| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marios Politis, Gennaro Pagano, Flavia Niccolin. Imaging in Parkinson's Disease. International review of neurobiology. vol 132. 2018-03-19. PMID:28554409. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by the loss of nigrostriatal dopaminergic neurons and aggregation of misfolded α-synuclein in lewy bodies. |
2018-03-19 |
2023-08-13 |
Not clear |
| A P Lan, J Chen, Z F Chai, Y H. The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 29. issue 4. 2018-03-05. PMID:27349232. |
parkinson's disease (pd) is the second most common neurodegenerative disease with gradual loss of dopaminergic neurons. |
2018-03-05 |
2023-08-13 |
Not clear |
| Siamak Afshin-Majd, Keyhan Bashiri, Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Reza Sedaghat, Mehrdad Roghan. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-27. PMID:28199883. |
parkinson's disease (pd) is a movement disorder and the second most common neurodegenerative disease worldwide in which nigrostriatal dopaminergic neurons within substantia nigra pars compacta (snc) are lost, with clinical motor and non-motor symptoms including bradykinesia, resting tremor, rigidity, stooping posture and cognitive deficits. |
2018-02-27 |
2023-08-13 |
rat |
| Seyed Soheil Saeedi Saravi, Seyed Sobhan Saeedi Saravi, Katayoun Khoshbin, Ahmad Reza Dehpou. Current insights into pathogenesis of Parkinson's disease: Approach to mevalonate pathway and protective role of statins. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-16. PMID:28419968. |
dopaminergic neuronal cell death caused by mutations and accumulation of α-synuclein in lewy bodies and neurites was suggested as the main strategy for pd, but current studies have paid attention to the role of mevalonate pathway in incidence of neurodegenerative diseases including pd. |
2018-02-16 |
2023-08-13 |
Not clear |
| Ching-Hsiang Fan, Chung-Yin Lin, Hao-Li Liu, Chih-Kuang Ye. Ultrasound targeted CNS gene delivery for Parkinson's disease treatment. Journal of controlled release : official journal of the Controlled Release Society. vol 261. 2018-01-29. PMID:28690161. |
parkinson's disease (pd) is a potent neurodegenerative disease in which a progressive loss of dopaminergic neurons eventually produces a loss of movement control and other symptoms. |
2018-01-29 |
2023-08-13 |
Not clear |
| Sean L Hammond, Ashley N Leek, Evan H Richman, Ronald B Tjalken. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PloS one. vol 12. issue 12. 2018-01-08. PMID:29244806. |
because aav-mediated transgene expression is of interest in neurodegenerative diseases such as parkinson's disease, we examined the sn with microscopy techniques, such as clarity tissue transmutation, to identify aav serotypes that resulted in optimal transgene expression in either astrocytes or dopaminergic neurons. |
2018-01-08 |
2023-08-13 |
mouse |
| Jacob J Crouse, Joseph R Phillips, Marjan Jahanshahi, Ahmed A Moustaf. Postural instability and falls in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 5. 2018-01-02. PMID:26966928. |
the delayed effect of dopaminergic medication combined with the success of extrastriatal deep brain stimulation suggests that pi involves neurotransmitter systems other than dopamine and brain regions extending beyond the basal ganglia, further challenging the traditional view of pd as a predominantly single-system neurodegenerative disease. |
2018-01-02 |
2023-08-13 |
Not clear |
| Joseph R Phillips, Abeer M Eissa, Doaa H Hewedi, Marjan Jahanshahi, Mohamed El-Gamal, Szabolcs Keri, Ahmed A Moustaf. Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 7. 2018-01-02. PMID:27362959. |
pd is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. |
2018-01-02 |
2023-08-13 |
Not clear |
| Zhange Yu, Shuai Zhang, Dongdong Wang, Meng Fan, Fuqiang Gao, Wei Sun, Zirong Li, Shiliang L. The significance of uric acid in the diagnosis and treatment of Parkinson disease: An updated systemic review. Medicine. vol 96. issue 45. 2017-12-04. PMID:29137045. |
parkinson disease (pd) is a neurodegenerative disease characterized by chronic and progressive loss of dopaminergic neurons in substansia nigra pars compacta. |
2017-12-04 |
2023-08-13 |
Not clear |
| Douglas A Grow, John R McCarrey, Christopher S Navar. Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease. Stem cell research. vol 17. issue 2. 2017-11-22. PMID:27622596. |
the derivation of dopaminergic neurons from induced pluripotent stem cells brings new hope for a patient-specific, stem cell-based replacement therapy to treat parkinson's disease (pd) and related neurodegenerative diseases; and this novel cell-based approach has already proven effective in animal models. |
2017-11-22 |
2023-08-13 |
human |
| Zhan-Ying Hu, Bo Chen, Jing-Pu Zhang, Yuan-Yuan M. Up-regulation of autophagy-related gene 5 ( The Journal of biological chemistry. vol 292. issue 44. 2017-11-21. PMID:28928221. |
up-regulation of autophagy-related gene 5 ( parkinson's disease (pd) is one of the most epidemic neurodegenerative diseases and is characterized by movement disorders arising from loss of midbrain dopaminergic (da) neurons. |
2017-11-21 |
2023-08-13 |
Not clear |
| Chul Ju Hwang, Young Eun Kim, Dong Ju Son, Mi Hee Park, Dong-Young Choi, Pil-Hoon Park, Mats Hellström, Sang-Bae Han, Ki-Wan Oh, Eun Kyung Park, Jin Tae Hon. Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function. Redox biology. vol 11. 2017-11-20. PMID:28086194. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. |
2017-11-20 |
2023-08-13 |
mouse |
| Yeomoon Sim, Gunhyuk Park, Hyeyoon Eo, Eugene Huh, Pil Sung Gu, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook O. Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein. Neuroscience. vol 340. 2017-11-06. PMID:27771535. |
parkinson's disease (pd) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (snpc) and the striatum. |
2017-11-06 |
2023-08-13 |
mouse |
| Xue-Yuan Niu, Hou-Ju Huang, Jin-Bao Zhang, Chan Zhang, Wei-Guang Chen, Chen-You Sun, Yu-Qiang Ding, Min Lia. Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP. Neuroscience. vol 339. 2017-10-30. PMID:27693472. |
parkinson's disease (pd) is a neurodegenerative disease caused by a gradual loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta (snpc) during aging. |
2017-10-30 |
2023-08-13 |
mouse |
| Jenny Sassone, GiuliaMaia Serratto, Flavia Valtorta, Vincenzo Silani, Maria Passafaro, Andrea Ciammol. The synaptic function of parkin. Brain : a journal of neurology. vol 140. issue 9. 2017-10-30. PMID:28335015. |
loss of function mutations in the gene park2, which encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by degeneration of the dopaminergic neurons localized in the substantia nigra pars compacta. |
2017-10-30 |
2023-08-13 |
Not clear |
| Ana Tereza Di Lorenzo Alho, Claudia Kimie Suemoto, Lívia Polichiso, Edilaine Tampellini, Kátia Cristina de Oliveira, Mariana Molina, Glaucia Aparecida Bento Santos, Camila Nascimento, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferreti-Rebustini, Alexandre Valotta da Silva, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Helmut Heinsen, Lea Tenenholz Grinber. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26386691. |
the substantia nigra (sn), the source of major dopaminergic pathways in the brain, is particularly vulnerable to changes in the progression of several age-related neurodegenerative diseases. |
2017-09-29 |
2023-08-13 |
human |
| Qingxi Zhang, Wanling Chen, Sheng Tan, Tongxiang Li. Stem Cells for Modeling and Therapy of Parkinson's Disease. Human gene therapy. vol 28. issue 1. 2017-08-23. PMID:27762639. |
parkinson's disease (pd) is the second most frequent neurodegenerative disease after alzheimer's disease, which is characterized by a low level of dopamine being expressing in the striatum and a deterioration of dopaminergic neurons (dan) in the substantia nigra pars compacta. |
2017-08-23 |
2023-08-13 |
human |
| Sandy Stayte, Peggy Rentsch, Anna R Tröscher, Maximilian Bamberger, Kong M Li, Bryce Visse. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PloS one. vol 12. issue 1. 2017-08-10. PMID:28121982. |
parkinson's disease is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta region and a subsequent loss of dopamine within the striatum. |
2017-08-10 |
2023-08-13 |
mouse |
| Mahesh Ramalingam, Sung-Jin Ki. Insulin on activation of autophagy with integrins and syndecans against MPP Neuroscience letters. vol 633. 2017-07-27. PMID:27646116. |
insulin on activation of autophagy with integrins and syndecans against mpp parkinson's disease (pd) is the second most common neurodegenerative disease in the elderly caused by dopaminergic neuronal cell death. |
2017-07-27 |
2023-08-13 |
human |
| Shane V Hegarty, Eimear O'Leary, Franziska Solger, Joanna Stanicka, Aideen M Sullivan, Gerard W O'Keeff. A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27256286. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterised by motor and non-motor symptoms, resulting from the degeneration of nigrostriatal dopaminergic neurons and peripheral autonomic neurons. |
2017-07-26 |
2023-08-13 |
Not clear |