| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhai Kang, Li Sheng, Jia L. HINT1 promotes neuronal apoptosis and triggers schizophrenia-like behavior in rats. Behavioural brain research. 2024-10-19. PMID:39426527. |
this study aims to investigate the mechanism by which histidine triad nucleotide-binding protein 1 (hint1) promotes hippocampal neuronal apoptosis, triggering schizophrenia (sz)-like behavior in rats. |
2024-10-19 |
2024-10-22 |
rat |
| Di Huang, Ivan Ovcharenk. The contribution of silencer variants to human diseases. medRxiv : the preprint server for health sciences. 2024-05-27. PMID:38798661. |
the disruption of apoptosis in neuronal cells is associated with both schizophrenia and bipolar disorder and can largely be attributed to variants within candidate silencers. |
2024-05-27 |
2024-05-31 |
human |
| Shuhui Li, Jie Jiang, Wenli Zhu, Dandan Wang, Chaoqing Dong, Yangying Bu, Juan Zhang, Daiyutong Gao, Xiaowen Hu, Chunling Wa. Increased cell-free DNA is associated with oxidative damage in patients with schizophrenia. Journal of psychiatric research. vol 175. 2024-05-03. PMID:38701608. |
cell-free dna (cfdna) has been found to be elevated in patients with schizophrenia (sz), potentially derived from activated apoptosis, but the underlying mechanisms remain unknown. |
2024-05-03 |
2024-05-06 |
Not clear |
| Keke Hao, Fashuai Chen, Linyao Zhao, Shilin Xu, Ying Xiong, Rui Xu, Xinhui Xie, Huan Huang, Chang Shu, Zhongchun Liu, Huiling Wang, Gaohua Wan. Nicotinamide ameliorates mitochondria-related neuronal apoptosis and cognitive impairment via the NAD Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-05-20. PMID:37210391. |
nicotinamide ameliorates mitochondria-related neuronal apoptosis and cognitive impairment via the nad emerging evidence suggests that mitochondria play a central role in mental health disorders including schizophrenia. |
2023-05-20 |
2023-08-14 |
rat |
| Patricia Gassó, Albert Martínez-Pinteño, Natalia Rodríguez, Santiago Madero, Marta Gómez, Alex G Segura, Clemente García-Rizo, Constanza Morén, Sergi Mas, Eduard Parellad. Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768378. |
increased glutamate (glu) release would trigger neurotoxicity, leading to apoptosis and synaptic pruning, which is involved in the pathophysiology of schizophrenia. |
2023-02-11 |
2023-08-14 |
mouse |
| Xuhang Li, Xiulin Wu, Wenshi Li, Qiujin Yan, Ping Zhou, Yaru Xia, Wei Yao, Fan Zh. HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769337. |
herv-w env induces innate immune activation and neuronal apoptosis via linc01930/cgas axis in recent-onset schizophrenia. |
2023-02-11 |
2023-08-14 |
Not clear |
| Xuhang Li, Xiulin Wu, Wenshi Li, Qiujin Yan, Ping Zhou, Yaru Xia, Wei Yao, Fan Zh. HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769337. |
increased innate immune activation and neuronal apoptosis are common findings in schizophrenia. |
2023-02-11 |
2023-08-14 |
Not clear |
| Xuhang Li, Xiulin Wu, Wenshi Li, Qiujin Yan, Ping Zhou, Yaru Xia, Wei Yao, Fan Zh. HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769337. |
the totality of these results also showed that herv-w env facilitated antiviral innate immune response, resulting in neuronal apoptosis through the linc01930/cgas/sting pathway in schizophrenia. |
2023-02-11 |
2023-08-14 |
Not clear |
| Pinku Mani Talukdar, Fazal Abdul, Michael Maes, Michael Berk, Ganesan Venkatasubramanian, Bindu M Kutty, Monojit Debnat. A proof-of-concept study of maternal immune activation mediated induction of Toll-like receptor (TLR) and inflammasome pathways leading to neuroprogressive changes and schizophrenia-like behaviours in offspring. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 52. 2021-11-01. PMID:34261013. |
interestingly, few data exist on the pathway(s) such as tlr and inflammasome, primarily involved in sensing the microorganisms and inducing downstream inflammatory responses, apoptosis and neuroprogressive changes that drive prenatal infection-induced risk of schizophrenia. |
2021-11-01 |
2023-08-13 |
rat |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. |
2021-06-28 |
2023-08-13 |
Not clear |
| b' Faruk Kili\\xc3\\xa7, \\xc3\\x9cmit I\\xc5\\x9fik, Ay\\xc5\\x9fe Usta, Arif Demirda\\xc5\\x9. Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 43. issue 3. 2021-06-10. PMID:32785454.' |
serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia. |
2021-06-10 |
2023-08-13 |
Not clear |
| b' Faruk Kili\\xc3\\xa7, \\xc3\\x9cmit I\\xc5\\x9fik, Ay\\xc5\\x9fe Usta, Arif Demirda\\xc5\\x9. Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 43. issue 3. 2021-06-10. PMID:32785454.' |
the purpose of this study was to assess serum tumor necrosis factor-like weak inducer of apoptosis (tweak) concentrations to determine whether changes in patients with schizophrenia could have etiopathogenetic importance. |
2021-06-10 |
2023-08-13 |
Not clear |
| E A El Saftawy, R Y Shash, B E Aboulhoda, S F Arsanyos, E A Albadawi, S M Abou-Fandoud, R M Kamel, N M Ami. Insights into immunopathology and triggering of apoptosis in chronic cerebral toxoplasmosis using murine models. Tropical biomedicine. vol 38. issue 2. 2021-05-11. PMID:33973573. |
schizophrenia dependable on apoptosis in their pathogenesis. |
2021-05-11 |
2023-08-13 |
Not clear |
| Irina A Mednova, Alexander A Chernonosov, Marat F Kasakin, Elena G Kornetova, Arkadiy V Semke, Nikolay A Bokhan, Vladimir V Koval, Svetlana A Ivanov. Amino Acid and Acylcarnitine Levels in Chronic Patients with Schizophrenia: A Preliminary Study. Metabolites. vol 11. issue 1. 2021-02-18. PMID:33466490. |
amino acids and acylcarnitines play an important role as substrates and intermediate products in most of pathways involved in schizophrenia development such as mitochondrial dysfunction, inflammation, lipid oxidation, dna damage, oxidative stress, and apoptosis. |
2021-02-18 |
2023-08-13 |
Not clear |
| Kinga Szymona, Ewa Dudzińska, Hanna Karakuła-Juchnowicz, Paulina Gil-Kulik, Piotr Chomik, Małgorzata Świstowska, Joanna Gałaszkiewicz, Janusz Kock. Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017818. |
analysis of the expression of bax, bcl2, birc6, casp3, casp9 apoptosis genes during the first episode of schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Kayoko Esaki, Shabeesh Balan, Yoshimi Iwayama, Chie Shimamoto-Mitsuyama, Yoshio Hirabayashi, Brian Dean, Takeo Yoshikaw. Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia. Schizophrenia bulletin. 2020-10-01. PMID:32346731. |
a higher ratio of the sum of sphingosine and ceramide to s1p, which can induce apoptosis and cell-cycle arrest, was also observed in the samples of patients with schizophrenia than in controls. |
2020-10-01 |
2023-08-13 |
Not clear |
| Erika Velásquez, Daniel Martins-de-Souza, Ingrid Velásquez, Gabriel Reis Alves Carneiro, Andrea Schmitt, Peter Falkai, Gilberto B Domont, Fabio C S Nogueir. Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients. Journal of proteome research. vol 18. issue 12. 2020-08-31. PMID:31581776. |
based on our data analysis, we suggest the activation of nf-kb as a possible pathway that links the deregulation of glutamate, calcium, apoptosis, and the activation of the immune system in schizophrenia patients. |
2020-08-31 |
2023-08-13 |
Not clear |
| Charilaos Gerasimou, James N Tsoporis, Nikolaos Siafakas, Erifili Hatziagelaki, Maria Kallergi, Sofia N Chatziioannou, Thomas G Parker, John Parissis, Vasileios Salpeas, Charalabos Papageorgiou, Emmanouil Rizo. A Longitudinal Study of Alterations of S100B, sRAGE and Fas Ligand in Association to Olanzapine Medication in a Sample of First Episode Patients with Schizophrenia. CNS & neurological disorders drug targets. vol 17. issue 5. 2019-10-07. PMID:29875007. |
an increase in apoptosis may underlie a potential role of immune neuropathology in the etiopathogenesis of schizophrenia and specifically, the onset of the disorder. |
2019-10-07 |
2023-08-13 |
Not clear |
| I K Malashenkova, S A Krynskiy, D P Ogurtsov, M V Mamoshina, N V Zakharova, V L Ushakov, B M Velichkovsky, N A Didkovsk. [A role of the immune system in the pathogenesis of schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 12. 2019-05-30. PMID:30698566. |
neuroinflammation as a part of the pathophysiology of schizophrenia is characterized by the higher transcription of cns inflammatory mediators, excessive activation of microglia, inhibition of glutamatergic receptors that leads to the decrease in the number of cortical synapses and neuronal apoptosis. |
2019-05-30 |
2023-08-13 |
Not clear |
| Erika Velásquez, Fabio C S Nogueira, Ingrid Velásquez, Andrea Schmitt, Peter Falkai, Gilberto B Domont, Daniel Martins-de-Souz. Synaptosomal Proteome of the Orbitofrontal Cortex from Schizophrenia Patients Using Quantitative Label-Free and iTRAQ-Based Shotgun Proteomics. Journal of proteome research. vol 16. issue 12. 2018-08-15. PMID:28949146. |
our data contribute to a better understanding about apoptosis as a possible pathophysiological mechanism of this disease as well as neural systems supporting social behavior in schizophrenia. |
2018-08-15 |
2023-08-13 |
human |