| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rita F Marques, Kent E Dunca. SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269186. |
its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death. |
2021-10-22 |
2023-08-13 |
mouse |
| Khalid Sawalha, Krishna Kakker. Acute Respiratory Failure From Hypermagnesemia Requiring Prolonged Mechanical Ventilation. Journal of investigative medicine high impact case reports. vol 8. 2021-10-15. PMID:33371745. |
on physical examination the patient had flaccid paralysis in all his extremities along with absent brain stem reflexes. |
2021-10-15 |
2023-08-13 |
Not clear |
| Rominah Onintsoa Diarimalala, Meichun Hu, Yanhong Wei, Kanghong H. Recent advances of enterovirus 71 [Formula: see text] targeting Inhibitors. Virology journal. vol 17. issue 1. 2021-08-19. PMID:33176821. |
most of the time, hfmd is a mild disease but can progress to severe complications such as meningitis, brain stem encephalitis, acute flaccid paralysis (afp) and even death; ev71 has been identified in all severe cases. |
2021-08-19 |
2023-08-13 |
Not clear |
| Manoj Kumar Jaiswa. Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28111541. |
riluzole but not melatonin ameliorates acute motor neuron degeneration and moderately inhibits sod1-mediated excitotoxicity induced disrupted mitochondrial ca selective motoneurons (mns) degeneration in the brain stem, hypoglossal motoneurons (hmns), and the spinal cord resulting in patients paralysis and eventual death are prominent features of amyotrophic lateral sclerosis (als). |
2020-10-01 |
2023-08-13 |
Not clear |
| Kyung Yeon Le. Enterovirus 71 infection and neurological complications. Korean journal of pediatrics. vol 59. issue 10. 2020-09-30. PMID:27826325. |
however, ev71 occasionally involves the central nervous system (cns), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis. |
2020-09-30 |
2023-08-13 |
human |
| Roberta Bonafede, Raffaella Mariott. ALS Pathogenesis and Therapeutic Approaches: The Role of Mesenchymal Stem Cells and Extracellular Vesicles. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28377696. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by progressive muscle paralysis determined by the degeneration of motoneurons in the motor cortex brainstem and spinal cord. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rossana Sirabella, Valeria Valsecchi, Serenella Anzilotti, Ornella Cuomo, Antonio Vinciguerra, Pasquale Cepparulo, Paola Brancaccio, Natascia Guida, Nicolas Blondeau, Lorella M T Canzoniero, Cristina Franco, Salvatore Amoroso, Lucio Annunziato, Giuseppe Pignatar. Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30131665. |
amyotrophic lateral sclerosis (als) is one of the most threatening neurodegenerative disease since it causes muscular paralysis for the loss of motor neurons in the spinal cord, brainstem and motor cortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hui-Jun Wen, Jin-Shuo Yang, Yong-Qiang L. Transient unilateral facial paralysis induced by perimesencephalic non-aneurysmal subarachnoid hemorrhage: A case report and review of the literature. Experimental and therapeutic medicine. vol 10. issue 4. 2020-09-29. PMID:26622522. |
the paralysis may have resulted from the compression of a part of the facial nerve by the flow of the hemorrhage into the cavum subarachnoidale; alternatively, the paralysis may have been caused by disorder of the blood supply of the facial nucleus, with the hemorrhage leading to brainstem vasospasm. |
2020-09-29 |
2023-08-13 |
Not clear |
| Zoltan A Torontali, Jimmy J Fraigne, Paul Sanghera, Richard Horner, John Peeve. The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness. Current biology : CB. vol 29. issue 22. 2020-09-09. PMID:31679942. |
here, we tested the long-standing hypothesis that muscle paralysis during cataplexy is caused by recruitment of the brainstem circuit that induces muscle paralysis during rem sleep. |
2020-09-09 |
2023-08-13 |
Not clear |
| Dídac Casas-Alba, Ana Valero-Rello, Jordi Muchart, Thaís Armangué, Iolanda Jordan, María Cabrerizo, Marta Molero-Luís, Rafael Artuch, Claudia Fortuny, Carmen Muñoz-Almagro, Cristian Laune. Cerebrospinal Fluid Neopterin in Children With Enterovirus-Related Brainstem Encephalitis. Pediatric neurology. vol 96. 2020-05-01. PMID:30935719. |
enterovirus-a71 causes outbreaks of brainstem encephalitis, ranging from self-limited disease to acute flaccid paralysis. |
2020-05-01 |
2023-08-13 |
Not clear |
| Jia Liu, Fei Wan. Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications. Frontiers in immunology. vol 8. 2019-11-20. PMID:28871262. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease that affects upper motor neurons (mns) comprising the corticospinal tract and lower mns arising from the brain stem nuclei and ventral roots of the spinal cord, leading to fatal paralysis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yuan Chao Xue, Chelsea M Ruller, Gabriel Fung, Yasir Mohamud, Haoyu Deng, Huitao Liu, Jingchun Zhang, Ralph Feuer, Honglin Lu. Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo. The American journal of pathology. vol 188. issue 12. 2019-08-20. PMID:30273599. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that primarily affects motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to progressive paralysis and eventual death. |
2019-08-20 |
2023-08-13 |
mouse |
| Aymeric Amelot, Louis-Marie Terrier, Guillaume Lo. Predictive factors of neurological recovery after chronic craniovertebral brainstem compression. Acta neurochirurgica. vol 160. issue 6. 2019-08-15. PMID:29582153. |
neurologic manifestations of craniovertebral junction (cvj) disease may generate dramatic brainstem damage, which could evolve to paralysis. |
2019-08-15 |
2023-08-13 |
Not clear |
| Kassem Sharif, Alaa Sharif, Fareed Jumah, Rod Oskouian, R Shane Tubb. Rheumatoid arthritis in review: Clinical, anatomical, cellular and molecular points of view. Clinical anatomy (New York, N.Y.). vol 31. issue 2. 2018-09-10. PMID:28833647. |
in some instances, bony erosions subsequent to the ra disease process can result in life-threatening events including, for example, atlanto-axial subluxation, which can cause myelopathy and paralysis; and basilar invagination, which can cause brain stem injury and imminent death. |
2018-09-10 |
2023-08-13 |
Not clear |
| Marios G Krokidis, Panagiotis Vlamo. Transcriptomics in amyotrophic lateral sclerosis. Frontiers in bioscience (Elite edition). vol 10. 2018-06-19. PMID:28930607. |
amyotrophic lateral sclerosis (als) is an adult-onset, incurable neurodegenerative disease characterized by the selective death of upper and lowers motor neurons in the spinal cord, brainstem and motor cortex, which ultimately leads to paralysis and death within 2-3 years of onset. |
2018-06-19 |
2023-08-13 |
human |
| Kyung Yeon Lee, Myoung Sook Lee, Dong Bin Ki. Neurologic Manifestations of Enterovirus 71 Infection in Korea. Journal of Korean medical science. vol 31. issue 4. 2016-12-20. PMID:27051240. |
based on their clinical features, the patients were classified into 4 clinical groups: brainstem encephalitis (n = 21), meningitis (n = 7), encephalitis (n = 2), and acute flaccid paralysis (n = 1). |
2016-12-20 |
2023-08-13 |
Not clear |
| b' Cl\\xc3\\xa0udia Cerver\\xc3\\xb3, Neus Montull, Olga Tarabal, L\\xc3\\xaddia Piedrafita, Josep E Esquerda, Jordi Calder\\xc3\\xb. Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 13. issue 1. 2016-10-27. PMID:26582176.' |
spinal muscular atrophy (sma) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (mn) loss and skeletal muscle paralysis. |
2016-10-27 |
2023-08-13 |
mouse |
| Milan R Dimitrijevic, Simon M Danner, Winfried May. Neurocontrol of Movement in Humans With Spinal Cord Injury. Artificial organs. vol 39. issue 10. 2016-08-03. PMID:26471132. |
overall, we highlight that upper motor neuron paralysis does not entail complete absence of connectivity between cortex, brain stem, and spinal motor cells, but there can be altered anatomy and corresponding neurophysiological characteristics. |
2016-08-03 |
2023-08-13 |
Not clear |
| Muhammad Ikram Ullah, Arsalan Ahmad, Syed Irfan Raza, Ali Amar, Amjad Ali, Attya Bhatti, Peter John, Aisha Mohyuddin, Wasim Ahmad, Muhammad Jawad Hassa. In silico analysis of SIGMAR1 variant (rs4879809) segregating in a consanguineous Pakistani family showing amyotrophic lateral sclerosis without frontotemporal lobar dementia. Neurogenetics. vol 16. issue 4. 2016-06-13. PMID:26205306. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. |
2016-06-13 |
2023-08-13 |
Not clear |
| Zulay R Lugo, Marie-Aurélie Bruno, Olivia Gosseries, Athena Demertzi, Lizette Heine, Marie Thonnard, Véronique Blandin, Frédéric Pellas, Steven Laurey. Beyond the gaze: Communicating in chronic locked-in syndrome. Brain injury. vol 29. issue 9. 2016-05-24. PMID:26182228. |
locked-in syndrome (lis) usually follows a brainstem stroke and is characterized by paralysis of all voluntary muscles (except eyes' movements or blinking) and lack of speech with preserved consciousness. |
2016-05-24 |
2023-08-13 |
Not clear |