| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Francavilla, A Di Leo, S Q Wu, P Ove, D Van Thiel, C Sciascia, T E Starz. Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 16 Suppl 1. 1985-05-28. PMID:6099817. |
an apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased. |
1985-05-28 |
2023-08-12 |
rat |
| D J Smith, R M Venable, J Collin. Separation and quantitation of insulins and related substances in bulk insulin crystals and in injectables by reversed-phase high performance liquid chromatography and the effect of temperature on the separation. Journal of chromatographic science. vol 23. issue 2. 1985-04-16. PMID:3882729. |
the official method specified in the united states pharmacopeia (usp) is a bioassay measuring the depression of blood sugar concentrations in rabbits treated with the insulin under test and the official standard. |
1985-04-16 |
2023-08-11 |
human |
| F R Kuntschen, P M Galletti, C Hahn, J J Arnulf, C Isetta, V Do. Alterations of insulin and glucose metabolism during cardiopulmonary bypass under normothermia. The Journal of thoracic and cardiovascular surgery. vol 89. issue 1. 1985-02-11. PMID:3880848. |
elevated stress hormone levels, a concomitant reduction of insulin release and insulin action, and a depression of peripheral glucose utilization, as demonstrated by glucose clamp experiments, contributed to these perturbations of glucose and insulin metabolism. |
1985-02-11 |
2023-08-11 |
Not clear |
| G D Smith, D C Swenson, E J Dodson, G G Dodson, C D Reynold. Structural stability in the 4-zinc human insulin hexamer. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 22. 1985-01-02. PMID:6390430. |
unlike the surface of the 2-zinc insulin hexamer, which possesses a shallow depression containing a zinc ion and its coordinating water molecules, the 4-zinc human insulin hexamer contains a zinc and chloride ion at the bottom of an 8-a tunnel produced by three parallel alpha-helices. |
1985-01-02 |
2023-08-12 |
human |
| B Emmanuel, J J Kennell. Effect of propionic acid on kinetics of acetate and oleate and on plasma and milk fatty acid composition of goats. Journal of dairy science. vol 67. issue 6. 1984-09-07. PMID:6747042. |
data support the glucogenic theory that propionic acid either directly or through gluconeogenesis stimulates insulin secretion, which in turn inhibits release of fatty acids from adipose tissue, resulting in milk fat depression. |
1984-09-07 |
2023-08-12 |
Not clear |
| H Laborit, J F Bonifac. Action of adenosine on energy metabolism and on glucose-6-phosphate dehydrogenase in rat brains. Research communications in chemical pathology and pharmacology. vol 44. issue 1. 1984-06-27. PMID:6729244. |
the increased cerebral glucose concentration is perhaps a result of increased blood glucose levels, in turn resulting from the known depression of insulin release by adenosine, or from a preferential utilization of glycogen, resulting from the activation of adenylate cyclase. |
1984-06-27 |
2023-08-12 |
rat |
| A Schnabel, W Kindermann, V Steinkraus, O Salas-Fraire, G Bir. Metabolic and hormonal responses to exhaustive supramaximal running with and without beta-adrenergic blockade. European journal of applied physiology and occupational physiology. vol 52. issue 2. 1984-06-07. PMID:6143664. |
beta-blockade reduced the increases of lactate, glucose, glycerol, insulin, and growth hormone, exaggerated the depression of ffa and had no effect on cortisol. |
1984-06-07 |
2023-08-12 |
Not clear |
| D L Freerksen, N A Schroedl, C R Hartzel. Triiodothyronine depresses the NAD-linked glycerol-3-phosphate dehydrogenase activity of cultured neonatal rat heart cells. Archives of biochemistry and biophysics. vol 228. issue 2. 1984-03-12. PMID:6696442. |
the degree of depression was greater (65%) when the medium contained normal serum levels of hydrocortisone and insulin. |
1984-03-12 |
2023-08-12 |
rat |
| G S Spencer, G J Garssen, B Colenbrander, A A Macdonald, M M Bever. Glucose, growth hormone, somatomedin, cortisol and ACTH changes in the plasma of unanaesthetised pig foetuses following intravenous insulin administration in utero. Acta endocrinologica. vol 104. issue 2. 1983-12-17. PMID:6314725. |
following iv insulin administration there was a marked depression in plasma glucose (p less than 0.01), an elevation in growth hormone (p less than 0.05) and an increase in acth (p less than 0.01). |
1983-12-17 |
2023-08-12 |
Not clear |
| K C Gorray, W Y Fujimot. In vitro toxicity of alloxan for guinea pig B cells: comparison with rat B cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 173. issue 4. 1983-10-28. PMID:6351093. |
however, whereas the lowest concentration of the drug (1 mm) produced a significant depression in insulin release in rat islet cultures, with maximal depression occurring after exposure to 5 mm alloxan, insulin release from guinea pig cultures was not significantly depressed by 1 or 2 mm alloxan, and 5 mm alloxan treatment produced a submaximal depression. |
1983-10-28 |
2023-08-12 |
rat |
| K C Gorray, W Y Fujimot. In vitro toxicity of alloxan for guinea pig B cells: comparison with rat B cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 173. issue 4. 1983-10-28. PMID:6351093. |
treatment with high doses of the drug (40 mm or greater) caused the same maximal chronic depression of insulin release for both species. |
1983-10-28 |
2023-08-12 |
rat |
| A G Tahiliani, R V Vadlamudi, J H McNeil. Prevention and reversal of altered myocardial function in diabetic rats by insulin treatment. Canadian journal of physiology and pharmacology. vol 61. issue 5. 1983-10-21. PMID:6349759. |
these results demonstrate that depression of myocardial performance, which is evident 6 weeks after diabetes is induced, can be prevented if insulin treatment is initiated as the disease is induced. |
1983-10-21 |
2023-08-12 |
rat |
| H J Quabbe, M Trompke, A S Luyck. Influence of ketone body infusion on plasma growth hormone and glucagon in man. The Journal of clinical endocrinology and metabolism. vol 57. issue 3. 1983-09-20. PMID:6348066. |
the influence of ketone body infusion on the serum gh and glucagon response to ffa depression and insulin hypoglycemia was investigated in 10 healthy men. |
1983-09-20 |
2023-08-12 |
Not clear |
| P K Ganguly, G N Pierce, K S Dhalla, N S Dhall. Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. The American journal of physiology. vol 244. issue 6. 1983-07-29. PMID:6134470. |
the results of this study provide some evidence that the depression in cardiac sarcoplasmic reticular calcium accumulation during diabetes is a consequence of insulin deficiency and associated chronic metabolic changes but the hypothyroid condition that accompanies experimental diabetes does not appear to play any role in this defect. |
1983-07-29 |
2023-08-12 |
rat |
| G R Turner, J F Marks, G R Buchana. Relative hyperglucagonemia in L-asparaginase-and prednisone-induced glucose intolerance in management of acute lymphocytic leukemia. Clinical pediatrics. vol 22. issue 5. 1983-06-23. PMID:6340906. |
hyperglycemia induced by l-asparaginase and prednisone was associated with depression of plasma insulin and, despite the inhibiting action of l-asparaginase on protein synthesis, a corresponding elevation of plasma glucagon. |
1983-06-23 |
2023-08-12 |
Not clear |
| W W Lautt, D J Légaré, E S Marten. A possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage. Canadian journal of physiology and pharmacology. vol 61. issue 3. 1983-06-17. PMID:6132675. |
a possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage. |
1983-06-17 |
2023-08-12 |
cat |
| W W Lautt, D J Légaré, E S Marten. A possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage. Canadian journal of physiology and pharmacology. vol 61. issue 3. 1983-06-17. PMID:6132675. |
the hypothesis that depression of insulin and glucagon levels during rapid, acute hemorrhage is controlled by somatostatin was supported by hormonal changes measured in the cat. |
1983-06-17 |
2023-08-12 |
cat |
| H Sandler, P Webb, J Annis, N Pace, B W Grunbaum, D Dolkas, B Newso. Evaluation of a Reverse Gradient Garment for prevention of bed-rest deconditioning. Aviation, space, and environmental medicine. vol 54. issue 3. 1983-06-10. PMID:6342596. |
tests during the 7-d recovery period showed fluid/electrolyte and body composition values to have returned to pre-bed-rest levels with continued depression of acceleration tolerance times (56% decreased at +2.5 gz and 74% decreased at +3.0 gz compared to pre-bed-rest levels) and exaggerated blood insulin response on glucose tolerance testing (blood insulin for treated group increased 95% at 1 h before bed rest and 465% during recovery). |
1983-06-10 |
2023-08-12 |
human |
| H A Neufeld, J G Pace, M V Kaminski, P Sobocinski, D J Crawfor. Unique effects of infectious or inflammatory stress on fat metabolism in rats. JPEN. Journal of parenteral and enteral nutrition. vol 6. issue 6. 1983-05-05. PMID:6762445. |
among the most typical are elevation in body temperature, insulin, and glucagon and depression in the concentrations of plasma ketones and free fatty acids. |
1983-05-05 |
2023-08-12 |
rat |
| H A Neufeld, J G Pace, M V Kaminski, P Sobocinski, D J Crawfor. Unique effects of infectious or inflammatory stress on fat metabolism in rats. JPEN. Journal of parenteral and enteral nutrition. vol 6. issue 6. 1983-05-05. PMID:6762445. |
it appears that the depression in plasma ketone bodies during infection or inflammation is closely related to the rise in plasma insulin. |
1983-05-05 |
2023-08-12 |
rat |