| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayriye Soytürk, Cansu Önal, Ümit Kılıç, Şule Aydın Türkoğlu, Erol Aya. The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis. Journal of cellular and molecular medicine. vol 28. issue 14. 2024-07-24. PMID:39046369. |
hmgb1, tlr4, irak2, ikbkb, il10, il1b, il1b, and il8 in this signalling pathway are highly expressed in epilepsy patients in g1 and seizures occur with the stimulation of excitatory mechanisms by acting through this pathway. |
2024-07-24 |
2024-07-26 |
Not clear |
| Hayriye Soytürk, Cansu Önal, Ümit Kılıç, Şule Aydın Türkoğlu, Erol Aya. The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis. Journal of cellular and molecular medicine. vol 28. issue 14. 2024-07-24. PMID:39046369. |
the signalling pathway in epilepsy may be activated by hmgb1, tlr4, and tlr2, which are considered to increase the level of proinflammatory cytokines. |
2024-07-24 |
2024-07-26 |
Not clear |
| Irma Wati Ngadimon, Eryse Amira Seth, Mohd Farooq Shaik. Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational Challenges. Frontiers in bioscience (Landmark edition). vol 29. issue 6. 2024-06-28. PMID:38940048. |
exploring the neuroinflammatory pathway in epilepsy and cognitive impairment: role of hmgb1 and translational challenges. |
2024-06-28 |
2024-06-30 |
Not clear |
| Irma Wati Ngadimon, Eryse Amira Seth, Mohd Farooq Shaik. Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational Challenges. Frontiers in bioscience (Landmark edition). vol 29. issue 6. 2024-06-28. PMID:38940048. |
evidence reveals involvement of high mobility group box 1 (hmgb1) in blood-brain barrier disruption and correlations with epilepsy severity and drug resistance. |
2024-06-28 |
2024-06-30 |
Not clear |
| Irma Wati Ngadimon, Eryse Amira Seth, Mohd Farooq Shaik. Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational Challenges. Frontiers in bioscience (Landmark edition). vol 29. issue 6. 2024-06-28. PMID:38940048. |
this review synthesises knowledge on hmgb1 and related biomarkers in epilepsy and cognitive impairment to shape future research and treatments targeting these intricate inflammatory processes. |
2024-06-28 |
2024-06-30 |
Not clear |
| Zongwei Yue, Jingyi Tang, Sudan Peng, Xuehua Cai, Xiaoming Rong, Lianhong Yan. Serum concentration of high-mobility group box 1, Toll-like receptor 4 as biomarker in epileptic patients. Epilepsy research. vol 192. 2023-04-19. PMID:37075527. |
to explore whether hmgb1 and tlr4 could serve as clinical biomarkers in epileptic patients, we recruited a total of 72 epilepsy patients and measured the serum level of hmgb1 and tlr4 by flow fluorescence technology and elisa respectively. |
2023-04-19 |
2023-08-14 |
Not clear |
| Si-Jie Dai, Yu-Ying Shao, Yang Zheng, Jin-Yi Sun, Zhi-Sheng Li, Jia-Ying Shi, Meng-Qi Yan, Xiao-Yun Qiu, Ceng-Lin Xu, Wan-Sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Che. Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation. Acta pharmacologica Sinica. 2023-04-19. PMID:37076634. |
inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting hmgb1 translocation. |
2023-04-19 |
2023-08-14 |
mouse |
| Yue Chen, Xilu Chen, Ying Lian. Meta-analysis of HMGB1 levels in the cerebrospinal fluid and serum of patients with epilepsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-18. PMID:36933099. |
meta-analysis of hmgb1 levels in the cerebrospinal fluid and serum of patients with epilepsy. |
2023-03-18 |
2023-08-14 |
Not clear |
| Yue Chen, Xilu Chen, Ying Lian. Meta-analysis of HMGB1 levels in the cerebrospinal fluid and serum of patients with epilepsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-18. PMID:36933099. |
the purpose of this study was to quantify and assess the relationship between hmgb1 level and epilepsy. |
2023-03-18 |
2023-08-14 |
Not clear |
| Dongbin Li, Xiaosi Zhang, Ruoshi Liu, Meixin Long, Shanshan Zhou, Jinghan Lin, Liming Zhan. Kainic acid induced hyperexcitability in thalamic reticular nucleus that initiates an inflammatory response through the HMGB1/TLR4 pathway. Neurotoxicology. 2023-01-20. PMID:36669621. |
to explore the relationship between the proinflammatory factor high-mobility group box 1 (hmgb1) and glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors in the development of epilepsy. |
2023-01-20 |
2023-08-14 |
Not clear |
| Zhong Luo, Meng Xu, Linhai Zhang, Haiqing Zhang, Zucai Xu, Zhongxiang X. Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus. Molecular medicine reports. vol 27. issue 2. 2023-01-12. PMID:36633134. |
in recent decades, studies have reported that inflammation serves key roles in epilepsy and that high mobility group box protein‑1 (hmgb1) may be involved in status epilepticus. |
2023-01-12 |
2023-08-14 |
rat |
| Bryan Gervais de Liyis, Sevinna Geshie Tandy, Joana Fourta Endira, Komang Andjani Putri, Desak Ketut Indrasari Utam. Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics. The Egyptian journal of neurology, psychiatry and neurosurgery. vol 58. issue 1. 2022-10-31. PMID:36310854. |
high mobility group box 1 (hmgb1) as an initiator and amplifier of the neuroinflammation is responsible for the onset and progression of epilepsy by overexpressing p-glycoprotein on the blood brain barrier. |
2022-10-31 |
2023-08-14 |
Not clear |
| Mehmet Akif Kaya, Nuray Erin, Oznur Bozkurt, Nilgun Erkek, Ozgur Duman, Senay Haspola. Changes of HMGB-1 and sTLR4 levels in cerebrospinal fluid of patients with febrile seizures. Epilepsy research. vol 169. 2021-11-29. PMID:33276244. |
increased levels of hmgb1 (high mobility group box 1), one of the most important pro-inflammatory cytokines, are associated with prolongation of seizure duration, recurrence of seizures and the development of epilepsy. |
2021-11-29 |
2023-08-13 |
Not clear |
| Shu Wang, Yuguang Guan, Tianfu L. The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy. Current drug targets. vol 22. issue 2. 2021-11-26. PMID:32729417. |
recent studies suggest that hmgb1 via toll-like receptor (tlr) pathways can trigger inflammatory responses and play an important role in epilepsy. |
2021-11-26 |
2023-08-13 |
Not clear |
| Shu Wang, Yuguang Guan, Tianfu L. The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy. Current drug targets. vol 22. issue 2. 2021-11-26. PMID:32729417. |
in addition, studies of hmgb1 have shown its potential in the treatment of epilepsy. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lauren Elizabeth Walker, Graeme John Sills, Andrea Jorgensen, Tiina Alapirtti, Jukka Peltola, Martin J Brodie, Anthony Guy Marson, Annamaria Vezzani, Munir Pirmohame. High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. Epilepsia. 2021-11-08. PMID:34747496. |
patients with drug-resistant epilepsy express significantly higher levels of blood hmgb1 than those with drug-responsive, well-controlled seizures and healthy controls. |
2021-11-08 |
2023-08-13 |
Not clear |
| Lauren Elizabeth Walker, Graeme John Sills, Andrea Jorgensen, Tiina Alapirtti, Jukka Peltola, Martin J Brodie, Anthony Guy Marson, Annamaria Vezzani, Munir Pirmohame. High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. Epilepsia. 2021-11-08. PMID:34747496. |
no correlation existed between blood hmgb1 levels and total pretreatment seizure count or days since last seizure at new epilepsy diagnosis, indicating that blood hmgb1 does not solely reflect ongoing seizures. |
2021-11-08 |
2023-08-13 |
Not clear |
| Na Wang, Haipeng Liu, Bingqian Ma, Ting Zhao, Yanan Chen, Yongguang Yang, Pan Zhao, Xiong Ha. CSF high-mobility group box 1 is associated with drug-resistance and symptomatic etiology in adult patients with epilepsy. Epilepsy research. vol 177. 2021-11-01. PMID:34543830. |
this study aims to determine the expression profiles of hmgb1 in cerebrospinal fluid (csf) and paired serum, and to explore whether there is a relationship between csf hmgb1 concentrations with seizure parameters in adult patients with epilepsy. |
2021-11-01 |
2023-08-13 |
Not clear |
| Meng Fu, Jie Tao, Dongdong Wang, Zhiping Zhang, Xiaoli Wang, Yonghua Ji, Zhiping L. Downregulation of MicroRNA-34c-5p facilitated neuroinflammation in drug-resistant epilepsy. Brain research. vol 1749. 2021-10-27. PMID:32950487. |
downregulation of mir-34c-5p, elevated expression of hmgb1 and il-1β had been found in rats with drug-resistant epilepsy, compared to drug-sensitive epilepsy rats. |
2021-10-27 |
2023-08-13 |
rat |
| Meng Fu, Jie Tao, Dongdong Wang, Zhiping Zhang, Xiaoli Wang, Yonghua Ji, Zhiping L. Downregulation of MicroRNA-34c-5p facilitated neuroinflammation in drug-resistant epilepsy. Brain research. vol 1749. 2021-10-27. PMID:32950487. |
analysis manifested that mir-34c-5p was obviously decreased, while hmgb1 was increased on serum of children with drug-resistant epilepsy. |
2021-10-27 |
2023-08-13 |
rat |