| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timo Jendrik Faustmann, Franco Corvace, Pedro M Faustmann, Fatme Seval Ismai. Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte-microglia co-culture model. Frontiers in psychiatry. vol 16. 2025-04-02. PMID:40171306. |
this could lead to a better understanding of how typical and atypical antipsychotics can be used to address positive and negative symptoms in schizophrenia and comorbidities like inflammatory diseases or the status of low-grade inflammation. |
2025-04-02 |
2025-04-04 |
Not clear |
| S Rehan Ahmad, Md Zeyaullah, Abdullah M AlShahrani, Mohammad Suhail Khan, Adam Dawria, Ali Mohieldin, Haroon Ali, Abdelrhman Ag Altijani, Mohammad Shane Alam, Munzila Mehdi, Sabika Akram, Ejaz Rizvi Hussain, Mohammad Amjad Kama. Unlocking the potential of lumateperone and novel anti-psychotics for schizophrenia. BioImpacts : BI. vol 15. 2025-03-31. PMID:40161932. |
schizophrenia affects 1% of the population worldwide, and to date, two different classes of antipsychotics, i.e., typical and atypical antipsychotics, are available in the market, and there is an urgent need for promising antipsychotic drugs. |
2025-03-31 |
2025-04-03 |
Not clear |
| Júlio César Menezes Vieira, Edna Afonso Reis, Wallace Mateus Prata, Helian Nunes de Oliveira, Cristina Mariano Ruas, Augusto Afonso Guerr. Effectiveness of Clozapine Compared to Nonclozapine Antipsychotics in Older Adults With Schizophrenia in Brazil in a 16-Year Follow-Up. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2025-03-29. PMID:40157874. |
to assess the survival of older patients with schizophrenia using clozapine, compared with other atypical antipsychotics (aaps) provided by the brazilian national health system, in a 16-year follow-up. |
2025-03-29 |
2025-04-02 |
Not clear |
| Raphaëlle Haddad, Marina Sánchez-Rico, Katayoun Rezaei, Sandra Abou Kassm, Carlos Blanco, Mark Olfson, Frédéric Limosin, Nicolas Hoerte. Association of Typical and Atypical Antipsychotics with Mortality in Older Adults with Schizophrenia: a 5-year multicenter prospective study. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2025-03-15. PMID:40088473. |
association of typical and atypical antipsychotics with mortality in older adults with schizophrenia: a 5-year multicenter prospective study. |
2025-03-15 |
2025-03-18 |
Not clear |
| Chia-Hui Chen, Wen-Hua Chen, Chiao-Po Hsu, Tzong-Shyuan Le. Atypical antipsychotics impair the lipid-lowering and pleiotropic effects of simvastatin via activation of the ADMA-NOX-ROS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 185. 2025-03-09. PMID:40058152. |
patients with schizophrenia receiving atypical antipsychotics have an increased risk of metabolic syndrome; however, the efficacy of statins in mitigating cardiovascular risks in these patients remains unclear. |
2025-03-09 |
2025-03-12 |
Not clear |
| Chia-Hui Chen, Wen-Hua Chen, Chiao-Po Hsu, Tzong-Shyuan Le. Atypical antipsychotics impair the lipid-lowering and pleiotropic effects of simvastatin via activation of the ADMA-NOX-ROS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 185. 2025-03-09. PMID:40058152. |
this study examined the effects of typical and atypical antipsychotics on the lipid-lowering efficacy of statins in schizophrenia patients and investigated the underlying mechanisms of simvastatin action in hepatocytes and endothelial cells (ecs). |
2025-03-09 |
2025-03-12 |
Not clear |
| Chia-Hui Chen, Wen-Hua Chen, Chiao-Po Hsu, Tzong-Shyuan Le. Atypical antipsychotics impair the lipid-lowering and pleiotropic effects of simvastatin via activation of the ADMA-NOX-ROS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 185. 2025-03-09. PMID:40058152. |
collectively, atypical antipsychotics impair statin efficacy in schizophrenia patients by activating the adma-nox-ros pathway, which downregulates ldlr in hepatocytes and inhibits enos activity in ecs. |
2025-03-09 |
2025-03-12 |
Not clear |
| Keying Liu, Bide Zhang, Zhoufangyuan Chen, Fukun Chen, Zexu Li, Yunzhi Gao, Yuechao Zhao, Yihao Liu, Yanlong Wan. Efficacy of atypical antipsychotics in schizophrenia patients: effects of 5-HTR SNPs. Annals of general psychiatry. vol 24. issue 1. 2025-02-18. PMID:39966797. |
efficacy of atypical antipsychotics in schizophrenia patients: effects of 5-htr snps. |
2025-02-18 |
2025-02-23 |
Not clear |
| Keying Liu, Bide Zhang, Zhoufangyuan Chen, Fukun Chen, Zexu Li, Yunzhi Gao, Yuechao Zhao, Yihao Liu, Yanlong Wan. Efficacy of atypical antipsychotics in schizophrenia patients: effects of 5-HTR SNPs. Annals of general psychiatry. vol 24. issue 1. 2025-02-18. PMID:39966797. |
5-htr has a high degree of genetic polymorphism, and atypical antipsychotics are 5-htr antagonists widely used in treating schizophrenia. |
2025-02-18 |
2025-02-23 |
Not clear |
| Keying Liu, Bide Zhang, Zhoufangyuan Chen, Fukun Chen, Zexu Li, Yunzhi Gao, Yuechao Zhao, Yihao Liu, Yanlong Wan. Efficacy of atypical antipsychotics in schizophrenia patients: effects of 5-HTR SNPs. Annals of general psychiatry. vol 24. issue 1. 2025-02-18. PMID:39966797. |
specific genotypes of six types of 5-htr genes are associated with differential responses to atypical antipsychotics, which may help guide the development of individualized clinical treatments for patients with schizophrenia. |
2025-02-18 |
2025-02-23 |
Not clear |
| Jeong Eun Kim, Seon Yeong Kim, Jae Chul Cheong, Jin Young Ki. A dilute-and-shoot LC-MS/MS determination of low-dosage third-generation antipsychotics and their metabolites in urine using an ultra-short column. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1255. 2025-02-16. PMID:39955960. |
third-generation atypical antipsychotics, known for their enhanced efficacy and reduced side effects compared to previous generations, are now extensively utilized in the treatment of schizophrenia. |
2025-02-16 |
2025-02-23 |
Not clear |
| Courtney A Swain, Emily J Robbs, Lindsay Verma, Heaven Brandt, Alexandra L Seppaenen, Peter J Cavna. Characterization of the atypical antipsychotic drug aripiprazole cytotoxicity in the neutrophil model cell line HL-60. PloS one. vol 20. issue 2. 2025-02-12. PMID:39937830. |
atypical antipsychotics are widely used for the treatment of mental and behavioral disorders such as bipolar disorder, obsessive-compulsive disorder, and schizophrenia. |
2025-02-12 |
2025-02-15 |
human |
| Acelyne Marie Summerson, Jordan Kalosieh, Sindhura Kompella, Clara Alvarez Villalba, Yukthi Kodal. Treatment Analysis of Very Early and Early Onset Psychosis in the Youth Inpatient Setting. HCA healthcare journal of medicine. vol 5. issue 6. 2025-01-11. PMID:39790696. |
the united states food and drug administration approved 6 atypical antipsychotics for pediatric treatment of schizophrenia. |
2025-01-11 |
2025-01-13 |
Not clear |
| Hiram Tendilla-Beltrán, Diana Laura Perez-Osornio, David Javier Apam Castillejos, Gonzalo Flore. Atypical antipsychotics improve dendritic spine pathology in temporal lobe cortex neurons in a developmental rodent model of schizophrenia. Behavioural brain research. 2024-11-16. PMID:39549876. |
atypical antipsychotics improve dendritic spine pathology in temporal lobe cortex neurons in a developmental rodent model of schizophrenia. |
2024-11-16 |
2024-11-20 |
rat |
| Ruri Okubo, Motohiro Okada, Eishi Motomur. Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia. Biomolecules. vol 14. issue 9. 2024-09-28. PMID:39334894. |
for several decades, the dopamine hypothesis contributed to the discovery of numerous typical and atypical antipsychotics and was the sole hypothesis for the pathophysiology of schizophrenia. |
2024-09-28 |
2024-10-01 |
Not clear |
| Ruri Okubo, Motohiro Okada, Eishi Motomur. Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia. Biomolecules. vol 14. issue 9. 2024-09-28. PMID:39334894. |
however, neither typical nor atypical antipsychotics, other than clozapine, have been effective in addressing negative symptoms and cognitive impairments, which are indices for the prognostic and disability outcomes of schizophrenia. |
2024-09-28 |
2024-10-01 |
Not clear |
| Ahmed Tazi, Faouzi Errachidi, Dipesh Sonawane, Ghizlane Tahri, Sameer Rao, Suyog Meht. An economic model to understand the cost-effectiveness of olanzapine orally dispersible tablets (ODT) and olanzapine film coated tablets as a group compared with other oral atypical antipsychotics for treating schizophrenia in Morocco. Annals of general psychiatry. vol 23. issue 1. 2024-09-18. PMID:39294740. |
an economic model to understand the cost-effectiveness of olanzapine orally dispersible tablets (odt) and olanzapine film coated tablets as a group compared with other oral atypical antipsychotics for treating schizophrenia in morocco. |
2024-09-18 |
2024-09-21 |
Not clear |
| Michael P Caligiuri, Peter J Weiden, Anna Legedza, Sergey Yagoda, Amy Claxto. Handwriting Kinematics in Patients with Schizophrenia Treated with Long-Acting Injectable Atypical Antipsychotics: Results From the ALPINE Study. Schizophrenia bulletin open. vol 3. issue 1. 2024-08-15. PMID:39144789. |
handwriting kinematics in patients with schizophrenia treated with long-acting injectable atypical antipsychotics: results from the alpine study. |
2024-08-15 |
2024-08-17 |
Not clear |
| Xiaofeng Wang, Mathangi Gopalakrishnan, Benjamin Rich, Jogarao V Gobburu, Frank Larsen, Arash Raoufini. Exposure-Response Modeling in Adults and Adolescents With Schizophrenia to Support the Extrapolation of Brexpiprazole Efficacy to Adolescents. Journal of clinical pharmacology. 2024-07-08. PMID:38973383. |
in order to accelerate drug development and avoid unnecessary drug trials in vulnerable pediatric populations, the us food and drug administration (fda) released a general advice letter to sponsors permitting the effectiveness of atypical antipsychotics for the treatment of schizophrenia in adults to be extrapolated to adolescents. |
2024-07-08 |
2024-07-11 |
Not clear |
| Júlio César Menezes Vieira, Edna Afonso Reis, Augusto Afonso Guerra, Helian Nunes de Oliveira, Cristina Mariano Rua. Comparative effectiveness of clozapine and non-clozapine atypical antipsychotics provided by the Brazilian National Health System in adults with schizophrenia. Frontiers in psychiatry. vol 15. 2024-07-04. PMID:38962057. |
comparative effectiveness of clozapine and non-clozapine atypical antipsychotics provided by the brazilian national health system in adults with schizophrenia. |
2024-07-04 |
2024-07-10 |
Not clear |