| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard J Nuovo, David Suster, Dwitiya Sawant, Aditi Mishra, Jean-Jacques Michaille, Esmerina Til. The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection. Annals of diagnostic pathology. vol 61. 2022-11-05. PMID:36334414. |
in covid-19 tissues from people with dementia the widespread spike-induced microencephalitis with the concomitant microglial activation co-existed in the same areas where neurons had hyperphosphorylated tau protein suggesting that the already dysfunctional neurons were additionally stressed by the sars-cov2 induced microangiopathy. |
2022-11-05 |
2023-08-14 |
human |
| Gerard J Nuovo, David Suster, Dwitiya Sawant, Aditi Mishra, Jean-Jacques Michaille, Esmerina Til. The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection. Annals of diagnostic pathology. vol 61. 2022-11-05. PMID:36334414. |
it is concluded that fatal covid-19 induces a diffuse microencephalitis and microglial activation in the brain due to endocytosis of circulating viral spike protein that amplifies pre-existing dementia in at least two ways: 1) modulates the expression of proteins that may worsen alzheimer's disease and 2) stresses the already dysfunctional neurons by causing an acute proinflammatory/hypercoagulable/hypoxic microenvironment in areas with abundant hyperphosphorylated tau protein and/or βa-42. |
2022-11-05 |
2023-08-14 |
human |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
abnormalities in tau, aβ, and microglial activation are frequently observed in dementia patients and indicate that these elements may work in concert to cause cognitive impairment. |
2022-10-27 |
2023-08-14 |
human |
| Ramón Martínez-Mármol, Christopher Small, Anmin Jiang, Tishila Palliyaguru, Tristan P Wallis, Rachel S Gormal, Jean-Baptiste Sibarita, Jürgen Götz, Frédéric A Meunie. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular psychiatry. 2022-10-18. PMID:36258016. |
postsynaptic enrichment of fyn underpins synaptotoxicity in dementias such as alzheimer's disease and frontotemporal lobar degeneration with tau pathology (ftld-tau). |
2022-10-18 |
2023-08-14 |
Not clear |
| Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Wenshi Wei, Hiroaki Adach. CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-10-17. PMID:36253408. |
csf gap-43 was associated with a clinical diagnosis of ad dementia and with an individual's tau status, cognitive measurements and findings from neuroimaging. |
2022-10-17 |
2023-08-14 |
human |
| Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G Safa. Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias. Cells. vol 11. issue 19. 2022-10-14. PMID:36230957. |
populations of tau conformers drive prion-like strain effects in alzheimer's disease and related dementias. |
2022-10-14 |
2023-08-14 |
human |
| Ihab Hajjar, Zhiyi Yang, Maureen Okafor, Chang Liu, Teresa Waligorska, Felicia C Goldstein, Leslie M Sha. Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors. JAMA network open. vol 5. issue 10. 2022-10-06. PMID:36201209. |
differences in cerebrospinal fluid (csf) tau alzheimer dementia (ad) biomarkers by self-identified race have been observed in prior studies. |
2022-10-06 |
2023-08-14 |
Not clear |
| Qinghui Zhang, Jia Li, Wei Quan, Li Liu, Yidan Qin, Xiaochen Pei, Hang Su, Jing Xu, Jiajun Che. CSF α-Synuclein and Tau as Biomarkers for Dementia With Lewy Bodies: A Systematic Review and Meta-analysis. Alzheimer disease and associated disorders. 2022-10-02. PMID:36183420. |
csf α-synuclein and tau as biomarkers for dementia with lewy bodies: a systematic review and meta-analysis. |
2022-10-02 |
2023-08-14 |
Not clear |
| Qinghui Zhang, Jia Li, Wei Quan, Li Liu, Yidan Qin, Xiaochen Pei, Hang Su, Jing Xu, Jiajun Che. CSF α-Synuclein and Tau as Biomarkers for Dementia With Lewy Bodies: A Systematic Review and Meta-analysis. Alzheimer disease and associated disorders. 2022-10-02. PMID:36183420. |
this study investigated whether α-synuclein and tau in cerebrospinal fluid (csf) can be used as biomarkers to diagnose dementia with lewy bodies (dlb). |
2022-10-02 |
2023-08-14 |
Not clear |
| Jinho Kim, ShinWoo Kang, Keun-A Chan. Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142509. |
alzheimer's disease (ad) is a form of dementia associated with abnormal glucose metabolism resulting from amyloid-beta (aβ) plaques and intracellular neurofibrillary tau protein tangles. |
2022-09-23 |
2023-08-14 |
mouse |
| Zachary Valiukas, Ramya Ephraim, Kathy Tangalakis, Majid Davidson, Vasso Apostolopoulos, Jack Feeha. Immunotherapies for Alzheimer's Disease-A Review. Vaccines. vol 10. issue 9. 2022-09-23. PMID:36146605. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder that falls under the umbrella of dementia and is characterised by the presence of highly neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein within the brain. |
2022-09-23 |
2023-08-14 |
Not clear |
| Gary A Rosenber. Willis Lecture: Biomarkers for Inflammatory White Matter Injury in Binswanger Disease Provide Pathways to Precision Medicine. Stroke. 2022-09-23. PMID:36148658. |
it is possible to diagnose mixed dementia before autopsy with biomarkers for vascular disease derived from diffusor tensor images on magnetic resonance imaging and alzheimer disease proteins, aβ (amyloid β), and phosphorylated tau, in cerebrospinal fluid or in brain with positron emission tomography. |
2022-09-23 |
2023-08-14 |
Not clear |
| Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. |
in this study, cerebrospinal fluid (csf) concentration of aqp4, amyloid-β, total tau and p-tau were determined in 103 csf samples from patients affected by neurodegenerative dementias (ad and ftd) or psychiatric diseases and 21 controls. |
2022-09-17 |
2023-08-14 |
human |
| Heather Woo. Tau - the missing link between chronic pain and dementia? Nature reviews. Neurology. 2022-09-16. PMID:36114240. |
tau - the missing link between chronic pain and dementia? |
2022-09-16 |
2023-08-14 |
Not clear |
| Sarah Gregory, Kaj Blennow, Natalie Z M Homer, Craig W Ritchie, Graciela Muniz-Terrer. Self-reported diabetes is associated with allocentric spatial processing in the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study. The European journal of neuroscience. 2022-09-14. PMID:36103146. |
covariates included demographics (age, sex, family history of dementia, years of education), apoe4 carrier status, cognitive status (clinical dementia rating scale), cerebrospinal fluid phosphorylated tau and amyloid-beta 1-42. |
2022-09-14 |
2023-08-14 |
human |
| Morgan G Shelton, Kimberly A Kerns, Frank J Castora, Randolph A Colema. Incorporating Mitochondrial Gene Expression Changes Within a Testable Mathematical Model for Alzheimer's Disease: Stress Response Modulation Predicts Potential Therapeutic Targets. Journal of Alzheimer's disease : JAD. 2022-09-12. PMID:36093692. |
alzheimer's disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. |
2022-09-12 |
2023-08-14 |
Not clear |
| Qingling Sun, Jingnian Ni, Mingqing Wei, Siwei Long, Ting Li, Dongsheng Fan, Tao Lu, Jing Shi, Jinzhou Tia. Plasma β-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable Alzheimer's disease dementia in Chinese individuals. Frontiers in aging neuroscience. vol 14. 2022-09-05. PMID:36062146. |
plasma β-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable alzheimer's disease dementia in chinese individuals. |
2022-09-05 |
2023-08-14 |
Not clear |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. |
2022-09-02 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Garrett A Clemons, Alexandre Couto E Silva, Christina H Acosta, Mariana Sayuri Berto Udo, Vesna Tesic, Krista M Rodgers, Celeste Yin-Chieh Wu, Cristiane T Citadin, Reggie Hui-Chao Lee, Jake T Neumann, Shailaja Allani, Howard Prentice, Quanguang Zhang, Hung Wen Li. Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. Journal of cellular physiology. 2022-08-29. PMID:36036549. |
while ad-related dementia is associated with tau and amyloid beta accumulation, concurrent derangements in cerebral blood flow have been observed alongside these proteinopathies in humans and rodent models. |
2022-08-29 |
2023-08-14 |
mouse |