| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Zhu, Jing Chen, Hu Guo, Le Ding, Yue Zhang, Yun X. High Mobility Group Protein B1 (HMGB1) and Interleukin-1β as Prognostic Biomarkers of Epilepsy in Children. Journal of child neurology. vol 33. issue 14. 2019-10-04. PMID:30303442. |
furthermore, hmgb1 and il-1β were significant predictors of epilepsy prognosis. |
2019-10-04 |
2023-08-13 |
Not clear |
| Min Zhu, Jing Chen, Hu Guo, Le Ding, Yue Zhang, Yun X. High Mobility Group Protein B1 (HMGB1) and Interleukin-1β as Prognostic Biomarkers of Epilepsy in Children. Journal of child neurology. vol 33. issue 14. 2019-10-04. PMID:30303442. |
in conclusion, hmgb1 and il-1β have a predictive value for epilepsy prognosis in children. |
2019-10-04 |
2023-08-13 |
Not clear |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
this study aimed to investigate the association of serum high-mobility group box-1 (hmgb1) and toll-like receptor 4 (tlr4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
one hundred and five epilepsy patients and 100 healthy controls (hcs) were enrolled in this case-control study, and serum samples were collected from all participants to assess the hmgb1 and tlr4 expressions by enzyme-linked immunosorbent assay (elisa). |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
both serum hmgb1 (p<0.001) and tlr4 (p<0.001) expressions were higher in epilepsy patients than in hcs, and they displayed good predictive values for risk of epilepsy. |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
in conclusion, both hmgb1 and tlr4 expressions were correlated with increased risk and severity of epilepsy and their level was higher in patients resistant to anti-epilepsy drugs. |
2019-09-06 |
2023-08-13 |
human |
| Teresa Ravizza, Gaetano Terrone, Alessia Salamone, Federica Frigerio, Silvia Balosso, Daniel J Antoine, Annamaria Vezzan. High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29031614. |
moreover, both clinical and experimental data suggest that hmgb1 isoforms may serve as mechanistic biomarkers for epileptogenesis and drug-resistant epilepsy. |
2019-07-15 |
2023-08-13 |
Not clear |
| Ya-Jun Li, Lin Wang, Bei Zhang, Fei Gao, Chun-Mei Yan. Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus. The Journal of pharmacy and pharmacology. vol 71. issue 3. 2019-03-20. PMID:30417405. |
it has been proven that extracellular hmgb1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy. |
2019-03-20 |
2023-08-13 |
rat |
| Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Mia. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393419. |
hmgb1 mediates microglia activation via the tlr4/nf-κb pathway in coriaria lactone induced epilepsy. |
2018-08-27 |
2023-08-13 |
Not clear |
| Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Mia. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393419. |
hmgb1, tlr4, receptor for advanced glycation end products (rage), nf‑κb p65 and inducible nitric oxide synthase (inos) expression levels were detected by western blotting, and serum cytokine levels of interleukin (il)‑1, il‑6, tumor necrosis factor (tnf)‑α, transforming growth factor (tgf)‑β and il‑10 in patients with epilepsy and craniocerebral trauma were detected by elisa. |
2018-08-27 |
2023-08-13 |
Not clear |
| Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Mia. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393419. |
the results demonstrated that compared with the control group, levels of hmgb1, tlr4, rage, nf‑κb p65 and inos in the brain of the epilepsy group were significantly increased, and increased cytokine levels of il‑1, il‑6, tnf‑α, tgf‑β and il‑10 in patients with epilepsy were also observed. |
2018-08-27 |
2023-08-13 |
Not clear |
| Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I Shimizu, Yoshiaki Yano, Yoshito Ishizaki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukud. High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats. Metabolic brain disease. vol 32. issue 6. 2018-07-03. PMID:28879430. |
we demonstrate hmgb1's role in the pathogenesis of hyperthermia-induced seizures (hs) and secondary epilepsy after prolonged hyperthermia-induced seizures (phs). |
2018-07-03 |
2023-08-13 |
rat |
| Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I Shimizu, Yoshiaki Yano, Yoshito Ishizaki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukud. High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats. Metabolic brain disease. vol 32. issue 6. 2018-07-03. PMID:28879430. |
in developing rats, hmgb1 enhanced hs and secondary epilepsy after phs. |
2018-07-03 |
2023-08-13 |
rat |
| Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I Shimizu, Yoshiaki Yano, Yoshito Ishizaki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukud. High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats. Metabolic brain disease. vol 32. issue 6. 2018-07-03. PMID:28879430. |
our findings suggest that hmgb1 contributes to fs pathogenesis and plays an important role in the acquired epileptogenesis of secondary epilepsy associated with prolonged fs. |
2018-07-03 |
2023-08-13 |
rat |
| Ai-Hua Liu, Ya-Ting Wu, Yu-Ping Wan. MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway. Brain research bulletin. vol 132. 2018-02-09. PMID:28528202. |
microrna-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting hmgb1 through the tlr4/nf-kb signaling pathway. |
2018-02-09 |
2023-08-13 |
rat |
| Ai-Hua Liu, Ya-Ting Wu, Yu-Ping Wan. MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway. Brain research bulletin. vol 132. 2018-02-09. PMID:28528202. |
the study aimed to explore the effects of microrna-129-5p (mir-129-5p) on the development of autoimmune encephalomyelitis (ae)-related epilepsy by targeting hmgb1 through the tlr4/nf-kb signaling pathway in a rat model. |
2018-02-09 |
2023-08-13 |
rat |
| Ai-Hua Liu, Ya-Ting Wu, Yu-Ping Wan. MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway. Brain research bulletin. vol 132. 2018-02-09. PMID:28528202. |
compared with the model and control groups, neuronal injury of the hippocampus and ae-related epilepsy decreased and microglial cells increased in the mir-129-5p mimics, hmgb1 shrna and tlr4/nf-kb groups; however, in the mir-129-5p inhibitor group, mir-129-5p expression decreased, hmgb1 expression increased, tlr4/nf-kb signaling pathway was activated, latency to a first epilepsy seizure attack was shortened, and neuronal injury increased. |
2018-02-09 |
2023-08-13 |
rat |
| Ai-Hua Liu, Ya-Ting Wu, Yu-Ping Wan. MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway. Brain research bulletin. vol 132. 2018-02-09. PMID:28528202. |
this study provides evidence that mir-129-5p inhibits the development of ae-related epilepsy by suppressing hmgb1 expression and inhibiting tlr4/nf-kb signaling pathway. |
2018-02-09 |
2023-08-13 |
rat |
| Lauren Elizabeth Walker, Federica Frigerio, Teresa Ravizza, Emanuele Ricci, Karen Tse, Rosalind E Jenkins, Graeme John Sills, Andrea Jorgensen, Luca Porcu, Thimmasettappa Thippeswamy, Tiina Alapirtti, Jukka Peltola, Martin J Brodie, Brian Kevin Park, Anthony Guy Marson, Daniel James Antoine, Annamaria Vezzani, Munir Pirmohame. Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. The Journal of clinical investigation. vol 127. issue 6. 2017-09-26. PMID:28504645. |
the pathologic disulfide hmgb1 isoform progressively increased in blood before epilepsy onset and prospectively identified animals that developed the disease. |
2017-09-26 |
2023-08-13 |
Not clear |
| Lauren Elizabeth Walker, Federica Frigerio, Teresa Ravizza, Emanuele Ricci, Karen Tse, Rosalind E Jenkins, Graeme John Sills, Andrea Jorgensen, Luca Porcu, Thimmasettappa Thippeswamy, Tiina Alapirtti, Jukka Peltola, Martin J Brodie, Brian Kevin Park, Anthony Guy Marson, Daniel James Antoine, Annamaria Vezzani, Munir Pirmohame. Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. The Journal of clinical investigation. vol 127. issue 6. 2017-09-26. PMID:28504645. |
in contrast with patients with well-controlled epilepsy, patients with chronic, drug-refractory epilepsy persistently expressed the acetylated, disulfide hmgb1 isoforms. |
2017-09-26 |
2023-08-13 |
Not clear |