| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J W Perfield, A L Lock, J M Griinari, A Saebø, P Delmonte, D A Dwyer, D E Bauma. Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cows. Journal of dairy science. vol 90. issue 5. 2008-09-22. PMID:17430919. |
the first of these to be identified was trans-10, cis-12 conjugated linoleic acid (cla), but others are postulated to contribute to diet-induced milk fat depression (mfd). |
2008-09-22 |
2023-08-12 |
Not clear |
| L J Odens, R Burgos, M Innocenti, M J VanBaale, L H Baumgar. Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition period. Journal of dairy science. vol 90. issue 1. 2008-09-12. PMID:17183097. |
both cla treatments decreased overall milk fat content (26.0 and 18.3%) and yield (22.5 and 17.3%) with cla-induced milk fat depression becoming significant by d 8. |
2008-09-12 |
2023-08-12 |
Not clear |
| L J Odens, R Burgos, M Innocenti, M J VanBaale, L H Baumgar. Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition period. Journal of dairy science. vol 90. issue 1. 2008-09-12. PMID:17183097. |
the cla-induced milk fat depression increased in magnitude with progressing dim until reaching a plateau on d 18 for cla-1 (43%) and on d 14 for cla-2 (33%), although neither milk fat trans-10, cis-12 cla content (1.8 mg/g) nor its transfer efficiency (6.3%) changed over time. |
2008-09-12 |
2023-08-12 |
Not clear |
| Aileen F Keating, Feng-Qi Zhao, Kiera A Finucane, David R Glimm, John J Kennell. Effect of conjugated linoleic acid on bovine mammary cell growth, apoptosis and stearoyl Co-A desaturase gene expression. Domestic animal endocrinology. vol 34. issue 3. 2008-05-19. PMID:17959332. |
previous studies have shown that high concentrations of cla induced severe milk fat depression and have had negative effects on milk yield and composition whereas the impact of lower doses has been a modest depression in milk fat percent. |
2008-05-19 |
2023-08-12 |
cattle |
| Dale E Bauman, James W Perfield, Kevin J Harvatine, Lance H Baumgar. Regulation of fat synthesis by conjugated linoleic acid: lactation and the ruminant model. The Journal of nutrition. vol 138. issue 2. 2008-02-14. PMID:18203911. |
regulation by cla occurs naturally in dairy cows when specific cla isomers produced as intermediates in rumen biohydrogenation act to inhibit milk fat synthesis; this physiological example of nutritional genomics is referred to as diet-induced milk fat depression. |
2008-02-14 |
2023-08-12 |
Not clear |
| L Bernard, C Leroux, Y Chilliar. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Advances in experimental medicine and biology. vol 606. 2008-01-23. PMID:18183925. |
milk trans-10, cis-12 cla is often correlated with milk fat depression in cows but not in goats and, when postruminally infused, acts as an inhibitor of the expression of key lipogenic genes in cows. |
2008-01-23 |
2023-08-12 |
Not clear |
| Tina S Nielsen, Ellen M Straarup, Mogens Vestergaard, Kris Sejrse. Effect of silage type and concentrate level on conjugated linoleic acids, trans-C18:1 isomers and fat content in milk from dairy cows. Reproduction, nutrition, development. vol 46. issue 6. 2007-02-08. PMID:17169316. |
the results suggest that high levels of concentrate (grain) do not significantly alter the pattern of pufa biohydrogenation in the rumen, the concentration of cla and trans-c18:1 isomers in milk or cause milk fat depression unless combined with forage naturally high in starch and c18:2n-6 such as maize silage. |
2007-02-08 |
2023-08-12 |
Not clear |
| Daniel E Butz, Guangming Li, Mark E Coo. t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. The Journal of nutritional biochemistry. vol 17. issue 11. 2006-11-30. PMID:16517148. |
previous work demonstrated that feeding commercial preparations of conjugated linoleic acid (cla) [a 50:50 mixture of c9,t11 and t10,c12 cla (ccla)] partially overcame lipopolysaccharide (lps)-induced growth depression. |
2006-11-30 |
2023-08-12 |
mouse |
| Daniel E Butz, Guangming Li, Mark E Coo. t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. The Journal of nutritional biochemistry. vol 17. issue 11. 2006-11-30. PMID:16517148. |
the objective of this study was to determine which cla isomer was responsible for the reduction of lps-induced growth depression. |
2006-11-30 |
2023-08-12 |
mouse |
| Kevin J Harvatine, Dale E Bauma. SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA. The Journal of nutrition. vol 136. issue 10. 2006-10-27. PMID:16988111. |
srebp1 and thyroid hormone responsive spot 14 (s14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with cla. |
2006-10-27 |
2023-08-12 |
mouse |
| Kevin J Harvatine, Dale E Bauma. SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA. The Journal of nutrition. vol 136. issue 10. 2006-10-27. PMID:16988111. |
one of these inhibitory intermediates is trans-10, cis-12 conjugated linoleic acid (cla), and this milk fat depression (mfd) involves a coordinated decrease in mammary expression of lipogenic enzymes. |
2006-10-27 |
2023-08-12 |
mouse |
| J W Perfield, P Delmonte, A L Lock, M P Yurawecz, D E Bauma. Trans-10, trans-12 conjugated linoleic acid does not affect milk fat yield but reduces delta9-desaturase index in dairy cows. Journal of dairy science. vol 89. issue 7. 2006-09-20. PMID:16772575. |
trans-10, cis-12 conjugated linoleic acid (cla) is a potent inhibitor of milk fat synthesis, and the magnitude of milk fat depression is often correlated with the fat content of this isomer. |
2006-09-20 |
2023-08-12 |
Not clear |
| J A Bell, J M Griinari, J J Kennell. Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. Journal of dairy science. vol 89. issue 2. 2006-05-05. PMID:16428641. |
the addition of vitamin e to the diet partially prevented the depression in milk fat associated with oilseed feeding, but had no significant effect on the concentration of cla in milk. |
2006-05-05 |
2023-08-12 |
cattle |
| M J de Veth, S K Gulati, N D Luchini, D E Bauma. Comparison of calcium salts and formaldehyde-protected conjugated linoleic Acid in inducing milk fat depression. Journal of dairy science. vol 88. issue 5. 2005-06-30. PMID:15829659. |
our objective was to compare the efficacy of 2 forms of rumen-protected cla at inducing milk fat depression. |
2005-06-30 |
2023-08-12 |
Not clear |
| M J de Veth, S K Gulati, N D Luchini, D E Bauma. Comparison of calcium salts and formaldehyde-protected conjugated linoleic Acid in inducing milk fat depression. Journal of dairy science. vol 88. issue 5. 2005-06-30. PMID:15829659. |
overall, the extent of the reduction in milk fat yield indicates that both protection formulations are acceptable methods for the formulation of cla supplements to induce milk fat depression in lactating dairy cows. |
2005-06-30 |
2023-08-12 |
Not clear |
| C E Moore, H C Hafliger, O B Mendivil, S R Sanders, D E Bauman, L H Baumgar. Increasing amounts of conjugated linoleic acid progressively reduces milk fat synthesis immediately postpartum. Journal of dairy science. vol 87. issue 6. 2005-04-14. PMID:15453506. |
mixed conjugated linoleic acid (cla) isomers decrease milk fat synthesis during established lactation, but their ability to cause milk fat depression (mfd) immediately postpartum remains unclear. |
2005-04-14 |
2023-08-12 |
Not clear |
| Lai Changhua, Yin Jindong, Li Defa, Zhao Lidan, Qiao Shiyan, Xing Jianju. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. The Journal of nutrition. vol 135. issue 2. 2005-04-14. PMID:15671220. |
dietary cla alleviated growth depression and prevented the elevations in production and mrna expression of proinflammatory cytokines [i.e., interleukin (il)-6 and tumor necrosis factor (tnf)-alpha] induced by the lps challenge. |
2005-04-14 |
2023-08-12 |
Not clear |
| Daniel G Peterson, Elvina A Matitashvili, Dale E Bauma. The inhibitory effect of trans-10, cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1. The Journal of nutrition. vol 134. issue 10. 2004-11-08. PMID:15465741. |
the trans-10, cis-12 cla isomer has been causally related to milk fat depression in dairy cows, although no molecular mechanism has been established. |
2004-11-08 |
2023-08-12 |
cattle |
| S Viswanadha, J G Giesy, T W Hanson, M A McGuir. Dose response of milk fat to intravenous administration of the trans-10, cis-12 isomer of conjugated linoleic acid. Journal of dairy science. vol 86. issue 10. 2003-12-19. PMID:14594243. |
intravenous infusion of conjugated linoleic acid (cla) was evaluated as a simpler method than abomasal infusion and the feeding of calcium salts to examine milk fat depression. |
2003-12-19 |
2023-08-12 |
Not clear |
| Daniel G Peterson, Elvina A Matitashvili, Dale E Bauma. Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis. The Journal of nutrition. vol 133. issue 10. 2003-12-01. PMID:14519791. |
diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 cla in milk fat and coordinate suppression of mrna abundance for mammary enzymes involved in milk fat synthesis. |
2003-12-01 |
2023-08-12 |
Not clear |