| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumaiya Khan, Arunabh Choudhury, Taj Mohammad, Anas Shamsi, Md Imtaiyaz Hassan, Asimul Isla. Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1. Scientific reports. vol 15. issue 1. 2025-04-19. PMID:40253440. |
a promising approach that has been suggested in neurodegenerative diseases, especially ad, is the prevention of tau phosphorylation by using kinase inhibitors. |
2025-04-19 |
2025-04-22 |
Not clear |
| Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Igor Klyubin, Michael J Rowa. Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo. Molecular brain. vol 18. issue 1. 2025-04-19. PMID:40251677. |
neurofibrillary tangles (nfts), composed of tau protein fibrils, together with brain inflammation and synaptic loss, are neuropathological hallmarks of several neurodegenerative diseases, including alzheimer's disease. |
2025-04-19 |
2025-04-21 |
rat |
| Sabrina M Wölfel, Catherine N Widmann, Sergio Castro-Gomez, Patrick Weydt, Pawel Tacik, Michael T Henek. Cognitive capacity in amyotrophic lateral sclerosis: the value of diagnostic markers in cerebrospinal fluid and the influence of nutrition and pulmonary function. Brain communications. vol 7. issue 2. 2025-04-17. PMID:40241787. |
a retrospective data analysis of 99 patients with amyotrophic lateral sclerosis cases examined between 2018 and 2021 at the department for neurodegenerative diseases and gerontopsychiatry at the university hospital of bonn, using edinburgh cognitive and behavioural als screen, revealed that elevated levels of total tau and phospho-tau 181 were associated with diminished performance of patients with amyotrophic lateral sclerosis on the edinburgh cognitive and behavioural als screen. |
2025-04-17 |
2025-04-19 |
Not clear |
| Zijiao Liu, Jun Zhang, Fei Jiang, Cong Liu, Yaping Shao, Weidong L. Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations. CNS neuroscience & therapeutics. vol 31. issue 4. 2025-04-17. PMID:40245176. |
alzheimer's disease (ad), the most prevalent form of dementia, is a complex neurodegenerative disease characterized by the abnormal deposition of extracellular amyloid β-protein (aβ) and the aggregation of intracellular tau protein to form neurofibrillary tangles (nfts). |
2025-04-17 |
2025-04-20 |
Not clear |
| Anita K Ho, Fiona Jeganathan, Magda Bictash, Han-Jou Che. Identification of novel small molecule chaperone activators for neurodegenerative disease treatment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 187. 2025-04-16. PMID:40239269. |
activation of hsps target aberrant tdp-43, tau and amyloid to rescue neurodegenerative disease. |
2025-04-16 |
2025-04-19 |
Not clear |
| Chunbin Sun, Xiaoyu Gao, Shuang Sha, Si Wang, Yubang Shan, Luping Li, Cencan Xing, Hongyan Guan, Hongwu D. Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway. International immunopharmacology. vol 155. 2025-04-11. PMID:40215776. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by amyloid beta (aβ) deposition, phosphorylated tau protein aggregation, inflammation, and neuronal damage. |
2025-04-11 |
2025-04-14 |
Not clear |
| Carmela Vitale, Fanny Jaudon, Rafael Lujan, Martina Bartolucci, Lucia Celora, Elisa Reisoli, Riccardo Ruggeri, Andrea Petretto, Agnes Thalhammer, Lorenzo A Cingolan. Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism. Brain : a journal of neurology. 2025-04-10. PMID:40209105. |
furthermore, we identified tau, a protein traditionally linked to neurodegenerative diseases, as part of the sk2 channel interactome. |
2025-04-10 |
2025-04-14 |
mouse |
| Swetaleena Shaw, Pratyush Porel, Khadga Raj Ara. Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer's disease. Molecular biology reports. vol 52. issue 1. 2025-04-08. PMID:40195175. |
alzheimer's disease (ad) is the most common neurodegenerative disease for causing memory deficits and primarily characterized by extracellular deposition of amyloid-β (aβ) plaques, intracellular neurofibrillary tangles (nfts), and hyperphosphorylation of tau protein, all are pathological hallmarks for ad. |
2025-04-08 |
2025-04-10 |
Not clear |
| Mingkai Lin, Yue Zhou, Peixian Liang, Ruoyi Zheng, Minwei Du, Xintong Ke, Wenjing Zhang, Pei Shan. Identification of Alzheimer's disease biomarkers and their immune function characterization. Archives of medical science : AMS. vol 21. issue 1. 2025-04-07. PMID:40190307. |
alzheimer's disease (ad) is a neurodegenerative disease with neurogenic fiber tangles caused by amyloid-β protein plaques and tau protein hyperphosphorylation as the pathological manifestations. |
2025-04-07 |
2025-04-09 |
Not clear |
| Subashchandrabose Chinnathambi, Nagaraj Rangappa, Madhura Chandrasheka. Internalization of extracellular Tau oligomers in Alzheimer's disease. Advances in clinical chemistry. vol 126. 2025-04-04. PMID:40185532. |
this review highlights the urgent need for innovative approaches to prevent the spread of tau pathology, emphasizing its implications for ad and related neurodegenerative diseases. |
2025-04-04 |
2025-04-08 |
Not clear |
| Elena Vacchi, Iñigo Ruiz-Barrio, Giorgia Mell. Tau biomarkers for neurodegenerative diseases: Current state and perspectives. Parkinsonism & related disorders. 2025-04-04. PMID:40185651. |
tau biomarkers for neurodegenerative diseases: current state and perspectives. |
2025-04-04 |
2025-04-08 |
Not clear |
| John D Arena, William Stewart, Gabor G Kovacs, Edward B Lee, John L Robinson, Virginia M-Y Lee, John Q Trojanowski, Andrea L C Schneider, Douglas H Smith, Victoria E Johnso. Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy. Brain : a journal of neurology. 2025-04-02. PMID:40171950. |
these findings support history of rhi and tbi as independent risk factors for the development of thorn-shaped tau astrogliopathy, over and above artag observed in aging and wider neurodegenerative disease. |
2025-04-02 |
2025-04-04 |
human |
| Anna-Lisa Fischer, Matthias Schmitz, Tobias Thom, Saima Zafar, Neelam Younas, Susana da Silva Correia, Angela da Silva Correia, Sezgi Canaslan Eyyuboglu, Inga Zer. Alpha-Synuclein Demonstrates Varying Binding Affinities With Different Tau Isoforms. Journal of neurochemistry. vol 169. issue 4. 2025-04-01. PMID:40165586. |
the hallmark of various neurodegenerative diseases is the accumulation and aggregation of amyloidogenic proteins, such as amyloid-beta (aβ) and tau in alzheimer's disease (ad) and alpha-synuclein (asyn) in synucleinopathies. |
2025-04-01 |
2025-04-03 |
Not clear |
| Ali I Al-Gareeb, Morkoss Fakhry, Ali K Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition. Chemistry & biodiversity. 2025-04-01. PMID:40167033. |
ad is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (aβ). |
2025-04-01 |
2025-04-03 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Geometry based prediction of tau protein sites and motifs associated with misfolding and aggregation. Scientific reports. vol 15. issue 1. 2025-03-26. PMID:40133414. |
recent studies of tau proteins point to specific sites or motifs along the protein related to its misfolding and aggregation propensity, which is associated with neurodegenerative diseases of structure-dependent pathology. |
2025-03-26 |
2025-03-28 |
Not clear |
| Jinguo Wang, Shelley L Forrest, Sathish Dasari, Hidetomo Tanaka, Ekaterina Rogaeva, M Carmela Tartaglia, Susan Fox, Anthony E Lang, Subha Kalyaanamoorthy, Gabor G Kovac. Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy. Immunobiology. vol 230. issue 3. 2025-03-25. PMID:40132252. |
progressive supranuclear palsy (psp) is a neurodegenerative disease showing pathological tau accumulation in subcortical neurons and glial cells. |
2025-03-25 |
2025-03-28 |
human |
| Yuanyue Zhang, Zhi Yang, Na Jiang, Xiaosheng Tan, Peng Jiang, Gaoyuan Cao, Qi Yan. MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice. Journal of neuroinflammation. vol 22. issue 1. 2025-03-21. PMID:40114233. |
accumulation of misfolded tau proteins is a hallmark of neurodegenerative diseases. |
2025-03-21 |
2025-03-23 |
mouse |
| Jingyu Mu, Zengrui Zhang, Chao Jiang, Haoming Geng, Junguo Dua. Role of Tau Protein Hyperphosphorylation in Diabetic Retinal Neurodegeneration. Journal of ophthalmology. vol 2025. 2025-03-20. PMID:40109357. |
tau, a microtubule-associated protein, is a key mediator of neurotoxicity in neurodegenerative diseases, with functions in phosphorylation-dependent microtubule assembly and stabilization, axonal transport, and neurite outgrowth. |
2025-03-20 |
2025-03-22 |
Not clear |
| Meaghan Van Alstyne, James Pratt, Roy Parke. Diverse influences on tau aggregation and implications for disease progression. Genes & development. 2025-03-20. PMID:40113250. |
tau is an intrinsically disordered protein that accumulates in fibrillar aggregates in neurodegenerative diseases. |
2025-03-20 |
2025-03-23 |
Not clear |
| Kazuki Muguruma, Tetsuya Takahashi, Yuichiro Tagane, Keyoumu Nazere, Naoyuki Hara, Masahiro Nakamori, Yu Yamazaki, Hiroyuki Morino, Hirofumi Maruyam. Intracellular anionic substances cause tau liquid-liquid phase separation. Biochemical and biophysical research communications. vol 757. 2025-03-19. PMID:40107109. |
tau protein aggregation plays an important role in the pathophysiology of neurodegenerative diseases, including alzheimer's disease and niemann-pick disease type c. liquid-liquid phase separation has emerged as a key mechanism in the early stages of protein aggregation for these disorders. |
2025-03-19 |
2025-03-22 |
human |