| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evangelos K Oikonomou, Phyllis M Thangaraj, Deepak L Bhatt, Joseph S Ross, Lawrence H Young, Harlan M Krumholz, Marc A Suchard, Rohan Kher. An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized controlled trials. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961715. |
in simulated group sequential analyses of two large cardiovascular outcomes rcts of (1) a therapeutic drug (pioglitazone versus placebo; insulin resistance intervention after stroke (iris) trial), and (2) a disease management strategy (intensive versus standard systolic blood pressure reduction in the systolic blood pressure intervention trial (sprint)), we constructed dynamic phenotypic representations to infer response profiles during interim analyses and examined their association with study outcomes. |
2023-11-14 |
2023-11-20 |
Not clear |
| Zhengzhao Lu, Yunyun Xiong, Xueyan Feng, Kaixuan Yang, Hongqiu Gu, Xingquan Zhao, Xia Meng, Yongjun Wan. Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients. Cardiovascular diabetology. vol 22. issue 1. 2023-08-26. PMID:37633905. |
estimated glucose disposal rate (egdr), a simple and noninvasive measure of insulin resistance, has been proven to be an independent risk factor for first-time stroke and all-cause mortality. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yanbo Yu, Ying Meng, Jing Li. Association between the triglyceride-glucose index and stroke in middle-aged and older non-diabetic population: A prospective cohort study. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 33. issue 9. 2023-08-13. PMID:37574222. |
data regarding the association between insulin resistance (ir) and stroke among the non-diabetic population is still limited and inconsistent. |
2023-08-13 |
2023-08-16 |
Not clear |
| Crystal J Smith, Serena-Kaye Sims, Stacy Nguyen, Alexus Williams, Taylor McLeod, Catrina Sims-Robinso. Intranasal insulin helps overcome brain insulin deficiency and improves survival and post-stroke cognitive impairment in male mice. Journal of neuroscience research. 2023-08-12. PMID:37571837. |
our data suggests that brain insulin deficiency correlates with worse post-stroke outcomes in a diet-induced mouse model of insulin resistance and increasing brain insulin levels may be a therapeutic target to improve stroke recovery. |
2023-08-12 |
2023-08-16 |
mouse |
| Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P Nawroth, Karel D Klika, Rakad Isa, Inke R König, Georg Royl, Markus Schwaninge. Glyoxal in hyperglycaemic ischemic stroke - a cohort study. Cardiovascular diabetology. vol 22. issue 1. 2023-07-12. PMID:37438755. |
however, in clinical trials treatment of elevated glucose levels with insulin did not improve stroke outcome, suggesting that collateral effects rather than hyperglycaemia itself aggravate ischemic brain damage. |
2023-07-12 |
2023-08-14 |
Not clear |
| Victoria Sircu, Silvia-Iaroslava Colesnic, Serghei Covantsev, Olga Corlateanu, Anna Sukhotko, Cristian Popovici, Alexandru Corlatean. The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & sleep. vol 5. issue 2. 2023-06-27. PMID:37366660. |
micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (osas), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. |
2023-06-27 |
2023-08-14 |
Not clear |
| Mingzhe Wang, Zheng Dai, Xiaohao Zhang, Xiaochen Xu, Yan Sun, Fan Gong, Baofeng Qin, Jun Wang, Bin Liu, Haiyan Tang, Tingting Li, Jinsi Zhang, Jiecheng Wang, Wenjie Chen, Ling Ma, Zhenxiang Han, Dezhi Li. The metabolic score for insulin resistance as a predictor of clinical outcome in stroke patients treated by intravenous thrombolysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-05-18. PMID:37202593. |
the metabolic score for insulin resistance as a predictor of clinical outcome in stroke patients treated by intravenous thrombolysis. |
2023-05-18 |
2023-08-14 |
Not clear |
| Mingzhe Wang, Zheng Dai, Xiaohao Zhang, Xiaochen Xu, Yan Sun, Fan Gong, Baofeng Qin, Jun Wang, Bin Liu, Haiyan Tang, Tingting Li, Jinsi Zhang, Jiecheng Wang, Wenjie Chen, Ling Ma, Zhenxiang Han, Dezhi Li. The metabolic score for insulin resistance as a predictor of clinical outcome in stroke patients treated by intravenous thrombolysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-05-18. PMID:37202593. |
we aimed to investigate the association between metabolic score for insulin resistance (mets-ir) and clinical outcomes in stroke patients treated by intravenous thrombolysis (ivt). |
2023-05-18 |
2023-08-14 |
Not clear |
| Inna I Zorina, Natalia F Avrova, Irina O Zakharova, Alexander O Shpako. Prospects for the Use of Intranasally Administered Insulin and Insulin-Like Growth Factor-1 in Cerebral Ischemia. Biochemistry. Biokhimiia. vol 88. issue 3. 2023-04-19. PMID:37076284. |
insulin and igf-1 produce multiple effects in the brain, including neuroprotective action in cerebral ischemia and stroke. |
2023-04-19 |
2023-08-14 |
Not clear |
| Yongle Wang, Tingting Liu, Yanan Li, Kaili Zhang, Haimei Fan, Jing Ren, Juan Li, Yali Li, Xinyi Li, Xuemei Wu, Junhui Wang, Lixi Xue, Xiaolei Gao, Yuping Yan, Gaimei Li, Qingping Liu, Wenhua Niu, Wenxian Du, Yuting Liu, Xiaoyuan Ni. Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension. Cardiovascular diabetology. vol 22. issue 1. 2023-04-19. PMID:37076850. |
the triglyceride-glucose (tyg) index, a simple measure of insulin resistance, is associated with intracranial atherosclerosis (icas) and stroke. |
2023-04-19 |
2023-08-14 |
Not clear |
| Mengyue Yao, Yulei Hao, Tian Wang, Meizhen Xie, Hui Li, Jiachun Feng, Liangshu Feng, Di M. A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy. Frontiers in neurology. vol 14. 2023-04-07. PMID:37025208. |
a review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: definition, underlying mechanisms, and the status of insulin therapy. |
2023-04-07 |
2023-08-14 |
Not clear |
| Wenbo Yang, Xintian Cai, Junli Hu, Wen Wen, Heizhati Mulalibieke, Xiaoguang Yao, Ling Yao, Qing Zhu, Jing Hong, Qin Luo, Shasha Liu, Nanfang L. The Metabolic Score for Insulin Resistance (METS-IR) Predicts Cardiovascular Disease and Its Subtypes in Patients with Hypertension and Obstructive Sleep Apnea. Clinical epidemiology. vol 15. 2023-02-23. PMID:36815173. |
we aimed to evaluate the mets-ir (metabolic score for insulin resistance) index for the prediction of incident cardiovascular disease (cvd) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (osa). |
2023-02-23 |
2023-08-14 |
Not clear |
| Shuaiyu Chen, Yan E, Xiaohao Zhang, Bin Wei, Siyu Wang, Zhaohan Xu, Pengyu Gong, Yi Xie, Chunhua Qin, Yingdong Zhan. A Novel Metabolic Score for Insulin Resistance and Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients After Endovascular Thrombectomy. Neuropsychiatric disease and treatment. vol 19. 2023-02-13. PMID:36778533. |
this study aimed to determine the relationship between the novel metabolic score for insulin resistance (mets-ir) and symptomatic intracranial hemorrhage (sich) after endovascular thrombectomy (evt) in stroke patients. |
2023-02-13 |
2023-08-14 |
Not clear |
| Aoming Jin, Shukun Wang, Jiejie Li, Mengxing Wang, Jinxi Lin, Hao Li, Xia Meng, Yongjun Wang, Yuesong Pa. Mediation of Systemic Inflammation on Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke. Stroke. 2023-02-01. PMID:36722344. |
insulin resistance is associated with stroke recurrence and poor functional outcomes of nondiabetic patients with ischemic stroke. |
2023-02-01 |
2023-08-14 |
Not clear |
| Xintian Cai, Junli Hu, Qing Zhu, Mengru Wang, Shasha Liu, Yujie Dang, Jing Hong, Nanfang L. Relationship of the metabolic score for insulin resistance and the risk of stroke in patients with hypertension: A cohort study. Frontiers in endocrinology. vol 13. 2022-12-22. PMID:36545329. |
relationship of the metabolic score for insulin resistance and the risk of stroke in patients with hypertension: a cohort study. |
2022-12-22 |
2023-08-14 |
Not clear |
| Xintian Cai, Junli Hu, Qing Zhu, Mengru Wang, Shasha Liu, Yujie Dang, Jing Hong, Nanfang L. Relationship of the metabolic score for insulin resistance and the risk of stroke in patients with hypertension: A cohort study. Frontiers in endocrinology. vol 13. 2022-12-22. PMID:36545329. |
the current status of the dose-response relationship between the metabolic score for insulin resistance (mets-ir) and new-onset stroke in hypertensive patients and its subtypes is unclear. |
2022-12-22 |
2023-08-14 |
Not clear |
| Vijayakumar Natesa. Therapeutics in Metabolic Diseases. Advances in experimental medicine and biology. vol 1396. 2022-12-01. PMID:36454472. |
metabolic diseases are characterized as the accumulation of many conditions that collectively increase a person's risk of atherosclerotic coronary disease, insulin, and diabetes mellitus intolerance, as well as vascular and neurological complications, such as stroke. |
2022-12-01 |
2023-08-14 |
Not clear |
| Daniel F Arteaga, Robin Ulep, Kevin K Kumar, Andrew M Southerland, Mark R Conaway, James Faber, Max Wintermark, David Joyner, Vera Sharashidze, Karen Hirsch, Dan-Victor Giurgiutiu, Yousef Hannawi, Yasmin Aziz, Lori Shutter, Anita Visweswaran, Alana Williams, Kori Williams, Sonya Gunter, Heather M Haughey, Askiel Bruno, Karen C Johnston, Vishal N Pate. Collateral status, hyperglycemia, and functional outcome after acute ischemic stroke. BMC neurology. vol 22. issue 1. 2022-11-05. PMID:36333676. |
we sought to determine whether collateral status modifies the association between treatment group and functional outcome in a subset of patients with large vessel occlusion enrolled in the stroke hyperglycemia insulin network effort (shine) trial. |
2022-11-05 |
2023-08-14 |
Not clear |
| Mashfiqul Hasan, Mohammad Atiqur-Rahman, Sharmin Chowdhury, Tareq Esteak, Jobaida Naznin, Mohammad Selim Shah. Efficacy and safety of analog insulin in comparison to human insulin in hospitalized acute stroke patients with hyperglycemia: A randomized, open-label, single center trial. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2022-11-04. PMID:36332823. |
efficacy and safety of analog insulin in comparison to human insulin in hospitalized acute stroke patients with hyperglycemia: a randomized, open-label, single center trial. |
2022-11-04 |
2023-08-14 |
human |
| Jesse Dawson, Yannick Béjot, Louisa M Christensen, Gian Marco De Marchis, Martin Dichgans, Guri Hagberg, Mirjam R Heldner, Haralampos Milionis, Linxin Li, Francesca Romana Pezzella, Martin Taylor Rowan, Cristina Tiu, Alastair Web. European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack. European stroke journal. vol 7. issue 3. 2022-09-09. PMID:36082250. |
to reduce the long-term risk of recurrent stroke or other important outcomes after ischaemic stroke or tia, we recommend: bp lowering treatment to a target of <130/80 mmhg, except in subgroups at increased risk of harm; hmgcoa-reductase inhibitors (statins) and targeting a low density lipoprotein level of <1.8 mmol/l (70 mg/dl); avoidance of dual antiplatelet therapy with aspirin and clopidogrel after the first 90 days; to not give direct oral anticoagulant drugs (doacs) for embolic stroke of undetermined source and to consider pioglitazone in people with diabetes or insulin resistance, after careful consideration of potential risks. |
2022-09-09 |
2023-08-14 |
Not clear |