| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zdenek Fisar, Lucie Kalisová, Ivo Paclt, Martin Anders, Jan Vever. Platelet serotonin uptake in drug-naïve depressive patients before and after treatment with citalopram. Psychiatry research. vol 161. issue 2. 2009-01-23. PMID:18817980. |
there was a significantly lower v(max) and v(max)/k(m) in the female compared with the male depressed patients before citalopram treatment; a hypothesis was supported that lowered 5-ht uptake may reflect a gender-linked vulnerability to a serotonin-related depression. |
2009-01-23 |
2023-08-12 |
human |
| John R Cashman, Troy Voelker, Robert Johnson, Aaron Janowsk. Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorganic & medicinal chemistry. vol 17. issue 1. 2009-01-23. PMID:19014888. |
stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Aroldo Cupello, Fabio Bandini, Claudio Albano, Emilio Favale, Roberta Marchese, Simona Scarrone, Carlo Trompett. Catatonic features in major depression relieved by electroconvulsive treatment: parallel evaluation of the status of platelet serotonin transporter. The International journal of neuroscience. vol 118. issue 10. 2009-01-21. PMID:18788029. |
catatonic features in major depression relieved by electroconvulsive treatment: parallel evaluation of the status of platelet serotonin transporter. |
2009-01-21 |
2023-08-12 |
Not clear |
| Aroldo Cupello, Fabio Bandini, Claudio Albano, Emilio Favale, Roberta Marchese, Simona Scarrone, Carlo Trompett. Catatonic features in major depression relieved by electroconvulsive treatment: parallel evaluation of the status of platelet serotonin transporter. The International journal of neuroscience. vol 118. issue 10. 2009-01-21. PMID:18788029. |
the aim of this research was to follow parallelly the clinical status of a patient and the dynamics of the serotonin transporter (sert), a likely player in the effect of electroconvulsive treatment (ect), a powerful tool against deep depression. |
2009-01-21 |
2023-08-12 |
Not clear |
| Chi-Un Pae, David M Marks, Changsu Han, Ashwin A Patkar, David Steffen. Does neurotropin-3 have a therapeutic implication in major depression? The International journal of neuroscience. vol 118. issue 11. 2009-01-16. PMID:18853330. |
there is emerging evidence suggesting that the etiopathogenesis of depression involves transmitters other than the major neurotransmitters such as serotonin, norepinephrine, and dopamine. |
2009-01-16 |
2023-08-12 |
Not clear |
| Chi-Un Pae, David M Marks, Changsu Han, Ashwin A Patkar, David Steffen. Does neurotropin-3 have a therapeutic implication in major depression? The International journal of neuroscience. vol 118. issue 11. 2009-01-16. PMID:18853330. |
animal studies have shown that it also modulates the neurotransmitters, serotonin and noradrenaline, which are essential in the development and treatment of depression. |
2009-01-16 |
2023-08-12 |
Not clear |
| Kimmo A Michelsen, Jos Prickaerts, Harry W M Steinbusc. The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Progress in brain research. vol 172. 2009-01-15. PMID:18772036. |
the dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and alzheimer's disease. |
2009-01-15 |
2023-08-12 |
Not clear |
| Kimmo A Michelsen, Jos Prickaerts, Harry W M Steinbusc. The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Progress in brain research. vol 172. 2009-01-15. PMID:18772036. |
special emphasis is put on serotonin and its central role in neuroplasticity, which is proving to be of high priority in unraveling the full picture of the cellular mechanisms and their interconnections in the etiology of major depression and alzheimer's disease. |
2009-01-15 |
2023-08-12 |
Not clear |
| Kelly A Berg, John A Harvey, Umberto Spampinato, William P Clark. Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression. Progress in brain research. vol 172. 2009-01-15. PMID:18772038. |
physiological and therapeutic relevance of constitutive activity of 5-ht 2a and 5-ht 2c receptors for the treatment of depression. |
2009-01-15 |
2023-08-12 |
Not clear |
| Kelly A Berg, John A Harvey, Umberto Spampinato, William P Clark. Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression. Progress in brain research. vol 172. 2009-01-15. PMID:18772038. |
alterations in the constitutive activity of 5-ht(2a) and 5-ht(2c) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit. |
2009-01-15 |
2023-08-12 |
Not clear |
| Fu-Quan Huo, Chao-Ling Qu, Yun-Qing Li, Jing-Shi Tang, Hong Ji. GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT 1A receptor activation-induced antinociception in the rat. Pain. vol 139. issue 2. 2009-01-13. PMID:18579305. |
these findings provide support for the hypothesis that 5-ht 1a receptor activation may inhibit the inhibitory action of the gabaergic interneurons on the output neurons projecting to pag leading to activation of the brainstem descending inhibitory system and depression of nociceptive inputs at the spinal cord level. |
2009-01-13 |
2023-08-12 |
rat |
| Sara Eugenia Cruz-Morales, Norma Laura García-Saldívar, María Reyes González-López, Georgina Castillo-Roberto, Juana Monroy, Roberto Domíngue. Acute restriction impairs memory in the elevated T-maze (ETM) and modifies serotonergic activity in the dorsolateral striatum. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18378013. |
serotonin (5-ht) is involved in behaviors such as sleep, eating, memory, in mental disorders like anxiety and depression and plays an important role in the modulation of stress. |
2009-01-12 |
2023-08-12 |
Not clear |
| B Bert, H Fink, J Rothe, J Walstab, H Bönisc. Learning and memory in 5-HT(1A)-receptor mutant mice. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18396339. |
the serotonin 1a (5-ht(1a))-receptor is involved in a wide range of physiological functions, but has also been implicated in the pathophysiology of anxiety disorders and depression. |
2009-01-12 |
2023-08-12 |
mouse |
| Jacqueline Bor. Molecular imaging of the 5-HT(1A) receptor in relation to human cognition. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18606193. |
positron emission tomography (pet) imaging of the 5-ht(1a) receptor in patients with alzheimer's disease, schizophrenia and depression implicate an alteration in 5-ht(1a) receptor binding compared to control subjects, but it is yet unknown whether these alterations are related to the cognitive impairment associated with these disorders. |
2009-01-12 |
2023-08-12 |
human |
| Adina T Michael-Titus, Monika Albert, Gregory J Michael, Thomas Michaelis, Takashi Watanabe, Jens Frahm, Olga Pudovkina, Marieke G C van der Hart, Mayke B Hesselink, Eberhard Fuchs, Boldizsár Czé. SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. European journal of pharmacology. vol 598. issue 1-3. 2009-01-09. PMID:18822282. |
sonu20176289, a compound combining partial dopamine d(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. |
2009-01-09 |
2023-08-12 |
Not clear |
| Adina T Michael-Titus, Monika Albert, Gregory J Michael, Thomas Michaelis, Takashi Watanabe, Jens Frahm, Olga Pudovkina, Marieke G C van der Hart, Mayke B Hesselink, Eberhard Fuchs, Boldizsár Czé. SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. European journal of pharmacology. vol 598. issue 1-3. 2009-01-09. PMID:18822282. |
we investigated the efficacy of sonu20176289, a member of a group of novel phenylpiperazine derivatives with a mixed dopamine d(2) receptor partial agonist and specific serotonin reuptake inhibitor (ssri) activity, in a chronic stress model of depression in male tree shrews. |
2009-01-09 |
2023-08-12 |
Not clear |
| C-W Tsao, Y-S Lin, J-T Cheng, C-F Lin, H-T Wu, S-R Wu, W-H Tsa. Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. Journal of psychopharmacology (Oxford, England). vol 22. issue 7. 2009-01-06. PMID:18308792. |
interferon (ifn)-alpha upregulates serotonin (5-ht) uptake and serotonin transporter (5-htt) messenger ribonucleic acid (mrna) expression in immune cells, which implies the mechanism underlying ifn-alpha-induced depression. |
2009-01-06 |
2023-08-12 |
Not clear |
| C-W Tsao, Y-S Lin, J-T Cheng, C-F Lin, H-T Wu, S-R Wu, W-H Tsa. Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. Journal of psychopharmacology (Oxford, England). vol 22. issue 7. 2009-01-06. PMID:18308792. |
these results appear to clarify the association of depression with ifn-alpha-induced 5-ht uptake that reduces the 5-ht levels and ifn-alpha-regulated transcription of 5-htt; further, the results suggest the involvement of mapk in this process. |
2009-01-06 |
2023-08-12 |
Not clear |
| Renee S Martin, Robert A Henningsen, Alexander Suen, Subbu Apparsundaram, Becky Leung, Zhongjiang Jia, Rama K Kondru, Marcos E Mill. Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18801948. |
several serotonin reuptake inhibitors are in clinical use for treatment of depression and anxiety disorders. |
2009-01-05 |
2023-08-12 |
Not clear |