| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Fredrik Jarsko. Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations. Current opinion in psychiatry. vol 19. issue 3. 2006-10-03. PMID:16612218. |
apoptosis in schizophrenia: pathophysiologic and therapeutic considerations. |
2006-10-03 |
2023-08-12 |
Not clear |
| L Fredrik Jarsko. Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations. Current opinion in psychiatry. vol 19. issue 3. 2006-10-03. PMID:16612218. |
this paper will review studies of apoptotic regulatory proteins, dna fragmentation, and gene microarrays to highlight the potential role of apoptosis in the pathophysiology and treatment of schizophrenia. |
2006-10-03 |
2023-08-12 |
Not clear |
| Piotr Gałecki, Tadeusz Pietras, Janusz Szemraj, Kinga Florkowska, Antoni Florkowski, Krzysztof Zboralsk. [Functional polymorphism of manganese superoxide dismutase (MnSOD) gene correlates with schizophrenia in Polish population]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 20. issue 117. 2006-09-12. PMID:16780268. |
neuro-developmental theory paid attention to an apoptosis role and reactive oxygen species (ros) in schizophrenia pathogenesis. |
2006-09-12 |
2023-08-12 |
Not clear |
| Vibeke Sørensen Catts, Stanley Victor Catts, John Joseph McGrath, François Féron, Duncan McLean, Elizabeth Jane Coulson, Louise Helen Lutze-Man. Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia research. vol 84. issue 1. 2006-09-08. PMID:16626937. |
apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. |
2006-09-08 |
2023-08-12 |
Not clear |
| Vibeke Sørensen Catts, Stanley Victor Catts, John Joseph McGrath, François Féron, Duncan McLean, Elizabeth Jane Coulson, Louise Helen Lutze-Man. Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia research. vol 84. issue 1. 2006-09-08. PMID:16626937. |
the aim of this study was to investigate whether there is an increased susceptibility to apoptosis in cultured fibroblasts from patients with schizophrenia. |
2006-09-08 |
2023-08-12 |
Not clear |
| André Schrattenholz, Vukic Soski. NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling. Current topics in medicinal chemistry. vol 6. issue 7. 2006-08-01. PMID:16719808. |
nmda receptors are thought to be responsible for excitotoxicity and subsequent downstream events like neuroinflammation and apoptosis and thus have been implicated in many important human pathologies, ranging from amyotrophic lateral sclerosis, alzheimer's and parkinson' disease, depression, epilepsy, trauma and stroke to schizophrenia. |
2006-08-01 |
2023-08-12 |
human |
| F M Benes, D Matzilevich, R E Burke, J Wals. The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Molecular psychiatry. vol 11. issue 3. 2006-05-02. PMID:16288314. |
post-mortem studies conducted over the past 15 years suggest that apoptosis could play a role in the pathophysiology of bipolar disorder (bd) and, to a lesser degree, schizophrenia (sz). |
2006-05-02 |
2023-08-12 |
Not clear |
| L Fredrik Jarskog, Leisa A Glantz, John H Gilmore, Jeffrey A Lieberma. Apoptotic mechanisms in the pathophysiology of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 5. 2005-08-26. PMID:15908096. |
given that the neuropathology of schizophrenia is subtle and includes reduced neuropil (especially synaptic elements), limited and often layer-specific reductions of neurons, as well as neuroimaging data suggesting progressive loss of cortical gray matter in first-episode psychosis, a role for apoptosis in schizophrenia appears plausible. |
2005-08-26 |
2023-08-12 |
Not clear |
| L Fredrik Jarskog, Leisa A Glantz, John H Gilmore, Jeffrey A Lieberma. Apoptotic mechanisms in the pathophysiology of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 5. 2005-08-26. PMID:15908096. |
although the exact role of apoptosis in schizophrenia remains uncertain, the potential involvement of non-lethal localized apoptosis is intriguing, especially in earlier stages of the illness. |
2005-08-26 |
2023-08-12 |
Not clear |
| L Fredrik Jarskog, Leisa A Glantz, John H Gilmore, Jeffrey A Lieberma. Apoptotic mechanisms in the pathophysiology of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 5. 2005-08-26. PMID:15908096. |
studies that have examined markers of apoptosis and levels of apoptotic regulatory proteins in postmortem schizophrenia brain tissue will be reviewed in context of this hypothesis. |
2005-08-26 |
2023-08-12 |
Not clear |
| L Fredrik Jarskog, Leisa A Glantz, John H Gilmore, Jeffrey A Lieberma. Apoptotic mechanisms in the pathophysiology of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 5. 2005-08-26. PMID:15908096. |
while schizophrenia is generally considered a neurodevelopmental disorder, evidence for progressive clinical deterioration and subtle neurostructural changes following the onset of psychosis has led to the hypothesis that apoptosis may contribute to the pathophysiology of schizophrenia. |
2005-08-26 |
2023-08-12 |
Not clear |
| Lei Zhang, Rulun Zhou, Guoqiang Xian. Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15871910. |
the fundamental pathological process(es) associated with schizophrenia (sz) remain(s) uncertain, but multiple lines of evidence suggest that this condition is associated with excessive stimulation of striatal dopamine (da) d2 receptors, deficient stimulation of medial prefrontal cortex (mpfc) d1 receptors as well as neuronal apoptosis. |
2005-08-09 |
2023-08-12 |
rat |
| Z R Xi, W Qin, Y F Yang, G He, S H Gao, M S Ren, Y W Peng, Z Zhang, L H. Transmission disequilibrium analysis of the GSN gene in a cohort of family trios with schizophrenia. Neuroscience letters. vol 372. issue 3. 2005-01-05. PMID:15542240. |
apoptosis is thought to play a role in neuronal pathology in schizophrenia. |
2005-01-05 |
2023-08-12 |
Not clear |
| W Ukai, H Ozawa, M Tateno, E Hashimoto, T Sait. Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 6. 2004-09-14. PMID:15168214. |
haloperidol but not risperidone induces caspase-dependent apoptosis by reducing cellular survival signaling, which possibly contributes to the differential clinical therapeutic efficacy and expression of side effects in schizophrenia. |
2004-09-14 |
2023-08-12 |
rat |
| R James, R R Adams, S Christie, S R Buchanan, D J Porteous, J K Milla. Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Molecular and cellular neurosciences. vol 26. issue 1. 2004-07-20. PMID:15121183. |
moreover, of the many cellular functions performed by mitochondria, their role in oxidative phosphorylation, calcium homeostasis, and apoptosis may hold particular relevance for the neuronal disturbances believed to be involved in the pathogenesis of schizophrenia. |
2004-07-20 |
2023-08-12 |
Not clear |
| Natalya A Uranova, Victor M Vostrikov, Diana D Orlovskaya, Valentina I Rachmanov. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophrenia research. vol 67. issue 2-3. 2004-06-28. PMID:14984887. |
our previous electron microscopic study of the prefrontal cortex (pfc) demonstrated ultrastructural signs of apoptosis and necrosis of oligodendroglial cells in schizophrenia (sch) and bipolar disorder (bpd). |
2004-06-28 |
2023-08-12 |
human |
| Gregor E Berger, Stephen Wood, Patrick D McGorr. Incipient neurovulnerability and neuroprotection in early psychosis. Psychopharmacology bulletin. vol 37. issue 2. 2004-01-28. PMID:14566217. |
medline databases were searched from 1966 to 2002 using the following key words: stem cells, progenitor cells, glia, neurogenesis, apoptosis, and combined with brain and schizophrenia. |
2004-01-28 |
2023-08-12 |
Not clear |
| Laura Wiseman Harris, Trevor Sharp, Jane Gartlon, Declan N C Jones, Paul J Harriso. Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511349. |
the effects are reminiscent of alterations reported in schizophrenia and, as such, are consistent with hypotheses advocating a role for nmda receptor hypofunction, and aberrant apoptosis, in the neurodevelopmental pathogenesis of the disorder. |
2003-12-05 |
2023-08-12 |
rat |
| Carmit Nadri, Nitsan Kozlovsky, Galila Aga. [Schizophrenia, neurodevelopment and glycogen synthase kinase-3]. Harefuah. vol 142. issue 8-9. 2003-10-23. PMID:14518171. |
the neurodevelopmental hypothesis of the etiology of schizophrenia suggests that interaction between genetic and environmental events occurring during critical early periods in neuronal growth may negatively influence the way by which nerve cells are laid down, differentiated and selectively culled by apoptosis. |
2003-10-23 |
2023-08-12 |
Not clear |
| Francine M Benes, John Walsh, Sujoy Bhattacharyya, Archna Sheth, Sabina Berrett. DNA fragmentation decreased in schizophrenia but not bipolar disorder. Archives of general psychiatry. vol 60. issue 4. 2003-05-09. PMID:12695312. |
apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder. |
2003-05-09 |
2023-08-12 |
Not clear |