| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephan Heckers, Christine Konrad. Hippocampal pathology in schizophrenia. Current topics in behavioral neurosciences. vol 4. 2011-03-03. PMID:21312412. |
hippocampal lesion models in rodents have replicated some of the pharmacological, anatomical and behavioral phenotype of schizophrenia. |
2011-03-03 |
2023-08-12 |
Not clear |
| Susan B Powel. Models of neurodevelopmental abnormalities in schizophrenia. Current topics in behavioral neurosciences. vol 4. 2011-03-03. PMID:21312409. |
developmental models specific to schizophrenia have focused on epidemiological risk factors (e.g., prenatal viral insult, birth complications) or more heuristic models aimed at understanding the developmental neuropathology of the disease (e.g., ventral hippocampal lesions). |
2011-03-03 |
2023-08-12 |
Not clear |
| Arata Oh-Nishi, Shigeru Obayashi, Izumi Sugihara, Takafumi Minamimoto, Tetsuya Suhar. Maternal immune activation by polyriboinosinic-polyribocytidilic acid injection produces synaptic dysfunction but not neuronal loss in the hippocampus of juvenile rat offspring. Brain research. vol 1363. 2011-02-24. PMID:20863817. |
there are many reports about hippocampal structural pathology in schizophrenia. |
2011-02-24 |
2023-08-12 |
rat |
| Arata Oh-Nishi, Shigeru Obayashi, Izumi Sugihara, Takafumi Minamimoto, Tetsuya Suhar. Maternal immune activation by polyriboinosinic-polyribocytidilic acid injection produces synaptic dysfunction but not neuronal loss in the hippocampus of juvenile rat offspring. Brain research. vol 1363. 2011-02-24. PMID:20863817. |
these results indicate that maternal immune activation leads to synaptic dysfunction without neuronal loss in the hippocampus of juvenile offspring, and this may be one of the early stages of schizophrenia pathologies. |
2011-02-24 |
2023-08-12 |
rat |
| Michael J Coleman, Debra Titone, Olga Krastoshevsky, Verena Krause, Zhuying Huang, Nancy R Mendell, Howard Eichenbaum, Deborah L Lev. Reinforcement ambiguity and novelty do not account for transitive inference deficits in schizophrenia. Schizophrenia bulletin. vol 36. issue 6. 2011-02-23. PMID:19460878. |
these findings implicate a disturbance in relational memory organization, likely subserved by hippocampal dysfunction, in the pathophysiology of schizophrenia. |
2011-02-23 |
2023-08-12 |
human |
| Kaichi Yoshizaki, Noriko Osum. [Molecular mechanism and mental function of postnatal neurogenesis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 12. 2011-02-17. PMID:21139184. |
reduction in hippocampal neurogenesis during the infantile and adult stages has been observed in some animal models of mental illness such as schizophrenia and major depression, implicating that postnatal neurogenesis may contribute to a part of the symptoms of mental illness. |
2011-02-17 |
2023-08-12 |
human |
| Anne Marie Brady, Ronald D Saul, Matthew K Wies. Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia. Neuropharmacology. vol 59. issue 7-8. 2011-02-07. PMID:20732335. |
selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia. |
2011-02-07 |
2023-08-12 |
rat |
| Anne Marie Brady, Ronald D Saul, Matthew K Wies. Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia. Neuropharmacology. vol 59. issue 7-8. 2011-02-07. PMID:20732335. |
the neonatal ventral hippocampal lesion (nvhl) manipulation is a neurodevelopmental animal model of schizophrenia that produces abnormalities in the prefrontal cortex and nucleus accumbens, both efferent targets of the hippocampus, and leads to spatial working memory impairments. |
2011-02-07 |
2023-08-12 |
rat |
| Nada M-B Ben Abdallah, Johannes Fuss, Massimo Trusel, Michael J Galsworthy, Kristin Bobsin, Giovanni Colacicco, Robert M J Deacon, Marco A Riva, Christoph Kellendonk, Rolf Sprengel, Hans-Peter Lipp, Peter Gas. The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20851119. |
we evaluated the use of the puzzle box to explore executive functioning in five different mouse models of schizophrenia: mice with prefrontal cortex and hippocampus lesions, mice treated sub-chronically with the nmda-receptor antagonist mk-801, mice constitutively lacking the glua1 subunit of ampa-receptors, and mice over-expressing dopamine d2 receptors in the striatum. |
2011-02-04 |
2023-08-12 |
mouse |
| Li Gu-Cai, Wei Wen-Ting, Yuan Li-Hua, Gao Tang-Ji. Synthesis of benzopyrano[3,4-c]pyridin-5-ones as dopamine D4 receptor ligands. Die Pharmazie. vol 65. issue 11. 2011-01-10. PMID:21155383. |
the dopamine d4 receptor is highly expressed in prefrontal cortex, hippocampus, amygdala, hypothalamus and is hypothesized to relate with the pathophysiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower. |
2011-01-10 |
2023-08-12 |
Not clear |
| Andreas Arthur Klär, Martina Ballmaier, Karolina Leopold, Ines Häke, Martin Schaefer, Rüdiger Brühl, Florian Schubert, Jürgen Gallina. Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study. NeuroImage. vol 53. issue 1. 2011-01-04. PMID:20541020. |
interaction of hippocampal volume and n-acetylaspartate concentration deficits in schizophrenia: a combined mri and 1h-mrs study. |
2011-01-04 |
2023-08-12 |
Not clear |
| Guy Sandner, Marie-Josée Angst, Thierry Guiberteau, Blandine Guignard, David Brass. MRI and X-ray scanning images of the brain of 3-, 6- and 9-month-old rats with bilateral neonatal ventral hippocampus lesions. NeuroImage. vol 53. issue 1. 2011-01-04. PMID:20547225. |
rats with bilateral neonatal ventral hippocampus lesions (nvhl) are commonly used for modeling developmental aspects of the pathophysiology of schizophrenia. |
2011-01-04 |
2023-08-12 |
rat |
| Xianjin Zhou, Zhiguo Nie, Amanda Roberts, Dongxian Zhang, Jonathan Sebat, Dheeraj Malhotra, John R Kelsoe, Mark A Geye. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Human molecular genetics. vol 19. issue 19. 2011-01-04. PMID:20634195. |
the reduced expression of the sp4 gene in sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric disorders. |
2011-01-04 |
2023-08-12 |
mouse |
| Stefan Ehrlich, Eric M Morrow, Joshua L Roffman, Stuart R Wallace, Melissa Naylor, H Jeremy Bockholt, Antonia Lundquist, Anastasia Yendiki, Beng-Choon Ho, Tonya White, Dara S Manoach, Vincent P Clark, Vince D Calhoun, Randy L Gollub, Daphne J Hol. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:20026221. |
here we measured the effects of comt val108/158met genotype on the volume of two regions within the medial temporal lobe, the amygdala and hippocampus, in patients with schizophrenia and healthy control subjects. |
2011-01-03 |
2023-08-12 |
human |
| Michael Bodnar, Ashok K Malla, Yvonne Czechowska, Audrey Benoit, Ferid Fathalli, Ridha Joober, Marita Pruessner, Jens Pruessner, Martin Lepag. Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala. Schizophrenia research. vol 122. issue 1-3. 2010-12-30. PMID:20630708. |
neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala. |
2010-12-30 |
2023-08-12 |
Not clear |
| Michael Bodnar, Ashok K Malla, Yvonne Czechowska, Audrey Benoit, Ferid Fathalli, Ridha Joober, Marita Pruessner, Jens Pruessner, Martin Lepag. Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala. Schizophrenia research. vol 122. issue 1-3. 2010-12-30. PMID:20630708. |
more specifically, significantly smaller hippocampal volumes but not amygdala volumes have been identified at onset in first-episode schizophrenia (fes) patients. |
2010-12-30 |
2023-08-12 |
Not clear |
| Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agart. An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20638435. |
an exploratory model for g x e interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. |
2010-12-29 |
2023-08-12 |
Not clear |
| Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agart. An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20638435. |
smaller hippocampal volume has repeatedly been reported in schizophrenia patients. |
2010-12-29 |
2023-08-12 |
Not clear |
| Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agart. An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20638435. |
obstetric complications (ocs) and single nucleotide polymorphism (snp) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume. |
2010-12-29 |
2023-08-12 |
Not clear |
| Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agart. An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20638435. |
we investigated putative independent and interaction effects of severe hypoxia-related ocs and variation in four hypoxia-regulated schizophrenia susceptibility genes (bdnf, dtnbp1, grm3 and nrg1) on hippocampal volume in schizophrenia patients and healthy controls. |
2010-12-29 |
2023-08-12 |
Not clear |