| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D O Roberts, B Covert, T Lindsey, V Edwards, L McLaughlin, J Theus, R J Wray, K Jupka, D Baker, M Robbins, M R DeBau. Directed blood donor program decreases donor exposure for children with sickle cell disease requiring chronic transfusion. Immunohematology. vol 28. issue 1. 2012-10-05. PMID:22646143. |
in children with sickle cell disease (scd), primary and secondary prevention of strokes require indefinite regular blood transfusion therapy. |
2012-10-05 |
2023-08-12 |
Not clear |
| Raffaella Colombatti, Giorgio Meneghetti, Mario Ermani, Marta Pierobon, Laura Sainat. Primary stroke prevention for sickle cell disease in north-east Italy: the role of ethnic issues in establishing a Transcranial Doppler screening program. Italian journal of pediatrics. vol 35. 2012-10-02. PMID:19545422. |
stroke is a serious complication of sickle cell disease (scd) in children. |
2012-10-02 |
2023-08-12 |
Not clear |
| Raffaella Colombatti, Giorgio Meneghetti, Mario Ermani, Marta Pierobon, Laura Sainat. Primary stroke prevention for sickle cell disease in north-east Italy: the role of ethnic issues in establishing a Transcranial Doppler screening program. Italian journal of pediatrics. vol 35. 2012-10-02. PMID:19545422. |
a comprehensive care program for children with scd was established in our center since 2004, but a wide and routine screening for primary stroke prevention needs to be developed. |
2012-10-02 |
2023-08-12 |
Not clear |
| Noorjahan Ali, Rothtida Srey, Steven Pavlaki. Hemoglobinopathies and stroke: strategies for prevention and treatment. Current treatment options in cardiovascular medicine. vol 14. issue 3. 2012-10-02. PMID:22392612. |
current treatment options for stroke in sickle cell disease (scd) and thalassemia are limited. |
2012-10-02 |
2023-08-12 |
Not clear |
| Noorjahan Ali, Rothtida Srey, Steven Pavlaki. Hemoglobinopathies and stroke: strategies for prevention and treatment. Current treatment options in cardiovascular medicine. vol 14. issue 3. 2012-10-02. PMID:22392612. |
exchange transfusion is the mainstay of therapy of acute stroke in scd whereas blood transfusions and hydroxyurea appear to be the most effective current treatments. |
2012-10-02 |
2023-08-12 |
Not clear |
| Bruce Ovbiagele, Robert J Adam. Trends in comorbid sickle cell disease among stroke patients. Journal of the neurological sciences. vol 313. issue 1-2. 2012-09-20. PMID:21992814. |
stroke is a major complication of sickle cell disease (scd). |
2012-09-20 |
2023-08-12 |
Not clear |
| Bruce Ovbiagele, Robert J Adam. Trends in comorbid sickle cell disease among stroke patients. Journal of the neurological sciences. vol 313. issue 1-2. 2012-09-20. PMID:21992814. |
in an era of chronic red cell transfusions for stroke prophylaxis in children and greater life expectancy, nationwide data on stroke rates among pediatric and adult patients with scd are scarce. |
2012-09-20 |
2023-08-12 |
Not clear |
| Bruce Ovbiagele, Robert J Adam. Trends in comorbid sickle cell disease among stroke patients. Journal of the neurological sciences. vol 313. issue 1-2. 2012-09-20. PMID:21992814. |
we evaluated recent time trends in stroke hospitalization among children (0-17 years) and adults (>17 years) with scd in the united states. |
2012-09-20 |
2023-08-12 |
Not clear |
| Emily Riehm Meier, Jeffery L Mille. Sickle cell disease in children. Drugs. vol 72. issue 7. 2012-07-26. PMID:22519940. |
routine transcranial doppler screening with the institution of chronic transfusion decreases the risk of stroke from 10% to 1% in paediatric scd patients. |
2012-07-26 |
2023-08-12 |
Not clear |
| IkeOluwa Lagunju, Olugbemiro Sodeinde, Paul Telfe. Prevalence of transcranial Doppler abnormalities in Nigerian children with sickle cell disease. American journal of hematology. vol 87. issue 5. 2012-06-19. PMID:22460323. |
transcranial doppler (tcd) ultrasonography helps to identify children with sickle cell disease (scd) who are at an increased risk of stroke,making primary stroke prevention a reality. |
2012-06-19 |
2023-08-12 |
Not clear |
| Carleton Jen Chang Hsia, Li M. A hemoglobin-based multifunctional therapeutic: polynitroxylated pegylated hemoglobin. Artificial organs. vol 36. issue 2. 2012-06-05. PMID:21955160. |
preliminary results on the potential utility of pnph for neurovascular protection in thrombolytic stroke therapy and for correction of vascular dysfunction through transfusion in sickle-cell disease (scd) are also discussed. |
2012-06-05 |
2023-08-12 |
Not clear |
| Carleton Jen Chang Hsia, Li M. A hemoglobin-based multifunctional therapeutic: polynitroxylated pegylated hemoglobin. Artificial organs. vol 36. issue 2. 2012-06-05. PMID:21955160. |
we hypothesize that with pnph, hb has more than been tamed--it has become a therapeutic and not just a nontoxic extracellular oxygen carrier--and that successful pnph development as a multifunctional therapeutic that protects the neurovasculature and reduces oxidative stress may represent a paradigm shift in transfusion and critical care medicine, which may meet a number of unmet medical needs resulting from oxidative stress and inadequate blood flow, such as hs, tbi, scd, and stroke. |
2012-06-05 |
2023-08-12 |
Not clear |
| Abdulrahman Alsultan, Aamer Aleem, Hazem Ghabbour, Farjah H AlGahtani, Ali Al-Shehri, Mohamed Elfaki Osman, Kadijah Kurban, Mohammed S Alsultan, Hasan Bahakim, AbdelKareem M Al-Mome. Sickle cell disease subphenotypes in patients from Southwestern Province of Saudi Arabia. Journal of pediatric hematology/oncology. vol 34. issue 2. 2012-04-09. PMID:22322941. |
frequency of various scd complications was as follows: painful episodes of variable severity occurred in majority of patients (98%), osteonecrosis (14%), acute chest syndrome (22%), splenic sequestration (23%), gallstones (34%), stroke (7.5%), priapism (2.6%), serious infections (11.5%), and persistent splenomegaly (11%) beyond 5 years of age. |
2012-04-09 |
2023-08-12 |
Not clear |
| Michael R DeBau. Secondary prevention of overt strokes in sickle cell disease: therapeutic strategies and efficacy. Hematology. American Society of Hematology. Education Program. vol 2011. 2012-04-04. PMID:22160069. |
nevertheless, children and adults with scd continue to have overt strokes, and in the foreseeable future will continue to require secondary prevention of strokes. |
2012-04-04 |
2023-08-12 |
Not clear |
| Michael R DeBau. Secondary prevention of overt strokes in sickle cell disease: therapeutic strategies and efficacy. Hematology. American Society of Hematology. Education Program. vol 2011. 2012-04-04. PMID:22160069. |
with the exception of the most recently completed "stroke with transfusions changing to hydroxyurea" trial (switch; nct00122980), randomized trials providing best evidence for long-term management of overt strokes in scd is lacking. |
2012-04-04 |
2023-08-12 |
Not clear |
| M Arkuszewski, J Krejza, R Chen, J L Kwiatkowski, R Ichord, R Zimmerman, K Ohene-Frempong, L Desiderio, E R Melhe. Sickle cell disease: reference values and interhemispheric differences of nonimaging transcranial Doppler blood flow parameters. AJNR. American journal of neuroradiology. vol 32. issue 8. 2012-01-23. PMID:21700785. |
tcd screening is widely used to identify children with scd at high risk of stroke. |
2012-01-23 |
2023-08-12 |
Not clear |
| Susanna Bortolusso Ali, Michelle Moosang, Lesley King, Jennifer Knight-Madden, Marvin Rei. Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke. American journal of hematology. vol 86. issue 10. 2011-12-29. PMID:21898530. |
chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in children with sickle cell disease (scd). |
2011-12-29 |
2023-08-12 |
Not clear |
| Susanna Bortolusso Ali, Michelle Moosang, Lesley King, Jennifer Knight-Madden, Marvin Rei. Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke. American journal of hematology. vol 86. issue 10. 2011-12-29. PMID:21898530. |
our data support the role of hu as a useful intervention for prevention of stroke recurrence in scd when transfusion programs are not available or practical. |
2011-12-29 |
2023-08-12 |
Not clear |
| M S Islam, P Anoo. Current concepts in the management of stroke in children with sickle cell disease. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 27. issue 7. 2011-11-08. PMID:21258808. |
stroke is the most significant complication of sickle cell disease (scd) in children with the potential for major morbidity and mortality. |
2011-11-08 |
2023-08-12 |
Not clear |
| M S Islam, P Anoo. Current concepts in the management of stroke in children with sickle cell disease. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 27. issue 7. 2011-11-08. PMID:21258808. |
published studies on primary and secondary prevention of stroke in children with scd are analysed with respect to the levels of evidence, in favour of preventative and therapeutic strategies. |
2011-11-08 |
2023-08-12 |
Not clear |