| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606065. |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-08-12 |
human |
| Christian Wider, Zbigniew K Wszole. Clinical genetics of Parkinson's disease and related disorders. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267241. |
autosomal dominant dementia and parkinsonism is caused by mutations in the mapt gene, and in the most recently discovered pgrn gene. |
2009-04-01 |
2023-08-12 |
Not clear |
| Takeshi Ikeuchi, Hiroyuki Kaneko, Akinori Miyashita, Hiroaki Nozaki, Kensaku Kasuga, Tamao Tsukie, Miyuki Tsuchiya, Toru Imamura, Hideki Ishizu, Kenju Aoki, Atsushi Ishikawa, Osamu Onodera, Ryozo Kuwano, Masatoyo Nishizaw. Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations. Dementia and geriatric cognitive disorders. vol 26. issue 1. 2008-10-07. PMID:18587238. |
although rare, a tau-related dementia with mutations in the microtubule-associated protein tau gene (mapt) has been identified in patients showing clinical presentations similar to those of ad. |
2008-10-07 |
2023-08-12 |
Not clear |
| Stuart M Pickering-Brown, Sara Rollinson, Daniel Du Plessis, Karen E Morrison, Anoop Varma, Anna M T Richardson, David Neary, Julie S Snowden, David M A Man. Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Brain : a journal of neurology. vol 131. issue Pt 3. 2008-05-01. PMID:18192287. |
however, a family history of dementia in a first-degree relative was invariably present in mapt cases, but not always so in pgrn cases. |
2008-05-01 |
2023-08-12 |
Not clear |
| J-M Gallo, W Noble, T Rodriguez Marti. RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategies. Cellular and molecular life sciences : CMLS. vol 64. issue 13. 2007-08-29. PMID:17453144. |
the importance of tau in neuronal dysfunction and degeneration has been demonstrated by the discovery of dominant mutations in the mapt gene, encoding tau, in some rare dementias. |
2007-08-29 |
2023-08-12 |
Not clear |
| Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton, Christopher B Eckma. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular neurodegeneration. vol 1. 2007-07-26. PMID:16930453. |
the microtubule-associated protein tau (mapt) is a pathological component of several neurodegenerative diseases and clinical dementias. |
2007-07-26 |
2023-08-12 |
Not clear |
| Purnima Desai Sundar, Chang-En Yu, Weiva Sieh, Ellen Steinbart, Ralph M Garruto, Kiyomitsu Oyanagi, Ulla-Katrina Craig, Thomas D Bird, Ellen M Wijsman, Douglas R Galasko, Gerard D Schellenber. Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia. Human molecular genetics. vol 16. issue 3. 2007-04-26. PMID:17185385. |
two sites in the mapt region confer genetic risk for guam als/pdc and dementia. |
2007-04-26 |
2023-08-12 |
human |
| Maria Grazia Spillantini, Jill R Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghett. Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD). Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914875. |
mutations in the tau gene (mapt) in ftdp-17: the family with multiple system tauopathy with presenile dementia (mstd). |
2006-10-19 |
2023-08-12 |
Not clear |
| Roberta Ghidoni, Simona Signorini, Laura Barbiero, Elena Sina, Paola Cominelli, Aldo Villa, Luisa Benussi, Giuliano Binett. The H2 MAPT haplotype is associated with familial frontotemporal dementia. Neurobiology of disease. vol 22. issue 2. 2006-07-25. PMID:16410051. |
the role of mapt haplotypes in neurodegenerative diseases has been suggested, but their contribution in familial dementia has not been extensively investigated. |
2006-07-25 |
2023-08-12 |
Not clear |
| P Poorkaj, A Kas, I D'Souza, Y Zhou, Q Pham, M Stone, M V Olson, G D Schellenber. A genomic sequence analysis of the mouse and human microtubule-associated protein tau. Mammalian genome : official journal of the International Mammalian Genome Society. vol 12. issue 9. 2001-12-07. PMID:11641718. |
mapt is also a candidate gene for progressive supranuclear palsy and hereditary dysphagic dementia. |
2001-12-07 |
2023-08-12 |
mouse |