| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng, Bo-Ram Mun, Won-Seok Choi, Kyung-Hwa Lee, Hyun-Sun Park, Duc Tien Nguyen, Min-Cheol Lee, Kwangjoon Jeong, Jin Hai Zheng, Young Kim, Shee Eun Lee, Joon Haeng Rhe. Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers. NPJ vaccines. vol 9. issue 1. 2024-06-15. PMID:38879560. |
alzheimer's disease (ad) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in neurofibrillary degeneration and dementia. |
2024-06-15 |
2024-06-18 |
mouse |
| Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta neuropathologica communications. vol 12. issue 1. 2024-06-13. PMID:38867338. |
this dementia is attributed to the increased gene dosage of the amyloid-β (aβ) precursor protein gene, the formation of self-propagating aβ and tau prion conformers, and the deposition of neurotoxic aβ plaques and tau neurofibrillary tangles. |
2024-06-13 |
2024-06-15 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta neuropathologica communications. vol 12. issue 1. 2024-06-13. PMID:38867338. |
samples from the youngest individual with no documented dementia had sparse tau deposits. |
2024-06-13 |
2024-06-15 |
Not clear |
| Colin Groot, Ruben Smith, Lyduine E Collij, Sophie E Mastenbroek, Erik Stomrud, Alexa Pichet Binette, Antoine Leuzy, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Olof Strandberg, Hanna Cho, Chul Hyoung Lyoo, Giovanni B Frisoni, Debora E Peretti, Valentina Garibotto, Renaud La Joie, David N Soleimani-Meigooni, Gil Rabinovici, Rik Ossenkoppele, Oskar Hansso. Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment. JAMA neurology. 2024-06-10. PMID:38857029. |
tau positron emission tomography for predicting dementia in individuals with mild cognitive impairment. |
2024-06-10 |
2024-06-14 |
Not clear |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including alzheimer's disease (ad), lewy body dementia (lbd), chronic traumatic encephalopathy (cte), and frontotemporal dementia (ftd). |
2024-06-10 |
2024-06-14 |
rat |
| Tabea M Soelter, Timothy C Howton, Amanda D Clark, Vishal H Oza, Brittany N Lasseign. Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq. Cell communication and signaling : CCS. vol 22. issue 1. 2024-06-08. PMID:38849813. |
alzheimer's disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. |
2024-06-08 |
2024-06-10 |
Not clear |
| Shan Luo, Yifei Wang, Tatsuhiro Hisatsun. P2Y1 receptor in Alzheimer's disease. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819047. |
alzheimer's disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau. |
2024-06-06 |
2024-06-08 |
Not clear |
| Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. |
alzheimer disease (ad) copathologies of β-amyloid and tau are common in the lewy body diseases (lbd), dementia with lewy bodies (dlb) and parkinson disease (pd), and target distinct hippocampal subfields compared with lewy pathology, including subiculum and ca1. |
2024-05-30 |
2024-07-16 |
Not clear |
| Magdalena Pszczołowska, Kamil Walczak, Weronika Miśków, Magdalena Mroziak, Gracjan Kozłowski, Jan Aleksander Beszłej, Jerzy Lesze. Association between Female Reproductive Factors and Risk of Dementia. Journal of clinical medicine. vol 13. issue 10. 2024-05-25. PMID:38792524. |
using hormonal contraception can result in decreased risk of dementia as estrogen stimulates microglia-related aβ removal and reduces tau hyperphosphorylation. |
2024-05-25 |
2024-05-27 |
Not clear |
| Chao Qi, Sofia Lövestam, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Marika Bogdani, Caitlin Latimer, Jill R Murrell, Patrick W Cullinane, Zane Jaunmuktane, Thomas D Bird, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments with the Alzheimer fold in cases with bioRxiv : the preprint server for biology. 2024-05-24. PMID:38746388. |
tau filaments with the alzheimer fold in cases with frontotemporal dementia (ftd) and alzheimer's disease are the most common forms of early-onset dementia. |
2024-05-24 |
2024-05-27 |
Not clear |
| Graham Andrew Mackay, Claire Gall, Ravi Jampana, Carolyn Sleith, Gregory Li. Scottish Intercollegiate Guidelines Network (SIGN) Guidance on Dementia. The investigation of suspected dementia (SIGN 168) with focus on biomarkers. Thrombosis and haemostasis. 2024-05-24. PMID:38788775. |
the evidence review supports consideration of the use of structural imaging, nuclear medicine imaging and established alzheimer's cerebrospinal fluid (csf) biomarkers (amyloid and tau) in the diagnosis of dementia. |
2024-05-24 |
2024-05-27 |
Not clear |
| Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Lídia Vaqué-Alcázar, Laura Videla, Juan Domingo Gispert, Marc Suárez-Calvet, Sterling C Johnson, Reisa Sperling, Alexandre Bejanin, Alberto Lleó, Víctor Monta. APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease. Nature medicine. vol 30. issue 5. 2024-05-21. PMID:38710950. |
however, in the dementia stage, there were no differences in amyloid or tau positron emission tomography across haplotypes, despite earlier clinical and biomarker changes. |
2024-05-21 |
2024-05-27 |
Not clear |
| Stephanie Barsoum, Caitlin S Latimer, Amber L Nolan, Alexander Barrett, Koping Chang, Juan Troncoso, C Dirk Keene, Dan Benjamin. Resiliency to Alzheimer's disease neuropathology can be distinguished from dementia using cortical astrogliosis imaging. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766087. |
despite the presence of significant alzheimer's disease (ad) pathology, characterized by amyloid β (aβ) plaques and phosphorylated tau (ptau) tangles, some cognitively normal elderly individuals do not inevitably develop dementia. |
2024-05-20 |
2024-05-27 |
human |
| Hasi Huhe, Sarah M Shapley, Duc Duong, Fang Wu, Seung-Kwon Ha, Sang-Ho Choi, Julia Kofler, Yongshan Mou, Thais Rafael Guimaraes, Amantha Thathiah, Lauren K H Schaeffer, Gregory W Carter, Nicholas T Seyfried, Afonso C Silva, Stacey J Sukoff Rizz. Marmosets as model systems for the study of Alzheimer's disease and related dementias: substantiation of physiological Tau 3R and 4R isoform expression and phosphorylation. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746277. |
marmosets as model systems for the study of alzheimer's disease and related dementias: substantiation of physiological tau 3r and 4r isoform expression and phosphorylation. |
2024-05-15 |
2024-05-27 |
marmoset |
| Farida Dakterzada, Raffaela Cipriani, Ricard López-Ortega, Alfonso Arias, Iolanda Riba-Llena, Maria Ruiz-Julián, Raquel Huerto, Nuria Tahan, Carlos Matute, Estibaliz Capetillo-Zarate, Gerard Piñol-Ripol. Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731812. |
we quantified the plasma levels of amyloid beta 42 (aβ42), aβ40, phosphorylated tau (ptau181), and total tau biomarkers in 81 patients with mild cognitive impairment (mci), 30 with ad, and 16 with non-ad dementia. |
2024-05-11 |
2024-05-27 |
Not clear |
| Mohit Kumar, Sharma Anita Ashok, Ashok Kumar Datusalia, Gopal L Khati. PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). 2024-05-10. PMID:38726789. |
alzheimer's disease (ad) is a neurodegenerative disease leading to dementia because of complex phathomechanisms like amyloid β (aβ) aggregation, tau aggregates, and neurofibrillary tangles. |
2024-05-10 |
2024-05-27 |
human |
| T M Axelsen, P Høgh, A R Bihlet, M A Karsdal, K Henriksen, S G Hasselbalch, A H Simonse. Serum Tau-A and Tau-C Levels and Their Association with Cognitive Impairment and Dementia Progression in a Memory Clinic Derived Cohort. The journal of prevention of Alzheimer's disease. vol 11. issue 3. 2024-05-06. PMID:38706289. |
serum-measured fragments of tau cleaved by adam-10 (tau-a) and caspase-3 (tau-c) have been found linked to change in cognitive function and risk of dementia. |
2024-05-06 |
2024-05-08 |
Not clear |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
tau pathology and its spatial propagation in alzheimer's disease (ad) play crucial roles in the neurodegenerative cascade leading to dementia. |
2024-05-04 |
2024-05-07 |
human |
| Walter Ángel Trujillo-Rangel, Sofía Acuña-Vaca, Danna Jocelyn Padilla-Ponce, Florencia Guillermina García-Mercado, Blanca Miriam Torres-Mendoza, Fermín P Pacheco-Moises, Martha Escoto-Delgadillo, Leonel García-Benavides, Daniela L C Delgado-Lar. Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673986. |
additionally, oxidative stress in vascular dementia can arise from ischemia-reperfusion injury, amyloid-beta production, the abnormal phosphorylation of tau protein, and alterations in neurotransmitters, among others. |
2024-04-27 |
2024-04-29 |
Not clear |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
this cohort study included a total of 601 individuals from the wisconsin registry for alzheimer's prevention and wisconsin alzheimer's disease research center that underwent amyloid and tau pet, longitudinal neuropsychological assessments, and met clinical criteria for three clinical diagnosis groups: cognitively unimpaired (cu; n=537); mild cognitive impairment (mci; n=48); or dementia (n=16)). |
2024-04-26 |
2024-04-28 |
human |