| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren Elizabeth Walker, Federica Frigerio, Teresa Ravizza, Emanuele Ricci, Karen Tse, Rosalind E Jenkins, Graeme John Sills, Andrea Jorgensen, Luca Porcu, Thimmasettappa Thippeswamy, Tiina Alapirtti, Jukka Peltola, Martin J Brodie, Brian Kevin Park, Anthony Guy Marson, Daniel James Antoine, Annamaria Vezzani, Munir Pirmohame. Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. The Journal of clinical investigation. vol 127. issue 6. 2017-09-26. PMID:28504645. |
our data suggest that hmgb1 isoforms are mechanistic biomarkers for epileptogenesis and drug-resistant epilepsy in humans, necessitating evaluation in larger-scale prospective studies. |
2017-09-26 |
2023-08-13 |
Not clear |
| Stéphane Auvin, Lauren Walker, William Gallentine, Sergiusz Jozwiak, Mario Tombini, Graeme J Sill. Prospective clinical trials to investigate clinical and molecular biomarkers. Epilepsia. vol 58 Suppl 3. 2017-08-17. PMID:28675556. |
we provide an overview of the inflammatory biomarkers under investigation in prospective clinical studies in epilepsy: proinflammatory cytokines in prolonged febrile seizure; high mobility group box 1 (hmgb1) as a prognosis biomarker in epilepsy and the interaction between inflammation and metabolism, in particular, iron metabolism, in epilepsy. |
2017-08-17 |
2023-08-13 |
Not clear |
| J-S Huang, Y Wu, Q Huang, S-J Li, J-M Ye, X Wei, Q-D Liu, Y Liu, M-G M. Expression level and distribution of HMGB1 in Sombati's cell model and kainic acid-induced epilepsy model. European review for medical and pharmacological sciences. vol 19. issue 15. 2016-03-14. PMID:26241550. |
expression level and distribution of hmgb1 in sombati's cell model and kainic acid-induced epilepsy model. |
2016-03-14 |
2023-08-13 |
rat |
| Angela Chiavegato, Emanuele Zurolo, Gabriele Losi, Eleonora Aronica, Giorgio Carmignot. The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy. Frontiers in cellular neuroscience. vol 8. 2014-06-17. PMID:24936172. |
the purpose of the present study was to investigate the role of interleukin-1β (il-1β) and high mobility group b1 (hmgb1) in the generation of seizure-like discharges using two models of focal epilepsy in a rat entorhinal cortex slice preparation. |
2014-06-17 |
2023-08-13 |
rat |
| Jieun Choi, Hyun Jin Min, Jeon-Soo Shi. Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures. Journal of neuroinflammation. vol 8. 2012-03-30. PMID:21989210. |
in order to determine whether active inflammation, including high mobility group box-1 (hmgb1) and pro-inflammatory cytokines, occurs in children with febrile seizures or epilepsy, we analyzed cytokine profiles of patients with febrile seizures or epilepsy. |
2012-03-30 |
2023-08-12 |
Not clear |
| Mattia Maroso, Silvia Balosso, Teresa Ravizza, Jaron Liu, Eleonora Aronica, Anand M Iyer, Carlo Rossetti, Monica Molteni, Maura Casalgrandi, Angelo A Manfredi, Marco E Bianchi, Annamaria Vezzan. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nature medicine. vol 16. issue 4. 2010-04-23. PMID:20348922. |
increased expression of hmgb1 and tlr4 in human epileptogenic tissue, like that observed in the mouse model of chronic seizures, suggests a role for the hmgb1-tlr4 axis in human epilepsy. |
2010-04-23 |
2023-08-12 |
mouse |