| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Urrutia, Y Ying, K J Harvatin. The effect of conjugated linoleic acid, acetate, and their interaction on adipose tissue lipid metabolism in nonlactating cows. Journal of dairy science. vol 100. issue 6. 2018-05-02. PMID:28434739. |
however, the direct effect of trans-10,cis-12 conjugated linoleic acid (cla) and the indirect effect of spared nutrients on adipose tissue lipogenesis during milk fat depression is not clear. |
2018-05-02 |
2023-08-13 |
Not clear |
| E Ticiani, M Urio, R Ferreira, K J Harvatine, D E De Oliveir. Transcriptional regulation of acetyl-CoA carboxylase α isoforms in dairy ewes during conjugated linoleic acid induced milk fat depression. Animal : an international journal of animal bioscience. vol 10. issue 10. 2017-01-30. PMID:27113332. |
this study evaluated promoter-specific acc-α expression in mammary and adipose tissue of lactating cross-bred lacaune/texel ewes during milk fat depression induced by rumen-unprotected trans-10, cis-12 cla supplement. |
2017-01-30 |
2023-08-13 |
Not clear |
| Thomas C Jenkins, Kevin J Harvatin. Lipid feeding and milk fat depression. The Veterinary clinics of North America. Food animal practice. vol 30. issue 3. 2015-04-10. PMID:25239061. |
three specific cla intermediates of biohydrogenation have been shown to cause milk fat depression in dairy cattle through coordinated suppression of mammary lipogenic genes by a transcription factor that is a central regulator of lipid synthesis. |
2015-04-10 |
2023-08-13 |
cattle |
| Diwakar Vyas, Beverly B Teter, Pierluigi Delmonte, Richard A Erdma. Rosiglitazone, a PPAR-γ agonist, fails to attenuate CLA-induced milk fat depression and hepatic lipid accumulation in lactating mice. Lipids. vol 49. issue 7. 2015-03-06. PMID:24781388. |
overall, feeding cla to lactating mice induced milk fat depression and increased hepatic lipid accumulation, probably due to the presence of trans-10, cis-12 cla isomer, while rosi failed to significantly attenuate both hepatic steatosis and reduction in milk fat content. |
2015-03-06 |
2023-08-13 |
mouse |
| Rui Yang, Hongbo Zhang, Xiaoping Wu, Junle Yang, Mingyue Ma, Yanjun Gao, Hongsheng Liu, Shengbin L. Hypothalamus-anchored resting brain network changes before and after sertraline treatment in major depression. BioMed research international. vol 2014. 2014-11-21. PMID:24772438. |
after eight weeks of antidepressant treatment, patients with depression showed significantly increased connectivity between the hypothalamus and dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, insula, putamen, caudate, and claustrum. |
2014-11-21 |
2023-08-13 |
human |
| Kevin J Harvatine, Yves R Boisclair, Dale E Bauma. Liver x receptors stimulate lipogenesis in bovine mammary epithelial cell culture but do not appear to be involved in diet-induced milk fat depression in cows. Physiological reports. vol 2. issue 3. 2014-04-24. PMID:24760520. |
we have previously reported decreased mammary expression of sterol response element-binding protein 1 (srebp1), srebp1-activating proteins, and thyroid hormone-responsive spot 14 (s14) in the cow during diet-induced milk fat depression (mfd), and treatment with trans-10, cis-12 cla. |
2014-04-24 |
2023-08-13 |
cattle |
| M Baldin, M A S Gama, R Dresch, K J Harvatine, D E Oliveir. A rumen unprotected conjugated linoleic acid supplement inhibits milk fat synthesis and improves energy balance in lactating goats. Journal of animal science. vol 91. issue 7. 2014-02-19. PMID:23798520. |
feeding trans-10, cis-12 cla supplements in a rumen-protected form has been shown to cause milk fat depression (mfd) in cows, ewes, and goats. |
2014-02-19 |
2023-08-12 |
Not clear |
| Kristin Hötger, Harald M Hammon, Claudia Weber, Solvig Görs, Arnulf Tröscher, Rupert M Bruckmaier, Cornelia C Metge. Supplementation of conjugated linoleic acid in dairy cows reduces endogenous glucose production during early lactation. Journal of dairy science. vol 96. issue 4. 2013-09-23. PMID:23375968. |
trans-10,cis-12 conjugated linoleic acid (cla) supplementation causes milk fat depression in dairy cows, but cla effects on glucose metabolism are not clear. |
2013-09-23 |
2023-08-12 |
Not clear |
| A M O'Donnell-Megaro, J L Capper, W P Weiss, D E Bauma. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. Journal of dairy science. vol 95. issue 12. 2013-05-17. PMID:23063161. |
conjugated linoleic acid concentrations in milk fat can be markedly increased by dietary manipulation; however, high levels of cla are difficult to sustain as rumen biohydrogenation shifts and milk fat depression (mfd) is often induced. |
2013-05-17 |
2023-08-12 |
human |
| G Schlegel, R Ringseis, W Windisch, F J Schwarz, K Ede. Effects of a rumen-protected mixture of conjugated linoleic acids on hepatic expression of genes involved in lipid metabolism in dairy cows. Journal of dairy science. vol 95. issue 7. 2012-11-05. PMID:22720945. |
in conclusion, the present study shows that cla supplementation at a dose effective for milk fat depression does not induce adverse effects on hepatic lipid metabolism in dairy cows. |
2012-11-05 |
2023-08-12 |
Not clear |
| Q C Dang Van, M Focant, D Deswysen, E Mignolet, C Turu, J Pottier, E Froidmont, Y Larondell. Influence of an increase in diet structure on milk conjugated linoleic acid content of cows fed extruded linseed. Animal : an international journal of animal bioscience. vol 2. issue 10. 2012-10-02. PMID:22443913. |
this experiment studied the effect of a modest difference in diet structure value (sv) on milk conjugated linoleic acid (cla) contents of cows fed diets supplemented with extruded linseed, in situations where the diets provided enough sv and therefore did not induce milk fat depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| R Mohammed, J J Kennelly, J K G Kramer, K A Beauchemin, C S Stanton, J J Murph. Effect of grain type and processing method on rumen fermentation and milk rumenic acid production. Animal : an international journal of animal bioscience. vol 4. issue 8. 2012-10-02. PMID:22444662. |
variability in milk fat yield was strongly related (r2 = 0.55; p < 0.01) to total starch intake (45%) and milk c9t11-cla (10%) and none of the t-18:1 isomers or cla isomers that are typically associated with milk fat depression entered the model. |
2012-10-02 |
2023-08-12 |
Not clear |
| D E Oliveira, M A S Gama, D Fernandes, L O Tedeschi, D E Bauma. An unprotected conjugated linoleic acid supplement decreases milk production and secretion of milk components in grazing dairy ewes. Journal of dairy science. vol 95. issue 3. 2012-07-13. PMID:22365226. |
pronounced milk fat depression coupled with the deleterious effects on milk yield, milk scc, and secretion of all milk solids observed in ewes fed an unprotected cla supplement is likely to be associated with high doses of trans-10,cis-12 cla reaching the mammary gland, corroborating previous results obtained with dairy cows. |
2012-07-13 |
2023-08-12 |
Not clear |
| G Maxin, F Glasser, C Hurtaud, J L Peyraud, H Rulqui. Combined effects of trans-10,cis-12 conjugated linoleic acid, propionate, and acetate on milk fat yield and composition in dairy cows. Journal of dairy science. vol 94. issue 4. 2011-06-27. PMID:21426996. |
diets inducing milk fat depression (mfd) are known to alter ruminal lipid metabolism, leading to the formation of specific isomers [such as trans-10,cis-12 conjugated linoleic acid (cla)] that inhibit milk fat synthesis in lactating dairy cows. |
2011-06-27 |
2023-08-12 |
Not clear |
| P G Toral, P Frutos, G Hervás, P Gómez-Cortés, M Juárez, M A de la Fuent. Changes in milk fatty acid profile and animal performance in response to fish oil supplementation, alone or in combination with sunflower oil, in dairy ewes. Journal of dairy science. vol 93. issue 4. 2010-05-31. PMID:20338438. |
although the mechanisms involved in fo-induced milk fat depression are not yet well established, the observed increase in some milk trans-fa that are putative inhibitors of milk fat synthesis, such as trans-9,cis-11 cla, and the 63% decrease in c18:0 (consistent with the theory of reduced milk fat fluidity) may be involved. |
2010-05-31 |
2023-08-12 |
Not clear |
| Anil K G Kadegowda, Erin E Connor, Beverly B Teter, Joseph Sampugna, Pierluigi Delmonte, Liliana S Piperova, Richard A Erdma. Dietary trans fatty acid isomers differ in their effects on mammary lipid metabolism as well as lipogenic gene expression in lactating mice. The Journal of nutrition. vol 140. issue 5. 2010-05-04. PMID:20220207. |
dietary trans-7 18:1 could lead to milk fat depression in lactating mice, possibly through its desaturation product trans-7, cis-9 cla. |
2010-05-04 |
2023-08-12 |
mouse |
| M C Fuentes, S Calsamiglia, P W Cardozo, B Vlaeminc. Effect of pH and level of concentrate in the diet on the production of biohydrogenation intermediates in a dual-flow continuous culture. Journal of dairy science. vol 92. issue 9. 2009-11-30. PMID:19700707. |
milk fat depression in cows fed high-grain diets has been related to an increase in the concentration of trans-10 c(18:1) and trans-10,cis-12 conjugated linoleic acid (cla) in milk. |
2009-11-30 |
2023-08-12 |
Not clear |
| S X Chen, M Rovai, A L Lock, D E Bauman, T A Gipson, F Z Ren, S S Zen. Short communication: Effects of milk fat depression induced by a dietary supplement containing trans-10, cis-12 conjugated linoleic acid on properties of semi-hard goat cheese. Journal of dairy science. vol 92. issue 6. 2009-07-09. PMID:19447985. |
this study investigated effects of milk fat depression induced by dietary cla supplements on the properties of semi-hard goat cheese. |
2009-07-09 |
2023-08-12 |
Not clear |
| S X Chen, M Rovai, A L Lock, D E Bauman, T A Gipson, F Z Ren, S S Zen. Short communication: Effects of milk fat depression induced by a dietary supplement containing trans-10, cis-12 conjugated linoleic acid on properties of semi-hard goat cheese. Journal of dairy science. vol 92. issue 6. 2009-07-09. PMID:19447985. |
in conclusion, milk fat depression induced by a dietary cla supplement containing trans-10, cis-12 cla resulted in changes of fat-to-protein ratio in cheese milk and consequently affected properties of semi-hard goat cheese. |
2009-07-09 |
2023-08-12 |
Not clear |
| Alexandra Schmid, Marius Collomb, Giuseppe Bee, Ulrich Bütikofer, Daniel Wechsler, Pius Eberhard, Robert Siebe. Effect of dietary alpine butter rich in conjugated linoleic acid on milk fat composition of lactating sows. The British journal of nutrition. vol 100. issue 1. 2009-01-19. PMID:18279547. |
in summary, the findings show that adding alpine butter to the diet does not provoke a milk fat depression and does not alter the composition of total sfa, mufa and pufa in sow milk but increases its cla concentration. |
2009-01-19 |
2023-08-12 |
Not clear |