| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sean J Colloby, Michael J Firbank, Sanjeet Pakrasi, Jim J Lloyd, Ian Driver, Ian G McKeith, E David Williams, John T O'Brie. A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies. International psychogeriatrics. vol 20. issue 6. 2008-12-12. PMID:18752700. |
the aim of this study is to investigate the diagnostic value of perfusion 99mtc-exametazime single photon emission computed tomography (spect) in the diagnosis of dementia with lewy bodies (dlb) and alzheimer's disease (ad) in comparison with dopaminergic 123i-2beta-carbomethoxy-3beta-(4-iodophenyl)-n-(3-fluoropropyl) nortropane (fp-cit) spect imaging. |
2008-12-12 |
2023-08-12 |
Not clear |
| Richard Dodel, Ilona Csoti, Georg Ebersbach, Gerd Fuchs, Matthias Hahne, Wilfried Kuhn, Matthias Oechsner, Wolfgang Jost, Heinz Reichmann, Jörg B Schul. Lewy body dementia and Parkinson's disease with dementia. Journal of neurology. vol 255 Suppl 5. 2008-12-12. PMID:18787881. |
currently, two different clinical presentations are distinguished in pd patients, who present with dementia: parkinson's disease with dementia (pdd) and dementia with lewy bodies (dlb), which are two different presentations of a single underlying disease process leading to the deposition of alpha-synuclein. |
2008-12-12 |
2023-08-12 |
Not clear |
| Richard Dodel, Ilona Csoti, Georg Ebersbach, Gerd Fuchs, Matthias Hahne, Wilfried Kuhn, Matthias Oechsner, Wolfgang Jost, Heinz Reichmann, Jörg B Schul. Lewy body dementia and Parkinson's disease with dementia. Journal of neurology. vol 255 Suppl 5. 2008-12-12. PMID:18787881. |
therefore, cholinesterase inhibitors are used in the treatment of dementia and accompanying behavioral symptoms in pdd and dlb. |
2008-12-12 |
2023-08-12 |
Not clear |
| B Borroni, M Turla, V Bertasi, C Agosti, N Gilberti, A Padovan. Cognitive and behavioral assessment in the early stages of neurodegenerative extrapyramidal syndromes. Archives of gerontology and geriatrics. vol 47. issue 1. 2008-11-18. PMID:17765337. |
parkinson's disease (pd), dementia with lewy bodies (dlb), progressive supranuclear palsy (psp) and corticobasal degeneration syndrome (cbds) are the most common neurodegenerative extrapyramidal syndromes. |
2008-11-18 |
2023-08-12 |
Not clear |
| V M Miller, R A Kenny, J Y Slade, A E Oakley, R N Kalari. Medullary autonomic pathology in carotid sinus hypersensitivity. Neuropathology and applied neurobiology. vol 34. issue 4. 2008-11-18. PMID:18005097. |
csh is highly prevalent in alzheimer's disease (ad), parkinson's disease (pd) and dementia with lewy bodies (dlb); diseases that are associated with variable degeneration of medullary autonomic nuclei which regulate baroreflex responses. |
2008-11-18 |
2023-08-12 |
Not clear |
| Masaru Tateno, Kumiko Utsumi, Seiju Kobayashi, Akira Takahashi, Masaki Saitoh, Hidetoshi Morii, Kazuki Fujii, Masatoshi Teraok. Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18433968. |
in the latest criteria for the clinical diagnosis of dementia with lewy bodies (dlb), supportive features include generalized low uptake on spect/pet perfusion scan with reduced occipital activity. |
2008-11-05 |
2023-08-12 |
human |
| O S Levin, L A Batukaeva, I G Smolentseva, N A Amosov. [Efficacy and safety of memantine in dementia with Lewy bodies]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 108. issue 5. 2008-10-23. PMID:18577956. |
dementia with lewy bodies (dlb) is a progressive disease of the nervous system manifested with dementia, parkinsonism, psychotic and autonomic disturbances. |
2008-10-23 |
2023-08-12 |
Not clear |
| Yasuhiro Kawamoto, Yoshito Kobayashi, Yasuyuki Suzuki, Haruhisa Inoue, Hidekazu Tomimoto, Ichiro Akiguchi, Herbert Budka, L Miguel Martins, Julian Downward, Ryosuke Takahash. Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies. Journal of neuropathology and experimental neurology. vol 67. issue 10. 2008-10-23. PMID:18800009. |
we performed immunohistochemical studies of htra2/omi on brains from patients with alpha-synuclein-related disorders, including pd, dementia with lewy bodies (dlb), and multiple-system atrophy (msa); patients with other neurodegenerative diseases; and controls. |
2008-10-23 |
2023-08-12 |
mouse |
| S N Gomperts, D M Rentz, E Moran, J A Becker, J J Locascio, W E Klunk, C A Mathis, D R Elmaleh, T Shoup, A J Fischman, B T Hyman, J H Growdon, K A Johnso. Imaging amyloid deposition in Lewy body diseases. Neurology. vol 71. issue 12. 2008-10-16. PMID:18794492. |
extrapyramidal motor symptoms precede dementia in parkinson disease (pdd) by many years, whereas dementia occurs early in dementia with lewy bodies (dlb). |
2008-10-16 |
2023-08-12 |
Not clear |
| Kurt A Jellinge. A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18592254. |
sporadic parkinson disease (spd) or brainstem-predominant type of lewy body (lb) disease, and dementia with lewy bodies (dlb), the two most frequent alpha-synucleinopathies, are progressive multisystem neurodegenerative disorders with widespread occurrence of alpha-synuclein (as) deposits in the central, peripheral, and autonomic nervous system. |
2008-10-14 |
2023-08-12 |
human |
| Kurt A Jellinge. A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18592254. |
there is considerable clinical and pathologic overlap between pd (with or without dementia) and dlb, corresponding to braak lb stages 5 and 6, both frequently associated with variable alzheimer-type pathology. |
2008-10-14 |
2023-08-12 |
human |
| Francesca Anzellotti, Laura Bonanni, Eva Iorio, Fabiana Di Baldassarre, Anna D'Andreagiovanni, Daniela Monaco, Astrid Thomas, Marco Onofr. Delayed blink reflex in dementia with Lewy bodies is sensitive to cholinergic modulation. Clinical neuropharmacology. vol 31. issue 4. 2008-10-09. PMID:18670247. |
to assess the possible responsiveness of blink reflex alterations present in dementia with lewy bodies (dlb) to treatment with cholinesterase inhibitors. |
2008-10-09 |
2023-08-12 |
Not clear |
| Brit Mollenhauer, Valerie Cullen, Ilana Kahn, Bryan Krastins, Tiago F Outeiro, Imelda Pepivani, Juliana Ng, Walter Schulz-Schaeffer, Hans A Kretzschmar, Pamela J McLean, Claudia Trenkwalder, David A Sarracino, Jean-Paul Vonsattel, Joseph J Locascio, Omar M A El-Agnaf, Michael G Schlossmache. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18625222. |
in a cross-sectional study of 100 living donors, we examined cell-free csf samples from subjects clinically diagnosed with advanced pd, dementia with lewy bodies (dlb), alzheimer disease (ad), and a group of non-neurodegenerative disease controls (nco). |
2008-10-08 |
2023-08-12 |
human |
| Yasuhiro Nagahama, Tomoko Okina, Norio Suzuki, Minoru Matsud. Cerebral substrates related to impaired performance in the clock-drawing test in dementia with Lewy bodies. Dementia and geriatric cognitive disorders. vol 25. issue 6. 2008-10-07. PMID:18477845. |
to identify the neural correlates of impaired performance in the clock-drawing test (cdt) in patients with dementia with lewy bodies (dlb). |
2008-10-07 |
2023-08-12 |
Not clear |
| Robert Perneczky, Alexander Drzezga, Henning Boecker, Hans Förstl, Alexander Kurz, Peter Häusserman. Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations. Dementia and geriatric cognitive disorders. vol 25. issue 6. 2008-10-07. PMID:18477846. |
to identify the pattern of cerebral hypometabolism in patients with dementia with lewy bodies (dlb) and visual hallucinations (vh). |
2008-10-07 |
2023-08-12 |
Not clear |
| Nicholas MacInnes, Mahmoud M Iravani, Elaine Perry, Margaret Piggott, Robert Perry, Peter Jenner, Clive Ballar. Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18401540. |
dementia with lewy bodies (dlb) accounts for 15-20% of the millions of people worldwide with dementia. |
2008-10-03 |
2023-08-12 |
Not clear |
| Nicholas MacInnes, Mahmoud M Iravani, Elaine Perry, Margaret Piggott, Robert Perry, Peter Jenner, Clive Ballar. Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18401540. |
analysis of post-mortem cortical tissue indicated levels of the alpha-subunit of the 20s proteasome were significantly reduced in dlb cortex, but not alzheimer's, in comparison to control and this reduction correlated with both the severity and duration of dementia. |
2008-10-03 |
2023-08-12 |
Not clear |
| Carles Gaig, Mario Ezquerra, Maria José Martí, Francesc Valldeoriola, Esteban Muñoz, Albert Lladó, Maria Jesús Rey, Adriana Cardozo, José Luis Molinuevo, Eduardo Tolos. Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration. Journal of the neurological sciences. vol 270. issue 1-2. 2008-09-24. PMID:18353371. |
while the prevalence of lrrk2 mutations has been extensively studied in parkinson's disease (pd), limited information is available on the frequency of lrrk2 mutations in dementia with lewy bodies (dlb) and in other pathological conditions associated with these mutations, such as non-specific nigral degeneration without lb, tau-immunopositive neurofibrillary tangle pathology, and ubiquitin-positive neuronal inclusions resembling those observed in a subtype of frontotemporal lobar degeneration (ftld-u). |
2008-09-24 |
2023-08-12 |
Not clear |
| Hsing-Cheng Liu, Chaur-Jong Hu, Yun-Chin Tang, Jan-Gowth Chan. A pilot study for circadian gene disturbance in dementia patients. Neuroscience letters. vol 435. issue 3. 2008-09-24. PMID:18358604. |
dementia with lewy body (dlb) patients had the significantly highest frequency of circadian gene cpg island methylation (35.7%). |
2008-09-24 |
2023-08-12 |
Not clear |
| Hsing-Cheng Liu, Chaur-Jong Hu, Yun-Chin Tang, Jan-Gowth Chan. A pilot study for circadian gene disturbance in dementia patients. Neuroscience letters. vol 435. issue 3. 2008-09-24. PMID:18358604. |
it suggested that epigenetic methylation of circadian gene was more prevalent in dementia patients, especially for the dlb patients. |
2008-09-24 |
2023-08-12 |
Not clear |