| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn A Wyman-Chick, Matthew J Barrett, Michael J Miller, Jennifer L Kuntz, Ella A Chrenka, Rebecca C Rosso. Factors Associated With Increased Health Care Utilization for Patients With Dementia With Lewy Bodies: A Narrative Review. Journal of patient-centered research and reviews. vol 11. issue 2. 2024-07-24. PMID:39044852. |
dementia with lewy bodies (dlb) is associated with greater costs of care relative to other forms of dementia due to higher rates of hospitalization and nursing home placement directly related to neuropsychiatric symptoms, parkinsonism, increased susceptibility to delirium, and elevated rates of caregiver burden. |
2024-07-24 |
2024-07-26 |
Not clear |
| Ying Yang, Xiaoqian Nie, Yajie Wang, Jie Sun, Xiaofei Gao, Jing Zhan. Evolving insights into erythrocytes in synucleinopathies. Trends in neurosciences. 2024-07-23. PMID:39043489. |
synucleinopathies, including parkinson's disease (pd), multiple system atrophy (msa), and dementia with lewy bodies (dlb), are characterized by neuronal loss accompanied by α-synuclein (α-syn) accumulation in the brain. |
2024-07-23 |
2024-07-26 |
Not clear |
| Jose Miguel Flores-Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal-Juarez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M Cortez, Valerie L Sim, Gültekin Tamgüney, Holger Will. Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders. Bioengineering & translational medicine. vol 9. issue 4. 2024-07-22. PMID:39036077. |
synucleinopathies, including parkinson's disease (pd), multiple system atrophy (msa), and dementia with lewy bodies (dlb), are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. |
2024-07-22 |
2024-07-24 |
mouse |
| Kausar Raheel, Qi Rui See, Veronica Munday, Basma Fakhroo, Olga Ivanenko, Marcello Luigi Salvatelli, Carlotta Mutti, Peter J Goadsby, Alessio Delogu, Sharon L Naismith, Phil Holland, Liborio Parrino, K Ray Chaudhuri, Ivana Rosenzwei. Orexin and Sleep Disturbances in Alpha-Synucleinopathies: a Systematic Review. Current neurology and neuroscience reports. 2024-07-20. PMID:39031323. |
sleep disturbances are amongst most frequent non-motor symptoms of parkinson's disease (pd), and they are similarly frequently reported in other alpha-syncleinopathies, such as dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2024-07-20 |
2024-07-24 |
Not clear |
| Kausar Raheel, Qi Rui See, Veronica Munday, Basma Fakhroo, Olga Ivanenko, Marcello Luigi Salvatelli, Carlotta Mutti, Peter J Goadsby, Alessio Delogu, Sharon L Naismith, Phil Holland, Liborio Parrino, K Ray Chaudhuri, Ivana Rosenzwei. Orexin and Sleep Disturbances in Alpha-Synucleinopathies: a Systematic Review. Current neurology and neuroscience reports. 2024-07-20. PMID:39031323. |
in this systematic review, studies investigating orexin and sleep in alpha-synucleinopathies (rapid eye movement (rem) behaviour disorder (rbd), parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy (msa)) were identified using electronic database searches of pubmed, web of science and psychinfo using mesh terms, keywords, and title words such as "alpha-synucleinopathies" and "orexin" and "sleep disturbances". |
2024-07-20 |
2024-07-24 |
Not clear |
| Jonas Folke, Marie Skougaard, Trine-Line Korsholm, Anne-Line Strange Laursen, Lisette Salvesen, Anne-Mette Hejl, Sara Bech, Annemette Løkkegaard, Tomasz Brudek, Sisse Bolm Ditlev, Susana Azna. Assessing serum anti-nuclear antibodies HEp-2 patterns in synucleinopathies. Immunity & ageing : I & A. vol 21. issue 1. 2024-07-18. PMID:39026277. |
this study investigates the presence of antinuclear antibodies (ana) in three primary synucleinopathies - parkinson's disease (pd), multiple system atrophy (msa), and dementia with lewy bodies (dlb), compared to healthy controls. |
2024-07-18 |
2024-07-21 |
Not clear |
| Cui Yang, Guangdong Liu, Xi Chen, Weidong L. Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier. MedComm. vol 5. issue 7. 2024-07-16. PMID:39006764. |
alzheimer's disease (ad), alongside other dementias such as vascular dementia (vad), lewy body dementia (dlb), and frontotemporal dementia (ftd), as well as other neurodegenerative diseases (nds) like parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), and spinocerebellar ataxias (sca), are characterized by specific and non-specific neurodegenerations in central nervous system. |
2024-07-16 |
2024-07-18 |
Not clear |
| David G Coughlin, Karen R MacLeod, John S Middleton, Andrea C Bozoki, James E Galvin, David J Irwin, Carol F Lippa, Irene Litvan, Oscar L Lopez, Sarah Berman, Debby W Tsuang, Cyrus P Zabetian, Lawrence S Honig, Karen S Marder, Jori E Fleisher, Marwan Sabbagh, Dylan Wint, Angela S Taylor, Lynn Bekris, James B Leverenz, Douglas Galask. Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies. Neurology. vol 103. issue 3. 2024-07-16. PMID:39013126. |
the clinical diagnosis of dementia with lewy bodies (dlb) depends on identifying significant cognitive decline accompanied by core features of parkinsonism, visual hallucinations, cognitive fluctuations, and rem sleep behavior disorder (rbd). |
2024-07-16 |
2024-07-19 |
human |
| Claudia Carrarini, Cristina Nardulli, Laura Titti, Francesco Iodice, Francesca Miraglia, Fabrizio Vecchio, Paolo Maria Rossin. Neuropsychological and electrophysiological measurements for diagnosis and prediction of dementia: a review on Machine Learning approach. Ageing research reviews. 2024-07-13. PMID:39002643. |
the purpose of this review was to discuss the current ml application in the field of neuropsychology and electrophysiology, exploring its results in both prediction and diagnosis for different forms of dementia, such as alzheimer's disease (ad), vascular dementia (vad), dementia with lewy bodies (dlb), and frontotemporal dementia (ftd). |
2024-07-13 |
2024-07-16 |
Not clear |
| Megha Murthy, Katherine Fodder, Yasuo Miki, Naiomi Rambarack, Eduardo De Pablo Fernandez, Lasse Pihlstrøm, Jonathan Mill, Thomas T Warner, Tammaryn Lashley, Conceição Bettencour. DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson's disease, and progressive supranuclear palsy: a cross-comparative investigation. Acta neuropathologica. vol 148. issue 1. 2024-07-12. PMID:38995454. |
clinical presentations of msa overlap with other parkinsonian disorders, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and progressive supranuclear palsy (psp), posing challenges in early diagnosis. |
2024-07-12 |
2024-07-14 |
Not clear |
| Weijie Zhai, Anguo Zhao, Chunxiao Wei, Yanjiao Xu, Xinran Cui, Yan Zhang, Lingjie Meng, Li Su. Undetected Association Between Fatty Acids and Dementia with Lewy Bodies: A Bidirectional Two-Sample Mendelian Randomization Study. Journal of Alzheimer's disease : JAD. 2024-07-12. PMID:38995791. |
although observational studies indicated connections between fatty acids (fas) and alzheimer's disease and dementia, uncertainty persists regarding how these relationships extend to dementia with lewy bodies (dlb). |
2024-07-12 |
2024-07-15 |
Not clear |
| Melissa Scholefield, Stephanie J Church, Jingshu Xu, Garth J S Coope. Metallomic analysis of brain tissues distinguishes between cases of dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease dementia. Frontiers in neuroscience. vol 18. 2024-07-11. PMID:38988772. |
dementia with lewy bodies (dlb) can be difficult to distinguish from alzheimer's disease (ad) and parkinson's disease dementia (pdd) at different stages of its progression due to some overlaps in the clinical and neuropathological presentation of these conditions compared with dlb. |
2024-07-11 |
2024-07-13 |
Not clear |
| Kasandra Scholz, Rudradip Pattanayak, Ekkatine Roschonporn, Frank Sanders Pair, Amber Nobles, Talene A Yacoubia. Rab27b promotes lysosomal function and alpha-synuclein clearance in neurons. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979346. |
alpha-synuclein (αsyn) is the key pathogenic protein implicated in synucleinopathies including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2024-07-09 |
2024-07-12 |
mouse |
| Amanda Attreed, Louisa R Morand, Dimity C Pond, Joachim P Sturmber. The Clinical Role of Heart Rate Variability Assessment in Cognitively Impaired Patients and Its Applicability in Community Care Settings: A Systematic Review of the Literature. Cureus. vol 16. issue 6. 2024-07-08. PMID:38975380. |
the literature identified that the brain regions controlling hrv are also those affected by dementias of alzheimer's type (ad) and lewy body types (dlb). |
2024-07-08 |
2024-07-11 |
Not clear |
| Nolwazi Z Gcwensa, Dreson L Russell, Khaliah Y Long, Charlotte F Brzozowski, Xinran Liu, Karen L Gamble, Rita M Cowell, Laura A Volpicelli-Dale. Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala. Neurobiology of disease. 2024-07-07. PMID:38972360. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are characterized by neuronal α-synuclein (α-syn) inclusions termed lewy pathology, which are abundant in the amygdala. |
2024-07-07 |
2024-07-11 |
mouse |
| Qiuyi Chen, Chengcheng Zhang, Shiyang Wu, Yiwei He, Yuhan Liu, Libin Zheng, Bin Li, Guiyou Liu, Lu Li. Genetic evidence for causal association between migraine and dementia: a mendelian randomization study. BMC medical genomics. vol 17. issue 1. 2024-07-06. PMID:38970023. |
this study employed bidirectional two-sample mendelian randomization (mr) to investigate the potential causal relationship between migraine and dementia and its subtypes: alzheimer's disease (ad), vascular dementia (vad), frontotemporal dementia (ftd), and dementia with lewy bodies (dlb). |
2024-07-06 |
2024-07-08 |
Not clear |
| M A Adom, W N Hahn, T D McCaffery, T E Moors, X Zhang, P Svenningsson, D J Selkoe, S Fanning, S Nube. Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism. Neurobiology of disease. 2024-07-06. PMID:38971480. |
impaired lipid metabolism is a risk factor for parkinson's disease (pd) and dementia with lewy bodies (dlb) and can shift the physiological α-synuclein (αs) tetramer-monomer (t:m) ratio toward aggregation prone monomers. |
2024-07-06 |
2024-07-12 |
mouse |
| Luisa Maria Gatzemeier, Franc Meyer, Tiago Fleming Outeir. Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies. Chembiochem : a European journal of chemical biology. 2024-07-05. PMID:38965889. |
a protein of high interest in the field of biomedicine is alpha-synuclein (asyn), a protein deeply associated with several devastating neurodegenerative disorders such as parkinson's disease (pd), dementia with lewy bodies (dlb), or multiple systems atrophy (msa). |
2024-07-05 |
2024-07-11 |
Not clear |
| Agathe Vrillon, Olivier Bousiges, Karl Götze, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Nathalie Philippi, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Benjamin Cretin, Frédéric Blanc, Claire Paque. Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-07-04. PMID:38961441. |
however, their performance for positive and differential diagnosis of dementia with lewy bodies (dlb) in clinical settings is still uncertain. |
2024-07-04 |
2024-07-10 |
Not clear |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
in this study, we developed toxic tau conformation-specific monoclonal antibody-2 (ttcm2), which selectively recognized pathological tau aggregates in brain tissues from patients with ad, dementia with lewy bodies (dlb), and progressive supranuclear palsy (psp). |
2024-07-03 |
2024-07-10 |
mouse |