| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole R Silva, Shokouh Arjmand, Luana B Domingos, Adriano M Chaves-Filho, Melina Mottin, Caroline C Real, Anna L Waszkiewicz, Pedro H Gobira, Alessio Nicola Ferraro, Anne M Landau, Carolina H Andrade, Heidi K Müller, Gregers Wegener, Sâmia R L Joc. Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression. Pharmacological research. vol 211. 2024-12-15. PMID:39667543. |
s-ket (15 mg/kg) effects were assessed in rats exposed to the open field and forced swimming test (fst), followed by analysis of the ecb signaling in the rat prefrontal cortex (pfc), a brain region involved in depression neurobiology. |
2024-12-15 |
2024-12-21 |
rat |
| Hariom, Prerna Kumari, Sushma Chaturvedi, Sonika Shrivastav, Sushma Maratha, Vaibhav Wali. Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression. Pharmacology, biochemistry, and behavior. 2024-12-07. PMID:39644931. |
depression related behavior was determined using tail suspension test (tst) and forced swim test (fst) whereas for the determination of anxiety related behavior elevated plus maze (epm) test was used. |
2024-12-07 |
2024-12-10 |
mouse |
| Hürmet Küçükkatırcı Baykan, Neslihan Öner, Ayça Lekesizca. Effects of Krill Oil and Coconut Oil on Inflammatory Processes in Rats With Chronic Unpredictable Mild Stress-Induced Depression and Obesity Model. Journal of medicinal food. 2024-10-24. PMID:39446626. |
the open field test (oft), forced swimming test (fst), and sucrose preference test were performed at baseline, end of the depression induction, and dietary intervention to observe behavioral changes in rats. |
2024-10-24 |
2024-10-28 |
rat |
| Wenjia Liu, Xiaolin Zhong, Yan Yi, Lihua Xie, Wenyan Zhou, Wenyu Cao, Ling Che. Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis. Journal of agricultural and food chemistry. 2024-09-14. PMID:39276097. |
depression and anxiety-like behaviors were separately evaluated using a forced swimming test (fst), a tail suspension test (tst), a light-dark box test (ldbt), and an open field test (oft). |
2024-09-14 |
2024-09-17 |
mouse |
| V Kafetzopoulos, N Kokras, Filippos Katsaitis, N Sousa, H Leite-Almeida, I Sotiropoulos, C Dall. Prefrontal cortex-nucleus reuniens-hippocampus network exhibits sex-differentiated responses to stress and antidepressant treatment in rats. Psychopharmacology. 2024-08-20. PMID:39162717. |
we have recently shown that lesioning or inactivation of the nucleus reuniens (re), which interconnects the prefrontal cortex (pfc) and hippocampus, promoted resilience to stress in males, exerts an antidepressant effect in the forced swim test (fst) and prevents the development of behavioral and neurobiological alterations induced by the chronic mild stress model of depression. |
2024-08-20 |
2024-08-22 |
rat |
| Cuijie Shi, Zihan Qi, Chang Yang, Shuting Luo, Shihao Huang, Yixiao Lu. Shikonin ameliorates depressive- and anxiogenic-like behaviors in rats via the suppression of inflammation in the hippocampus. Neuroscience letters. 2024-07-12. PMID:38997082. |
second, chronic shikonin administration (10 mg/kg) reversed depressive- and anxiety-like behaviors in lps-induced and cums depression models, as shown in the sucrose preference test (spt), fst, epm, and novel object recognition test (nort). |
2024-07-12 |
2024-07-15 |
rat |
| Diksha, Lovedeep Sing. Glycitein prevents reserpine-induced depression and associated comorbidities in mice: modulation of lipid peroxidation and TNF-α levels. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-02. PMID:38430231. |
administration for the first 3 days induced depression and associated comorbidities as evidenced by increased immobility time in forced swim test (fst) and tail suspension test (tst), along with reduced locomotor activity in the open field test (oft) and increased latency to reach the platform in the morris water maze (mwm) test. |
2024-03-02 |
2024-03-04 |
mouse |
| Fayezeh Hosseini, Fatemeh Khakpai, Soheila Fazli-Tabaei, Mohammad Nasehi, Mohammad-Reza Zarrindas. Interaction between citalopram and omega-3 fatty acids on anxiety and depression behaviors and maintaining the stability of brain pyramidal neurons in mice. Neuroscience letters. 2024-02-15. PMID:38360146. |
elevated plus-maze (epm) and forced swimming test (fst) were used to assess anxiety and depression symptoms in non-restraint stress (nrs), acute restraint stress (ars), and chronic restraint stress (crs) mice. |
2024-02-15 |
2024-02-18 |
mouse |
| Hao Zhang, Mingqi Qiao, Dongmei Gao, Jieqiong Wang, Chunyan Sun, Ya Sun, Yang Zhang, Huayuan Liu, Zhen Zhang, Mingzhou Ga. Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus. Asian journal of psychiatry. vol 90. 2023-10-28. PMID:37898099. |
to reveal the exact changes of allopregnanolone-mediated γ-aminobutyric acid a receptor pathways and its specific therapeutic targets by shuyu capsule treating premenstrual depression, female wistar rat models of premenstrual depression was established by forced swimming test (fst). |
2023-10-28 |
2023-11-08 |
rat |
| Sadia Tabassam Arif, Muhammad Ayub Khan, Shahiq Uz Zaman, Hafiz Shoaib Sarwar, Abida Raza, Muhammad Sarfraz, Yousef A Bin Jardan, Muhammad Umair Amin, Muhammad Farhan Sohai. Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice. Pharmaceuticals (Basel, Switzerland). vol 16. issue 9. 2023-09-28. PMID:37765028. |
an improved antidepressant effect of lsp-nlcs on lps-induced depression showed an increase in swimming time (237 ± 51 s) and struggling time (226 ± 15 s) with a reduction in floating (123 ± 51 s) and immobility time (134 ± 15 s) in fst and tst. |
2023-09-28 |
2023-10-07 |
mouse |
| Hanan H Ahmed, Reham M Essam, Muhammed F El-Yamany, Kawkab A Ahmed, Ayman E El-Saha. Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats. Food & function. 2023-09-28. PMID:37767889. |
depression was evidenced by a reduced grooming time in the splash test and an increased immobility time in the tail suspension test (tst) and forced swimming test (fst). |
2023-09-28 |
2023-10-07 |
rat |
| Xin-Yuan Wu, Xiang Jin, Xiao-Ming Sheng, Yan Fan, Wei Gua. miR-204-5p plays a critical role in the pathogenesis of depression and anti-depression action of Venlafaxine in the hippocampus of mice. Current medicinal chemistry. 2023-06-26. PMID:37357509. |
method a chronic social defeat stress (csds) was initially adopted for establishing a mice model of depression in this research and depression-like behaviors were evaluated by a series of behavioral experiments including the sucrose preference test (spt), the tail suspension test (tst), the forced swim test (fst) and the social interaction test (sit). |
2023-06-26 |
2023-08-14 |
mouse |
| Mariam D Oduola-Akande, Ismail O Ishola, Taiwo G Olubodun-Obadun, Adeola J Akande, Olufunmilayo O Adeyem. Glimepiride Prevents 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Induced Dopamine Neurons Degeneration Through Attenuation of Glia Activation and Oxidative Stress in Mice. Neurotoxicity research. 2023-01-27. PMID:36705862. |
effect of glimepiride on motor activities were appraised with the use of open-field test and rotarod performance while non-motor activity was evaluated using force swim test (fst; depression) and y-maze test (working memory). |
2023-01-27 |
2023-08-14 |
mouse |
| Yan Zhuang, Runying Zeng, Xiao Liu, Longhe Yang, Zhuhua Cha. Neoagaro-Oligosaccharides Ameliorate Chronic Restraint Stress-Induced Depression by Increasing 5-HT and BDNF in the Brain and Remodeling the Gut Microbiota of Mice. Marine drugs. vol 20. issue 11. 2022-11-24. PMID:36422003. |
anxiety and depression behaviors were assessed by open field tests (oft) and forced swimming tests (fst), while interleukin 18 (il-18), 5-hydroxytryptamine (5-ht) and brain-derived neurotrophic factor (bdnf) were the molecular biomarkers of depression. |
2022-11-24 |
2023-08-14 |
mouse |
| Satya Kumar Avula, Ajmal Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Imran Khan, Rene Csuk, Biswanath Das, Ahmed Al-Harras. Synthesis and antidepressant-like effects of new 5-epi-incensole and 5-epi- incensole acetate in chronic unpredictable mild stress model of depression; behavioural and biochemical correlates. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411640. |
the resulting compounds were evaluated for their ability to ameliorate depressive symptoms in forced swim test (fst) and tail suspension test (tst) in chronic unpredictable mild stress (cums) induced depression paradigm. |
2022-11-22 |
2023-08-14 |
mouse |
| Zifan Ding, Longfei D. Swimming exercise ameliorates depressive-like behavior by anti-inflammation activity, rebalancing gut Escherichia coli and Lactobacilli. Brain research. 2022-10-04. PMID:36195262. |
major depressive disorder (mdd) is a common mental disease with high morbidity, recurrence and mortality and is a serious global health problem.aerobic exercise produces beneficial effects on depression and associated comorbidities.swimming exercise with high motor complexity may be particularly beneficial for patients with depression.we hypothesized that swimming exercise improves various types of depression-like behaviors and these effects are related to improved immune and inflammatory response by regulating microbiota-gut-brain axis.we established the lipopolysaccharides (lps)/ chronic unpredictable stress (cus) mice model of depression.the forced swimming test (fst) and tail suspension test (tst) were used as predictive animal models of antidepressant-like activity.swimming exercise significantly decreased the duration of immobility in fst and tst.we found that swimming exercise could significantly decrease the levels of pro-inflammatory cytokines in the central nervous system (cns). |
2022-10-04 |
2023-08-14 |
mouse |
| Lin-Sheng Shi, Chun-Hui Ji, Wen-Qian Tang, Yue Liu, Wei Zhang, Wei Gua. Hippocampal miR-124 participates in the pathogenesis of depression via regulating the expression of BDNF in a Chronic Social Defeat Stress model of depression. Current neurovascular research. 2022-07-15. PMID:35838216. |
methods in the study, we used the forced swim test (fst), the tail suspension test (tst), and a chronic social defeat stress (csds) mice model of depression. |
2022-07-15 |
2023-08-14 |
mouse |
| Yan Wang, Sixu Zhou, Xujiao Song, Shanshan Ding, Baogui Wang, Jiangfeng Wen, Chunlin Che. Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway. Neurochemical research. 2022-07-08. PMID:35804209. |
the depression model was established by chronic unpredictable mild stress (cums), and its antidepressant effect was estimated by open field test (oft), forced swimming test (fst), and tail suspension test (tst). |
2022-07-08 |
2023-08-14 |
mouse |
| Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harras. Incensole derivatives from frankincense: Isolation, enhancement, synthetic modification, and a plausible mechanism of their anti-depression activity. Bioorganic chemistry. vol 126. 2022-06-07. PMID:35671644. |
demonstrated promising anti-depression activities in classical mouse models of depression of fst and tst. |
2022-06-07 |
2023-08-14 |
mouse |
| Xin Liang, Jing Tang, Ying-Qiang Qi, Yan-Min Luo, Chun-Mao Yang, Xiao-Yun Dou, Lin Jiang, Qian Xiao, Lei Zhang, Feng-Lei Chao, Chun-Ni Zhou, Yong Tan. Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model. Experimental neurology. 2022-05-07. PMID:35525307. |
the sucrose preference test (spt), the forced swimming test (fst), the tail suspension test (tst), immunohistochemistry, immunofluorescence and stereological analyses were used to clarify the difference in therapeutic efficacy and mechanism between exercise and fluoxetine in the treatment of depression. |
2022-05-07 |
2023-08-13 |
mouse |