| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Munehisa Maeshiba, Hiroshi Kajiya, Takashi Tsutsumi, Keisuke Migita, Kazuko Goto-T, Yuri Kono, Takashi Tsuzuki, Jun Ohn. Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules. Biochemical and biophysical research communications. vol 594. 2022-01-25. PMID:35078110. |
occlusal disharmony-induced interleukin-1β expression may contribute to accumulation of cognitive suppressor molecules such as amyloid-β and phosphorylated tau and activate their clearance proteins, resulting in protection against transient dementia in young but not older individuals. |
2022-01-25 |
2023-08-13 |
mouse |
| Rebecca L Miller, Dhruva D Dhavale, Jennifer Y O'Shea, Kristin M Andruska, Jialu Liu, Erin E Franklin, Chandana Buddhala, Susan K Loftin, John R Cirrito, Richard J Perrin, Nigel J Cairns, Meghan C Campbell, Joel S Perlmutter, Paul T Kotzbaue. Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia. Annals of clinical and translational neurology. 2022-01-21. PMID:35060360. |
quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia. |
2022-01-21 |
2023-08-13 |
Not clear |
| Gloria S Benson, Chris Bauer, Lucrezia Hausner, Samuel Couturier, Piotr Lewczuk, Oliver Peters, Michael Hüll, Holger Jahn, Frank Jessen, Johannes Pantel, Stefan J Teipel, Michael Wagner, Johannes Schuchhardt, Jens Wiltfang, Johannes Kornhuber, Lutz Frölic. Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network. Journal of neural transmission (Vienna, Austria : 1996). 2022-01-21. PMID:35061102. |
don't forget about tau: the effects of apoe4 genotype on alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the dementia competence network. |
2022-01-21 |
2023-08-13 |
human |
| Ruiqing Ni, Roger M Nitsc. Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia. Frontiers in aging neuroscience. vol 13. 2022-01-20. PMID:35046791. |
there is currently still a gap in specific 4-repeat tau imaging probes for 4-repeat tauopathies and α-synuclein imaging probes for parkinson's disease and dementia with lewy body. |
2022-01-20 |
2023-08-13 |
Not clear |
| Ruiqing Ni, Roger M Nitsc. Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia. Frontiers in aging neuroscience. vol 13. 2022-01-20. PMID:35046791. |
in this review, we focused on recent development in molecular imaging biomarkers for assisting the early diagnosis of proteinopathies (i.e., amyloid-β, tau, and α-synuclein) in dementia and discussed future perspectives. |
2022-01-20 |
2023-08-13 |
Not clear |
| Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue La. Zeaxanthin Attenuates the Vicious Circle Between Endoplasmic Reticulum Stress and Tau Phosphorylation: Involvement of GSK-3β Activation. Journal of Alzheimer's disease : JAD. 2022-01-17. PMID:35034906. |
alzheimer's disease (ad) characterized by neurofibrillary tangles caused by hyperphosphorylated tau is the most common cause of dementia. |
2022-01-17 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008731. |
data indicate that amyloid and tau protein, derived from brain tissue and blood due to increased permeability of the blood-brain barrier after ischemia, play a key role in post-ischemic neurodegeneration of the hippocampus, with concomitant development of full-blown dementia. |
2022-01-11 |
2023-08-13 |
Not clear |
| Qi Wang, Kewei Chen, Yi Su, Eric M Reiman, Joel T Dudley, Benjamin Readhea. Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease. Brain communications. vol 4. issue 1. 2022-01-07. PMID:34993477. |
here, we use a deep learning method to analyse rna-seq data from 1114 brain donors from the accelerating medicines project for alzheimer's disease consortium to characterize post-mortem brain transcriptome signatures associated with amyloid-β plaque, tau neurofibrillary tangles and clinical severity in multiple alzheimer's disease dementia populations. |
2022-01-07 |
2023-08-13 |
Not clear |
| Miguel Minaya, Rita Martinez, Abdallah Eteleeb, Carlos Cruchaga, Oscar Harari, Celeste M Karc. Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient-derived pluripotent cell models. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971166. |
mutations in the microtubule-associated protein tau (mapt) cause heterogeneous forms of frontotemporal lobar dementia with tau inclusions (ftld-tau). |
2021-12-31 |
2023-08-13 |
Not clear |
| Sushma, Amal Chandra Monda. Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes. CNS & neurological disorders drug targets. 2021-12-29. PMID:34963438. |
these proteins are amyloid-β peptide, tau, α-synuclein, and mhtt, which cause alzheimer's disease, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, parkinson's disease, multiple system atrophy, dementia with lewy-body and huntington's disease. |
2021-12-29 |
2023-08-13 |
Not clear |
| Jozsef Gal, Yuriko Katsumata, Haining Zhu, Sukanya Srinivasan, Jing Chen, Lance Allen Johnson, Wang-Xia Wang, Lesley Renee Golden, Donna M Wilcock, Gregory A Jicha, Matthew D Cykowski, Peter Tobias Nelso. Apolipoprotein E proteinopathy is a major dementia-associated pathologic biomarker in individuals with or without the APOE epsilon 4 allele. The American journal of pathology. 2021-12-26. PMID:34954207. |
among all detected peptides, apolipoprotein e (apoe) stood out: even more than the expected tau, app/aβ, and α-synuclein peptides, apoe peptides were strongly enriched in dementia cases - including from individuals lacking the apoe ε4 genotype. |
2021-12-26 |
2023-08-13 |
human |
| Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996). 2021-12-17. PMID:34919190. |
alzheimer's disease (ad), the most common form of dementia worldwide, is a mixed proteinopathy (β-amyloid, tau and other proteins). |
2021-12-17 |
2023-08-13 |
Not clear |
| Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996). 2021-12-17. PMID:34919190. |
its morphological hallmarks are extracellular β-amyloid (amyloid plaques) and intraneuronal tau aggregates forming neurofibrillary tangles and neurites, vascular amyloid deposits (cerebral amyloid angiopathy), synapse and neuronal loss as well as neuroinflammation and reactive astrogliosis, leading to cerebral atrophy and progressive mental/cognitive impairment (dementia). |
2021-12-17 |
2023-08-13 |
Not clear |
| Allan I Levey, Deqiang Qiu, Liping Zhao, William T Hu, Duc M Duong, Lenora Higginbotham, Eric B Dammer, Nicholas T Seyfried, Thomas S Wingo, Chadwick M Hales, Malú Gámez Tansey, David S Goldstein, Anees Abrol, Vince D Calhoun, Felicia C Goldstein, Ihab Hajjar, Anne M Fagan, Doug Galasko, Steven D Edland, John Hanfelt, James J Lah, David Weinshenke. A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment. Brain : a journal of neurology. 2021-12-17. PMID:34919634. |
the locus coeruleus (lc) is the initial site of alzheimer's disease neuropathology, with hyperphosphorylated tau appearing in early adulthood followed by neurodegeneration in dementia. |
2021-12-17 |
2023-08-13 |
human |
| Cecilia S Lee, Caitlin S Latimer, Jonathan C Henriksen, Marian Blazes, Eric B Larson, Paul K Crane, C Dirk Keene, Aaron Y Le. Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain pathology (Zurich, Switzerland). vol 31. issue 6. 2021-12-11. PMID:34009663. |
we have previously reported lower neocortical levels of hyperphosphorylated tau (ptau) and less limbic-predominant age-related tdp-43 encephalopathy neuropathologic change (late-nc) in the resilient participants compared to those with dementia and similar adnc as determined by current nia-aa recommendations using traditional semi-quantitative assessments of amyloid β and pathological tau burden. |
2021-12-11 |
2023-08-13 |
human |
| Alby Elias, Christopher Rowe, Malcolm Hopwoo. Risk of Dementia in Posttraumatic Stress Disorder. Journal of geriatric psychiatry and neurology. vol 34. issue 6. 2021-12-10. PMID:32912067. |
laboratory studies reported the accelerated formation of β-amyloid and tau, which represent the primary pathology of alzheimer's dementia in animal models of ptsd. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
tau biomarkers in dementia: positron emission tomography radiopharmaceuticals in tauopathy assessment and future perspective. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
abnormal accumulation of tau protein is closely associated with neurodegeneration and cognitive impairment and it is a biomarker of neurodegeneration in the dementia field, especially in alzheimer's disease (ad); therefore, it is crucial to be able to assess the tau deposits in vivo. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
in recent years, several first-generation tau pet tracers have been developed and applied in the dementia field. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
we also describe the distribution patterns of tau tracers in ad, in atypical ad, and further neurodegenerative diseases in the dementia field. |
2021-12-10 |
2023-08-13 |
Not clear |