| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tian-Ya Liu, Xiao-Ying Yang, Long-Tai Zheng, Guang-Hui Wang, Xue-Chu Zhe. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. Journal of neurochemistry. vol 140. issue 4. 2017-07-13. PMID:27889907. |
taken together, these findings revealed the first evidence that nur77 was an important modulator in microglia function that associated with microglia-mediated dopaminergic neurotoxicity, and thus modulation of nur77 may represent a potential novel target for treatment for neurodegenerative disease. |
2017-07-13 |
2023-08-13 |
mouse |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
pre-b-cell leukemia homeobox (pbx) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mdan) as well as their role in neurodegenerative diseases are unknown. |
2017-06-28 |
2023-08-13 |
human |
| Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Pen. Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 3. 2017-06-26. PMID:28268219. |
regulatory t (treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of parkinson's disease (pd), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in the nigrostriatal system. |
2017-06-26 |
2023-08-13 |
Not clear |
| Ádám Annus, László Vécse. Spotlight on opicapone as an adjunct to levodopa in Parkinson's disease: design, development and potential place in therapy. Drug design, development and therapy. vol 11. 2017-05-15. PMID:28123288. |
parkinson's disease (pd) is a progressive, chronic, neurodegenerative disease characterized by rigidity, tremor, bradykinesia and postural instability secondary to dopaminergic deficit in the nigrostriatal system. |
2017-05-15 |
2023-08-13 |
Not clear |
| William M Johnson, Marcin Golczak, Kyonghwan Choe, Pierce L Curran, Olga Gorelenkova Miller, Chen Yao, Wenzhang Wang, Jiusheng Lin, Nicole M Milkovic, Ajit Ray, Vijayalakshmi Ravindranath, Xiongwei Zhu, Mark A Wilson, Amy L Wilson-Delfosse, Shu G Chen, John J Mieya. Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease. Biochemistry. vol 55. issue 32. 2017-05-01. PMID:26894491. |
parkinson's disease (pd) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. |
2017-05-01 |
2023-08-13 |
mouse |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Tourandokht Baluchnejadmojarad, Nida Jamali-Raeufy, Sedigheh Zabihnejad, Nafiseh Rabiee, Mehrdad Roghan. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson's disease: Possible involvement of PI3K/ERβ signaling. European journal of pharmacology. vol 801. 2017-04-17. PMID:28284752. |
parkinson's disease (pd) is a neurodegenerative disease with progressive loss of mesencephalic dopaminergic neurons of the substantia nigra and with multiple incapacitating motor and non-motor symptoms. |
2017-04-17 |
2023-08-13 |
rat |
| Md Zeeshan Rasheed, Heena Tabassum, Suhel Parve. Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease. Protoplasma. vol 254. issue 1. 2017-03-27. PMID:26825389. |
among the neurodegenerative diseases (nd), parkinson's disease affects 6.3 million people worldwide characterized by the progressive loss of dopaminergic neurons in substantia nigra. |
2017-03-27 |
2023-08-13 |
Not clear |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
parkinson's disease (pd) is the second most common neurodegenerative disease in the world, being characterized by dopaminergic neurodegeneration of substantia nigra pars compacta. |
2017-03-23 |
2023-08-13 |
mouse |
| Wei Zhu, Jie Li, Yigang Liu, Kun Xie, Le Wang, Jianmin Fan. Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways. Immunopharmacology and immunotoxicology. vol 38. issue 3. 2017-03-21. PMID:27075782. |
mesencephalic astrocyte-derived neurotrophic factor (manf), a new evolutionary conserved neurotrophic factor (ntf), has been reported to protect midbrain dopaminergic neurons of neurodegenerative diseases such as parkinson's disease (pd) model. |
2017-03-21 |
2023-08-13 |
Not clear |
| Noriko Nakano, Satoru Matsuda, Mayuko Ichimura, Akari Minami, Mako Ogino, Toshiyuki Murai, Yasuko Kitagish. PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review). International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28000847. |
parkinson's disease (pd) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| W J Zhang, X L Shang, J Peng, M H Zhou, W J Su. Expression of prion protein in the cerebrospinal fluid of patients with Parkinson's disease complicated with rapid eye movement sleep behavior disorder. Genetics and molecular research : GMR. vol 16. issue 1. 2017-03-16. PMID:28128401. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases and mainly manifests with decreasing numbers of dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| Anu Planken, Lille Kurvits, Ene Reimann, Liis Kadastik-Eerme, Külli Kingo, Sulev Kõks, Pille Tab. Looking beyond the brain to improve the pathogenic understanding of Parkinson's disease: implications of whole transcriptome profiling of Patients' skin. BMC neurology. vol 17. issue 1. 2017-02-27. PMID:28068941. |
parkinson's disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are also common. |
2017-02-27 |
2023-08-13 |
Not clear |
| Sunoh Kwon, Byung-Kwan Seo, Seungtae Ki. Acupuncture points for treating Parkinson's disease based on animal studies. Chinese journal of integrative medicine. vol 22. issue 10. 2017-02-22. PMID:27460492. |
parkinson's disease (pd) is a well-known neurodegenerative disease caused by dopaminergic cell death in the nigrostriatal pathway. |
2017-02-22 |
2023-08-13 |
Not clear |
| Ben Newland, Paul Wolff, Dezhong Zhou, Wei Wang, Hong Zhang, Anne Rosser, Wenxin Wang, Carsten Werne. Synthesis of ROS scavenging microspheres from a dopamine containing poly(β-amino ester) for applications for neurodegenerative disorders. Biomaterials science. vol 4. issue 3. 2017-02-06. PMID:26756041. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by a substantial decrease of dopaminergic neurons in the substantia nigra pars compacta. |
2017-02-06 |
2023-08-13 |
rat |
| Shreesh Ojha, Hayate Javed, Sheikh Azimullah, M Emdadul Haqu. β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27316720. |
parkinson disease (pd) is a neurodegenerative disease characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta (snc) area. |
2017-02-02 |
2023-08-13 |
rat |
| Yubin Wu, Yingying Zhang, Xun Han, Xiaoyuan Li, Li Xue, Anmu Xi. Association of VEGF gene polymorphisms with sporadic Parkinson's disease in Chinese Han population. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 37. issue 12. 2017-02-01. PMID:27481110. |
parkinson's disease (pd) is a progressive neurodegenerative disease caused by the degeneration of nigrostriatal dopaminergic neurons. |
2017-02-01 |
2023-08-13 |
human |
| Shuei Sugama, Kazunari Sekiyama, Tohru Kodama, Yoshiki Takamatsu, Takato Takenouchi, Makoto Hashimoto, Conti Bruno, Yoshihiko Kakinum. Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease. Brain, behavior, and immunity. vol 51. 2017-01-10. PMID:26291405. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) and, to a lesser extent, in the noradrenergic neurons of the locus coeruleus (lc). |
2017-01-10 |
2023-08-13 |
rat |
| Sheng-Huang Lin, Shih-Wei Chen, Yu-Chun Lo, Hsin-Yi Lai, Chich-Haung Yang, Shin-Yuan Chen, Yuan-Jen Chang, Chin-Hsing Chen, Wen-Tzeng Huang, Fu-Shan Jaw, You-Yin Chen, Siny Tsang, Lun-De Lia. Quantitative measurement of Parkinsonian gait from walking in monocular image sequences using a centroid tracking algorithm. Medical & biological engineering & computing. vol 54. issue 2-3. 2017-01-09. PMID:26109520. |
parkinson's disease (pd) is a neurodegenerative disease of the central nervous system that results from the degeneration of dopaminergic neurons in the substantia nigra. |
2017-01-09 |
2023-08-13 |
human |
| Armando De Virgilio, Antonio Greco, Giovanni Fabbrini, Maurizio Inghilleri, Maria Ida Rizzo, Andrea Gallo, Michela Conte, Chiara Rosato, Mario Ciniglio Appiani, Marco de Vincentii. Parkinson's disease: Autoimmunity and neuroinflammation. Autoimmunity reviews. vol 15. issue 10. 2017-01-03. PMID:27497913. |
parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. |
2017-01-03 |
2023-08-13 |
Not clear |