| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ankit Kolay, Neelam Singh, Puneet Gupta, Ayaz Mukarram Shaikh, Radha Goel, Dheeraj Nagpal, Havagiray Chitm. Immunotherapies: A Treasure Trove of Alzheimer's Disease. Current pharmaceutical biotechnology. 2024-07-23. PMID:39039684. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein inside the brain. |
2024-07-23 |
2024-07-25 |
Not clear |
| Lili Donner, Irena Krüger, Susanne Pfeiler, Norbert Gerdes, Martin Schaller, Malte Kelm, Margitta Elver. Reduced platelet activation and thrombus formation in male transgenic model mice of Alzheimer's disease suggests early sex-specific differences in platelet pathophysiology. Molecular and cellular neurosciences. 2024-07-13. PMID:39002827. |
alzheimer's disease (ad) is the most common form of dementia and characterized by extracellular amyloid-β (aβ) plaques, intracellular neurofibrillary tau tangles and neurodegeneration. |
2024-07-13 |
2024-07-16 |
mouse |
| Eunhee Kim, Rudolph E Tanzi, Se Hoon Cho. Therapeutic potential of exercise-hormone irisin in Alzheimer's disease. Neural regeneration research. 2024-07-12. PMID:38993140. |
studies reveal that irisin/fndc5 has neuroprotective functions against alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of alzheimer's disease. |
2024-07-12 |
2024-07-14 |
Not clear |
| Astrid Devulder, Greet Vanderlinden, Leen Van Langenhoven, Dries Testelmans, Maarten Van Den Bossche, François-Laurent De Winter, Mathieu Vandenbulcke, Rik Vandenberghe, Tom Theys, Koen Van Laere, Wim Van Paessche. Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease. Brain : a journal of neurology. 2024-07-11. PMID:38990981. |
to investigate this, we performed multiple day simultaneous foramen ovale (fo) plus scalp eeg and polysomnography (psg) recordings and acquired 18f-mk6240 tau pet-mr in three patients in the prodromal stage of ad and in two patients with mild and moderate dementia due to ad, respectively. |
2024-07-11 |
2024-07-14 |
human |
| Meghraj S Baghel, Grace D Burns, Margarita Tsapatsis, Aswathy Peethambaran Mallika, Anna Lourdes F Cruz, Tianyu Cao, Xiaoke K Chen, Isabel De La Rosa, Shaelyn R Marx, Yingzhi Ye, Shuying Sun, Tong Li, Philip C Won. Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979270. |
depletion of tdp-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of multiple etiology dementia. |
2024-07-09 |
2024-07-12 |
mouse |
| Michael R Duggan, Gabriela T Gomez, Cassandra M Joynes, Murat Bilgel, Jingsha Chen, Nicola Fattorelli, Timothy J Hohman, Renzo Mancuso, Jenifer Cordon, Tonnar Castellano, Mary Ellen I Koran, Julián Candia, Alexandria Lewis, Abhay Moghekar, Nicholas J Ashton, Przemysław R Kac, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Anna Martinez-Muriana, Bart De Strooper, Madhav Thambisetty, Luigi Ferrucci, Rebecca F Gottesman, Josef Coresh, Susan M Resnick, Keenan A Walke. Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression. Brain, behavior, and immunity. 2024-07-08. PMID:38977137. |
in addition to associations with tau pet and plasma ad biomarker changes, as well as expression patterns in human microglia subtypes and neurovascular cells in ad brain tissue, we showed that 31 % of candidate proteins were related to mid-life (20-year) or late-life (8-year) dementia risk in aric. |
2024-07-08 |
2024-07-12 |
human |
| Agathe Vrillon, Olivier Bousiges, Karl Götze, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Nathalie Philippi, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Benjamin Cretin, Frédéric Blanc, Claire Paque. Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-07-04. PMID:38961441. |
plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with lewy bodies. |
2024-07-04 |
2024-07-10 |
Not clear |
| Agathe Vrillon, Olivier Bousiges, Karl Götze, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Nathalie Philippi, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Benjamin Cretin, Frédéric Blanc, Claire Paque. Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-07-04. PMID:38961441. |
increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of dementia. |
2024-07-04 |
2024-07-10 |
Not clear |
| Seungmin Lee, In Gyoung Ju, Hyeyoon Eo, Jin Hee Kim, Yujin Choi, Myung Sook O. Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse. Chinese medicine. vol 19. issue 1. 2024-07-04. PMID:38965625. |
alzheimer's disease (ad) is a common type of dementia characterized by amyloid-β (aβ) accumulation, lysosomal dysfunction, and tau hyperphosphorylation, leading to neurite dystrophy and memory loss. |
2024-07-04 |
2024-07-11 |
mouse |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
in this study, we developed toxic tau conformation-specific monoclonal antibody-2 (ttcm2), which selectively recognized pathological tau aggregates in brain tissues from patients with ad, dementia with lewy bodies (dlb), and progressive supranuclear palsy (psp). |
2024-07-03 |
2024-07-10 |
mouse |
| Elinor Thompson, Anna Schroder, Tiantian He, Cameron Shand, Sonja Soskic, Neil P Oxtoby, Frederik Barkhof, Daniel C Alexande. Combining multimodal connectivity information improves modelling of pathology spread in Alzheimer's disease. Imaging neuroscience (Cambridge, Mass.). vol 2. 2024-07-01. PMID:38947941. |
in this work, we compare five types of connectomes for modelling both tau and atrophy patterns with the network diffusion model, which are validated against tau pet and structural mri data from individuals with either mild cognitive impairment or dementia. |
2024-07-01 |
2024-07-03 |
Not clear |
| Sierra Jaye, Ursula S Sandau, Trevor J McFarland, Randy L Woltjer, Julie A Saugsta. A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-06-25. PMID:38915309. |
alzheimer's disease (ad) is the most common form of dementia and is characterized by the accumulation of amyloid-beta (aβ) plaques and neurofibrillary tau tangles in the brain. |
2024-06-25 |
2024-06-27 |
human |
| Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Mauric. The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-18. PMID:38887858. |
alzheimer's disease (ad) is a devastating dementia characterized by extracellular amyloid-β (aβ) protein aggregates and intracellular tau protein deposition. |
2024-06-18 |
2024-06-21 |
mouse |
| Araya Dimtsu Assfaw, Suzanne E Schindler, John C Morri. Advances in blood biomarkers for Alzheimer disease (AD): A review. The Kaohsiung journal of medical sciences. 2024-06-18. PMID:38888066. |
ad is a progressive neurodegenerative disorder characterized pathologically by amyloid plaques and tau neurofibrillary tangles that are the primary cause of dementia in older individuals. |
2024-06-18 |
2024-06-21 |
Not clear |
| Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng, Bo-Ram Mun, Won-Seok Choi, Kyung-Hwa Lee, Hyun-Sun Park, Duc Tien Nguyen, Min-Cheol Lee, Kwangjoon Jeong, Jin Hai Zheng, Young Kim, Shee Eun Lee, Joon Haeng Rhe. Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers. NPJ vaccines. vol 9. issue 1. 2024-06-15. PMID:38879560. |
alzheimer's disease (ad) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in neurofibrillary degeneration and dementia. |
2024-06-15 |
2024-06-18 |
mouse |
| Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta neuropathologica communications. vol 12. issue 1. 2024-06-13. PMID:38867338. |
this dementia is attributed to the increased gene dosage of the amyloid-β (aβ) precursor protein gene, the formation of self-propagating aβ and tau prion conformers, and the deposition of neurotoxic aβ plaques and tau neurofibrillary tangles. |
2024-06-13 |
2024-06-15 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta neuropathologica communications. vol 12. issue 1. 2024-06-13. PMID:38867338. |
samples from the youngest individual with no documented dementia had sparse tau deposits. |
2024-06-13 |
2024-06-15 |
Not clear |
| Colin Groot, Ruben Smith, Lyduine E Collij, Sophie E Mastenbroek, Erik Stomrud, Alexa Pichet Binette, Antoine Leuzy, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Olof Strandberg, Hanna Cho, Chul Hyoung Lyoo, Giovanni B Frisoni, Debora E Peretti, Valentina Garibotto, Renaud La Joie, David N Soleimani-Meigooni, Gil Rabinovici, Rik Ossenkoppele, Oskar Hansso. Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment. JAMA neurology. 2024-06-10. PMID:38857029. |
tau positron emission tomography for predicting dementia in individuals with mild cognitive impairment. |
2024-06-10 |
2024-06-14 |
Not clear |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including alzheimer's disease (ad), lewy body dementia (lbd), chronic traumatic encephalopathy (cte), and frontotemporal dementia (ftd). |
2024-06-10 |
2024-06-14 |
rat |
| Tabea M Soelter, Timothy C Howton, Amanda D Clark, Vishal H Oza, Brittany N Lasseign. Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq. Cell communication and signaling : CCS. vol 22. issue 1. 2024-06-08. PMID:38849813. |
alzheimer's disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. |
2024-06-08 |
2024-06-10 |
Not clear |