| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily C Acker, Elizabeth A Sinclair, Andrew L Beardsley, Sheikh S Ahmed, Blake A Frober. Acute Vilazodone Toxicity in a Pediatric Patient. The Journal of emergency medicine. vol 49. issue 3. 2016-05-23. PMID:26099909. |
vilazodone is a selective serotonin reuptake inhibitor and 5ht1a agonist recently approved to treat depression in adults. |
2016-05-23 |
2023-08-13 |
Not clear |
| Michel O Melancon, Dominique Lorrain, Isabelle J Dionn. Changes in markers of brain serotonin activity in response to chronic exercise in senior men. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 39. issue 11. 2016-05-12. PMID:25126826. |
aging is associated with noticeable impairments in brain serotonin transmission, which might contribute to increased vulnerability to developing depression in later life. |
2016-05-12 |
2023-08-13 |
human |
| K O'Sullivan, F Boland, U Reulbach, N Motterlini, D Kelly, K Bennett, T Fahe. Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning. BMC pediatrics. vol 15. 2016-05-09. PMID:26362648. |
in 2003, the irish medicines board (imb) warned against the treatment of childhood depression with selective serotonin reuptake inhibitors (ssris) due to increased risk of suicide. |
2016-05-09 |
2023-08-13 |
Not clear |
| Fatemeh Haghighi, Yongchao Ge, Sean Chen, Yurong Xin, Michelle U Umali, Rita De Gasperi, Miguel A Gama Sosa, Stephen T Ahlers, Gregory A Elde. Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury. Journal of neurotrauma. vol 32. issue 16. 2016-05-06. PMID:25594545. |
in particular, increased methylation and decreased gene expression were observed in the aanat gene, which is involved in converting serotonin to the circadian hormone melatonin and is implicated in sleep disturbance and depression associated with traumatic brain injury. |
2016-05-06 |
2023-08-13 |
rat |
| Salvatore Gentil. Early pregnancy exposure to selective serotonin reuptake inhibitors, risks of major structural malformations, and hypothesized teratogenic mechanisms. Expert opinion on drug metabolism & toxicology. vol 11. issue 10. 2016-05-05. PMID:26135630. |
selective serotonin reuptake inhibitors (ssris) are commonly used to manage antenatal depression. |
2016-05-05 |
2023-08-13 |
Not clear |
| Markus Wöhr, Marcel M van Gaalen, Rainer K W Schwartin. Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26221830. |
consequently, the 5-ht system is implicated in various neuropsychiatric disorders, such as anxiety disorders and depression or autism spectrum disorders (asd), with selective 5-ht reuptake inhibitors being the frontline medication. |
2016-05-05 |
2023-08-13 |
mouse |
| Aurore N Voisin, Ouissame Mnie-Filali, Nicolas Giguère, Guillaume M Fortin, Erika Vigneault, Salah El Mestikawy, Laurent Descarries, Louis-Éric Trudea. Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons. Frontiers in neuroanatomy. vol 10. 2016-05-05. PMID:27147980. |
our results demonstrate that raphe 5-ht neurons express sert and vglut3 mainly in segregated axon terminals and that vglut3 regulates the vulnerability of these neurons and the neurochemical identity of their axonal domain, offering new perspectives on the functional connectivity of a cell population involved in anxiety disorders and depression. |
2016-05-05 |
2023-08-13 |
mouse |
| Frank Petrak, Harald Baumeister, Timothy C Skinner, Alex Brown, Richard I G Hol. Depression and diabetes: treatment and health-care delivery. The lancet. Diabetes & endocrinology. vol 3. issue 6. 2016-05-03. PMID:25995125. |
the evidence for improved glycaemic control in the treatment of depression by use of selective serotonin reuptake inhibitors or psychological approaches is conflicting; only some analyses show small to moderate improvements in glycaemic control. |
2016-05-03 |
2023-08-13 |
Not clear |
| Joseph P Kambeitz, Oliver D Howe. The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression. Journal of affective disorders. vol 186. 2016-05-03. PMID:26281039. |
the serotonin transporter in depression: meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression. |
2016-05-03 |
2023-08-13 |
Not clear |
| Kristian Lundsgaard Kraglund, Janne Kaergaard Mortensen, Erik Lerkevang Grove, Søren Paaske Johnsen, Grethe Anderse. TALOS: a multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. International journal of stroke : official journal of the International Stroke Society. vol 10. issue 6. 2016-05-02. PMID:25854537. |
selective serotonin reuptake inhibitors (ssri) are effective in the treatment of post-stroke depression and may have potential neuroprotective and vascular effects. |
2016-05-02 |
2023-08-13 |
Not clear |
| Timo Siepmann, Jessica Kepplinger, Charlotte Zerna, Ulrike Schatz, Ana Isabel Penzlin, Lars-Peder Pallesen, Ben Min-Woo Illigens, Kerstin Weidner, Heinz Reichmann, Volker Puetz, Ulf Bodechtel, Kristian Barlin. The Effects of Pretreatment versus De Novo Treatment with Selective Serotonin Reuptake Inhibitors on Short-term Outcome after Acute Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 24. issue 8. 2016-05-02. PMID:26099557. |
selective serotonin reuptake inhibitors (ssris) administered in patients following acute ischemic stroke have shown to improve clinical recovery independently of changes in depression. |
2016-05-02 |
2023-08-13 |
Not clear |
| K Hüfner, A Oberguggenberger, C Kohl, S Geisler, E Gamper, V Meraner, J Egeter, M Hubalek, B Beer, D Fuchs, B Sperner-Unterwege. Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer. Psychoneuroendocrinology. vol 60. 2016-05-02. PMID:26112459. |
aside from identifying underlying pathophysiological mechanisms, these results could be the basis for future treatment studies: in bca(+) patients with depression the use of serotonin-noradrenaline reuptake inhibitors might be recommended while in those with predominant anxiety selective serotonin reuptake inhibitors might be the treatment of choice. |
2016-05-02 |
2023-08-13 |
human |
| Nicole Mavrides, Charles B Nemerof. Treatment of affective disorders in cardiac disease. Dialogues in clinical neuroscience. vol 17. issue 2. 2016-04-29. PMID:26246788. |
the evidence from randomized controlled clinical trials indicates that antidepressants, especially selective serotonin uptake inhibitors, are overwhelmingly safe, and likely to be effective in the treatment of depression in patients with cvd. |
2016-04-29 |
2023-08-13 |
Not clear |
| M V Bezrukov, Iu E Shilov, N V Shestakova, T P Kliushni. [The biological evaluation of depression severity: a novel method for the determination of platelet serotonin concentration]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 114. issue 8. 2016-04-28. PMID:25345631. |
[the biological evaluation of depression severity: a novel method for the determination of platelet serotonin concentration]. |
2016-04-28 |
2023-08-13 |
Not clear |
| Samantha J Podurgiel, Meredith N Milligan, Samantha E Yohn, Laura J Purcell, Hector M Contreras-Mora, Mercè Correa, John D Salamon. Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 9. 2016-04-26. PMID:25759301. |
depression is also commonly associated with pd, and clinical data indicate that selective serotonin reuptake inhibitors (ssris) such as fluoxetine ((±)-n-methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride; flx) are frequently used to treat depression in pd patients. |
2016-04-26 |
2023-08-13 |
rat |
| Janna N Vrijsen, Indira Tendolkar, Alejandro Arias-Vásquez, Barbara Franke, Aart H Schene, Guillén Fernández, Iris van Oostro. Interaction of the 5-HTTLPR and childhood trauma influences memory bias in healthy individuals. Journal of affective disorders. vol 186. 2016-04-25. PMID:26232751. |
the 5-httlpr polymorphism in the gene's promoter region has a short (s) and a long (l) allele, of which l contains a further snp (rs25531), resulting in a triallelic polymorphism: la, lg, and s. both s and lg result in increased serotonin signaling (to simplify, we refer to both alleles as 's'), which in turn appears associated with depression vulnerability, specifically in individuals with stressful events. |
2016-04-25 |
2023-08-13 |
Not clear |
| Klaus-Peter Lesc. When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. Current topics in behavioral neurosciences. vol 7. 2016-04-23. PMID:21225411. |
for example, a remarkable number of studies reported an association of variation in the human serotonin (5-ht) transporter gene (slc6a4, 5-htt, sert) with emotional and cognitive traits as well as increased risk for depression in interaction with psychosocial adversity. |
2016-04-23 |
2023-08-12 |
mouse |
| M Bellani, M Nobile, V Bianchi, J van Os, P Brambill. G × E interaction and neurodevelopment II. Focus on adversities in paediatric depression: the moderating role of serotonin transporter. Epidemiology and psychiatric sciences. vol 22. issue 1. 2016-04-23. PMID:23114056. |
focus on adversities in paediatric depression: the moderating role of serotonin transporter. |
2016-04-23 |
2023-08-12 |
Not clear |
| C E Ong, L K Teh, R Ismai. Involvement of cytochromes p450 in drug-drug interactions: an overview. The Medical journal of Malaysia. vol 57. issue 2. 2016-04-23. PMID:24326665. |
renewed interest in the topic interactions has been generated by the fatal interactions involving non-sedating histamine h-1 antagonists and the recent intriduction of two therapeutic agents, the selective serotonin reuptake inhibitors (ssris) and hiv protease inhibitors, for the treatment of depression and aids, respectively. |
2016-04-23 |
2023-08-12 |
Not clear |
| Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMaho. Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Current biology : CB. vol 25. issue 10. 2016-04-21. PMID:25959961. |
dysregulation of serotonin neurotransmission is implicated in neurobehavioral disorders, such as depression and anxiety, and alterations in the serotonergic phenotype of raphe neurons have dramatic effects on affective behaviors in rodents. |
2016-04-21 |
2023-08-13 |
mouse |