| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Goedert, Bernardino Ghetti, Maria Grazia Spillantin. Frontotemporal dementia: implications for understanding Alzheimer disease. Cold Spring Harbor perspectives in medicine. vol 2. issue 2. 2013-06-17. PMID:22355793. |
the discovery that mutations in mapt cause neurodegeneration and dementia has important implications for understanding alzheimer disease. |
2013-06-17 |
2023-08-12 |
Not clear |
| b' Mart\\xc3\\xad Colom-Cadena, Ellen Gelpi, Mar\\xc3\\xada J Mart\\xc3\\xad, Sara Charif, Oriol Dols-Icardo, Rafael Blesa, Jordi Clarim\\xc3\\xb3n, Alberto Lle\\xc3\\xb. MAPT H1 haplotype is associated with enhanced \\xce\\xb1-synuclein deposition in dementia with Lewy bodies. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819391.' |
mapt h1 haplotype is associated with enhanced α-synuclein deposition in dementia with lewy bodies. |
2013-05-24 |
2023-08-12 |
Not clear |
| b' Mart\\xc3\\xad Colom-Cadena, Ellen Gelpi, Mar\\xc3\\xada J Mart\\xc3\\xad, Sara Charif, Oriol Dols-Icardo, Rafael Blesa, Jordi Clarim\\xc3\\xb3n, Alberto Lle\\xc3\\xb. MAPT H1 haplotype is associated with enhanced \\xce\\xb1-synuclein deposition in dementia with Lewy bodies. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819391.' |
our aim was to investigate the relationship between mapt haplotypes and pathologic aggregates of tau and α-synuclein in pathologically confirmed cases of dementia with lewy bodies (dlb). |
2013-05-24 |
2023-08-12 |
Not clear |
| Edo Richard, Sandrine Andrieu, Alina Solomon, Francesca Mangialasche, Satu Ahtiluoto, Eric P Moll van Charante, Nicola Coley, Laura Fratiglioni, Anna Stigsdotter Neely, Bruno Vellas, Willem A van Gool, Miia Kivipelt. Methodological challenges in designing dementia prevention trials - the European Dementia Prevention Initiative (EDPI). Journal of the neurological sciences. vol 322. issue 1-2. 2013-04-11. PMID:22818266. |
three large rcts on multi-component interventions to prevent dementia (prediva, finger, mapt) have been initiated in europe to address these issues. |
2013-04-11 |
2023-08-12 |
human |
| Ismael Santa-Maria, Aya Haggiagi, Xinmin Liu, Jessica Wasserscheid, Peter T Nelson, Ken Dewar, Lorraine N Clark, John F Crar. The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta neuropathologica. vol 124. issue 5. 2013-03-25. PMID:22802095. |
the mapt h1 haplotype is associated with tangle-predominant dementia. |
2013-03-25 |
2023-08-12 |
human |
| Tara M Caffrey, Richard Wade-Martin. The role of MAPT sequence variation in mechanisms of disease susceptibility. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817717. |
the microtubule-associated protein tau (mapt or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the mapt gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement disorders. |
2012-12-07 |
2023-08-12 |
Not clear |
| Sophie Gillette-Guyonnet, Bruno Vella. The Toulouse Gérontopôle Research Center: report of activities, 2007-2011. Journal of Alzheimer's disease : JAD. vol 28. issue 3. 2012-06-15. PMID:22258518. |
in addition, the gérontopôle coordinates several national clinical trials with promising drugs with potential effect on the mechanisms and evolution of ad and actively participates in studies on biomarkers; 2) to develop health promotion actions and prevention trials for healthy elderly people, through the institute of aging: the gérontopôle has implemented the guidage (phase iii trial concerning the efficiency of ginkgo biloba on the impact and delay of appearance of an alzheimer type dementia) and mapt (multi-domain alzheimer preventive trial) studies on prevention of ad and cognitive decline. |
2012-06-15 |
2023-08-12 |
Not clear |
| Carlos Cruchaga, Gabe Haller, Sumitra Chakraverty, Kevin Mayo, Francesco L M Vallania, Robi D Mitra, Kelley Faber, Jennifer Williamson, Tom Bird, Ramon Diaz-Arrastia, Tatiana M Foroud, Bradley F Boeve, Neill R Graff-Radford, Pamela St Jean, Michael Lawson, Margaret G Ehm, Richard Mayeux, Alison M Goat. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PloS one. vol 7. issue 2. 2012-06-14. PMID:22312439. |
pathogenic mutations in app, psen1, psen2, mapt and grn have previously been linked to familial early onset forms of dementia. |
2012-06-14 |
2023-08-12 |
Not clear |
| Michel Goedert, Maria Grazia Spillantin. Pathogenesis of the tauopathies. Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21785996. |
the existence of mapt mutations has established that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia. |
2012-03-19 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
the effect of mapt h1 and apoe ε4 on transition from mild cognitive impairment to dementia. |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
we prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive impairment (mci) and analyzed whether mapt h1/h2 haplotypes and apoe ε4 polymorphisms accelerated the rate of progression from mci to dementia. |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
apoe ε4 and mapt h1/h1 were independently associated with an increased rate of progression to dementia in the combined sample. |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
cox regression models of the combined mci sample showed that mapt h1/h1 carriers had an increased rate of progression to dementia compared with non carriers (hazard ratio =1.45; 95% ci=1.04-2.02; p=0.028) and time-to-progression was shortened by 1.37 years. |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
additionally, mapt h1/h1 genotype and apoe ε4 allele had an additive effect in progression to dementia, increasing progression rate to dementia (hazard ratio=2.24, 95% ci =1.40-3.58; p=0.001) and shortening time-to-progression to dementia by 2.92 years. |
2011-05-25 |
2023-08-12 |
human |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
our results suggest that both mapt h1/h1 genotype and apoe ε4 allele lead to a more rapid progression to dementia among mci subjects, probably mediating an increased rate of amyloid-β and tau brain deposition. |
2011-05-25 |
2023-08-12 |
human |
| Núria Setó-Salvia, Jordi Clarimón, Javier Pagonabarraga, Berta Pascual-Sedano, Antonia Campolongo, Onofre Combarros, Jose Ignacio Mateo, Daniel Regaña, Merce Martínez-Corral, Marta Marquié, Daniel Alcolea, Marc Suárez-Calvet, Laura Molina-Porcel, Oriol Dols, Teresa Gómez-Isla, Rafael Blesa, Alberto Lleó, Jaime Kulisevsk. Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes. Archives of neurology. vol 68. issue 3. 2011-05-19. PMID:21403021. |
dementia risk in parkinson disease: disentangling the role of mapt haplotypes. |
2011-05-19 |
2023-08-12 |
Not clear |
| Christian Wider, Tatiana Foroud, Zbigniew K Wszole. Clinical implications of gene discovery in Parkinson's disease and parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187245. |
in addition, autosomal-dominant dementia and parkinsonism has been shown to be caused by mutations in the mapt and pgrn genes. |
2010-06-14 |
2023-08-12 |
Not clear |
| Caroline H Williams-Gray, Jonathan R Evans, An Goris, Thomas Foltynie, Maria Ban, Trevor W Robbins, Carol Brayne, Bhaskar S Kolachana, Daniel R Weinberger, Stephen J Sawcer, Roger A Barke. The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain : a journal of neurology. vol 132. issue Pt 11. 2010-01-15. PMID:19812213. |
mapt h1/h1 genotype was an independent predictor of dementia risk (odds ratio = 12.1) and the h1 versus h2 haplotype was associated with a 20% increase in transcription of 4-repeat tau in lewy body disease brains. |
2010-01-15 |
2023-08-12 |
Not clear |
| Caroline H Williams-Gray, Jonathan R Evans, An Goris, Thomas Foltynie, Maria Ban, Trevor W Robbins, Carol Brayne, Bhaskar S Kolachana, Daniel R Weinberger, Stephen J Sawcer, Roger A Barke. The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain : a journal of neurology. vol 132. issue Pt 11. 2010-01-15. PMID:19812213. |
hence, we have identified three highly informative predictors of dementia in parkinson's disease, which can be easily translated into the clinic, and established that mapt h1/h1 genotype is an important risk factor with functional effects on tau transcription. |
2010-01-15 |
2023-08-12 |
Not clear |
| Anna Kowalsk. [The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)]. Postepy higieny i medycyny doswiadczalnej (Online). vol 63. 2009-10-27. PMID:19535823. |
in contrast to alzheimer's disease(ad), there are neither senile plaques nor neurofibrillary tangles in the brains of ftd patients.frontotemporal dementias are tauopathies, a group of disorders caused by aberrant metabolism of tau protein, a family of proteins associated with microtubules (mapt: macro-tubule-associated tau protein). |
2009-10-27 |
2023-08-12 |
human |