All Relations between Synucleinopathies and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. 2024-05-06 2024-05-08 mouse
Wen Li, Jia-Yi L. Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration. Translational neurodegeneration. vol 13. issue 1. 2024-03-26. PMID:38528629. we and other researchers have sequentially shown the cross-seeding phenomenon of α-synuclein (α-syn) and tau, reinforcing pathologies between synucleinopathies and tauopathies. 2024-03-26 2024-03-28 Not clear
Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H Nies, Hongping Ye, Xianlin Han, Marius T Chiasseu, Guilin Wang, Ian R Mackenzie, Stephen M Strittmatte. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365772. pgrn reduction in male tauopathy attenuates activity of β-glucocerebrosidase (gcase), a protein previously associated with synucleinopathy, while increasing glucosylceramide (glccer)-positive tau inclusions. 2024-02-16 2024-02-19 mouse
. Expression of Concern: Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer's Diseases. PloS one. vol 18. issue 12. 2023-12-05. PMID:38051714. expression of concern: identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and alzheimer's diseases. 2023-12-05 2023-12-10 Not clear
Mingyue Jin, Shengming Wang, Xiaodie Gao, Zhenyou Zou, Shinji Hirotsune, Liyuan Su. Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843221. interestingly, the co-occurrence of α-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies, some of which share similarities in clinical manifestations. 2023-10-16 2023-11-08 mouse
Ana Ojeda, Valentina Cofré, Francisco Melo, Leonardo Caballero, Denis Fuentealba, Alberto Cornej. α-synuclein drives tau´s cytotoxic aggregates formation through hydrophobic interactions. ChemPlusChem. 2023-09-14. PMID:37708459. tau and α-synuclein are proteins involved in pathologies known as tauopathies and synucleinopathies, respectively. 2023-09-14 2023-10-07 Not clear
Nahuel N Foressi, Leandro Cruz Rodríguez, M Soledad Cele. Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies. Biochimica et biophysica acta. Proteins and proteomics. 2023-08-13. PMID:37574035. tauopathies and synucleinopathies are characterized by the aggregation of tau and α-synuclein (as) into amyloid structures, respectively. 2023-08-13 2023-08-16 Not clear
Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). 2023-07-10 2023-08-14 Not clear
Kurt A Jellinge. Morphological characteristics differentiate dementia with Lewy bodies from Parkinson disease with and without dementia. Journal of neural transmission (Vienna, Austria : 1996). 2023-06-12. PMID:37306790. the particular impact of both caa and tau pathology supports the concept of a pathogenic continuum ranging from pdnd to dlb + ad within the spectrum of age-related synucleinopathies. 2023-06-12 2023-08-14 Not clear
Yixiang Jiang, Yan Lin, Senthilkumar Krishnaswamy, Ruimin Pan, Qian Wu, Leslie A Sandusky-Beltran, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Erin E Congdon, Einar M Sigurdsso. Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology. Science advances. vol 9. issue 19. 2023-05-10. PMID:37163602. intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. 2023-05-10 2023-08-14 mouse
Yixiang Jiang, Yan Lin, Senthilkumar Krishnaswamy, Ruimin Pan, Qian Wu, Leslie A Sandusky-Beltran, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Erin E Congdon, Einar M Sigurdsso. Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology. Science advances. vol 9. issue 19. 2023-05-10. PMID:37163602. recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable. 2023-05-10 2023-08-14 mouse
Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. in addition, alzheimer's tau seeds occur in the vast majority of cases evaluated here inclusive of primary synucleinopathies, frontotemporal lobar degeneration and even controls albeit at multi-log lower levels than alzheimer's cases. 2023-05-08 2023-08-14 Not clear
Kah Hui Yap, Shahrul Azmin, Suzana Makpol, Hanafi Ahmad Damanhuri, Muzaimi Mustapha, Jemaima Che Hamzah, Norlinah Mohamed Ibrahi. Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review. Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453391. this systematic review summarizes the effects of trehalose on its underlying mechanisms in animal models of selected neurodegenerative disorders (tau pathology, synucleinopathy, polyglutamine tract, and motor neuron diseases). 2022-12-01 2023-08-14 human
Bernhard Iglseder, Rüdiger Lang. [Atypical Parkinson's syndrome in old age]. Zeitschrift fur Gerontologie und Geriatrie. 2022-06-24. PMID:35748931. the dlb and msa are characterized by deposition of the protein alpha-synuclein (synucleinopathy), psp and cbd are characterized by deposition of tau protein, often in the form of neurofibrillary tangles in nerve and glial cells (tauopathy). 2022-06-24 2023-08-14 Not clear
Wei-Ting Lin, Jin-Siang Shaw, Fang-Yu Cheng, Pei-Hao Che. Plasma total tau predicts executive dysfunction in Parkinson's disease. Acta neurologica Scandinavica. vol 145. issue 1. 2021-12-02. PMID:34398474. amyloid-β and tau pathologies are well-established in alzheimer's disease and commonly coexist with synucleinopathy in pd. 2021-12-02 2023-08-13 human
Patricia Richard, Lucie Kozlowski, Hélène Guillorit, Patrice Garnier, Nicole C McKnight, Antoine Danchin, Xavier Manièr. Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration. PloS one. vol 16. issue 8. 2021-11-29. PMID:34379627. after neurons were pretreated with stl-101 we observed a significant decrease in hyperphosphorylated alpha-synuclein, a marker of alpha-synuclein aggregation in a pd model of synucleinopathy, as well as a decrease in tau hyperphosphorylation in an acute and a chronic model of ad. 2021-11-29 2023-08-13 mouse
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. as we have previously demonstrated the presence of α-synuclein deposits in the pancreas of patients with synucleinopathies, as well as tau and aβ deposits in the pancreatic tissue of alzheimer's disease patients, we studied the immunoreactivity of amylin, tau and α-synuclein in the pancreas of 138 subjects with neurodegenerative diseases or type two diabetes and assessed whether the pancreatic β-cells of these subjects present cooccurrence of misfolded proteins. 2021-11-10 2023-08-13 human
Chialin Cheng, Surya A Reis, Emily T Adams, Daniel M Fass, Steven P Angus, Timothy J Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T Wang, Debasis Patnaik, Roberta L Beauchamp, Danielle A Feldman, M Catarina Silva, Mriganka Sur, Gary L Johnson, Vijaya Ramesh, Bruce L Miller, Sally Temple, Kenneth S Kosik, Bradford C Dickerson, Stephen J Haggart. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:34426604. recently, a p.a152t tau variant was identified as a risk factor for ftd, alzheimer's disease, and synucleinopathies. 2021-11-04 2023-08-13 human
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. tau and mapt genetics in tauopathies and synucleinopathies. 2021-10-11 2023-08-13 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. abnormal tau can also be observed in secondary tauopathies such as alzheimer's disease (ad) and synucleinopathies such as parkinson's disease (pd). 2021-10-11 2023-08-13 Not clear