Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Michel T Torbey, Qi Pauls, Nina Gentile, Mercedes Falciglia, William Meurer, Creed L Pettigrew, Valerie L Durkalski, Thomas Bleck, Askiel Brun. Intensive Versus Standard Treatment of Hyperglycemia in Acute Ischemic Stroke Patient: A Randomized Clinical Trial Subgroups Analysis. Stroke. 2022-03-25. PMID:35331007. |
we evaluated for associations between the shine (stroke hyperglycemia insulin network effort) randomized treatment group and the shine predefined 90-day functional outcome, within-patient subgroups defined by various glycemic parameters. |
2022-03-25 |
2023-08-13 |
Not clear |
Xiaomeng Yang, Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Qian Jia, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, Yongjun Wang, Yilong Wan. Association of triglyceride-glucose index and stroke recurrence among nondiabetic patients with acute ischemic stroke. BMC neurology. vol 22. issue 1. 2022-03-09. PMID:35260102. |
we investigated the association between tyg index and stroke recurrence and compared the effectiveness of tyg index with homeostasis model assessment of insulin resistance (homa-ir) in predicting stroke recurrence and death in nondiabetic acute ischemic stroke patients. |
2022-03-09 |
2023-08-13 |
Not clear |
J David Spence, Catherine Viscoli, Walter N Kernan, Lawrence H Young, Karen Furie, Ralph DeFronzo, Muhammad Abdul-Ghani, Paresh Dandona, Silvio E Inzucch. Efficacy of Lower Doses of Pioglitazone after Stroke or Transient Ischemic Attack In Patients with Insulin Resistance. Diabetes, obesity & metabolism. 2022-03-07. PMID:35253334. |
efficacy of lower doses of pioglitazone after stroke or transient ischemic attack in patients with insulin resistance. |
2022-03-07 |
2023-08-13 |
human |
J David Spence, Catherine Viscoli, Walter N Kernan, Lawrence H Young, Karen Furie, Ralph DeFronzo, Muhammad Abdul-Ghani, Paresh Dandona, Silvio E Inzucch. Efficacy of Lower Doses of Pioglitazone after Stroke or Transient Ischemic Attack In Patients with Insulin Resistance. Diabetes, obesity & metabolism. 2022-03-07. PMID:35253334. |
we assessed the benefits and risks of lower versus higher doses of pioglitazone taken by participants in the insulin resistance intervention in stroke trial. |
2022-03-07 |
2023-08-13 |
human |
Marcin Gierach, Anna Rasmus, Edyta Orłowsk. Verbal Fluency in Metabolic Syndrome. Brain sciences. vol 12. issue 2. 2022-02-25. PMID:35204018. |
type 2 diabetes (t2dm) constitutes insulin resistance, which is a strong risk factor for strokes. |
2022-02-25 |
2023-08-13 |
human |
Ying Wu, Liankun Sun, Zhoudao Zhuang, Xiaoqing Hu, Delu Don. Mitochondrial-Derived Peptides in Diabetes and Its Complications. Frontiers in endocrinology. vol 12. 2022-02-21. PMID:35185787. |
we mainly focus on mdps that have been discovered so far, such as humanin (hn), mitochondrial open reading frame of the 12s rrna-c (mots-c) and small humanin-like peptides (shlp 1-6), and elucidated the role of mdps in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. |
2022-02-21 |
2023-08-13 |
human |
Ya-Yu Wang, Shih-Yi Lin, Cheng-Yi Chang, Chih-Cheng Wu, Wen-Ying Chen, Su-Lan Liao, Yu-Fan Chen, Wen-Yi Wang, Chun-Jung Che. Jak2 Inhibitor AG490 Improved Poststroke Central and Peripheral Inflammation and Metabolic Abnormalities in a Rat Model of Ischemic Stroke. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943061. |
in conclusion, ag490 improved the inflammation and oxidative stress of neuronal, hepatic, and muscle tissues of stroke rats as well as impairing insulin signaling in the liver and skeletal muscles. |
2021-12-24 |
2023-08-13 |
rat |
Malihe Nejati, Saeed Abbasi, Shadi Farsaei, Fatemeh Shafie. L-carnitine supplementation ameliorates insulin resistance in critically ill acute stroke patients: a randomized, double-blinded, placebo-controlled clinical trial. Research in pharmaceutical sciences. vol 17. issue 1. 2021-12-15. PMID:34909045. |
l-carnitine supplementation ameliorates insulin resistance in critically ill acute stroke patients: a randomized, double-blinded, placebo-controlled clinical trial. |
2021-12-15 |
2023-08-13 |
Not clear |
Mengyuan Zhou, Hao Li, Yongjun Wang, Yuesong Pan, Yilong Wan. Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis. European journal of neurology. 2021-12-07. PMID:34797599. |
causal effect of insulin resistance on small vessel stroke and alzheimer's disease: a mendelian randomization analysis. |
2021-12-07 |
2023-08-13 |
Not clear |
Mengyuan Zhou, Hao Li, Yongjun Wang, Yuesong Pan, Yilong Wan. Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis. European journal of neurology. 2021-12-07. PMID:34797599. |
the causal effect of insulin resistance on small vessel stroke and alzheimer's disease (ad) was controversial in previous studies. |
2021-12-07 |
2023-08-13 |
Not clear |
Mengyuan Zhou, Hao Li, Yongjun Wang, Yuesong Pan, Yilong Wan. Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis. European journal of neurology. 2021-12-07. PMID:34797599. |
we therefore applied mendelian randomization (mr) analyses to identify the causal effect of insulin resistance on small vessel stroke and ad. |
2021-12-07 |
2023-08-13 |
Not clear |
M Reza Azarpazhooh, Chrysi Bogiatzi, J David Spenc. Stroke Prevention: Little-Known and Neglected Aspects. Cerebrovascular diseases (Basel, Switzerland). vol 50. issue 6. 2021-12-02. PMID:34044404. |
these include the following: (1) implementation of a mediterranean diet; (2) b vitamins to lower homocysteine; (3) coordinated approaches to smoking cessation; (4) intensive lipid-lowering therapy; (5) lipid lowering in the elderly; (6) physiologically individualized therapy for hypertension based on renin/aldosterone phenotyping; (7) avoiding excessive blood pressure reduction in patients with stiff arteries; (8) treatment of insulin resistance with pioglitazone in stroke patients with prediabetes and diabetes; (9) impaired activation of clopidogrel in patients with variants of cyp2c19; (10) aspirin pseudoresistance due to enteric coating; (11) rationale for anticoagulation in patients with embolic stroke of unknown source; (12) pharmacologic properties of direct-acting oral anticoagulants that should be considered when choosing among them; (13) the identification of which patients with asymptomatic carotid stenosis are at a high enough risk to benefit from carotid endarterectomy or stenting; and (14) the importance of age in choosing between endarterectomy and stenting. |
2021-12-02 |
2023-08-13 |
Not clear |
Matthew J Krinock, Neel S Singha. Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia. Annals of the New York Academy of Sciences. vol 1495. issue 1. 2021-11-16. PMID:33638222. |
in patients with diabetes, stroke recovery is impaired by insulin resistance, endothelial dysfunction, and inflammation, which impair key neuroresilience pathways maintaining cerebrovascular integrity, resolving poststroke inflammation, stimulating neural plasticity, and preventing neurodegeneration. |
2021-11-16 |
2023-08-13 |
Not clear |
Alexander Zabala, Vladimer Darsalia, Marcus Lind, Ann-Marie Svensson, Stefan Franzén, Björn Eliasson, Cesare Patrone, Magnus Jonsson, Thomas Nyströ. Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study. Cardiovascular diabetology. vol 20. issue 1. 2021-11-15. PMID:34615525. |
the aim of this study was to investigate the potential association between insulin resistance measured by estimated glucose disposal rate (egdr) and risk of stroke and mortality thereof in people with t2d. |
2021-11-15 |
2023-08-13 |
Not clear |
Sung-Chun Tang, Shyang-Rong Shih, Shin-Yi Lin, Chih-Hao Chen, Shin-Joe Yeh, Li-Kai Tsai, Wei-Shiung Yang, Jiann-Shing Jen. A randomized trial to investigate the efficacy and safety of insulin glargine in hyperglycemic acute stroke patients receiving intensive care. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34075142. |
a randomized trial to investigate the efficacy and safety of insulin glargine in hyperglycemic acute stroke patients receiving intensive care. |
2021-11-03 |
2023-08-13 |
Not clear |
Sung-Chun Tang, Shyang-Rong Shih, Shin-Yi Lin, Chih-Hao Chen, Shin-Joe Yeh, Li-Kai Tsai, Wei-Shiung Yang, Jiann-Shing Jen. A randomized trial to investigate the efficacy and safety of insulin glargine in hyperglycemic acute stroke patients receiving intensive care. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34075142. |
this pilot, randomized, open-label controlled study compared the basal-bolus regimens of insulin glargine (ig) and neutral protamine hagedorn (nph) insulin in stroke patients with hyperglycemia receiving intensive care. |
2021-11-03 |
2023-08-13 |
Not clear |
Kyle D Klingbeil, Sebastian Koch, Kunjan R Dav. Potential link between post-acute ischemic stroke exposure to hypoglycemia and hemorrhagic transformation. International journal of stroke : official journal of the International Stroke Society. vol 15. issue 5. 2021-10-25. PMID:29134928. |
recent pilot clinical trials have attempted to use intensive insulin therapy during stroke treatment to reduce the severity of cerebral infarction and possibly alleviate the risk of hemorrhagic transformation. |
2021-10-25 |
2023-08-13 |
Not clear |
Michael R Lyon, Veronica Kacini. Is There a Place for Dietary Fiber Supplements in Weight Management? Current obesity reports. vol 1. issue 2. 2021-10-21. PMID:22611521. |
epidemiological and experimental evidence point to a significant association between a lack of fiber intake and ischemic heart disease, stroke atherosclerosis, type 2 diabetes, overweight and obesity, insulin resistance, hypertension, dyslipidemia, as well as gastrointestinal disorders such as diverticulosis, irritable bowel disease, colon cancer, and cholelithiasis. |
2021-10-21 |
2023-08-12 |
Not clear |
Huinan Zhang, Yunhan Liu, Liusiyuan Cheng, Xue Ma, Xiaoxing Lu. Exendin-4 induces a novel extended effect of ischemic tolerance via crosstalk with IGF-1R. Brain research bulletin. vol 169. 2021-10-07. PMID:33197537. |
although glp-1 analogs were reported to induce sustained insulin secretion and glucose tolerance improved after cessation of treatment, no study has revealed whether ex-4 exerts sustained neuroprotection against stroke and the underlying mechanism after treatment cessation. |
2021-10-07 |
2023-08-13 |
mouse |
Sedigheh Eskandari, Soraya Sajadimajd, Loghman Alaei, Zhaleh Soheilikhah, Hossein Derakhshankhah, Gholamreza Bahram. Targeting Common Signaling Pathways for the Treatment of Stroke and Alzheimer's: a Comprehensive Review. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34169405. |
on the basis of literature appraisal, the most common signaling cascades implicated in the pathogenesis of ad and stroke including notch, autophagy, inflammatory, and insulin signaling pathways were reviewed. |
2021-09-10 |
2023-08-13 |
Not clear |