| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel I Kaufe. Pharmacologic therapy of dementia with Lewy bodies. Journal of geriatric psychiatry and neurology. vol 15. issue 4. 2003-04-16. PMID:12489919. |
increasing recognition of dlb as a common form of dementia in the elderly underscores the need for large-scale, placebo-controlled therapeutic trials. |
2003-04-16 |
2023-08-12 |
Not clear |
| Thanasak Teaktong, Alison Graham, Jennifer Court, Robert Perry, Evelyn Jaros, Mary Johnson, Ros Hall, Elaine Perr. Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia. vol 41. issue 2. 2003-04-02. PMID:12509811. |
alzheimer's disease (ad) and dementia with lewy bodies (dlb) are common forms of dementia in the elderly associated with cholinergic dysfunction, including reductions in nicotinic acetylcholine receptors (nachrs). |
2003-04-02 |
2023-08-12 |
human |
| Clive G Ballard, Jennifer A Court, Margaret Piggott, Mary Johnson, John O'Brien, Ian McKeith, Clive Holmes, Peter Lantos, Evelyn Jaros, Robert Perry, E Perr. Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex. Consciousness and cognition. vol 11. issue 3. 2003-04-01. PMID:12435378. |
disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with lewy bodies (dlb). |
2003-04-01 |
2023-08-12 |
Not clear |
| Oliver Wirths, Thomas A Baye. Alpha-synuclein, Abeta and Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 1. 2003-04-01. PMID:12551731. |
missense mutations in the alpha-synuclein gene are linked to familial cases of parkinson's disease (pd), and it has further been shown that alpha-synuclein is a major constituent of the lewy bodies in sporadic pd and dementia with lewy body (dlb). |
2003-04-01 |
2023-08-12 |
Not clear |
| Andrew B Singleton, Anna Wharton, Kirsty K O'Brien, Matthew P Walker, Ian G McKeith, Clive G Ballard, John O'Brien, Robert H Perry, Paul G Ince, James A Edwardson, Christopher M Morri. Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411758. |
dementia with lewy bodies (dlb) represents the second commonest cause of dementia in the elderly following alzheimer's disease (ad). |
2003-03-28 |
2023-08-12 |
Not clear |
| S Calzetti, E Bortone, A Negrotti, L Zinno, D Manci. Frontal intermittent rhythmic delta activity (FIRDA) in patients with dementia with Lewy bodies: a diagnostic tool? Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 23 Suppl 2. 2003-03-28. PMID:12548346. |
the accuracy of the clinical diagnosis of dementia with lewy bodies (dlb) remains poor, especially in early phases of the disease, in spite of applying current consensus diagnostic criteria. |
2003-03-28 |
2023-08-12 |
Not clear |
| Teresa Gomez-Isla, Michael C Irizarry, Ami Mariash, Bonnie Cheung, Oscar Soto, Stefanie Schrump, Jesse Sondel, Linda Kotilinek, John Day, Michael A Schwarzschild, Jang-Ho J Cha, Kathy Newell, David W Miller, Kenji Uéda, Anne B Young, Bradley T Hyman, Karen H Ash. Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiology of aging. vol 24. issue 2. 2003-03-26. PMID:12498958. |
alpha-synuclein is a major component of lewy bodies (lbs) in the substantia nigra and cortex in parkinson's disease (pd) and dementia with lewy bodies (dlb), and in glial inclusions in multiple systems atrophy (msa). |
2003-03-26 |
2023-08-12 |
mouse |
| Irene Hegeman Richard, Michelle Papka, Ana Rubio, Roger Kurla. Parkinson's disease and dementia with Lewy bodies: one disease or two? Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 6. 2003-03-24. PMID:12465052. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) have clinical features in common and are both characterized neuropathologically by the presence of lewy bodies (lbs). |
2003-03-24 |
2023-08-12 |
human |
| C Martin-Ruiz, S Lawrence, M Piggott, A Kuryatov, J Lindstrom, C Gotti, M R Cookson, R H Perry, E Jaros, E K Perry, J A Cour. Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression. Neuroscience letters. vol 335. issue 2. 2003-03-20. PMID:12459516. |
a reduction in nicotinic receptor (nachr) binding has previously been observed in putamen in parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2003-03-20 |
2023-08-12 |
Not clear |
| Ronit Sharon, Ifat Bar-Joseph, Matthew P Frosch, Dominic M Walsh, James A Hamilton, Dennis J Selko. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. vol 37. issue 4. 2003-03-07. PMID:12597857. |
in parkinson's disease (pd) and dementia with lewy bodies (dlb), alpha-synuclein (alpha s) accumulates in insoluble inclusions. |
2003-03-07 |
2023-08-12 |
mouse |
| Clive Ballard, Mary Johnson, Margaret Piggott, Robert Perry, John O'Brien, Elise Rowan, Elaine Perry, Peter Lantos, Nigel Cairns, Clive Holme. A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. Journal of affective disorders. vol 69. issue 1-3. 2003-02-24. PMID:12103469. |
depression is a common and distressing problem in the context of dementia, and is significantly more common in dementia with lewy bodies (dlb) than in alzheimer's disease. |
2003-02-24 |
2023-08-12 |
Not clear |
| Joseph H Friedman, Hubert H Fernande. Atypical antipsychotics in Parkinson-sensitive populations. Journal of geriatric psychiatry and neurology. vol 15. issue 3. 2003-02-13. PMID:12230086. |
in addition, parkinsonism is a frequent accompaniment to the more common dementing syndromes, alzheimer's disease (ad), vascular dementia, and dementia with lewy bodies (dlb). |
2003-02-13 |
2023-08-12 |
Not clear |
| Adesola Ogunnyi, Effiong E U Akang, Oye Gureje, Masaki Takao, Pedro Piccardo, Olusegun Baiyewu, Kathleen S Hall, Bernardino Ghetti, Hugh C Hendri. Dementia with Lewy bodies in a Nigerian: a case report. International psychogeriatrics. vol 14. issue 2. 2003-02-13. PMID:12243211. |
dementia with lewy bodies (dlb) is the second most common neuropathologically diagnosed cause of degenerating dementia after alzheimer's disease. |
2003-02-13 |
2023-08-12 |
human |
| Adesola Ogunnyi, Effiong E U Akang, Oye Gureje, Masaki Takao, Pedro Piccardo, Olusegun Baiyewu, Kathleen S Hall, Bernardino Ghetti, Hugh C Hendri. Dementia with Lewy bodies in a Nigerian: a case report. International psychogeriatrics. vol 14. issue 2. 2003-02-13. PMID:12243211. |
the case presented highlights the varied clinical presentation of dlb, and is intended to raise awareness about another possible cause of dementia in nigerian subjects. |
2003-02-13 |
2023-08-12 |
human |
| Osamu Yokota, Seishi Terada, Hideki Ishizu, Hiroshi Ujike, Takeshi Ishihara, Hanae Nakashima, Minoru Yasuda, Yoshihiro Kitamura, Kenji Uéda, Frédéric Checler, Shigetoshi Kurod. NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases. Acta neuropathologica. vol 104. issue 6. 2003-02-12. PMID:12410385. |
one case presented with typical clinical features of ad, but the other case also developed clinical characteristics of dementia with lewy bodies (dlb), including visual hallucinations, delusions, and parkinsonism. |
2003-02-12 |
2023-08-12 |
Not clear |
| H Uchikado, E Iseki, K Tsuchiya, T Togo, O Katsuse, K Uéda, M Kato, K Kosak. Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia. Clinical neuropathology. vol 21. issue 6. 2003-01-30. PMID:12489676. |
the present study concerns an autopsied case of dementia with lewy bodies (dlb) showing advanced lewy pathology but minimal alzheimer pathology. |
2003-01-30 |
2023-08-12 |
Not clear |
| Satoru Mor. Responses to donepezil in Alzheimer's disease and Parkinson's disease. Annals of the New York Academy of Sciences. vol 977. 2003-01-21. PMID:12480791. |
in the clinical trial of tacrine, a first developed cholinesterase inhibitor, three cases markedly improved and, several years later, they were pathologically confirmed as dementia with lewy bodies (dlb). |
2003-01-21 |
2023-08-12 |
Not clear |
| Satoru Mor. Responses to donepezil in Alzheimer's disease and Parkinson's disease. Annals of the New York Academy of Sciences. vol 977. 2003-01-21. PMID:12480791. |
both dlb and parkinson's disease with dementia show characteristic cbf patterns: while the parietal and temporal lobes are involved in alzheimer's disease, the occipital lobe is additionally affected in these diseases. |
2003-01-21 |
2023-08-12 |
Not clear |
| C G Ballard, D Aarsland, I McKeith, J O'Brien, A Gray, F Cormack, D Burn, T Cassidy, R Starfeldt, J-P Larsen, R Brown, M Tove. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology. vol 59. issue 11. 2003-01-10. PMID:12473758. |
fluctuations in attention: pd dementia vs dlb with parkinsonism. |
2003-01-10 |
2023-08-12 |
Not clear |
| C G Ballard, D Aarsland, I McKeith, J O'Brien, A Gray, F Cormack, D Burn, T Cassidy, R Starfeldt, J-P Larsen, R Brown, M Tove. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology. vol 59. issue 11. 2003-01-10. PMID:12473758. |
marked impairments in and fluctuation of attention are characteristic of dementia with lewy bodies (dlb). |
2003-01-10 |
2023-08-12 |
Not clear |