| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B S Pickard, A Christoforou, P A Thomson, A Fawkes, K L Evans, S W Morris, D J Porteous, D H Blackwood, W J Mui. Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Molecular psychiatry. vol 14. issue 9. 2009-11-06. PMID:18317462. |
the neuronal pas domain 3 (npas3) gene encodes a neuronal transcription factor that is implicated in psychiatric disorders by the identification of a human chromosomal translocation associated with schizophrenia and a mouse knockout model with behavioural and hippocampal neurogenesis defects. |
2009-11-06 |
2023-08-12 |
mouse |
| Kate D Meyer, Jill A Morri. Disc1 regulates granule cell migration in the developing hippocampus. Human molecular genetics. vol 18. issue 17. 2009-11-02. PMID:19502360. |
in order to better understand how disruption of hippocampal development may contribute to the etiology of psychiatric disease, we investigated the function of a highly promising schizophrenia susceptibility gene, disc1 (disrupted-in-schizophrenia 1), in the development of the hippocampus. |
2009-11-02 |
2023-08-12 |
mouse |
| Kate D Meyer, Jill A Morri. Disc1 regulates granule cell migration in the developing hippocampus. Human molecular genetics. vol 18. issue 17. 2009-11-02. PMID:19502360. |
these findings support the idea that disc1 abnormalities that contribute to the onset of schizophrenia may do so through their influences on hippocampal development. |
2009-11-02 |
2023-08-12 |
mouse |
| Rana El-Rawas, Nayef E Saadé, Nathalie Thiriet, Samir Atweh, Mohamed Jaber, Hassen A Al-Ami. Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion. Schizophrenia research. vol 113. issue 2-3. 2009-10-29. PMID:19500946. |
the neonatal lesion of the ventral hippocampus (vh) in rats has been established as an animal model of schizophrenia and is used to study postpubertal changes in behavior and neurobiology. |
2009-10-29 |
2023-08-12 |
rat |
| Inna Gaisler-Salomon, Gretchen M Miller, Nao Chuhma, Sooyeon Lee, Hong Zhang, Farhad Ghoddoussi, Nicole Lewandowski, Stephen Fairhurst, Yvonne Wang, Agnès Conjard-Duplany, Justine Masson, Peter Balsam, René Hen, Ottavio Arancio, Matthew P Galloway, Holly M Moore, Scott A Small, Stephen Raypor. Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 10. 2009-10-29. PMID:19516252. |
glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. |
2009-10-29 |
2023-08-12 |
mouse |
| Charles B Mikell, Guy M McKhann, Solomon Segal, Robert A McGovern, Matthew B Wallenstein, Holly Moor. The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia. Stereotactic and functional neurosurgery. vol 87. issue 4. 2009-10-21. PMID:19556835. |
the hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia. |
2009-10-21 |
2023-08-12 |
Not clear |
| Charles B Mikell, Guy M McKhann, Solomon Segal, Robert A McGovern, Matthew B Wallenstein, Holly Moor. The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia. Stereotactic and functional neurosurgery. vol 87. issue 4. 2009-10-21. PMID:19556835. |
hallucinations and delusions) in schizophrenia are reliably correlated with excess dopamine levels in the striatum, and have more recently been related to excess metabolic activity in the hippocampus. |
2009-10-21 |
2023-08-12 |
Not clear |
| Charles B Mikell, Guy M McKhann, Solomon Segal, Robert A McGovern, Matthew B Wallenstein, Holly Moor. The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia. Stereotactic and functional neurosurgery. vol 87. issue 4. 2009-10-21. PMID:19556835. |
in the present paper, we hypothesize that inhibition or stabilization of neural activity with high-frequency electrical stimulation of the hippocampus or nucleus accumbens, through different mechanisms, would treat the positive symptoms of schizophrenia. |
2009-10-21 |
2023-08-12 |
Not clear |
| Dennis Velakoulis, Mark Walterfang, Ramon Mocellin, Christos Pantelis, Brian Dean, Catriona McLea. Abnormal hippocampal distribution of TDP-43 in patients with-late onset psychosis. The Australian and New Zealand journal of psychiatry. vol 43. issue 8. 2009-10-21. PMID:19629795. |
the purpose of the present study was therefore to determine whether ftd-like abnormalities in tardna binding protein (tdp-43) and ubiquitin are detectable in hippocampal dentate gyrus of patients with schizophrenia and bipolar disorder. |
2009-10-21 |
2023-08-12 |
Not clear |
| Henning Witthaus, Christian Kaufmann, Georg Bohner, Seza Ozgürdal, Yehonala Gudlowski, Jürgen Gallinat, Stephan Ruhrmann, Martin Brüne, Andreas Heinz, Randolf Klingebiel, Georg Jucke. Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry research. vol 173. issue 3. 2009-10-20. PMID:19616415. |
first-episode patients with schizophrenia showed smaller gray matter volume in the cingulate cortex bilaterally, in the left orbitofrontal gyrus, in the right inferior frontal and superior temporal gyrus, in the right temporal pole, in the left and right hippocampus, in the left parahippocampus, left amygdala, and in the left fusiform gyrus compared to the uhr patients. |
2009-10-20 |
2023-08-12 |
human |
| Anqi Qiu, Lei Wang, Laurent Younes, Michael P Harms, J Tilak Ratnanather, Michael I Miller, John G Csernansk. Neuroanatomical asymmetry patterns in individuals with schizophrenia and their non-psychotic siblings. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19481156. |
the surfaces of the left and right amygdala, hippocampus, thalamus, caudate nucleus, putamen, globus pallidus, and nucleus accumbens were assessed in 40 pairs of healthy comparison controls (con) and their siblings (con-sib) and 25 pairs of patients with schizophrenia (scz) and their siblings (scz-sib) in magnetic resonance (mr) images using large deformation diffeomorphic metric mapping (lddmm) and parallel transport techniques. |
2009-10-15 |
2023-08-12 |
human |
| Rubelia Isaura Martínez-Téllez, Elizabeth Hernández-Torres, Citlalli Gamboa, Gonzalo Flore. Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. Synapse (New York, N.Y.). vol 63. issue 9. 2009-10-09. PMID:19489049. |
these results suggest that prenatal stress carried out during the middle of pregnancy affect the spine density and basal dendrites of pyramidal neurons of hippocampus, as well as the dendritic morphology of nucleus accumbens which may reflect important changes in the mesocorticolimbic dopaminergic transmission and behaviors associated with the development of psychiatric diseases such as schizophrenia. |
2009-10-09 |
2023-08-12 |
rat |
| Ju Young Kim, Xin Duan, Cindy Y Liu, Mi-Hyeon Jang, Junjie U Guo, Nattapol Pow-anpongkul, Eunchai Kang, Hongjun Song, Guo-li Min. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. vol 63. issue 6. 2009-10-09. PMID:19778506. |
here, we show that disc1 suppression in newborn neurons of the adult hippocampus leads to overactivated signaling of akt, another schizophrenia susceptibility gene. |
2009-10-09 |
2023-08-12 |
Not clear |
| Kuei Y Tseng, R Andrew Chambers, Barbara K Lipsk. The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behavioural brain research. vol 204. issue 2. 2009-09-25. PMID:19100784. |
the neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. |
2009-09-25 |
2023-08-12 |
human |
| Fabio Fumagalli, Angelisa Frasca, Giorgio Racagni, Marco Andrea Riv. Cognitive effects of second-generation antipsychotics: current insights into neurochemical mechanisms. CNS drugs. vol 23. issue 7. 2009-09-15. PMID:19552487. |
in this review, we discuss recent preclinical research efforts, including investigation of synaptic mechanisms as well as intracellular signalling pathways and mechanisms involved in neuroplasticity and cell resilience, that may represent new mechanisms participating in the pathogenesis of schizophrenia, particularly at the level of the prefrontal cortex and hippocampus, and that might lead to the development of drugs that can counteract, at least partially, the cognitive impairments typical of schizophrenia. |
2009-09-15 |
2023-08-12 |
Not clear |
| M M Cox, A M Tucker, J Tang, K Talbot, D C Richer, L Yeh, S E Arnol. Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19220483. |
as similar deficits in spatial learning and memory have been found in schizophrenia, where decreased dysbindin-1 has been found in the hippocampus, the sandy mouse may also model certain aspects of cognition and behavior relevant to schizophrenia. |
2009-09-11 |
2023-08-12 |
mouse |
| Yukihiro Noda, Akihiro Mouri, Yukari Waki, Toshitaka Nabeshim. [Development of animal models for schizophrenia based on clinical evidence: expectation for psychiatrists]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 29. issue 2. 2009-09-03. PMID:19562941. |
the disrupted in schizophrenia 1 (disc1) gene has been identified as a schizophrenia susceptibility gene based on linkage and single nucleotide polymorphism (snp) association studies and clinical data, demonstrating that risk snps impact on the hippocampal structure and function in clinical and functional roles of disc1 are analyzed in many kinds of transgenic mice developed. |
2009-09-03 |
2023-08-12 |
mouse |
| Florian Ebner, Ralf Tepest, Indra Dani, Ute Pfeiffer, Thomas G Schulze, Marcella Rietschel, Wolfgang Maier, Frank Träber, Wolfgang Block, Hans H Schild, Michael Wagner, Helmuth Steinmetz, Wolfgang Gaebel, William G Honer, Thomas Schneider-Axmann, Peter Falka. The hippocampus in families with schizophrenia in relation to obstetric complications. Schizophrenia research. vol 104. issue 1-3. 2009-08-28. PMID:18656329. |
the hippocampus in families with schizophrenia in relation to obstetric complications. |
2009-08-28 |
2023-08-12 |
human |
| Florian Ebner, Ralf Tepest, Indra Dani, Ute Pfeiffer, Thomas G Schulze, Marcella Rietschel, Wolfgang Maier, Frank Träber, Wolfgang Block, Hans H Schild, Michael Wagner, Helmuth Steinmetz, Wolfgang Gaebel, William G Honer, Thomas Schneider-Axmann, Peter Falka. The hippocampus in families with schizophrenia in relation to obstetric complications. Schizophrenia research. vol 104. issue 1-3. 2009-08-28. PMID:18656329. |
hippocampal volume reduction is a well replicated finding in schizophrenia. |
2009-08-28 |
2023-08-12 |
human |
| Subroto Ghose, Ronald Chin, Analysa Gallegos, Rosalinda Roberts, Joseph Coyle, Carol Tamming. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia. Schizophrenia research. vol 111. issue 1-3. 2009-08-25. PMID:19403271. |
localization of naag-related gene expression deficits to the anterior hippocampus in schizophrenia. |
2009-08-25 |
2023-08-12 |
human |