| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariangela Scarduzio, Chelsea N Zimmerman, Karen L Jaunarajs, Qin Wang, David G Standaert, Lori L McMaho. Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental neurology. vol 295. 2017-08-14. PMID:28587876. |
strength of cholinergic tone dictates the polarity of dopamine d2 receptor modulation of striatal cholinergic interneuron excitability in dyt1 dystonia. |
2017-08-14 |
2023-08-13 |
mouse |
| Mariangela Scarduzio, Chelsea N Zimmerman, Karen L Jaunarajs, Qin Wang, David G Standaert, Lori L McMaho. Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental neurology. vol 295. 2017-08-14. PMID:28587876. |
in dyt1, an early-onset genetic form of dystonia caused by a mutation in the protein torsina (tora), the suspected heightened cholinergic tone is commonly attributed to faulty dopamine d2 receptor (d2r) signaling where d2r agonists cause excitation of striatal cholinergic interneurons (chis), rather than the normal inhibition of firing observed in wild-type animals, an effect known as "paradoxical excitation". |
2017-08-14 |
2023-08-13 |
mouse |
| Roderick P P W M Maas, Tessa Wassenberg, Jean-Pierre Lin, Bart P C van de Warrenburg, Michèl A A P Willemse. l-Dopa in dystonia: A modern perspective. Neurology. vol 88. issue 19. 2017-06-02. PMID:28389587. |
rather, in high-resource countries, we suggest to use l-dopa after biochemical corroboration of a defect in dopamine biosynthesis, in genetically confirmed drd, or if nigrostriatal degeneration has been demonstrated by nuclear imaging in adult patients presenting with lower limb dystonia. |
2017-06-02 |
2023-08-13 |
Not clear |
| Yuji Shiga, Yuhei Kanaya, Ryuhei Kono, Shinichi Takeshima, Yutaka Shimoe, Masaru Kuriyam. Dementia with Lewy bodies presenting marked tongue protrusion and bite due to lingual dystonia: A case report. Rinsho shinkeigaku = Clinical neurology. vol 56. issue 6. 2017-03-23. PMID:27212676. |
it is believed that these treatments stimulated and sensitized dopamine d1 receptors, thereby inducing lingual dystonia. |
2017-03-23 |
2023-08-13 |
Not clear |
| Dhanya Vijayakumar, Joseph Jankovi. Drug-Induced Dyskinesia, Part 1: Treatment of Levodopa-Induced Dyskinesia. Drugs. vol 76. issue 7. 2017-03-08. PMID:27091215. |
peak-dose dyskinesia is treated mainly by reducing individual doses of levodopa and adding amantadine and dopamine agonists, whereas off-period dystonia often responds to baclofen and botulinum toxin injections. |
2017-03-08 |
2023-08-13 |
Not clear |
| Camila Oliveira Dos Santos, Ikuo Masuho, Francisco Pereira da Silva-Júnior, Egberto Reis Barbosa, Sonia Maria Cesar Azevedo Silva, Vanderci Borges, Henrique Ballalai Ferraz, Maria Sheila Guimarães Rocha, João Carlos Papaterra Limongi, Kirill A Martemyanov, Patricia de Carvalho Aguia. Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function. Journal of neurology. vol 263. issue 4. 2017-01-25. PMID:26810727. |
the f133l mutant exhibited significantly elevated levels of basal bret and severely diminished amplitude of response elicited by dopamine, that both indicate substantial functional impairment of gαolf in transducing receptor signals, which could be involved in dystonia pathophysiology. |
2017-01-25 |
2023-08-13 |
Not clear |
| Lin Zhang, Deirdre M McCarthy, Nutan Sharma, Pradeep G Bhid. Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development. PloS one. vol 10. issue 4. 2015-12-30. PMID:25860259. |
neuroimaging studies and studies using mouse models suggest that dyt1 dystonia is associated with dopamine imbalance. |
2015-12-30 |
2023-08-13 |
mouse |
| Lin Zhang, Deirdre M McCarthy, Nutan Sharma, Pradeep G Bhid. Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development. PloS one. vol 10. issue 4. 2015-12-30. PMID:25860259. |
however, whether dopamine imbalance is key to dyt1 or other forms of dystonia continues to be debated. |
2015-12-30 |
2023-08-13 |
mouse |
| Samuel J Rose, Xin Y Yu, Ann K Heinzer, Porter Harrast, Xueliang Fan, Robert S Raike, Valerie B Thompson, Jean-Francois Pare, David Weinshenker, Yoland Smith, Hyder A Jinnah, Ellen J Hes. A new knock-in mouse model of l-DOPA-responsive dystonia. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26220941. |
for instance, mutations in genes critical for the synthesis of dopamine, including gch1 and th cause l-dopa-responsive dystonia. |
2015-12-28 |
2023-08-13 |
mouse |
| Samuel J Rose, Xin Y Yu, Ann K Heinzer, Porter Harrast, Xueliang Fan, Robert S Raike, Valerie B Thompson, Jean-Francois Pare, David Weinshenker, Yoland Smith, Hyder A Jinnah, Ellen J Hes. A new knock-in mouse model of l-DOPA-responsive dystonia. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26220941. |
despite evidence that implicates abnormal dopamine neurotransmission in dystonia, the precise nature of the pre- and postsynaptic defects that result in dystonia are not known. |
2015-12-28 |
2023-08-13 |
mouse |
| Samuel J Rose, Xin Y Yu, Ann K Heinzer, Porter Harrast, Xueliang Fan, Robert S Raike, Valerie B Thompson, Jean-Francois Pare, David Weinshenker, Yoland Smith, Hyder A Jinnah, Ellen J Hes. A new knock-in mouse model of l-DOPA-responsive dystonia. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26220941. |
surprisingly, the striatal dopamine concentration was reduced to ∼1% of normal, a concentration more typically associated with akinesia, suggesting that (mal)adaptive postsynaptic responses may also play a role in the development of dystonia. |
2015-12-28 |
2023-08-13 |
mouse |
| Samuel J Rose, Xin Y Yu, Ann K Heinzer, Porter Harrast, Xueliang Fan, Robert S Raike, Valerie B Thompson, Jean-Francois Pare, David Weinshenker, Yoland Smith, Hyder A Jinnah, Ellen J Hes. A new knock-in mouse model of l-DOPA-responsive dystonia. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26220941. |
together, our findings suggest that the development of dystonia may depend on a reduction in dopamine in combination with specific abnormal receptor responses. |
2015-12-28 |
2023-08-13 |
mouse |
| Daniel Pushparaju Yeggoni, Rajagopal Subramanya. Binding studies of L-3,4-dihydroxyphenylalanine with human serum albumin. Molecular bioSystems. vol 10. issue 12. 2015-08-14. PMID:25209359. |
l-dopa has been used to increase dopamine concentrations in the treatment of parkinson's disease and dopamine-responsive dystonia. |
2015-08-14 |
2023-08-13 |
human |
| Jin A Cho, Xuan Zhang, Gregory M Miller, Wayne I Lencer, Flavia C Ner. 4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models. PloS one. vol 9. issue 11. 2015-07-13. PMID:25379658. |
multiple lines of evidence suggest that the clinical symptoms of dystonia result from abnormalities in dopamine (da) signaling, and possibly involving its down-stream effector adenylate cyclase that produces the second messenger cyclic adenosine-3', 5'-monophosphate (camp). |
2015-07-13 |
2023-08-13 |
Not clear |
| G Sciamanna, G Ponterio, A Tassone, M Maltese, G Madeo, G Martella, S Poli, T Schirinzi, P Bonsi, A Pisan. Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia. Neuropharmacology. vol 85. 2015-03-30. PMID:24951854. |
evidence suggests that tor1a mutation produces dystonia through an aberrant neuronal signalling within the striatum, where d2 dopamine receptors (d2r) produce an abnormal excitatory response in cholinergic interneurons (chis) in different models of dyt1 dystonia. |
2015-03-30 |
2023-08-13 |
mouse |
| Morvarid Karimi, Joel S Perlmutte. The role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging. Tremor and other hyperkinetic movements (New York, N.Y.). vol 5. 2015-02-25. PMID:25713747. |
the role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging. |
2015-02-25 |
2023-08-13 |
Not clear |
| Morvarid Karimi, Joel S Perlmutte. The role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging. Tremor and other hyperkinetic movements (New York, N.Y.). vol 5. 2015-02-25. PMID:25713747. |
in this review, we critically evaluate recent neuroimaging studies that investigate dopamine receptors, endogenous dopamine release, morphology of striatum, and structural or functional connectivity in cortico-basal ganglia-thalamo-cortical and related cerebellar circuits in dystonia. |
2015-02-25 |
2023-08-13 |
Not clear |
| Justus L Groen, Katja Ritz, Tom T Warner, Frank Baas, Marina A J Tijsse. DRD1 rare variants associated with tardive-like dystonia: a pilot pathway sequencing study in dystonia. Parkinsonism & related disorders. vol 20. issue 7. 2015-02-07. PMID:24768614. |
these findings indicate a role for rare genetic variation in dopamine processing genes in dystonia pathophysiology. |
2015-02-07 |
2023-08-13 |
Not clear |
| Niccolò E Mencacci, Ioannis U Isaias, Martin M Reich, Christos Ganos, Vincent Plagnol, James M Polke, Jose Bras, Joshua Hersheson, Maria Stamelou, Alan M Pittman, Alastair J Noyce, Kin Y Mok, Thomas Opladen, Erdmute Kunstmann, Sybille Hodecker, Alexander Münchau, Jens Volkmann, Samuel Samnick, Katie Sidle, Tina Nanji, Mary G Sweeney, Henry Houlden, Amit Batla, Anna L Zecchinelli, Gianni Pezzoli, Giorgio Marotta, Andrew Lees, Paulo Alegria, Paul Krack, Florence Cormier-Dequaire, Suzanne Lesage, Alexis Brice, Peter Heutink, Thomas Gasser, Steven J Lubbe, Huw R Morris, Pille Taba, Sulev Koks, Elisa Majounie, J Raphael Gibbs, Andrew Singleton, John Hardy, Stephan Klebe, Kailash P Bhatia, Nicholas W Woo. Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a journal of neurology. vol 137. issue Pt 9. 2014-11-06. PMID:24993959. |
loss-of-function mutations in gch1 result in severe reduction of dopamine synthesis in nigrostriatal cells and are the most common cause of dopa-responsive dystonia, a rare disease that classically presents in childhood with generalized dystonia and a dramatic long-lasting response to levodopa. |
2014-11-06 |
2023-08-13 |
human |
| Morvarid Karimi, Stephen M Moerlein, Tom O Videen, Yi Su, Hubert P Flores, Joel S Perlmutte. Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 14. 2014-07-29. PMID:24151192. |
striatal dopamine d1-like receptor binding is unchanged in primary focal dystonia. |
2014-07-29 |
2023-08-12 |
Not clear |