| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes. Glia. 2023-09-05. PMID:37668005. |
tauopathies are a collection of neurodegenerative diseases characterized by the accumulation of pathogenic aggregates of the microtubule-associated protein tau. |
2023-09-05 |
2023-09-07 |
mouse |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes. Glia. 2023-09-05. PMID:37668005. |
in total, our findings suggest that the apoe4 isoform lowers the threshold of astrocytic resilience to pathogenic tau, rendering them susceptible to bioenergetic deficits in the early stages of neurodegenerative diseases such as traumatic brain injury, potentially contributing to neurological decline. |
2023-09-05 |
2023-09-07 |
mouse |
| Bassel Eldeen Makki, Sarah Rahma. Alzheimer's Disease in Diabetic Patients: A Lipidomic Prospect. Neuroscience. 2023-08-31. PMID:37652288. |
type 2 dm (t2dm) is a metabolic disease depicted by insulin resistance, dyslipidemia, and chronic hyperglycemia while ad is a neurodegenerative disease marked by amyloid \xce\xb2 (a\xce\xb2) accumulation, neurofibrillary tangles aggregation, and tau phosphorylation. |
2023-08-31 |
2023-09-07 |
Not clear |
| Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwick. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645969. |
microtubule-associated protein tau (mapt/tau) accumulates in a family of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-08-30 |
2023-09-07 |
Not clear |
| Jafar Sadeghzadeh, Parviz Shahabi, Mehdi Farhoudi, Abbas Ebrahimi-Kalan, Ahmad Mobed, Kourosh Shahpasan. Tau Protein Biosensors in the Diagnosis of Neurodegenerative Diseases. Advanced pharmaceutical bulletin. vol 13. issue 3. 2023-08-30. PMID:37646056. |
tau protein biosensors in the diagnosis of neurodegenerative diseases. |
2023-08-30 |
2023-09-07 |
human |
| Jafar Sadeghzadeh, Parviz Shahabi, Mehdi Farhoudi, Abbas Ebrahimi-Kalan, Ahmad Mobed, Kourosh Shahpasan. Tau Protein Biosensors in the Diagnosis of Neurodegenerative Diseases. Advanced pharmaceutical bulletin. vol 13. issue 3. 2023-08-30. PMID:37646056. |
tau protein plays a crucial role in diagnosing neurodegenerative diseases. |
2023-08-30 |
2023-09-07 |
human |
| Tong Zhang, Nshunge Musheshe, Christina H J T M van der Veen, Helmut W Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmid. The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626593. |
alzheimer's disease (ad) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (a\xce\xb2) and hyperphosphorylated tau accumulation in the brain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Michal J Halicki, Karen Hind, Paul L Chazo. Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628736. |
however, several molecules, such as different phosphorylated tau isoforms, were able to discern cte from different neurodegenerative diseases. |
2023-08-26 |
2023-09-07 |
Not clear |
| Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musie. Microglial REV-ERB\\xce\\xb1 regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nature communications. vol 14. issue 1. 2023-08-25. PMID:37626048. |
alzheimer's disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. |
2023-08-25 |
2023-09-07 |
mouse |
| Lijuan Shu, Chunfu Du, Yunxia Zu. Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases. Journal of neuropathology and experimental neurology. 2023-08-17. PMID:37589710. |
in the cns of patients with neurodegenerative diseases, a variety of abnormally phosphorylated proteins play important roles in pathological processes such as neuroinflammation and intracellular accumulation of \xce\xb2-amyloid plaques and tau. |
2023-08-17 |
2023-09-07 |
Not clear |
| Ryan J Keenan, Heather Daykin, Jeremy Metha, Linda Cornthwaite-Duncan, David K Wright, Kyra Clarke, Sara Oberrauch, Maddison Brian, Sarah Stephenson, Cameron J Nowell, Giancarlo Allocca, Kevin J Barnham, Daniel Hoyer, Laura H Jacobso. Orexin 2 receptor antagonism sex-dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice. British journal of pharmacology. 2023-08-09. PMID:37553894. |
tau pathology contributes to a bidirectional relationship between sleep disruption and neurodegenerative disease. |
2023-08-09 |
2023-08-16 |
mouse |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
advances in tau biology and the difficulties of amyloid-directed immunotherapeutics have heightened interest in tau as a target for small molecule drug discovery for neurodegenerative diseases. |
2023-08-09 |
2023-08-16 |
mouse |
| Jiayi Zhong, Xiaochen Zhang, Huanyu Xu, Xiaoran Zheng, Luyao Wang, Jiehui Jiang, Yunxia L. Unlocking the enigma: unraveling multiple cognitive dysfunction linked to glymphatic impairment in early Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-08-07. PMID:37547134. |
alzheimer's disease (ad) is one of the world's well-known neurodegenerative diseases, which is related to the balance mechanism of production and clearance of two proteins (amyloid-\xce\xb2 and tau) regulated by the glymphatic system. |
2023-08-07 |
2023-08-14 |
Not clear |
| Sanghyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heonsu Kim, Kiseok Han, Yerim Lee, Gyuho Choi, Tae-Jin Ki. TAUCON and TAUCOM: A novel biosensor based on fluorescence resonance energy transfer for detecting tau hyperphosphorylation-associated cellular pathologies. Biosensors & bioelectronics. vol 237. 2023-07-30. PMID:37517333. |
tauopathies are neurodegenerative diseases characterized by abnormal conformational changes in tau protein. |
2023-07-30 |
2023-08-14 |
Not clear |
| George E Barret. Repurposing of Tibolone in Alzheimer's Disease. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509151. |
alzheimer's disease (ad) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sarah E Torraville, Cassandra M Flynn, Tori L Kendall, Qi Yua. Life Experience Matters: Enrichment and Stress Can Influence the Likelihood of Developing Alzheimer's Disease via Gut Microbiome. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509523. |
alzheimer's disease (ad) is a chronic neurodegenerative disease, characterized by the presence of \xce\xb2-amyloid (a\xce\xb2) plaques and neurofibrillary tangles (nfts) formed from abnormally phosphorylated tau proteins (ptau). |
2023-07-29 |
2023-08-14 |
Not clear |
| Zhikai Zeng, Vishnu Vijayan, Karen Tsay, Matthew P Frost, Athena Quddus, Alexa Albert, Michael Vigers, Amanda L Woerman, Songi Ha. CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502998. |
the recent discovery by cryo-electron microscopy that the neuropatho-logical hallmarks of different tauopathies, including alzheimer's disease, corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), are caused by unique misfolded conformations of the protein tau is among the most profound developments in neurodegenerative disease research. |
2023-07-28 |
2023-08-14 |
Not clear |
| Xinlu Li, Jianfeng Chen, Wennuo Feng, Chao Wang, Minyu Chen, Yifan Li, Jinghong Chen, Xinwei Liu, Qiong Liu, Jing Tia. Berberine ameliorates iron levels and ferroptosis in the brain of 3\\xc2\\xa0\\xc3\\x97\\xc2\\xa0Tg-AD mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 118. 2023-07-28. PMID:37506403. |
ad is a neurodegenerative disease characterized by \xce\xb2-amyloid (a\xce\xb2) deposition, hyperphosphorylated tau and other characters. |
2023-07-28 |
2023-08-14 |
mouse |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
tau, microtubule dynamics, and axonal transport: new paradigms for neurodegenerative disease. |
2023-07-25 |
2023-08-14 |
Not clear |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
the etiology of tauopathies, a diverse class of neurodegenerative diseases associated with the microtubule associated protein (map) tau, is usually described by a common mechanism in which tau dysfunction results in the loss of axonal microtubule stability. |
2023-07-25 |
2023-08-14 |
Not clear |