| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arpita Dave, Prakash P Pilla. Docosahexaenoic acid increased MeCP2 mediated mitochondrial respiratory complexes II and III enzyme activities in cortical astrocytes. Journal of biochemical and molecular toxicology. 2022-02-17. PMID:35174922. |
rett syndrome (rtt) is a neurodevelopmental disorder caused by mutations in the methyl-cpg-binding protein 2 (mecp2) in the neurons and glial cells of the central nervous system. |
2022-02-17 |
2023-08-13 |
Not clear |
| H Mira-Bontenbal, B Tan, C Gontan, S Goossens, R G Boers, J B Boers, C Dupont, M E van Royen, W F J IJcken, P French, A Bedalov, J Gribna. Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells. Stem cell reports. 2022-02-12. PMID:35148843. |
rett syndrome may be treated by reactivating the silent copy of mecp2 from the inactive x chromosome in female cells. |
2022-02-12 |
2023-08-13 |
mouse |
| Paras A Patel, Julia V Hegert, Ingrid Cristian, Alicia Kerr, Leslie E W LaConte, Michael A Fox, Sarika Srivastava, Konark Mukherje. Complete loss of the X-linked gene CASK causes severe cerebellar degeneration. Journal of medical genetics. 2022-02-12. PMID:35149592. |
heterozygous loss of x-linked genes like cask and mecp2 (rett syndrome) causes developmental delay in girls, while in boys, loss of the only allele of these genes leads to epileptic encephalopathy. |
2022-02-12 |
2023-08-13 |
Not clear |
| Cecilia Chávez-García, Jérôme Hénin, Mikko Karttune. Multiscale Computational Study of the Conformation of the Full-Length Intrinsically Disordered Protein MeCP2. Journal of chemical information and modeling. 2022-02-07. PMID:35130441. |
the malfunction of the methyl-cpg binding protein 2 (mecp2) is associated with the rett syndrome, one of the most common causes of cognitive impairment in females. |
2022-02-07 |
2023-08-13 |
Not clear |
| Mayara C Ribeiro, Jessica L MacDonal. Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model. Neurobiology of disease. 2022-01-29. PMID:35091041. |
vitamin d modulates cortical transcriptome and behavioral phenotypes in an mecp2 heterozygous rett syndrome mouse model. |
2022-01-29 |
2023-08-13 |
mouse |
| Mayara C Ribeiro, Jessica L MacDonal. Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model. Neurobiology of disease. 2022-01-29. PMID:35091041. |
rett syndrome (rtt) is an x-linked neurological disorder caused by mutations in the transcriptional regulator mecp2. |
2022-01-29 |
2023-08-13 |
mouse |
| Valeria Cordone, Francesca Ferrara, Alessandra Pecorelli, Anna Guiotto, Antonio Vitale, Fernanda Amicarelli, Carlo Cervellati, Joussef Hayek, Giuseppe Valacch. The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients. Free radical biology & medicine. 2022-01-27. PMID:35085773. |
rett syndrome (rtt), a devastating neurodevelopmental disorder, is caused in 95% of the cases by mutations in the x-chromosome-localized mecp2 gene. |
2022-01-27 |
2023-08-13 |
human |
| Jian Zhou, Hamdan Hamdan, Hari Krishna Yalamanchili, Kaifang Pang, Amy E Pohodich, Joanna Lopez, Yingyao Shao, Juan A Oses-Prieto, Lifang Li, Wonho Kim, Mark A Durham, Sameer S Bajikar, Donna J Palmer, Philip Ng, Michelle L Thompson, E Martina Bebin, Amelie J Müller, Alma Kuechler, Antje Kampmeier, Tobias B Haack, Alma L Burlingame, Zhandong Liu, Matthew N Rasband, Huda Y Zoghb. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 4. 2022-01-25. PMID:35074918. |
mecp2 is associated with rett syndrome (rtt), |
2022-01-25 |
2023-08-13 |
Not clear |
| Weiqin Ji, Xiaotong Su. Methyl-CpG-binding protein 2 promotes osteogenic differentiation of bone marrow mesenchymal stem cells through regulating forkhead box F1/Wnt/β-Catenin axis. Bioengineered. vol 13. issue 1. 2021-12-30. PMID:34967263. |
methyl-cpg-binding protein 2 (mecp2) has been reported to be implicated in bone formation during the development of rett syndrome. |
2021-12-30 |
2023-08-13 |
mouse |
| Clara Alice Musi, Anna Maria Castaldo, Anna Elisa Valsecchi, Sara Cimini, Noemi Morello, Riccardo Pizzo, Alessandra Renieri, Ilaria Meloni, Maurizio Bonati, Maurizio Giustetto, Tiziana Borsell. JNK signaling provides a novel therapeutic target for Rett syndrome. BMC biology. vol 19. issue 1. 2021-12-16. PMID:34911542. |
rett syndrome (rtt) is a monogenic x-linked neurodevelopmental disorder characterized by loss-of-function mutations in the mecp2 gene, which lead to structural and functional changes in synapse communication, and impairments of neural activity at the basis of cognitive deficits that progress from an early age. |
2021-12-16 |
2023-08-13 |
Not clear |
| María Abellán-Álvaro, Oliver Stork, Carmen Agustín-Pavón, Mónica Santo. MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice. Journal of neurodevelopmental disorders. vol 13. issue 1. 2021-12-13. PMID:34895132. |
moreover, mutations in the mecp2 gene are the primary cause of rett syndrome and, to a lesser extent, of a range of other major neurodevelopmental disorders. |
2021-12-13 |
2023-08-13 |
mouse |
| Sarah E Sinnett, Emily Boyle, Christopher Lyons, Steven J Gra. Engineered microRNA-based regulatory element permits safe high-dose miniMECP2 gene therapy in Rett mice. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33950254. |
mecp2 gene transfer has been shown to extend the survival of mecp2-/y knockout mice modelling rett syndrome, an x-linked neurodevelopmental disorder. |
2021-12-09 |
2023-08-13 |
mouse |
| Sarah E Sinnett, Emily Boyle, Christopher Lyons, Steven J Gra. Engineered microRNA-based regulatory element permits safe high-dose miniMECP2 gene therapy in Rett mice. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33950254. |
however, controlling deleterious overexpression of mecp2 remains the critical unmet obstacle towards a safe and effective gene therapy approach for rett syndrome. |
2021-12-09 |
2023-08-13 |
mouse |
| Nicolas Lebrun, Chloé Delépine, Mohamed Selloum, Hamid Meziane, Juliette Nectoux, Yann Herault, Thierry Bienven. HDAC inhibitor ameliorates behavioral deficits in Mecp2 Brain research. vol 1772. 2021-12-09. PMID:34582789. |
hdac inhibitor ameliorates behavioral deficits in mecp2 rett syndrome (rtt) is a rare x-linked neurodevelopmental disorder. |
2021-12-09 |
2023-08-13 |
mouse |
| Nicolas Lebrun, Chloé Delépine, Mohamed Selloum, Hamid Meziane, Juliette Nectoux, Yann Herault, Thierry Bienven. HDAC inhibitor ameliorates behavioral deficits in Mecp2 Brain research. vol 1772. 2021-12-09. PMID:34582789. |
more than 95% of classic rett syndrome cases result from pathogenic variants in the methyl-cpg binding protein 2 (mecp2) gene. |
2021-12-09 |
2023-08-13 |
mouse |
| Jhanvi Shah, Harsh Patel, Deepika Jain, Frenny Sheth, Harsh Shet. A rare case of a male child with post-zygotic de novo mosaic variant c.538C > T in MECP2 gene: a case report of Rett syndrome. BMC neurology. vol 21. issue 1. 2021-12-06. PMID:34856927. |
a rare case of a male child with post-zygotic de novo mosaic variant c.538c > t in mecp2 gene: a case report of rett syndrome. |
2021-12-06 |
2023-08-13 |
Not clear |
| Claudia Villani, Mirjana Carli, Anna Maria Castaldo, Giuseppina Sacchetti, Roberto William Invernizz. Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin. Scientific reports. vol 11. issue 1. 2021-11-29. PMID:34282222. |
fluoxetine increases brain mecp2 immuno-positive cells in a female mecp2 heterozygous mouse model of rett syndrome through endogenous serotonin. |
2021-11-29 |
2023-08-13 |
mouse |
| Hiroyasu Murasawa, Hiroyuki Kobayashi, Jun Imai, Takahiko Nagase, Hitomi Soumiya, Hidefumi Fukumits. Substantial acetylcholine reduction in multiple brain regions of Mecp2-deficient female rats and associated behavioral abnormalities. PloS one. vol 16. issue 10. 2021-11-29. PMID:34673817. |
rett syndrome (rtt) is a neurodevelopmental disorder with x-linked dominant inheritance caused mainly by mutations in the methyl-cpg-binding protein 2 (mecp2) gene. |
2021-11-29 |
2023-08-13 |
mouse |
| Mahir Abdulla Petkar, Thushara Rodrig. Primary cutaneous malignant melanoma in Rett syndrome: Report of a case with nuclear features resembling herpes simplex virus cytopathic effects-a hitherto unrecognized morphological variant. Journal of cutaneous pathology. vol 48. issue 7. 2021-11-26. PMID:33345376. |
rett syndrome (rtt) is a progressive neurological disorder, affecting females with mutations in the x-linked gene methyl-cpg-binding protein 2 (mecp2). |
2021-11-26 |
2023-08-13 |
Not clear |
| Sheryl Anne D Vermudez, Rocco G Gogliotti, Bright Arthur, Aditi Buch, Clarissa Morales, Yuta Moxley, Hemangi Rajpal, P Jeffrey Conn, Colleen M Niswende. Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model. Genes, brain, and behavior. 2021-11-19. PMID:34002468. |
profiling beneficial and potential adverse effects of mecp2 overexpression in a hypomorphic rett syndrome mouse model. |
2021-11-19 |
2023-08-13 |
mouse |