| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huixin Shen, Yueyi Yu, Jing Wang, Yuting Nie, Yi Tang, Miao Q. Plasma lipidomic signatures of dementia with Lewy bodies revealed by machine learning, and compared to alzheimer's disease. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-16. PMID:39407312. |
dementia with lewy bodies (dlb) is a complex neurodegenerative disorder that often overlaps clinically with alzheimer's disease (ad), presenting challenges in accurate diagnosis and underscoring the need for novel biomarkers. |
2024-10-16 |
2024-10-18 |
Not clear |
| Anna Planas-Ballvé, Jose Rios, Mireia Gea, Neus Rabaneda-Lombarte, Lourdes Ispierto, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vila. Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-16. PMID:39407323. |
diagnosis of dementia with lewy bodies (dlb) is challenging, especially in the earlier stages of the disease, owing to the clinical overlap with other neurodegenerative diseases such as alzheimer's (ad) and parkinson's disease (pd). |
2024-10-16 |
2024-10-18 |
Not clear |
| Cuilv Liang, Yaping Chen, Peihong Wang, Yin Zhan. Relationship of urate-lowering drugs with cognition and dementia: A Mendelian randomization and observational study. Archives of gerontology and geriatrics. vol 129. 2024-10-15. PMID:39405667. |
two-simple mendelian randomization (mr) and multivariable mr (mvmr) analyses were conducted to evaluate the causal associations of ulds for all common types of dementia, including alzheimer's disease (ad), vascular dementia (vd), frontotemporal dementia (ftd), and dementia with lewy bodies (dlb). |
2024-10-15 |
2024-10-18 |
Not clear |
| Cuilv Liang, Yaping Chen, Peihong Wang, Yin Zhan. Relationship of urate-lowering drugs with cognition and dementia: A Mendelian randomization and observational study. Archives of gerontology and geriatrics. vol 129. 2024-10-15. PMID:39405667. |
this study indicates that ulds may not be related to an increase or decrease risk of cognition function and dementia, including all common types of dementia (ad, vd, ftd, and dlb). |
2024-10-15 |
2024-10-18 |
Not clear |
| Wei Zhou, Samuel Daniels, Vijay Singh, Marissa Menard, Martha L Escobar Galvis, Hong-Yuan Ch. α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice. Neurobiology of disease. 2024-10-15. PMID:39406290. |
abnormal accumulation of insoluble α-synuclein (α-syn) inclusions in neurons, neurites, and glial cells is the defining neuropathology of synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy. |
2024-10-15 |
2024-10-18 |
mouse |
| Kathryn A Wyman-Chick, Tanis J Ferman, Daniel Weintraub, Melissa J Armstrong, Bradley F Boeve, Ece Bayram, Ella Chrenka, Matthew J Barret. Distinguishing Prodromal Dementia With Lewy Bodies From Prodromal Alzheimer Disease: A Longitudinal Study. Neurology. Clinical practice. vol 15. issue 1. 2024-10-14. PMID:39399551. |
it can be clinically challenging to differentiate dementia with lewy bodies (dlb) and alzheimer disease (ad). |
2024-10-14 |
2024-10-16 |
Not clear |
| Junyun Wu, Jia Nan Wu, Tao Chen, Jing Cai, Reng Re. Protein Aggregation and its Affecting Mechanisms in Neurodegenerative Diseases. Neurochemistry international. 2024-10-13. PMID:39396709. |
protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (nds), including the formation of amyloid β (aβ) and tau neurofibrillary tangles in alzheimer's disease, as well as α-synuclein (α-syn) aggregates in parkinson's disease, parkinson's disease-related dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2024-10-13 |
2024-10-16 |
Not clear |
| Xi Li, Linwei Yu, Xikai Liu, Tianyi Shi, Yu Zhang, Yushuo Xiao, Chen Wang, Liangliang Song, Ning Li, Xinran Liu, Yuchen Chen, Robert B Petersen, Xiang Cheng, Weikang Xue, Yanxun V Yu, Li Xu, Ling Zheng, Hong Chen, Kun Huan. β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein. Nature communications. vol 15. issue 1. 2024-10-10. PMID:39384788. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. |
2024-10-10 |
2024-10-12 |
caenorhabditis_elegans |
| Vincent Couture, Jean-François Carmel, Katerine Rousseau, Geneviève Létourneau, Doris Clerc, Philippe Huot, Marie-France Forget, Quoc Dinh Nguyen, Richard Camicioli, Philippe Desmarai. Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis. Movement disorders clinical practice. 2024-10-10. PMID:39385552. |
alpha-synucleinopathies, such as parkinson's disease (pd), parkinson's disease dementia (pdd), and dementia with lewy bodies (dlb), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. |
2024-10-10 |
2024-10-12 |
Not clear |
| Deepmala Nandanwar, Daniel D Truon. Multiple system atrophy: Diagnostic challenges and a proposed diagnostic algorithm. Clinical parkinsonism & related disorders. vol 11. 2024-10-09. PMID:39381077. |
it shares a common pathological origin with parkinson's disease (pd) and lewy body dementia (dlb) and they are collectively grouped as "synucleinopathies." |
2024-10-09 |
2024-10-11 |
Not clear |
| Liam Horan-Portelance, Michiyo Iba, Dominic J Acri, J Raphael Gibbs, Eliezer Masliah, Mark R Cookso. Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease. bioRxiv : the preprint server for biology. 2024-10-07. PMID:39372781. |
one of the unifying pathological hallmarks of parkinson's disease (pd) and dementia with lewy bodies (dlb) is the presence of misfolded, aggregated, and often phosphorylated forms of the protein α-synuclein in neurons. |
2024-10-07 |
2024-10-09 |
mouse |
| Alice Chen-Plotkin, George Kannarkat, Rebecca Zack, R Tyler Skrinak, James Morley, Roseanne Davila-Rivera, Sanaz Arezoumandan, Kelvin Luk, David Wolk, Daniel Weintraub, Thomas Tropea, Edward Lee, Sharon Xie, Ganesh Chandrasekaran, Virginia Lee, David Irwin, Rizwan Akhtar, Katherine Dorfma. Alpha-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies. Research square. 2024-10-07. PMID:39372921. |
aggregation of misfolded alpha-synuclein (asyn) within the brain is the pathologic hallmark of lewy body diseases (lbd), including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2024-10-07 |
2024-10-09 |
human |
| Ryuji Yajima, Yasuharu Saito, Takeshi Sato, Akiko Suzuki, Satoshi Narus. Cognitive Impairment Caused by Isolated Adrenocorticotropic Hormone Deficiency Mimicking Dementia with Lewy Bodies. Internal medicine (Tokyo, Japan). 2024-10-06. PMID:39370251. |
a 73-year-old man who presented with nonspecific general symptoms and cognitive impairment was initially diagnosed with mild cognitive impairment due to dementia with lewy bodies (dlb) based on a reduced blood flow in the parietal and occipital lobes on single-photon emission computed tomography (spect) imaging. |
2024-10-06 |
2024-10-09 |
Not clear |
| Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegaw. Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies. Scientific reports. vol 14. issue 1. 2024-10-02. PMID:39358446. |
our previous cryogenic electron microscopy (cryoem) analysis showed that the core structures of α-synuclein filaments accumulated in brains of patients diagnosed with dementia with lewy bodies (dlb) and multiple system atrophy (msa) patients are different. |
2024-10-02 |
2024-10-05 |
Not clear |
| S G Choi, T Tittle, R Barot, D Betts, J Gallagher, J H Kordower, Y Chu, B A Killinge. Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345456. |
primary synucleinopathies, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), are neurodegenerative disorders with some shared clinical and pathological features. |
2024-09-30 |
2024-10-02 |
Not clear |
| Shannon D Donofry, Claire E O'Hanlo. Measuring Cognition in Clinical Trials in Parkinson's Disease, Dementia with Lewy Bodies, and Related Disorders: Roundtable Proceedings and Roadmap for Research. Rand health quarterly. vol 11. issue 4. 2024-09-30. PMID:39346105. |
emerging research suggests that parkinson's disease (pd) and dementia with lewy bodies (dlb) share underlying pathology and may represent a single, biologically defined disease spectrum. |
2024-09-30 |
2024-10-02 |
Not clear |
| Lucy L Gibson, Christoph Mueller, Robert Stewart, Dag Aarslan. Characteristics associated with progression to probable dementia with Lewy bodies in a cohort with very late-onset psychosis. Psychological medicine. 2024-09-26. PMID:39324394. |
very late-onset psychosis (vlop) is associated with higher rates of dementia but the proportion who develop dementia with lewy bodies (dlb) is unknown. |
2024-09-26 |
2024-09-28 |
Not clear |
| Lucy L Gibson, Christoph Mueller, Robert Stewart, Dag Aarslan. Characteristics associated with progression to probable dementia with Lewy bodies in a cohort with very late-onset psychosis. Psychological medicine. 2024-09-26. PMID:39324394. |
we aimed to identify individuals with vlop who develop dementia and dlb and characterize the risk factors for progression. |
2024-09-26 |
2024-09-28 |
Not clear |
| Kazuki Miyaue, Hiroki Ison. A Case Report of Probable Dementia With Lewy Bodies Diagnosed Through Repeated Episodes of Depressed Consciousness. Cureus. vol 16. issue 8. 2024-09-24. PMID:39310588. |
this case report details the diagnostic challenges of an 84-year-old male with unrecognized dementia with lewy bodies (dlb) who presented to the emergency department (ed) with episodes of unresponsiveness and depressed consciousness. |
2024-09-24 |
2024-09-26 |
Not clear |
| Kazuki Miyaue, Hiroki Ison. A Case Report of Probable Dementia With Lewy Bodies Diagnosed Through Repeated Episodes of Depressed Consciousness. Cureus. vol 16. issue 8. 2024-09-24. PMID:39310588. |
this case underscores the importance of considering dlb in patients with unexplained recurrent depressed consciousness and highlights the importance of clarifying the etiologies of dementia. |
2024-09-24 |
2024-09-26 |
Not clear |