| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Eastwood, P W Burnet, P J Harriso. GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study. Brain research. Molecular brain research. vol 44. issue 1. 1997-05-22. PMID:9030702. |
they suggest that signal transduction through hippocampal ampa receptors is impaired in schizophrenia both by an overall loss of glur2 expression, and by the change in flip:flop ratio which is predicted to alter the desensitization kinetics of the remaining glur2 subunits. |
1997-05-22 |
2023-08-12 |
Not clear |
| C E Adams, B K DeMasters, R Freedma. Regional zinc staining in postmortem hippocampus from schizophrenic patients. Schizophrenia research. vol 18. issue 1. 1997-03-19. PMID:8929763. |
the results of the present study demonstrate that loss of ionic zinc within the hippocampus does not appear to be part of the pathology of schizophrenia. |
1997-03-19 |
2023-08-12 |
human |
| K A Flach, L E Adler, G A Gerhardt, C Miller, P Bickford, R J MacGrego. Sensory gating in a computer model of the CA3 neural network of the hippocampus. Biological psychiatry. vol 40. issue 12. 1997-03-19. PMID:8959288. |
we have developed a unique computer model of the ca3 region of the hippocampus that simulates the p50 auditory evoked potential response to repeated stimuli in order to study the neuronal circuits involved in a sensory processing deficit associated with schizophrenia. |
1997-03-19 |
2023-08-12 |
rat |
| F J Wan, S B Caine, N R Swerdlo. The ventral subiculum modulation of prepulse inhibition is not mediated via dopamine D2 or nucleus accumbens non-NMDA glutamate receptor activity. European journal of pharmacology. vol 314. issue 1-2. 1997-03-10. PMID:8957213. |
studies have demonstrated abnormalities within the hippocampal formation of schizophrenia patients, and animal studies have revealed that the hippocampus, and specifically the ventral subiculum, regulates prepulse inhibition. |
1997-03-10 |
2023-08-12 |
Not clear |
| R A Chambers, J Moore, J P McEvoy, E D Levi. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 6. 1997-02-25. PMID:8946433. |
cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. |
1997-02-25 |
2023-08-12 |
rat |
| R A Chambers, J Moore, J P McEvoy, E D Levi. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 6. 1997-02-25. PMID:8946433. |
lesioning the ventral hippocampus of neonatal rats has been proposed as an experimental model of schizophrenia. |
1997-02-25 |
2023-08-12 |
rat |
| R A Chambers, J Moore, J P McEvoy, E D Levi. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 6. 1997-02-25. PMID:8946433. |
persisting cognitive effects of neonatal ventral hippocampal lesions were assessed in the current study, because the hippocampus is critically important for a variety of cognitive functions and cognitive impairment and because it is an important feature of schizophrenia. |
1997-02-25 |
2023-08-12 |
rat |
| R A Chambers, J Moore, J P McEvoy, E D Levi. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 6. 1997-02-25. PMID:8946433. |
neonatal hippocampal lesions may provide a good model of the cognitive impairments of schizophrenia and may be useful to assess novel drug effects to counteract the cognitive deficits in schizophrenia. |
1997-02-25 |
2023-08-12 |
rat |
| M Maier, M A Ro. Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study. Schizophrenia research. vol 22. issue 1. 1997-02-21. PMID:8908686. |
hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study. |
1997-02-21 |
2023-08-12 |
Not clear |
| S E Arnold, J Q Trojanowsk. Recent advances in defining the neuropathology of schizophrenia. Acta neuropathologica. vol 92. issue 3. 1997-02-03. PMID:8870823. |
while substantial controversy exists in all areas, in sum: (1) diagnostic neuropathological investigations find only assorted and nonspecific abnormalities in the brains of schizophrenics that are likely to be representative of lesions found in age-compatible control groups; (2) morphometric studies of gross structures generally confirm the clinical in vivo neuroimaging findings of enlarged ventricles, decreased size of ventromedial temporal lobe structures, and decreased parahippocampal cortical thickness; (3) morphometric microscopy studies find frequent alterations in neuron density and decreased neuron size in limbic, temporal, and frontal regions; (4) investigations of connectivity are at an early stage but describe abnormal dendritic spine densities in the cortex, various changes in synaptic vesicle protein expression in limbic, temporal, and frontal cortices, and alterations in glutamatergic, catecholaminergic, and intrinsic innervation in anterior cingulate cortex- together, these findings suggest a "miswiring" in the schizophrenic brain; (5) investigations of aberrant neurodevelopment in schizophrenia describe abnormalities in cortical cytoarchitecture and several developmentally regulated proteins in the hippocampal region suggesting abnormal neuronal migration, differentiation, and/or cell pruning; and (6) studies of neurodegeneration and neural injury find a general lack of neurodegenerative disease lesions or ongoing astrocytosis that would indicate post-maturational neural injury. |
1997-02-03 |
2023-08-12 |
Not clear |
| M Beauregard, J Bachevalie. Neonatal insult to the hippocampal region and schizophrenia: a review and a putative animal model. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 41. issue 7. 1997-01-29. PMID:8884034. |
neonatal insult to the hippocampal region and schizophrenia: a review and a putative animal model. |
1997-01-29 |
2023-08-12 |
Not clear |
| M Beauregard, J Bachevalie. Neonatal insult to the hippocampal region and schizophrenia: a review and a putative animal model. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 41. issue 7. 1997-01-29. PMID:8884034. |
to review the mounting evidence implicating early hippocampal dysfunction in the pathogenesis and the pathophysiology of schizophrenia. |
1997-01-29 |
2023-08-12 |
Not clear |
| S Leonard, C Adams, C R Breese, L E Adler, P Bickford, W Byerley, H Coon, J M Griffith, C Miller, M Myles-Worsley, H T Nagamoto, Y Rollins, K E Stevens, M Waldo, R Freedma. Nicotinic receptor function in schizophrenia. Schizophrenia bulletin. vol 22. issue 3. 1997-01-02. PMID:8873294. |
expression of the alpha 7 receptor is decreased in hippocampal brain tissue, dissected postmortem, from schizophrenia subjects. |
1997-01-02 |
2023-08-12 |
human |
| L Naylor, B Dean, K Opeskin, G Pavey, C Hill, N Keks, D Copolo. Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 6. 1996-12-17. PMID:8836936. |
changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3h]paroxetine. |
1996-12-17 |
2023-08-12 |
human |
| L Naylor, B Dean, K Opeskin, G Pavey, C Hill, N Keks, D Copolo. Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 6. 1996-12-17. PMID:8836936. |
the affinity of [3h]paroxetine binding to hippocampal membrane was decreased in subjects with schizophrenia (kd = 0.50 +/- 0.04 vs. 0.24 +/- 0.02nm; mean +/- s.e.m. |
1996-12-17 |
2023-08-12 |
human |
| B Dean, W Hayes, K Opeskin, L Naylor, G Pavey, C Hill, N Keks, D L Copolo. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788497. |
the binding of [3h]paroxetine and [3h]ketanserin to particulate membranes from frontal cortex of subjects who had or did not have schizophrenia was measured as was [3h]paroxetine binding to particulate membranes from the hippocampus and caudate nucleus. |
1996-12-04 |
2023-08-12 |
human |
| B Dean, W Hayes, K Opeskin, L Naylor, G Pavey, C Hill, N Keks, D L Copolo. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788497. |
by contrast, there was a significant decrease in the affinity of [3h]paroxetine binding to the hippocampal membrane from subjects who had schizophrenia (0.40 +/- 0.06 nm vs 0.26 +/- 0.02 nm; p < 0.05). |
1996-12-04 |
2023-08-12 |
human |
| B Dean, W Hayes, K Opeskin, L Naylor, G Pavey, C Hill, N Keks, D L Copolo. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788497. |
by contrast, [3h]paroxetine binds to the serotonin transporter and therefore our data suggest that the serotonin transporter is altered in the hippocampus of subjects with schizophrenia. |
1996-12-04 |
2023-08-12 |
human |
| J A Gray, M H Joseph, D R Hemsley, A M Young, E C Warburton, P Boulenguez, G A Grigoryan, S L Peters, J N Rawlins, C T Tai. The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behavioural brain research. vol 71. issue 1-2. 1996-10-24. PMID:8747172. |
we review here evidence in support of the model, including experiments tending to show that: (1) disruption of li is characteristic of acute, positively-symptomatic schizophrenia; (2) li depends upon dopaminergic activity; (3) li depends specifically upon dopamine release in n. accumbens; (4) li depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in li are interconnected. |
1996-10-24 |
2023-08-12 |
Not clear |
| N R Swerdlow, B K Lipska, D R Weinberger, D L Braff, G E Jaskiw, M A Geye. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology. vol 122. issue 1. 1996-09-11. PMID:8711061. |
substantial evidence indicates that the pathophysiology of schizophrenia includes structural and functional deficits in prefrontal and temporal regions, particularly the dorsolateral prefrontal cortex and the hippocampus and parahippocampal gyrus. |
1996-09-11 |
2023-08-12 |
rat |