| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxine Yang, Arielle Rubin, Rebecca Wondimu, Theresa Grebe, Gaby Ritfel. Significant improvement of psychotic symptoms in treatment-resistant schizophrenia with clozapine in an adolescent with SHINE syndrome: a case report. BMC psychiatry. vol 23. issue 1. 2023-06-29. PMID:37386468. |
this case illustrates the impact of clozapine in treatment-resistant early-onset psychosis and exemplifies practical implications for genetic testing in early-onset schizophrenia. |
2023-06-29 |
2023-08-14 |
Not clear |
| Guillermo Hönig, Federico M Daray, Demián Rodante, Lucas Drucaroff, María Laura Gutiérrez, Mariela Lenze, Facundo García Bournissen, Silvia Wikinsk. Body mass index, waist circumference, insulin, and leptin plasma levels differentiate between clozapine-responsive and clozapine-resistant schizophrenia. Journal of psychopharmacology (Oxford, England). 2023-06-28. PMID:37377097. |
between 25% and 50% of patients suffering from treatment-resistant schizophrenia fail to achieve a clinical response with clozapine. |
2023-06-28 |
2023-08-14 |
Not clear |
| Asmaa F Sharif, H A Aouissi, Zeinab A Kasemy, H Byeon, Heba I Lashi. Development and validation of a risk prediction nomogram for disposition of acute clozapine intoxicated patients to intensive care unit. Human & experimental toxicology. vol 42. 2023-06-28. PMID:37379491. |
clozapine is an atypical antipsychotic drug used for the treatment of refractory schizophrenia. |
2023-06-28 |
2023-08-14 |
Not clear |
| Stefan J Berger, Alex Hofe. [Safety aspects during treatment with clozapine: : Adverse effects, titration, and therapeutic drug monitoring - a narrative review]. Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater. 2023-06-22. PMID:37349671. |
according to current guidelines, clozapine should be used as a third step in treatment resistant schizophrenia (trs). |
2023-06-22 |
2023-08-14 |
Not clear |
| Jurjen J Luykx, Jairo M Gonzalez-Diaz, Ta-Wei Guu, Marte Z van der Horst, Edwin van Dellen, Marco P Boks, Sinan Guloksuz, Lynn E DeLisi, Iris E Sommer, Russel Cummins, David Shiers, Jimmy Lee, Susanna Every-Palmer, Ahmed Mhalla, Zohra Chadly, Sherry K W Chan, Robert O Cotes, Shun Takahashi, Michael E Benros, Elias Wagner, Christoph U Correll, Alkomiet Hasan, Dan Siskind, Dominique Endres, James MacCabe, Jari Tiihone. An international research agenda for clozapine-resistant schizophrenia. The lancet. Psychiatry. 2023-06-17. PMID:37329895. |
we then revisit several clozapine guidelines, the diagnostic tests and treatment options for clozapine-resistant schizophrenia, and currently applied research approaches in clozapine-resistant schizophrenia. |
2023-06-17 |
2023-08-14 |
Not clear |
| Mustafa Özdemir, Yusuf Ezel Yıldırım, Ayşegül Kar. The Impacts of Clozapine Use on the Risk and Outcomes of COVID-19 Disease in Patients with Schizophrenia. Noro psikiyatri arsivi. vol 60. issue 2. 2023-06-08. PMID:37287549. |
the impacts of clozapine use on the risk and outcomes of covid-19 disease in patients with schizophrenia. |
2023-06-08 |
2023-08-14 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238731. |
enhanced l-β-aminoisobutyric acid is involved in the pathophysiology of effectiveness for treatment-resistant schizophrenia and adverse reactions of clozapine. |
2023-05-27 |
2023-08-14 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238731. |
clozapine is an effective antipsychotic for the treatment of antipsychotic-resistant schizophrenia; however, specific types of a/b adverse effects and clozapine-discontinuation syndromes are also well known. |
2023-05-27 |
2023-08-14 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238731. |
to date, both the critical mechanisms of clinical actions (effective for antipsychotic-resistant schizophrenia) and the adverse effects of clozapine remain to be elucidated. |
2023-05-27 |
2023-08-14 |
Not clear |
| Rosamaria Lombardo, Marika Ruponen, Jarkko Rautio, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Laura Calosi, Daniele Bani, Riikka Lampinen, Katja M Kanninen, Anne M Koivisto, Elina Penttilä, Heikki Löppönen, Rosario Pignatell. Development of Lyophilised Eudragit Pharmaceutics. vol 15. issue 5. 2023-05-27. PMID:37242796. |
development of lyophilised eudragit clozapine (czp) is the only effective drug in schizophrenia resistant to typical antipsychotics. |
2023-05-27 |
2023-08-14 |
Not clear |
| Can-Jun Ruan, Chuan-Yue Wang, Yan-Nan Zang, Chen-Geng Liu, Fang Dong, An-Ning Li, Zhou Wan, Wei Guo, Gang Wan. A brief history of clozapine in China with a look forward. Schizophrenia research. 2023-05-26. PMID:37236890. |
clozapine is currently used not only for treatment-refractory schizophrenia (trs), but also continues to be used in the treatment of patients with non-trs and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic therapy and in combination with other drugs. |
2023-05-26 |
2023-08-14 |
Not clear |
| Robert A Bittner, Andreas Reif, Mishal Quba. The ever-growing case for clozapine in the treatment of schizophrenia: an obligation for psychiatrists and psychiatry. Current opinion in psychiatry. 2023-05-24. PMID:37222196. |
the ever-growing case for clozapine in the treatment of schizophrenia: an obligation for psychiatrists and psychiatry. |
2023-05-24 |
2023-08-14 |
Not clear |
| Robert A Bittner, Andreas Reif, Mishal Quba. The ever-growing case for clozapine in the treatment of schizophrenia: an obligation for psychiatrists and psychiatry. Current opinion in psychiatry. 2023-05-24. PMID:37222196. |
clozapine remains the gold standard for treatment-resistant schizophrenia (trs). |
2023-05-24 |
2023-08-14 |
Not clear |
| Sidney Zisook, Isabel Domingues, Jason Compto. Pharmacologic Approaches to Suicide Prevention. Focus (American Psychiatric Publishing). vol 21. issue 2. 2023-05-18. PMID:37201142. |
for patients with chronic suicidality, clozapine remains the only u.s. food and drug administration (fda) approved antisuicidal medication, and its use is predominantly for patients with schizophrenia and schizoaffective disorder. |
2023-05-18 |
2023-08-14 |
Not clear |
| Hisashi Yamada, Ryota Hashimot. [Antipsychotics]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194535. |
when monotherapy of two or more antipsychotics fails to produce sufficient improvement, a diagnosis of treatment-resistant schizophrenia is made, and clozapine is used. |
2023-05-17 |
2023-08-14 |
Not clear |
| b' Vjekoslav Peitl, Antonia Pulji\\xc4\\x87, Mislav \\xc5\\xa0krobo, Sergej Nadalin, Lidija Fumi\\xc4\\x87 Dunki\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Clozapine in Treatment-Resistant Schizophrenia and Its Augmentation with Electroconvulsive Therapy in Ultra-Treatment-Resistant Schizophrenia. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189691.' |
clozapine in treatment-resistant schizophrenia and its augmentation with electroconvulsive therapy in ultra-treatment-resistant schizophrenia. |
2023-05-16 |
2023-08-14 |
Not clear |
| b' Vjekoslav Peitl, Antonia Pulji\\xc4\\x87, Mislav \\xc5\\xa0krobo, Sergej Nadalin, Lidija Fumi\\xc4\\x87 Dunki\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Clozapine in Treatment-Resistant Schizophrenia and Its Augmentation with Electroconvulsive Therapy in Ultra-Treatment-Resistant Schizophrenia. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189691.' |
clozapine is considered the gold standard for patients with treatment-resistant schizophrenia (trs) who have previously tried other antipsychotics at adequate doses (two or more, with at least one being atypical). |
2023-05-16 |
2023-08-14 |
Not clear |
| b' Vjekoslav Peitl, Antonia Pulji\\xc4\\x87, Mislav \\xc5\\xa0krobo, Sergej Nadalin, Lidija Fumi\\xc4\\x87 Dunki\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Clozapine in Treatment-Resistant Schizophrenia and Its Augmentation with Electroconvulsive Therapy in Ultra-Treatment-Resistant Schizophrenia. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189691.' |
however, despite optimal treatment, a subgroup of trs patients with what is known as ultra-treatment-resistant schizophrenia (utrs) fails to respond to clozapine, which occurs in 40-70% of cases. |
2023-05-16 |
2023-08-14 |
Not clear |
| Paulo Levi Bezerra Martins, Ian Araújo Moura, Gabrielle Mendes, Vitória Cristina Almeida Flexa Ribeiro, André Arnaud, Clarissa S Gama, Michael Maes, Danielle S Macedo, Joel Porfirio Pint. Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 73. 2023-05-06. PMID:37148631. |
immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: a meta-analysis. |
2023-05-06 |
2023-08-14 |
human |
| Yongqing Tao, Runlan Wan, Junji Wang, Qiuyi Liu, Meng Tian, Luchun Wang, Yulian Yang, Yuemeng Zou, Yuanning Luo, Famin Ke, Quan Zhou, Dandan Wang, Die Ga. Carbonized human hair derived carbon dots for detection of clozapine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 298. 2023-05-06. PMID:37148662. |
clozapine (clz) is known as the most effective antipsychotic medication for schizophrenia. |
2023-05-06 |
2023-08-14 |
human |