| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditi Halder, Eleanor Drummon. Strategies for translating proteomics discoveries into drug discovery for dementia. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488854. |
tauopathies, diseases characterized by neuropathological aggregates of tau including alzheimer's disease and subtypes of frontotemporal dementia, make up the vast majority of dementia cases. |
2023-07-25 |
2023-08-14 |
Not clear |
| S B Wharton, J E Simpson, P G Ince, C D Richardson, R Merrick, F E Matthews, C Brayn. Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies. Neuropathology and applied neurobiology. 2023-07-18. PMID:37462105. |
furthermore, additional pathologies such as limbic-predominant age related tdp-43 encephalopathy, ageing related tau astrogliopathy and primary age-related tauopathies contribute to late-life dementia. |
2023-07-18 |
2023-08-14 |
Not clear |
| Corinne Quadalti, Sebastian Palmqvist, Sara Hall, Marcello Rossi, Angela Mammana, Shorena Janelidze, Sofia Dellavalle, Niklas Mattsson-Carlgren, Simone Baiardi, Erik Stomrud, Oskar Hansson, Piero Parch. Clinical effects of Lewy body pathology in cognitively impaired individuals. Nature medicine. 2023-07-18. PMID:37464058. |
lb pathology was also associated with faster longitudinal decline in all examined cognitive functions, independent of amyloid-β, tau, cognitive stage and a baseline diagnosis of dementia with lewy bodies/parkinson's disease. |
2023-07-18 |
2023-08-14 |
Not clear |
| Karthivashan Govindarajan, Satyabrata Ka. Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of alzheimer's disease. Journal of nanobiotechnology. vol 21. issue 1. 2023-07-09. PMID:37424018. |
evidence suggests that increased level/aggregation of β-amyloid (aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of alzheimer's disease (ad), the leading cause of dementia in the elderly. |
2023-07-09 |
2023-08-14 |
mouse |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
her amnestic symptoms that were suggestive of alzheimer's type dementia are best explained by diffuse agd and medial temporal tdp-43 proteinopathy, and her motor symptoms were likely explained by neuronal loss and gliosis due to tau pathology in the substantia nigra. |
2023-07-06 |
2023-08-14 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Conceição Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
however, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in alzheimer's disease (ad), inclusions of hyperphosphorylated microtubule-binding tau in ad and other tauopathies, or inclusions containing α-synuclein in parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2023-06-29 |
2023-08-14 |
Not clear |
| Rachel Keszycki, Allegra Kawles, Grace Minogue, Antonia Zouridakis, Alyssa Macomber, Nathan Gill, My Vu, Hui Zhang, Christina Coventry, Emily Rogalski, Sandra Weintraub, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct and shared neuropsychiatric phenotypes in FTLD-tauopathies. Frontiers in aging neuroscience. vol 15. 2023-06-27. PMID:37358954. |
frontotemporal lobar degeneration (ftld) with tau pathology (ftld-tau) commonly causes dementia syndromes that include primary progressive aphasia (ppa) and behavioral variant frontotemporal dementia (bvftd). |
2023-06-27 |
2023-08-14 |
human |
| J Therriault, S Gauthier, P Rosa-Net. Adding the Topographical Information from Tau-PET to the A/T/(N) Framework: Steps Towards Staging AD in Vivo. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357279. |
while amyloid-β accumulation begins decades before the onset of clinical dementia in ad, tau pathology is more closely associated in both space and time to neurodegeneration and to clinical dysfunction. |
2023-06-25 |
2023-08-14 |
Not clear |
| Martina Sola, Azucena Rendon-Angel, Viviana Rojo Martinez, Jacopo Sgrignani, Claudia Magrin, Ester Piovesana, Andrea Cavalli, Paolo Paganetti, Stéphanie Papi. Tau protein binds to the P53 E3 ubiquitin ligase MDM2. Scientific reports. vol 13. issue 1. 2023-06-23. PMID:37353565. |
tau gene mutations cause a progressive dementia and neurotoxic tau forms deposited in neurofibrillary tangles are hallmarks of neurodegenerative tauopathies. |
2023-06-23 |
2023-08-14 |
Not clear |
| Daniela Melchiorri, Sara Merlo, Benjamin Micallef, John-Joseph Borg, František Dráf. Alzheimer's disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy? Frontiers in pharmacology. vol 14. 2023-06-19. PMID:37332353. |
ad, a devastating neurodegenerative pathology leading to dementia and death, is characterized by two pathological hallmarks, the extracellular deposits of amyloid beta (aβ) and the intraneuronal deposits of neurofibrillary tangles (nfts) consisting of altered hyperphosphorylated tau protein. |
2023-06-19 |
2023-08-14 |
Not clear |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
to further understand the relationships of peripheral tissues to ad, we utilized biochemical methods to evaluate protein levels of total tau and phosphorylated tau (p-tau) as well as other neuronal proteins (i.e., tyrosine hydroxylase (th), neurofilament heavy chain (nf-h), and microtubule-associated protein 2 (map2)) in the submandibular gland and frontal cortex of human cases across different clinicopathological stages of ad (n = 3 criteria not met or low, n = 6 intermediate, and n = 9 high likelihood that dementia is due to ad based on national institute on aging-reagan criteria). |
2023-06-17 |
2023-08-14 |
human |
| Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik, Daniel R Southworth, Jason E Gestwick. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of molecular biology. 2023-06-17. PMID:37330289. |
hyper-phosphorylated tau accumulates as insoluble fibrils in alzheimer's disease (ad) and related dementias. |
2023-06-17 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Neuropathology of the Alzheimer's continuum: an update. Free neuropathology. vol 1. 2023-06-07. PMID:37283686. |
alzheimer's disease (ad), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). |
2023-06-07 |
2023-08-14 |
Not clear |
| Deborah N Schoonhoven, Emma M Coomans, Ana P Millán, Anne M van Nifterick, Denise Visser, Rik Ossenkoppele, Hayel Tuncel, Wiesje M van der Flier, Sandeep S V Golla, Philip Scheltens, Arjan Hillebrand, Bart N M van Berckel, Cornelis J Stam, Alida A Gou. Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study. Brain : a journal of neurology. 2023-06-06. PMID:37279597. |
prediction accuracy declined for the mci and ad dementia stages, although the correlation between modelled tau and tau-pet binding remained highest for the functional networks (c=0.384; c=0.376). |
2023-06-06 |
2023-08-14 |
human |
| Lin Sun, Jie Zhang, Wei Li, Jianhua Sheng, Shifu Xia. Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia. BMC medicine. vol 21. issue 1. 2023-06-06. PMID:37280592. |
neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia. |
2023-06-06 |
2023-08-14 |
Not clear |
| Kai Sin Chin, Leonid Churilov, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Nawaf Yassi, Rosie Watso. Tau in dementia with Lewy bodies. The Australian and New Zealand journal of psychiatry. 2023-06-02. PMID:37264610. |
tau in dementia with lewy bodies. |
2023-06-02 |
2023-08-14 |
Not clear |
| Kai Sin Chin, Leonid Churilov, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Nawaf Yassi, Rosie Watso. Tau in dementia with Lewy bodies. The Australian and New Zealand journal of psychiatry. 2023-06-02. PMID:37264610. |
this study aimed to investigate tau in people with dementia with lewy bodies using a second-generation tau positron emission tomography tracer as well as plasma p-tau181. |
2023-06-02 |
2023-08-14 |
Not clear |
| Zhourui Wu, Ran Zhu, Yan Yu, Jianjie Wang, Xiao Hu, Wei Xu, Yilong Ren, Chen Li, Zhili Zeng, Bin Ma, Ning Xie, Gufa Lin, Bei Ma, Rongrong Zhu, Keqiang Ye, Liming Chen. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Progress in neurobiology. 2023-05-31. PMID:37257680. |
asparagine endopeptidase (aep) mediated dementia by enhancing amyloid plaque and tau hyperphosphorylation, indicating that it played an important role in neurodegeneration. |
2023-05-31 |
2023-08-14 |
mouse |
| Brian Sheng Yep Yeo, Jin Hean Koh, Adele Chin Wei Ng, Shaun Loh, Anna See, Dennis Chuen Chai Seow, Song Tar To. The association of obstructive sleep apnea with blood and cerebrospinal fluid biomarkers of Alzheimer's dementia - A systematic review and meta-analysis. Sleep medicine reviews. vol 70. 2023-05-28. PMID:37245474. |
alzheimer's disease (ad) is the most common type of dementia and is characterized by the aggregation of extracellular amyloid-beta and intracellular hyperphosphorylation of tau proteins. |
2023-05-28 |
2023-08-14 |
Not clear |
| Hidekazu Hiroak. Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges. Biophysics and physicobiology. vol 20. issue 1. 2023-05-26. PMID:37234855. |
there are two major hypotheses for the pathogenesis of alzheimer's dementia: the β-amyloid (aβ) hypothesis and the tau hypothesis. |
2023-05-26 |
2023-08-14 |
Not clear |