| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Fernandes, Agostino Chiaravalloti, Emanuele Cassetta, Fabio Placidi, Nicola Biagio Mercuri, Claudio Liguor. Sleep Fragmentation and Sleep-Wake Cycle Dysregulation Are Associated with Cerebral Tau Burden in Patients with Mild Cognitive Impairment due to Alzheimer's Disease: A Case Series. Journal of Alzheimer's disease reports. vol 8. issue 1. 2024-10-22. PMID:39434815. |
although disturbed sleep is frequent in patients with mild cognitive impairment (mci) and dementia due to alzheimer's disease (ad), the association between sleep and tau pathology is unclear. |
2024-10-22 |
2024-10-24 |
Not clear |
| Susantha K Ganegamage, Taiwo A Ademoye, Henika Patel, Heba Alnakhala, Arati Tripathi, Cuong Calvin Duc Nguyen, Khai Pham, Germán Plascencia-Villa, Xiongwei Zhu, George Perry, Shiliang Tian, Ulf Dettmer, Cristian Lasagna-Reeves, Jessica S Forti. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. ACS chemical neuroscience. 2024-10-22. PMID:39436010. |
considering the co-occurrence of α-syn and tau inclusions in the brains of patients afflicted with subtypes of dementia and lb disorders, the discovery and development of small molecules for the inhibition of α-syn and tau aggregation can be a potentially effective strategy to delay neurodegeneration. |
2024-10-22 |
2024-10-24 |
Not clear |
| Yuta Katsumi, Inola A Howe, Ryan Eckbo, Bonnie Wong, Megan Quimby, Daisy Hochberg, Scott M McGinnis, Deepti Putcha, David A Wolk, Alexandra Touroutoglou, Bradford C Dickerso. Default mode network tau predicts future clinical decline in atypical early Alzheimer's disease. Brain : a journal of neurology. 2024-10-16. PMID:39412999. |
here, we examined the relationship between baseline tau pet signal and the rate of subsequent clinical decline in a sample of 48 a+/t+/n+ patients with mild cognitive impairment or mild dementia due to ad with atypical clinical phenotypes: posterior cortical atrophy (n = 16), logopenic variant primary progressive aphasia (n = 15), and amnestic syndrome with multi-domain impairment and young age of onset < 65 years (n = 17). |
2024-10-16 |
2024-10-19 |
Not clear |
| Junyun Wu, Jia Nan Wu, Tao Chen, Jing Cai, Reng Re. Protein Aggregation and its Affecting Mechanisms in Neurodegenerative Diseases. Neurochemistry international. 2024-10-13. PMID:39396709. |
protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (nds), including the formation of amyloid β (aβ) and tau neurofibrillary tangles in alzheimer's disease, as well as α-synuclein (α-syn) aggregates in parkinson's disease, parkinson's disease-related dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2024-10-13 |
2024-10-16 |
Not clear |
| Ann-Charlotte Granholm, Lotta Larsson, Fredrik Öhman, Henrik Zetterberg, Oskar Hansson, Maria Eriksdotter, Silke Kern, Agneta Nordber. [Dementia in Down syndrome]. Lakartidningen. vol 121. 2024-10-02. PMID:39354735. |
diagnostic tools that can improve diagnosis and treatment of dementia in ds and differentiate between dementia and intellectual disabilities include cognitive batteries, sensitive plasma assays, and pet imaging for amyloid and tau. |
2024-10-02 |
2024-10-04 |
Not clear |
| Eda Karakaya, Yasir Abdul, Jazlyn Edwards, Sarah Jamil, Onder Albayram, Adviye Ergu. Complex Regulation of Tau Phosphorylation by the Endothelin System in Brain Microvascular Endothelial Cells (BMVECs): Link to Barrier Function. Clinical science (London, England : 1979). 2024-10-02. PMID:39356969. |
vascular contributions to cognitive impairment and dementia (vcid) is a leading adrd cause known to be free of neuronal tau pathology, a hallmark of ad. |
2024-10-02 |
2024-10-05 |
Not clear |
| Benjamin Creti. Epileptic variant in the spectrum of Alzheimer's disease - practical implications. Seizure. 2024-09-29. PMID:39343706. |
evad is one of the etiologies of late-onset epilepsy, which means that it carries a risk of later progression to dementia and that it can only be diagnosed by assessing amyloid and tau biomarkers. |
2024-09-29 |
2024-10-02 |
Not clear |
| Yura Jang, Sungtaek Oh, Anna J Hall, Zhen Zhang, Thomas F Tropea, Alice Chen-Plotkin, Liana S Rosenthal, Ted M Dawson, Chan Hyun Na, Alexander Y Pantelya. Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid. Clinical proteomics. vol 21. issue 1. 2024-09-28. PMID:39342078. |
psp is characterized by the accumulation of tau protein in specific brain regions, leading to loss of balance, gaze impairment, and dementia. |
2024-09-28 |
2024-10-01 |
human |
| Hannah Zuppe, Erin Ree. Common cytokine receptor gamma chain family cytokines activate MAPK, PI3K, and JAK/STAT pathways in microglia to influence Alzheimer's Disease. Frontiers in molecular neuroscience. vol 17. 2024-09-26. PMID:39324116. |
alzheimer's disease (ad) contributes to approximately 60-70% of dementia cases and is characterized by the accumulation of amyloid plaques and tau tangles in the brain. |
2024-09-26 |
2024-09-28 |
Not clear |
| Hoi-Khoanh Giong, Seung Jae Hyeon, Jae-Geun Lee, Hyun-Ju Cho, Uiyeol Park, Thor D Stein, Junghee Lee, Kweon Yu, Hoon Ryu, Jeong-Soo Le. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta neuropathologica. vol 148. issue 1. 2024-09-24. PMID:39316141. |
tauopathy, including frontotemporal lobar dementia and alzheimer's disease, describes a class of neurodegenerative diseases characterized by the aberrant accumulation of tau protein due to defects in proteostasis. |
2024-09-24 |
2024-09-26 |
human |
| Naoko Kishita, Rebecca L Gould, Lance M McCracken, Mizanur Khondoker, David A Turner, Polly-Anna Ashford, Emma Flanagan, Barbara Czyznikowska, Erica Richmond, Megan Riggey, Ana Paula Trucco, Matthew Hammond, Aditya Nautiyal, Morag Farquha. The clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): Study protocol for a randomised controlled trial with ethnically diverse family carers. Contemporary clinical trials. vol 146. 2024-09-15. PMID:39277168. |
this paper describes the design and protocol for a multi-site, parallel, single-blind, 2-arm rct evaluating the clinical and cost effectiveness of iact4carers plus treatment-as-usual (tau) in comparison to tau alone for reducing anxiety in family carers of people with dementia. |
2024-09-15 |
2024-09-18 |
Not clear |
| J Scott Roberts, Chelsea G Cox, Matthias Kirch, Preeti N Malani, Dianne C Singer, Erica Solway, Jeffrey T Kullgre. Developing Topics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 19 Suppl 24. 2024-08-09. PMID:39120540. |
blood-based biomarker testing (bbt) to detect amyloid-beta and tau is becoming part of dementia care, with likely future use in asymptomatic populations. |
2024-08-09 |
2024-08-12 |
Not clear |
| Sofia Egebäck Arulf, Robin Ziyue Zhou, Bjørn-Eivind Kirsebom, Alenka Jejcic, Tormod Fladby, Bengt Winblad, Lars Tjernberg, Sophia Schedin-Weis. Bisecting N-Acetylglucosamine Correlates with Phospho-Tau181 in Subjective Cognitive Decline but not in Control Cases. Journal of Alzheimer's disease : JAD. 2024-08-09. PMID:39121127. |
a recent population-based study showed that bisecting glcnac correlates with total tau also in blood and that this correlation could predict conversion to dementia. |
2024-08-09 |
2024-08-12 |
Not clear |
| Eric McDade, Haiyan Liu, Quoc Bui, Jason Hassenstab, Brian Gordon, Tammie Benzinger, Yuanyuan Shen, Jigyasha Timsina, Lihua Wang, Yun Ju Sung, Celeste Karch, Alan Renton, Alisha Daniels, John Morris, Chengjie Xiong, Laura Ibanez, Richard Perrin, Jorge J Llibre-Guerra, Gregory Day, Charlene Supnet-Bell, Xiong Xu, Sarah Berman, Jasmeer Chhatwal, Takeshi Ikeuchi, Kensaku Kasuga, Yoshiki Niimi, Edward Huey, Peter Schofield, William Brooks, Natalie Ryan, Mathias Jucker, Christoph Laske, Johannes Levin, Jonathan Vӧglein, Jee Hoon Roh, Francisco Lopera, Randall Bateman, Carlos Cruchag. Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease. Research square. 2024-08-07. PMID:39108475. |
this study explored the role of the ubiquitin-proteasome system (ups) in dominantly inherited alzheimer's disease (diad) by examining changes in cerebrospinal fluid (csf) levels of ups proteins along with disease progression, ad imaging biomarkers (pib pet, tau pet), neurodegeneration imaging measures (mri, fdg pet), and clinical dementia rating® (cdr®). |
2024-08-07 |
2024-08-09 |
Not clear |
| Rodrigo Canovas, Paul Maruff, Christopher J Fowler, Stephanie R Rainey-Smith, Colin L Masters, James D Doeck. Clinical Manifestations. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 19 Suppl 18. 2024-08-07. PMID:39112039. |
positive ad biomarkers, (e.g., amyloid, tau, or apoe ε4 carriage), increase rates of cognitive decline and transition to dementia. |
2024-08-07 |
2024-08-10 |
Not clear |
| Gourav Singh, Sunil Kumar, Samir Ranjan Panda, Prabhat Kumar, Sanskriti Rai, Himanshu Verma, Yash Pal Singh, Saroj Kumar, Saripella Srikrishna, V G M Naidu, Gyan Mod. Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease. ACS chemical neuroscience. 2024-07-30. PMID:39076038. |
alzheimer's disease (ad) is the most prevalent cause of dementia and is characterized by low levels of acetyl and butyrylcholine, increased oxidative stress, inflammation, accumulation of metals, and aggregations of aβ and tau proteins. |
2024-07-30 |
2024-08-02 |
Not clear |
| Yueli Zhu, Xiaoming Guo, Shumin Li, Yue Wu, Feng Zhu, Chengfan Qin, Qin Zhang, Yunmei Yan. Naringenin ameliorates amyloid-β pathology and neuroinflammation in Alzheimer's disease. Communications biology. vol 7. issue 1. 2024-07-28. PMID:39069528. |
alzheimer's disease (ad) is the most common cause of dementia characterized by amyloid-β (aβ) deposition, tau hyperphosphorylation, and neuroinflammation. |
2024-07-28 |
2024-08-02 |
mouse |
| Ankit Kolay, Neelam Singh, Puneet Gupta, Ayaz Mukarram Shaikh, Radha Goel, Dheeraj Nagpal, Havagiray Chitm. Immunotherapies: A Treasure Trove of Alzheimer's Disease. Current pharmaceutical biotechnology. 2024-07-23. PMID:39039684. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein inside the brain. |
2024-07-23 |
2024-07-25 |
Not clear |
| Lili Donner, Irena Krüger, Susanne Pfeiler, Norbert Gerdes, Martin Schaller, Malte Kelm, Margitta Elver. Reduced platelet activation and thrombus formation in male transgenic model mice of Alzheimer's disease suggests early sex-specific differences in platelet pathophysiology. Molecular and cellular neurosciences. 2024-07-13. PMID:39002827. |
alzheimer's disease (ad) is the most common form of dementia and characterized by extracellular amyloid-β (aβ) plaques, intracellular neurofibrillary tau tangles and neurodegeneration. |
2024-07-13 |
2024-07-16 |
mouse |
| Eunhee Kim, Rudolph E Tanzi, Se Hoon Cho. Therapeutic potential of exercise-hormone irisin in Alzheimer's disease. Neural regeneration research. 2024-07-12. PMID:38993140. |
studies reveal that irisin/fndc5 has neuroprotective functions against alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of alzheimer's disease. |
2024-07-12 |
2024-07-14 |
Not clear |