Shinichi Hisanaga, Kenji Uéd. Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein. Journal of Alzheimer's disease : JAD. vol 6. issue 4. 2004-12-30. PMID:15345814. |
now we can see a striking resemblance between alpha-synuclein and tau: both have the same physiological function and pathological features, making abnormal structures in diseased brains known as synucleinopathies and tauopathies. |
2004-12-30 |
2023-08-12 |
Not clear |
| G Pezzoli, M Canesi, C Gall. An overview of parkinsonian syndromes: data from the literature and from an Italian data-base. Sleep medicine. vol 5. issue 2. 2004-07-02. PMID:15033141. |
recent molecular biology research on neurodegenerative diseases, including parkinsonisms, has identified mutations in the genes that code for the proteins alpha-synuclein and tau, which have been used to classify them into synucleinopathies and tauopathies. |
2004-07-02 |
2023-08-12 |
Not clear |