| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie C Mayer, Constanze Breithaupt, Markus Reindl, Kathrin Schanda, Kevin Rostásy, Thomas Berger, Russell C Dale, Fabienne Brilot, Tomas Olsson, Dieter Jenne, Anne-Katrin Pröbstel, Klaus Dornmair, Hartmut Wekerle, Reinhard Hohlfeld, Brenda Banwell, Amit Bar-Or, Edgar Mein. Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. Journal of immunology (Baltimore, Md. : 1950). vol 191. issue 7. 2013-11-26. PMID:24014878. |
we expressed mutants of mog on human hela cells and analyzed sera from 111 patients (104 children, 7 adults) who recognized cell-bound human mog, but had different diseases, including acute disseminated encephalomyelitis (adem), one episode of transverse myelitis or optic neuritis, multiple sclerosis (ms), anti-aquaporin-4 (aqp4)-negative neuromyelitis optica (nmo), and chronic relapsing inflammatory optic neuritis (crion). |
2013-11-26 |
2023-08-12 |
mouse |
| Takeshi Kezuka, Yoshihiko Usui, Naoyuki Yamakawa, Yoshimichi Matsunaga, Ryusaku Matsuda, Masayuki Masuda, Hiroya Utsumi, Keiko Tanaka, Hiroshi Got. Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. vol 32. issue 2. 2012-11-06. PMID:22157536. |
mog antigen is currently considered as a cause of optic neuritis (on) associated with ms because immunization with mog antigen derived from oligodendrocytes induces murine on with myelitis. |
2012-11-06 |
2023-08-12 |
Not clear |
| Kevin Rostasy, Simone Mader, Kathrin Schanda, Peter Huppke, Jutta Gärtner, Verena Kraus, Michael Karenfort, Daniel Tibussek, Astrid Blaschek, Barbara Bajer-Kornek, Steffen Leitz, Mareike Schimmel, Franziska Di Pauli, Thomas Berger, Markus Reind. Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis. Archives of neurology. vol 69. issue 6. 2012-08-31. PMID:22371853. |
to study the humoral immune response directed at myelin oligodendrocyte glycoprotein (mog)in pediatric patients with isolated and recurrent optic neuritis(on). |
2012-08-31 |
2023-08-12 |
Not clear |
| Muriel B Sättler, Mauro Togni, Ivana Gadjanski, Kurt-Wolfram Sühs, Nadine Meyer, Mathias Bähr, Ricarda Die. Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. Journal of neuroimmunology. vol 193. issue 1-2. 2008-03-04. PMID:18037506. |
we detected important differences in neurodegeneration in various subtypes of myelin oligodendrocyte glycoprotein (mog)-induced optic neuritis. |
2008-03-04 |
2023-08-12 |
rat |
| Martha E Stokely, Manzoor A Bhat, Peter Koule. Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. Journal of neuroscience methods. vol 166. issue 2. 2008-02-14. PMID:17719649. |
tissue microfluorimetry was used to measure seven established markers for human ms pathology in normal and autoimmune optic nerves 13 days after antigen exposure, in a brown norway rat model of myelin oligodendrocyte glycoprotein (mog) peptide (35-55)-induced autoimmune optic neuritis. |
2008-02-14 |
2023-08-12 |
human |
| Estelle Bettell. Building different mouse models for human MS. Annals of the New York Academy of Sciences. vol 1103. 2007-07-25. PMID:17376825. |
here, we summarize our published findings on two mouse models: 2d2 myelin oligodendrocyte glycoprotein (mog)-specific t cell receptor (tcr) transgenic mice, which develop spontaneous isolated optic neuritis, and 2d2 mice crossed with mog-specific igh knockin (th) mice, which spontaneously develop a severe form of experimental autoimmune encephalomyelitis (eae) with a selective distribution of meningeal and parenchymal inflammatory lesions in the spinal cord and optic nerves similar to that found in human devic's disease. |
2007-07-25 |
2023-08-12 |
mouse |
| Muriel B Sättler, Iris Demmer, Sarah K Williams, Katharina Maier, Doron Merkler, Ivana Gadjanski, Christine Stadelmann, Mathias Bähr, Ricarda Die. Effects of interferon-beta-1a on neuronal survival under autoimmune inflammatory conditions. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16764858. |
we have characterized previously time course and mechanisms of neuronal apoptosis in a rat model of myelin oligodendrocyte glycoprotein (mog)-induced optic neuritis. |
2006-11-14 |
2023-08-12 |
rat |
| Yangtai Guan, Kenneth S Shindler, Philomela Tabuena, A M Rostam. Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. Journal of neuroimmunology. vol 178. issue 1-2. 2006-11-14. PMID:16828169. |
recently, myelin oligodendrocyte glycoprotein (mog)-specific tcr transgenic mice were found to develop spontaneous isolated optic neuritis in the absence of eae. |
2006-11-14 |
2023-08-12 |
mouse |
| M B Sättler, D Merkler, K Maier, C Stadelmann, H Ehrenreich, M Bähr, R Die. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell death and differentiation. vol 11 Suppl 2. 2005-06-09. PMID:15459752. |
in the present study, we show that, in rats suffering from myelin oligodendrocyte glycoprotein (mog)-induced optic neuritis, systemic application of erythropoietin (epo) significantly increased survival and function of retinal ganglion cells (rgcs), the neurons that form the axons of the optic nerve. |
2005-06-09 |
2023-08-12 |
rat |
| Hui Shao, Zhigang Huang, Sheher L Sun, Henry J Kaplan, Deming Su. Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse. Investigative ophthalmology & visual science. vol 45. issue 11. 2004-12-08. PMID:15505056. |
to determine the relationship between optic neuritis (on) and eae, we examined the incidence of on in c57bl/6 (b6) mice immunized with a myelin oligodendrocyte/glycoprotein (mog)-derived peptide or injected with mog-specific t cells, which are known to induce eae. |
2004-12-08 |
2023-08-12 |
mouse |
| Estelle Bettelli, Maria Pagany, Howard L Weiner, Christopher Linington, Raymond A Sobel, Vijay K Kuchro. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. The Journal of experimental medicine. vol 197. issue 9. 2003-06-20. PMID:12732654. |
optic neuritis without eae could also be induced in these mice by sensitization with suboptimal doses of mog. |
2003-06-20 |
2023-08-12 |
mouse |
| Estelle Bettelli, Maria Pagany, Howard L Weiner, Christopher Linington, Raymond A Sobel, Vijay K Kuchro. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. The Journal of experimental medicine. vol 197. issue 9. 2003-06-20. PMID:12732654. |
the predilection of these mice to develop optic neuritis is associated with higher expression of mog in the optic nerve than in the spinal cord. |
2003-06-20 |
2023-08-12 |
mouse |
| M K Storch, A Stefferl, U Brehm, R Weissert, E Wallström, M Kerschensteiner, T Olsson, C Linington, H Lassman. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain pathology (Zurich, Switzerland). vol 8. issue 4. 1999-01-29. PMID:9804377. |
the pathology found in our models closely reflects the spectrum of multiple sclerosis (ms) pathology: classical ms as well as variants such as optic neuritis, devic's disease and marburg's type of acute ms are mimicked in rats immunized with mog antigen. |
1999-01-29 |
2023-08-12 |
rat |