| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ankit Kolay, Neelam Singh, Puneet Gupta, Ayaz Mukarram Shaikh, Radha Goel, Dheeraj Nagpal, Havagiray Chitm. Immunotherapies: A Treasure Trove of Alzheimer's Disease. Current pharmaceutical biotechnology. 2024-07-23. PMID:39039684. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein inside the brain. |
2024-07-23 |
2024-07-25 |
Not clear |
| Yoshiyuki Soeda, Hideaki Yoshimura, Hiroko Bannai, Riki Koike, Isshin Shiiba, Akihiko Takashim. Intracellular tau fragment droplets serve as seeds for tau fibrils. Structure (London, England : 1993). 2024-07-20. PMID:39032487. |
these results suggest that tau droplet formation and n-terminal cleavage are necessary for neurofibrillary tangles formation in neurodegenerative diseases. |
2024-07-20 |
2024-07-24 |
Not clear |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
pathological tau is strongly implicated in the progression of neurodegenerative diseases, and the propagation of tau aggregates is associated with disease severity. |
2024-07-16 |
2024-07-19 |
human |
| Jiechao Zhou, Yang 'an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J Platero, Alexander H Barrett, Juan C Troncoso, Paul F Worley, Wenchi Zhan. The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation. Nature cell biology. 2024-07-15. PMID:39009640. |
multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. |
2024-07-15 |
2024-07-18 |
mouse |
| Harman Sharma, Sushma Koirala, Yee Lian Chew, Anna Konopk. DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration. Molecular neurobiology. 2024-07-08. PMID:38977621. |
this review focused on hallmark proteins involved in various neurodegenerative diseases, such as the microtubule-associated protein tau, tar dna/rna binding protein 43 (tdp-43), superoxide dismutase 1 (sod1), fused in sarcoma (fus), huntingtin (htt), α-synuclein, and β-amyloid precursor protein (app). |
2024-07-08 |
2024-07-12 |
Not clear |
| Yiyang Zhu, Wade K Self, David M Holtzma. An emerging role for the gut microbiome in tauopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-04. PMID:38964948. |
tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. |
2024-07-04 |
2024-07-11 |
human |
| Subashchandrabose Chinnathambi, Smita Eknath Desal. The crosstalk between extracellular matrix proteins and Tau. Advances in protein chemistry and structural biology. vol 141. 2024-07-03. PMID:38960482. |
alzheimer's disease is progressive neurodegenerative disease characterize by the presence of extracellular accumulation of amyloid-β plaques and intracellular deposits of neurofibrillary tangles of tau. |
2024-07-03 |
2024-07-10 |
Not clear |
| Jens Sobek, Junhao Li, Benjamin F Combes, Juan A Gerez, Martin T Henrich, Fanni F Geibl, Peter R Nilsson, Kuangyu Shi, Axel Rominger, Wolfgang H Oertel, Roger M Nitsch, Agneta Nordberg, Hans Ågren, Ruiqing N. Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein. European journal of nuclear medicine and molecular imaging. 2024-07-02. PMID:38953933. |
there is an unmet need for compounds to detect fibrillar forms of alpha-synuclein (αsyn) and 4-repeat tau, which are critical in many neurodegenerative diseases. |
2024-07-02 |
2024-07-06 |
Not clear |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including alzheimer's disease (ad). |
2024-07-02 |
2024-07-06 |
mouse |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
role of tau protein in neurodegenerative diseases and development of its targeted drugs: a literature review. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
tau protein aggregates abnormally and forms neurofibrillary tangles in neurodegenerative diseases, disrupting the structure and function of neurons and leading to neuronal death, which triggers the initiation and progression of neurological disorders. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
the aggregation of tau protein in neurodegenerative diseases is associated with post-translational modifications, which may affect the hydrophilicity, spatial conformation, and stability of tau protein, promoting tau protein aggregation and the formation of neurofibrillary tangles. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
therefore, studying the role of tau protein in neurodegenerative diseases and the mechanism of aberrant aggregation is important for understanding the mechanism of neurodegenerative diseases and finding therapeutic approaches. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
this review describes the possible mechanisms by which tau protein promotes neurodegenerative diseases, the post-translational modifications of tau protein and associated influencing factors, and the current status of drug discovery and development related to tau protein, which may contribute to the development of new therapeutic approaches to alleviate or treat neurodegenerative diseases. |
2024-06-27 |
2024-06-29 |
Not clear |
| Shenqing Zhang, Hui Dong, Jiang Bian, Dan Li, Cong Li. Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases. Fundamental research. vol 3. issue 4. 2024-06-27. PMID:38933553. |
abnormal aggregation and accumulation of pathological amyloid proteins such as amyloid-β, tau, and α-synuclein play key pathological roles and serve as histological hallmarks in different neurodegenerative diseases (nds) such as alzheimer's disease (ad) and parkinson's disease (pd). |
2024-06-27 |
2024-06-29 |
Not clear |
| Ahwon Kim, Do-Yeon Lee, Jung-Joon Sun. Cdk5 inhibition in the SOD1 Journal of neurochemistry. 2024-06-27. PMID:38934222. |
cdk5 inhibition in the sod1 deregulated cyclin-dependent kinase 5 (cdk5) activity closely correlates with hyperphosphorylated tau, a common pathology found in neurodegenerative diseases. |
2024-06-27 |
2024-06-29 |
mouse |
| Romain Perbet, Anastasie Mate de Gerando, Calina Glynn, Cameron Donahue, Angelica Gaona, Raquel N Taddei, Teresa Gomez-Isla, Aurelien Lathuiliere, Bradley T Hyma. In situ seeding assay: A novel technique for direct tissue localization of bioactive tau. Journal of neuropathology and experimental neurology. 2024-06-25. PMID:38917443. |
the probe specifically targeted ad-associated bioactive tau and did not recognize bioactive tau from other neurodegenerative diseases. |
2024-06-25 |
2024-06-29 |
human |
| Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A S Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L Chang, David L Brody, Mark W Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wan. Tryptophan Metabolism in Alzheimer's Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis. Aging and disease. 2024-06-25. PMID:38916729. |
alzheimer's disease (ad) is an age-dependent neurodegenerative disease characterized by extracellular amyloid aβ peptide (aβ) deposition and intracellular tau protein aggregation. |
2024-06-25 |
2024-06-27 |
human |