| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael R DeBau. Secondary prevention of overt strokes in sickle cell disease: therapeutic strategies and efficacy. Hematology. American Society of Hematology. Education Program. vol 2011. 2012-04-04. PMID:22160069. |
with the exception of the most recently completed "stroke with transfusions changing to hydroxyurea" trial (switch; nct00122980), randomized trials providing best evidence for long-term management of overt strokes in scd is lacking. |
2012-04-04 |
2023-08-12 |
Not clear |
| M Arkuszewski, J Krejza, R Chen, J L Kwiatkowski, R Ichord, R Zimmerman, K Ohene-Frempong, L Desiderio, E R Melhe. Sickle cell disease: reference values and interhemispheric differences of nonimaging transcranial Doppler blood flow parameters. AJNR. American journal of neuroradiology. vol 32. issue 8. 2012-01-23. PMID:21700785. |
tcd screening is widely used to identify children with scd at high risk of stroke. |
2012-01-23 |
2023-08-12 |
Not clear |
| Susanna Bortolusso Ali, Michelle Moosang, Lesley King, Jennifer Knight-Madden, Marvin Rei. Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke. American journal of hematology. vol 86. issue 10. 2011-12-29. PMID:21898530. |
chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in children with sickle cell disease (scd). |
2011-12-29 |
2023-08-12 |
Not clear |
| Susanna Bortolusso Ali, Michelle Moosang, Lesley King, Jennifer Knight-Madden, Marvin Rei. Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke. American journal of hematology. vol 86. issue 10. 2011-12-29. PMID:21898530. |
our data support the role of hu as a useful intervention for prevention of stroke recurrence in scd when transfusion programs are not available or practical. |
2011-12-29 |
2023-08-12 |
Not clear |
| M S Islam, P Anoo. Current concepts in the management of stroke in children with sickle cell disease. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 27. issue 7. 2011-11-08. PMID:21258808. |
stroke is the most significant complication of sickle cell disease (scd) in children with the potential for major morbidity and mortality. |
2011-11-08 |
2023-08-12 |
Not clear |
| M S Islam, P Anoo. Current concepts in the management of stroke in children with sickle cell disease. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 27. issue 7. 2011-11-08. PMID:21258808. |
published studies on primary and secondary prevention of stroke in children with scd are analysed with respect to the levels of evidence, in favour of preventative and therapeutic strategies. |
2011-11-08 |
2023-08-12 |
Not clear |
| Miguel R Abboud, Eunsil Yim, Khaled M Musallam, Robert J Adam. Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II. Blood. vol 118. issue 4. 2011-10-14. PMID:21633086. |
in the stop ii trial, discontinuation of prophylactic transfusions in high risk children with sickle cell disease (scd) resulted in a high rate of reversion to abnormal blood-flow velocities on transcranial doppler (tcd) ultrasonography and strokes. |
2011-10-14 |
2023-08-12 |
Not clear |
| Shyamal H Mehta, Robert J Adam. Treatment and prevention of stroke in children with sickle cell disease. Current treatment options in neurology. vol 8. issue 6. 2011-07-14. PMID:17032571. |
stroke is one of the major complications in children with sickle cell disease (scd). |
2011-07-14 |
2023-08-12 |
Not clear |
| Shyamal H Mehta, Robert J Adam. Treatment and prevention of stroke in children with sickle cell disease. Current treatment options in neurology. vol 8. issue 6. 2011-07-14. PMID:17032571. |
there have been no acute stroke treatment studies in scd, but hydration and exchange transfusion are often recommended. |
2011-07-14 |
2023-08-12 |
Not clear |
| Shyamal H Mehta, Robert J Adam. Treatment and prevention of stroke in children with sickle cell disease. Current treatment options in neurology. vol 8. issue 6. 2011-07-14. PMID:17032571. |
tcd screening of all children with scd, and initiation and maintenance of chronic transfusion to maintain hemoglobin s below 30% in the high-risk group, is the only proven prevention strategy for stroke in scd. |
2011-07-14 |
2023-08-12 |
Not clear |
| Shyamal H Mehta, Robert J Adam. Treatment and prevention of stroke in children with sickle cell disease. Current treatment options in neurology. vol 8. issue 6. 2011-07-14. PMID:17032571. |
bone marrow transplantation can be curative for scd, and limited data support its use to prevent stroke in scd. |
2011-07-14 |
2023-08-12 |
Not clear |
| William J Savage, Allen D Everett, James F Casell. Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke. Acta haematologica. vol 125. issue 3. 2011-05-06. PMID:21099215. |
a 12-year-old boy with hbss sickle cell disease (scd) was admitted with an acute febrile illness and developed overt stroke 3 days later. |
2011-05-06 |
2023-08-12 |
Not clear |
| William J Savage, Allen D Everett, James F Casell. Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke. Acta haematologica. vol 125. issue 3. 2011-05-06. PMID:21099215. |
stroke in scd can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful. |
2011-05-06 |
2023-08-12 |
Not clear |
| Monica L Hulbert, Robert C McKinstry, JoAnne L Lacey, Christopher J Moran, Julie A Panepinto, Alexis A Thompson, Sharada A Sarnaik, Gerald M Woods, James F Casella, Baba Inusa, Jo Howard, Fenella J Kirkham, Kofi A Anie, Jonathan E Mullin, Rebecca Ichord, Michael Noetzel, Yan Yan, Mark Rodeghier, Michael R Debau. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. vol 117. issue 3. 2011-04-14. PMID:20940417. |
children with sickle cell disease (scd) and strokes receive blood transfusion therapy for secondary stroke prevention; despite this, approximately 20% experience second overt strokes. |
2011-04-14 |
2023-08-12 |
Not clear |
| Monica L Hulbert, Robert C McKinstry, JoAnne L Lacey, Christopher J Moran, Julie A Panepinto, Alexis A Thompson, Sharada A Sarnaik, Gerald M Woods, James F Casella, Baba Inusa, Jo Howard, Fenella J Kirkham, Kofi A Anie, Jonathan E Mullin, Rebecca Ichord, Michael Noetzel, Yan Yan, Mark Rodeghier, Michael R Debau. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. vol 117. issue 3. 2011-04-14. PMID:20940417. |
given this rate of second overt strokes and the clinical significance of silent cerebral infarcts, we tested the hypothesis that silent cerebral infarcts occur among children with scd being transfused for secondary stroke prevention. |
2011-04-14 |
2023-08-12 |
Not clear |
| Monica L Hulbert, Robert C McKinstry, JoAnne L Lacey, Christopher J Moran, Julie A Panepinto, Alexis A Thompson, Sharada A Sarnaik, Gerald M Woods, James F Casella, Baba Inusa, Jo Howard, Fenella J Kirkham, Kofi A Anie, Jonathan E Mullin, Rebecca Ichord, Michael Noetzel, Yan Yan, Mark Rodeghier, Michael R Debau. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. vol 117. issue 3. 2011-04-14. PMID:20940417. |
a prospective cohort enrolled children with scd and overt strokes at 7 academic centers. |
2011-04-14 |
2023-08-12 |
Not clear |
| Monica L Hulbert, Robert C McKinstry, JoAnne L Lacey, Christopher J Moran, Julie A Panepinto, Alexis A Thompson, Sharada A Sarnaik, Gerald M Woods, James F Casella, Baba Inusa, Jo Howard, Fenella J Kirkham, Kofi A Anie, Jonathan E Mullin, Rebecca Ichord, Michael Noetzel, Yan Yan, Mark Rodeghier, Michael R Debau. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. vol 117. issue 3. 2011-04-14. PMID:20940417. |
children with scd and overt strokes receiving regular blood transfusion therapy experience silent cerebral infarcts at a higher rate than previously recognized. |
2011-04-14 |
2023-08-12 |
Not clear |
| Monica L Hulbert, Robert C McKinstry, JoAnne L Lacey, Christopher J Moran, Julie A Panepinto, Alexis A Thompson, Sharada A Sarnaik, Gerald M Woods, James F Casella, Baba Inusa, Jo Howard, Fenella J Kirkham, Kofi A Anie, Jonathan E Mullin, Rebecca Ichord, Michael Noetzel, Yan Yan, Mark Rodeghier, Michael R Debau. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. vol 117. issue 3. 2011-04-14. PMID:20940417. |
additional therapies are needed for secondary stroke prevention in children with scd. |
2011-04-14 |
2023-08-12 |
Not clear |
| M Arkuszewski, E R Melhem, J Krejz. Neuroimaging in assessment of risk of stroke in children with sickle cell disease. Advances in medical sciences. vol 55. issue 2. 2011-04-08. PMID:21109500. |
stroke and subclinical "silent infarcts" are major causes of morbidity in children with sickle cell disease (scd). |
2011-04-08 |
2023-08-12 |
Not clear |
| Pramil Cheriyath, Fan He, Ian Peters, Xian Li, Peter Alagona, Chuntao Wu, Min Pu, Wayne E Cascio, Duanping Lia. Relation of atrial and/or ventricular premature complexes on a two-minute rhythm strip to the risk of sudden cardiac death (the Atherosclerosis Risk in Communities [ARIC] study). The American journal of cardiology. vol 107. issue 2. 2011-04-05. PMID:21211594. |
in this study, we examined the prospective relation between baseline vpcs or apcs and scd, myocardial infarction, and fatal coronary heart disease (chd) in a population-based sample of subjects from the atherosclerosis risk in communities (aric) study excluding participants with known history of chd or stroke. |
2011-04-05 |
2023-08-12 |
human |